메뉴 건너뛰기




Volumn , Issue , 2009, Pages 535-558

Lamotrigine

Author keywords

Drug interactions; Gilbert's syndrome and uridine diphosphate glucuronyl transferase (UGT) activity; Lamotrigine; Lamotrigine protection against local cerebral ischaemia; Lamotrigine effects on co administered drug pharmacokinetics; Mechanism of action; Monotherapy studies in newly diagnosed epilepsy; Quality of life assessments

Indexed keywords


EID: 77953188558     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444316667.ch43     Document Type: Chapter
Times cited : (8)

References (260)
  • 1
    • 0015367889 scopus 로고
    • The epileptogenic action of Na-folate in the rat
    • Hommes OR, Obbens EAMT. The epileptogenic action of Na-folate in the rat. J Neurol Sci 1972; 16: 271-281.
    • (1972) J Neurol Sci , vol.16 , pp. 271-281
    • Hommes, O.R.1    Obbens, E.A.M.T.2
  • 2
    • 0024535118 scopus 로고
    • Effects of lamotrigine on electrically induced afterdischarge duration in anaesthetised rat, dog, and marmoset
    • Wheatley PL. Miller AA. Effects of lamotrigine on electrically induced afterdischarge duration in anaesthetised rat, dog, and marmoset. Epilepsia 1989; 30: 34-40.
    • (1989) Epilepsia , vol.30 , pp. 34-40
    • Wheatley, P.L.1    Miller, A.A.2
  • 3
    • 0000390033 scopus 로고
    • Lamotrigine
    • In: Meldrum BS, Porter RJ (eds), London: John Libbey
    • Miller AA, Sawyer DA, Ruth B, et al. Lamotrigine. In: Meldrum BS, Porter RJ (eds). New Anticonvulsant Drugs. London: John Libbey, 1986: 165-177.
    • (1986) New Anticonvulsant Drugs , pp. 165-177
    • Miller, A.A.1    Sawyer, D.A.2    Ruth, B.3
  • 4
    • 0022891177 scopus 로고
    • Pharmacological studies on lamotrigine: a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats
    • Miller AA, Wheatley P. Sawyer DA, et al. Pharmacological studies on lamotrigine: a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats. Epilepsia 1986; 27: 483-489.
    • (1986) Epilepsia , vol.27 , pp. 483-489
    • Miller, A.A.1    Wheatley, P.2    Sawyer, D.A.3
  • 5
    • 0027191022 scopus 로고
    • Excitatory amino acid antagonists Lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat
    • Smith SE, Al-Zubaidy ZA, Chapman AG, et al. Excitatory amino acid antagonists. Lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. Epilepsy Res 1993; 15: 101-111.
    • (1993) Epilepsy Res , vol.15 , pp. 101-111
    • Smith, S.E.1    Al-Zubaidy, Z.A.2    Chapman, A.G.3
  • 6
    • 0030835981 scopus 로고    scopus 로고
    • Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin
    • Dalby NO, Nielsen EB. Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. Epilepsy Res 1997; 28: 63-72.
    • (1997) Epilepsy Res , vol.28 , pp. 63-72
    • Dalby, N.O.1    Nielsen, E.B.2
  • 7
    • 0031000788 scopus 로고    scopus 로고
    • Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamoingine, vigabatrin, tiagabine, gahapentin, and topiramate against human absence seizures
    • Hosford DA, Wang Y. Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamoingine, vigabatrin, tiagabine, gahapentin, and topiramate against human absence seizures. Epilepsia 1997; 38: 408-414.
    • (1997) Epilepsia , vol.38 , pp. 408-414
    • Hosford, D.A.1    Wang, Y.2
  • 8
    • 0031877925 scopus 로고    scopus 로고
    • Effects of lamotrigine and conventional antiepileptic drugs on amygdala-and hippocampal-kindled seizures in rats
    • Otsuki K, Morimoto K, Sato K, et al. Effects of lamotrigine and conventional antiepileptic drugs on amygdala-and hippocampal-kindled seizures in rats. Epilepsy Res 1998; 31: 101-112.
