Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration

Journal of Biological Chemistry

Volumn 282, Issue 13, 2007, Pages 9740-9747

  Garcia Saez, Isabel ^a   DeBonis, Salvatore ^a   Lopez, Roman ^b   Trucco, Fernando ^b   Rousseau, Bernard ^b   Thuéry, Pierre ^b   Kozielski, Frank ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC INHIBITORS; CELL-BASED ASSAYS;

CELL DEATH; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENANTIOMERS; GROWTH KINETICS; PROTEINS; TUMORS;

MAMMALS;

ADENOSINE TRIPHOSPHATASE; ANTIMITOTIC AGENT; KINESIN; MONASTROL; PROTEIN EG5; UNCLASSIFIED DRUG; KIF11 PROTEIN, HUMAN; PYRIMIDINE DERIVATIVE; THIOKETONE;

ARTICLE; CORRELATION ANALYSIS; DRUG POTENCY; DRUG PROTEIN BINDING; ENANTIOMER; ENZYME ACTIVITY; IC 50; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; CHEMISTRY; DRUG ANTAGONISM; HUMAN; PROTEIN CONFORMATION; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ANTIMITOTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINESIN; PROTEIN CONFORMATION; PYRIMIDINES; STEREOISOMERISM; THIONES;

EID: 34248158214     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608883200     Document Type: Article

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