Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

Chemistry and Biology

Volumn 9, Issue 9, 2002, Pages 989-996

  Maliga, Zoltan ^a   Kapoor, Tarun M ^d   Mitchison, Timothy J ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b Harvard Inst Chem and Cell Biol   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; EG5 PROTEIN, XENOPUS; ENZYME INHIBITOR; FLUORESCENT DYE; KINESIN; MONASTROL; PYRIMIDINE DERIVATIVE; THIOKETONE; XENOPUS PROTEIN;

ALLOSTERISM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CERCOPITHECUS; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; HUMAN; HYDROLYSIS; KIDNEY; KINETICS; METABOLISM; MICROTUBULE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SPECTROFLUOROMETRY; STEREOISOMERISM;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; HYDROLYSIS; KIDNEY; KINESIN; KINETICS; MICROTUBULES; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM; THIONES; XENOPUS PROTEINS;

ANIMALIA; CERCOPITHECUS; XENOPUS LAEVIS;

EID: 0036752261     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(02)00212-0     Document Type: Article

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