    • (1998) Epilepsy Res , vol.31 , pp. 101-112
    • Otsuki, K.1    Morimoto, K.2    Sato, K.3
  • 9
    • 0034890813 scopus 로고    scopus 로고
    • Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
    • Halonen T, Nissinen J, Pitkanen A. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat. Epilepsy Res 2001; 46: 205-223.
    • (2001) Epilepsy Res , vol.46 , pp. 205-223
    • Halonen, T.1    Nissinen, J.2    Pitkanen, A.3
  • 10
    • 0028535070 scopus 로고
    • The role of glutamate in epilepsy and other CNS disorders
    • Meldrum BS. The role of glutamate in epilepsy and other CNS disorders. Neurology 1994; 44(Suppl. 8): S14-S23.
    • (1994) Neurology , vol.44 , Issue.SUPPL. 8
    • Meldrum, B.S.1
  • 11
    • 0028959228 scopus 로고
    • Cerebroprotective effect of lamotrigine afer focal ischemia in rats
    • Smith SE, Meldrum BS. Cerebroprotective effect of lamotrigine afer focal ischemia in rats. Stroke 1995; 26: 117-122.
    • (1995) Stroke , vol.26 , pp. 117-122
    • Smith, S.E.1    Meldrum, B.S.2
  • 12
    • 41649091371 scopus 로고    scopus 로고
    • Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy
    • Papazisis G, Kallaras K, Kaiki-Astara A, et al. Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. Int J Neuropsychopharmacol 2008; 11: 321-329.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 321-329
    • Papazisis, G.1    Kallaras, K.2    Kaiki-Astara, A.3
  • 13
    • 0026443902 scopus 로고
    • An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
    • Cheung H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992; 13: 107-112.
    • (1992) Epilepsy Res , vol.13 , pp. 107-112
    • Cheung, H.1    Kamp, D.2    Harris, E.3
  • 14
    • 0027507511 scopus 로고
    • Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG I mouse neuroblastoma cells
    • Lang DG, Wang CM, Cooper BP. Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG I mouse neuroblastoma cells. J Pharmacol Exp Ther 1993; 266: 829-835.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 829-835
    • Lang, D.G.1    Wang, C.M.2    Cooper, B.P.3
  • 15
    • 0027310109 scopus 로고
    • Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamnictal) using primary neuroglial cultures from rat cortex
    • Lees G, Leach MJ. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamnictal) using primary neuroglial cultures from rat cortex. Brain Res 1993; 612: 190-199.
    • (1993) Brain Res , vol.612 , pp. 190-199
    • Lees, G.1    Leach, M.J.2
  • 16
    • 0002179111 scopus 로고
    • Lamotrigine blocks voltage-dependent Na currents in a voltage-dependent manner with a small use-dependent component (abstract)
    • Mutoh K, Dichter MA. Lamotrigine blocks voltage-dependent Na currents in a voltage-dependent manner with a small use-dependent component (abstract). Epilepsia 1993; 34(Suppl. 6): 87.
    • (1993) Epilepsia , vol.34 , Issue.SUPPL. 6 , pp. 87
    • Mutoh, K.1    Dichter, M.A.2
  • 17
    • 0029432189 scopus 로고
    • Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters
    • Waldmeier PC, Baumann PA, Wicki P, et al. Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters. Neurology 1995; 45: 1907-1913.
    • (1995) Neurology , vol.45 , pp. 1907-1913
    • Waldmeier, P.C.1    Baumann, P.A.2    Wicki, P.3
  • 18
    • 0033842216 scopus 로고    scopus 로고
    • The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro
    • Cunningham MO, Jones RS. The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. Neuropharmacology 2000; 39: 2139-2146.
    • (2000) Neuropharmacology , vol.39 , pp. 2139-2146
    • Cunningham, M.O.1    Jones, R.S.2
  • 19
    • 0026644603 scopus 로고
    • Excitatory amino acids in epilepsy and potential novel therapies
    • Meldrum BS. Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res 1992; 12: 189-196.
    • (1992) Epilepsy Res , vol.12 , pp. 189-196
    • Meldrum, B.S.1
  • 21
    • 0030454477 scopus 로고    scopus 로고
    • Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones
    • Wang S-J, Huang C-C, Hsu K-S, et al. Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones. Neuroreport 1996; 7: 3037-3040.
    • (1996) Neuroreport , vol.7 , pp. 3037-3040
    • Wang, S.-J.1    Huang, C.-C.2    Hsu, K.-S.3
  • 22
    • 0029075471 scopus 로고
    • Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na channels and with native Na channels in rat hipoccampal neurones
    • Xie X, Lancaster B, Peakman T, et al. Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na channels and with native Na channels in rat hipoccampal neurones. Pflugers Arch 1995; 430: 437-446.
    • (1995) Pflugers Arch , vol.430 , pp. 437-446
    • Xie, X.1    Lancaster, B.2    Peakman, T.3
  • 23
    • 0022900644 scopus 로고
    • Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II Neurochemical studies on the mechanism of action
    • Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 1986; 27: 490-497.
    • (1986) Epilepsia , vol.27 , pp. 490-497
    • Leach, M.J.1    Marden, C.M.2    Miller, A.A.3
  • 24
    • 35048900124 scopus 로고    scopus 로고
    • Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures
    • Tomczyk T, Haberek G, Zuchora B, et al. Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures. Pharmacol Rep 2007; 59: 462-466.
    • (2007) Pharmacol Rep , vol.59 , pp. 462-466
    • Tomczyk, T.1    Haberek, G.2    Zuchora, B.3
  • 25
    • 0031783746 scopus 로고    scopus 로고
    • Modulation of calcium and potassium currents by lamotrigine
    • Grunze H, von Wegerer J, Greene RW, et al. Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 1998; 38: 131-138.
    • (1998) Neuropsychobiology , vol.38 , pp. 131-138
    • Grunze, H.1    von Wegerer, J.2    Greene, R.W.3
  • 26
    • 0031788811 scopus 로고    scopus 로고
    • On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89
    • Stefani A, Hainsworth AH, Spadoni F, et al. On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br J Pharmacol 1998; 125: 1058-1064.
    • (1998) Br J Pharmacol , vol.125 , pp. 1058-1064
    • Stefani, A.1    Hainsworth, A.H.2    Spadoni, F.3
  • 27
    • 0030594562 scopus 로고    scopus 로고
    • Lamotrigine inhibits Ca currents in cortical neurons: functional implication
    • Stefani A, Spadoni F, Sinicalchi A, et al. Lamotrigine inhibits Ca currents in cortical neurons: functional implication. Eur J Pharmacol 1996; 307: 113-116.
    • (1996) Eur J Pharmacol , vol.307 , pp. 113-116
    • Stefani, A.1    Spadoni, F.2    Sinicalchi, A.3
  • 28
    • 0035919746 scopus 로고    scopus 로고
    • Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity
    • Wang SJ, Sihra TS, Gean PW. Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity. Neuroreport 2001; 12: 2255-2258.
    • (2001) Neuroreport , vol.12 , pp. 2255-2258
    • Wang, S.J.1    Sihra, T.S.2    Gean, P.W.3
  • 29
    • 0036064909 scopus 로고    scopus 로고
    • Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine
    • Zona C, Tancredi V, Longone P, et al. Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine. Epilepsia 2002; 43: 685-690.
    • (2002) Epilepsia , vol.43 , pp. 685-690
    • Zona, C.1    Tancredi, V.2    Longone, P.3
  • 30
    • 0026304850 scopus 로고
    • Neurochemical and behavioral aspects of lamotrigine
    • Leach MJ, Baxiter MG, Critchley MAE. Neurochemical and behavioral aspects of lamotrigine. Epilepsia 1991; 32(Suppl. 2): 4-8.
    • (1991) Epilepsia , vol.32 , Issue.SUPPL. 2 , pp. 4-8
    • Leach, M.J.1    Baxiter, M.G.2    Critchley, M.A.E.3
  • 31
    • 0033811658 scopus 로고    scopus 로고
    • Effects of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices
    • Langosch JM, Zhou XY, Frick A, et al. Effects of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices. Epilepsia 2000; 41: 1102-1106.
    • (2000) Epilepsia , vol.41 , pp. 1102-1106
    • Langosch, J.M.1    Zhou, X.Y.2    Frick, A.3
  • 32
    • 0033646748 scopus 로고    scopus 로고
    • New insights into the mechanisms and sites of action of lamotrigine
    • Langosch JM, Zhou XY, Grunze H, et al. New insights into the mechanisms and sites of action of lamotrigine. Neuropsychobiology 2000; 42(Suppl. 1): 26-27.
    • (2000) Neuropsychobiology , vol.42 , Issue.SUPPL. 1 , pp. 26-27
    • Langosch, J.M.1    Zhou, X.Y.2    Grunze, H.3
  • 33
    • 0031414052 scopus 로고    scopus 로고
    • Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in?
    • Coulter D. Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? J Child Neurol 1997; 12(Suppl. 1): S2-S9.
    • (1997) J Child Neurol , vol.12 , Issue.SUPPL. 1
    • Coulter, D.1
  • 34
    • 0036321057 scopus 로고    scopus 로고
    • Pharmacologic upregulation of hchannels reduces the excitability of pyramidal neurone dendrites
    • Poolos NP, Miglore M, Johnston D. Pharmacologic upregulation of hchannels reduces the excitability of pyramidal neurone dendrites. Nature Neurosci 2002; 5: 767-774.
    • (2002) Nature Neurosci , vol.5 , pp. 767-774
    • Poolos, N.P.1    Miglore, M.2    Johnston, D.3
  • 35
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW. Neuropharmacology of quinolinic and kynurenic acids. Pharmacological Rev 1993; 45: 309-379.
    • (1993) Pharmacological Rev , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 36
    • 0025185844 scopus 로고
    • Effect of NMDA-and strychnineinsensitive glycine site antagonists on NMDA-mediated convulsions and learning
    • Chiamulera C, Costa S, Reggiani A. Effect of NMDA-and strychnineinsensitive glycine site antagonists on NMDA-mediated convulsions and learning. Psychopharmacology 1990; 102: 551-552.
    • (1990) Psychopharmacology , vol.102 , pp. 551-552
    • Chiamulera, C.1    Costa, S.2    Reggiani, A.3
  • 37
    • 0021186590 scopus 로고
    • Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid
    • Foster AC, Vezzani A, French ED, et al. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neurosci Lett 1984; 48: 273-278.
    • (1984) Neurosci Lett , vol.48 , pp. 273-278
    • Foster, A.C.1    Vezzani, A.2    French, E.D.3
  • 38
    • 0025110137 scopus 로고
    • 7-Chlorokynurenic acid, a strychnineinsensitive glycine receptor antagonist, inhibits limbic seizure kindling
    • Croucher MJ, Bradford HF. 7-Chlorokynurenic acid, a strychnineinsensitive glycine receptor antagonist, inhibits limbic seizure kindling. Neurosci Lett 1990; 118: 29-32.
    • (1990) Neurosci Lett , vol.118 , pp. 29-32
    • Croucher, M.J.1    Bradford, H.F.2
  • 39
    • 33745119043 scopus 로고    scopus 로고
    • Enhancement of brain kynurenic acid production by anticonvulsants-novel mechanism of antiepileptic activity?
    • Kocki T, Wielosz M, Turski WA, et al. Enhancement of brain kynurenic acid production by anticonvulsants-novel mechanism of antiepileptic activity?. Eur J Pharmacol 2006; 541: 147-151.
    • (2006) Eur J Pharmacol , vol.541 , pp. 147-151
    • Kocki, T.1    Wielosz, M.2    Turski, W.A.3
  • 40
    • 0032903194 scopus 로고    scopus 로고
    • Pharmacokinetics of lamotrigine in children in the absence of other antiepileptic drugs
    • Chen C, Casale EJ, Duncan B, et al. Pharmacokinetics of lamotrigine in children in the absence of other antiepileptic drugs. Pharmacotherapy 1999; 19: 437-441.
    • (1999) Pharmacotherapy , vol.19 , pp. 437-441
    • Chen, C.1    Casale, E.J.2    Duncan, B.3
  • 41
    • 0029816665 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy
    • Eriksson A-S, Hoppu K, Nergardh A, et al. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia 1996; 37: 769-773.
    • (1996) Epilepsia , vol.37 , pp. 769-773
    • Eriksson, A.-S.1    Hoppu, K.2    Nergardh, A.3
  • 42
    • 0023574269 scopus 로고
    • Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy
    • Jawad S, Yuen WC, Peck AW, et al. Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy. Epilepsy Res 1987; 1: 194-201.
    • (1987) Epilepsy Res , vol.1 , pp. 194-201
    • Jawad, S.1    Yuen, W.C.2    Peck, A.W.3
  • 43
    • 0029983078 scopus 로고    scopus 로고
    • Influence of concurrent antiepileptic medication on the pharmacokinetics of lamotrigine as add-on therapy in epileptic children
    • Vauzelle-Kervroëdan F, Rey E, Cieuta C, et al. Influence of concurrent antiepileptic medication on the pharmacokinetics of lamotrigine as add-on therapy in epileptic children. Br J Clin Pharmacol 1996; 41: 325-330.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 325-330
    • Vauzelle-Kervroëdan, F.1    Rey, E.2    Cieuta, C.3
  • 44
    • 0032951152 scopus 로고    scopus 로고
    • Lamotrigine serum con centrationto-dose ratio: influence of age and concomitant antiepileptic drugs and dosage implications
    • Armijo J, Bravo J, Cuadrado A, et al. Lamotrigine serum con centrationto-dose ratio: influence of age and concomitant antiepileptic drugs and dosage implications. Ther Drug Monit 1999; 21: 182-190.
    • (1999) Ther Drug Monit , vol.21 , pp. 182-190
    • Armijo, J.1    Bravo, J.2    Cuadrado, A.3
  • 45
    • 0031443389 scopus 로고    scopus 로고
    • Lamotrigine plasma concentrations in children and adults: influence of age and associated therapy
    • Battino D, Croci D, Granata T, et al. Lamotrigine plasma concentrations in children and adults: influence of age and associated therapy. Ther Drug Monit 1997; 19: 620-627.
    • (1997) Ther Drug Monit , vol.19 , pp. 620-627
    • Battino, D.1    Croci, D.2    Granata, T.3
  • 46
    • 0023475125 scopus 로고
    • Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans
    • Cohen AF, Land GS, Breimer DD, et al. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther 1987; 42: 535-541.
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 535-541
    • Cohen, A.F.1    Land, G.S.2    Breimer, D.D.3
  • 47
    • 0033767336 scopus 로고    scopus 로고
    • Add-on lamotrigine treatment in children and young adults with severe partial epilepsy: an open, prospective, long-term study
    • Parmeggiani L, Belmonte A, Ferrari AR, et al. Add-on lamotrigine treatment in children and young adults with severe partial epilepsy: an open, prospective, long-term study. J Child Neurol 2000; 15: 671-674.
    • (2000) J Child Neurol , vol.15 , pp. 671-674
    • Parmeggiani, L.1    Belmonte, A.2    Ferrari, A.R.3
  • 48
    • 0027440140 scopus 로고
    • Lamotrigine clinical pharmacokinctics
    • Rambeck B, Wolf P. Lamotrigine clinical pharmacokinctics. Clin Pharmacokinet 1993; 25: 433-443.
    • (1993) Clin Pharmacokinet , vol.25 , pp. 433-443
    • Rambeck, B.1    Wolf, P.2
  • 49
    • 0026005583 scopus 로고
    • Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy
    • Ramsay RE, Pellock IM, Garnett WR, et al. Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy. Epilepsy Res 1991; 10: 191-200.
    • (1991) Epilepsy Res , vol.10 , pp. 191-200
    • Ramsay, R.E.1    Pellock, I.M.2    Garnett, W.R.3
  • 50
    • 0024443169 scopus 로고
    • Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures
    • Mikati MA, Schachter SC, Schomer DL, et al. Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures. Clin Neuropharmacol 1989; 12: 312-321.
    • (1989) Clin Neuropharmacol , vol.12 , pp. 312-321
    • Mikati, M.A.1    Schachter, S.C.2    Schomer, D.L.3
  • 51
    • 0002431547 scopus 로고
    • A single dose, dose proportionality, and bioequivalence study of lamotrigine in normal volunteers (abstract)
    • Yau MK, Garnett WR, Wargin WA, et al. A single dose, dose proportionality, and bioequivalence study of lamotrigine in normal volunteers (abstract). Epilepsia 1991; 32(Suppl. 3): 8.
    • (1991) Epilepsia , vol.32 , Issue.SUPPL. 3 , pp. 8
    • Yau, M.K.1    Garnett, W.R.2    Wargin, W.A.3
  • 52
    • 39749110172 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of lamotrigine when converting from a twice-daily immediaterelease to a once-daily extended-release formulation in subjects with epilepsy (the COMPASS study)
    • Tompson DJ, Ali I, Oliver-Willwong R, et al. Steady-state pharmacokinetics of lamotrigine when converting from a twice-daily immediaterelease to a once-daily extended-release formulation in subjects with epilepsy (the COMPASS study). Epilepsia 2008; 49: 410-417.
    • (2008) Epilepsia , vol.49 , pp. 410-417
    • Tompson, D.J.1    Ali, I.2    Oliver-Willwong, R.3
  • 53
    • 0032920526 scopus 로고    scopus 로고
    • Lamotrigine concentrations in human serum, brain tissue, and tumor tissue
    • Meyer FP, Banditt P, Schubert A, et al. Lamotrigine concentrations in human serum, brain tissue, and tumor tissue. Epilepsia 1999; 40: 68-73.
    • (1999) Epilepsia , vol.40 , pp. 68-73
    • Meyer, F.P.1    Banditt, P.2    Schubert, A.3
  • 54
    • 0033810039 scopus 로고    scopus 로고
    • Lamotrigine distribution in two postmortem cases
    • Levine B, Jufer RA, Smialek JE. Lamotrigine distribution in two postmortem cases. J Anat Toxcol 2000; 24: 635-637.
    • (2000) J Anat Toxcol , vol.24 , pp. 635-637
    • Levine, B.1    Jufer, R.A.2    Smialek, J.E.3
  • 55
    • 33645529117 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age
    • Perucca E. Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age. Clin Pharmacokinet 2006; 45: 351-363.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 351-363
    • Perucca, E.1
  • 56
    • 0033866254 scopus 로고    scopus 로고
    • Validation of a population pharmacokinetic model for adjunctive lamotrigine therapy in children
    • Chen C. Validation of a population pharmacokinetic model for adjunctive lamotrigine therapy in children. Br J Clin Pharmacol 2000; 50: 135-145.
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 135-145
    • Chen, C.1
  • 57
    • 0026297624 scopus 로고
    • Clinical pharmacology of lamotrigine
    • Peck AW. Clinical pharmacology of lamotrigine. Epilepsia 1991; 32(Suppl. 2): S9-S12.
    • (1991) Epilepsia , vol.32 , Issue.SUPPL. 2
    • Peck, A.W.1
  • 58
    • 0000979733 scopus 로고
    • Investigation of the ability of lamotrigine, a novel antiepileptic drug, to induce mixed function oxygenase enzymes (abstract)
    • Posner J, Webster H, Yuen WC. Investigation of the ability of lamotrigine, a novel antiepileptic drug, to induce mixed function oxygenase enzymes (abstract). Br J Clin Pharmacol 1991; 32: 658P.
    • (1991) Br J Clin Pharmacol , vol.32
    • Posner, J.1    Webster, H.2    Yuen, W.C.3
  • 59
    • 0024312676 scopus 로고
    • The pharmacokinetics of lamotrigine (BW43OC) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome)
    • Posner J, Cohen AF, Land G, et al. The pharmacokinetics of lamotrigine (BW43OC) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome). Br J Clin Pharmacol 1989; 28: 117-120.
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 117-120
    • Posner, J.1    Cohen, A.F.2    Land, G.3
  • 60
    • 0037162365 scopus 로고    scopus 로고
    • Lamotrigine clearance during pregnancy
    • Tran TA, Leppik IE, Blesi K, et al. Lamotrigine clearance during pregnancy. Neurology 2002; 59: 251-255.
    • (2002) Neurology , vol.59 , pp. 251-255
    • Tran, T.A.1    Leppik, I.E.2    Blesi, K.3
  • 61
    • 0842282467 scopus 로고    scopus 로고
    • The impact of pregnancy and childbirth on the metabolism of lamotrigine
    • Pennell PB, Newport DJ, Stowe ZN, et al. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004; 62: 292-295.
    • (2004) Neurology , vol.62 , pp. 292-295
    • Pennell, P.B.1    Newport, D.J.2    Stowe, Z.N.3
  • 62
    • 3543083352 scopus 로고    scopus 로고
    • Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study
    • de Haan GJ, Edelbroek P, Segers J, et al. Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 2004; 63: 571-573.
    • (2004) Neurology , vol.63 , pp. 571-573
    • de Haan, G.J.1    Edelbroek, P.2    Segers, J.3
  • 63
    • 33646188524 scopus 로고    scopus 로고
    • Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry
    • EURAP Study Group.
    • EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 2006; 66: 354-360.
    • (2006) Neurology , vol.66 , pp. 354-360
  • 64
    • 33749842157 scopus 로고    scopus 로고
    • Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives
    • Tomson T, Luef G, Sabers A, et al. Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. Neurology 2006; 67: 1297-1299.
    • (2006) Neurology , vol.67 , pp. 1297-1299
    • Tomson, T.1    Luef, G.2    Sabers, A.3
  • 65
    • 0034026788 scopus 로고    scopus 로고
    • Anticonvulsants and breast feeding: a critical review
    • Bar-Oz B, Nulman I, Koren G, et al. Anticonvulsants and breast feeding: a critical review. Paediatr Drugs 2000; 2: 113-126.
    • (2000) Paediatr Drugs , vol.2 , pp. 113-126
    • Bar-Oz, B.1    Nulman, I.2    Koren, G.3
  • 66
    • 0034041253 scopus 로고    scopus 로고
    • Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation
    • Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000; 41: 709-713.
    • (2000) Epilepsia , vol.41 , pp. 709-713
    • Ohman, I.1    Vitols, S.2    Tomson, T.3
  • 67
    • 0037299332 scopus 로고    scopus 로고
    • Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo
    • Myllynen PK, Pienimaki PK, Vahakangas KH. Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo. Eur J Clin Pharmacol 2003; 58: 677-682.
    • (2003) Eur J Clin Pharmacol , vol.58 , pp. 677-682
    • Myllynen, P.K.1    Pienimaki, P.K.2    Vahakangas, K.H.3
  • 68
    • 1542348249 scopus 로고    scopus 로고
    • Concerns regarding lamotrigine and breast-feeding
    • Liporace J, Kao A, D'Abreu A. Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 2004; 5: 102-105.
    • (2004) Epilepsy Behav , vol.5 , pp. 102-105
    • Liporace, J.1    Kao, A.2    D'Abreu, A.3
  • 69
  • 70
    • 0031800865 scopus 로고    scopus 로고
    • A mechanistic approach to antiepileptic drug interactions
    • Anderson GD. A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother 1998; 32: 554-563.
    • (1998) Ann Pharmacother , vol.32 , pp. 554-563
    • Anderson, G.D.1
  • 71
    • 0029841727 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between antiepileptic drugs: clinical considerations
    • Riva R, Albani F, Contin M, et al. Pharmacokinetic interactions between antiepileptic drugs: clinical considerations. Clin Pharmacokinet 1996; 31: 470-493.
    • (1996) Clin Pharmacokinet , vol.31 , pp. 470-493
    • Riva, R.1    Albani, F.2    Contin, M.3
  • 72
    • 0033907007 scopus 로고    scopus 로고
    • Newer anticonvulsants: comparative review of drug interactions and adverse effects
    • Sabers A, Gram L. Newer anticonvulsants: comparative review of drug interactions and adverse effects. Drugs 2000; 60: 23-33.
    • (2000) Drugs , vol.60 , pp. 23-33
    • Sabers, A.1    Gram, L.2
  • 73
    • 0026539337 scopus 로고
    • Sodium valproate acutely inhibits lamotrigine metabolism
    • Yuen AWC, Land G, Wheatherley BC, et al. Sodium valproate acutely inhibits lamotrigine metabolism. Br Clin Pharmacol 1992; 33: 511-513.
    • (1992) Br Clin Pharmacol , vol.33 , pp. 511-513
    • Yuen, A.W.C.1    Land, G.2    Wheatherley, B.C.3
  • 74
    • 0842330657 scopus 로고    scopus 로고
    • Evaluation of valproic acid dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapy
    • Gidal BE, Sheth R, Parnell J, et al. Evaluation of valproic acid dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapy. Epilepsy Res 2003; 57: 85-93.
    • (2003) Epilepsy Res , vol.57 , pp. 85-93
    • Gidal, B.E.1    Sheth, R.2    Parnell, J.3
  • 75
    • 0035990459 scopus 로고    scopus 로고
    • Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin
    • Anderson GD, Gidal BE, Messenheimer JA, et al. Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin. Epilepsy Res 2002; 49: 211-217.
    • (2002) Epilepsy Res , vol.49 , pp. 211-217
    • Anderson, G.D.1    Gidal, B.E.2    Messenheimer, J.A.3
  • 76
    • 0034098269 scopus 로고    scopus 로고
    • Methsuximide lowers lamotrigine blood levels: a pharmacokinetic antiepileptic drug interaction
    • Besag FM, Berry DJ, Pool F. Methsuximide lowers lamotrigine blood levels: a pharmacokinetic antiepileptic drug interaction. Epilepsia 2000; 41: 624-627.
    • (2000) Epilepsia , vol.41 , pp. 624-627
    • Besag, F.M.1    Berry, D.J.2    Pool, F.3
  • 77
    • 0000891836 scopus 로고    scopus 로고
    • Pediatric dosing recommendations of lamotrigine based on a population pharmacokinctic model (abstract)
    • Chen C, Rudd D, Messenheimer J, et al. Pediatric dosing recommendations of lamotrigine based on a population pharmacokinctic model (abstract). Epilepsia 1999; 40(Suppl. 7): 113.
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. 7 , pp. 113
    • Chen, C.1    Rudd, D.2    Messenheimer, J.3
  • 78
    • 0031450994 scopus 로고    scopus 로고
    • The influence of dosage, age, and comedication on steady state plasma lamotrigine concentrations in epileptic children: a prospective study with preliminary assessment of correlations with clinical response
    • Bartoli A. Guerrini R, Belmonte A, et al. The influence of dosage, age, and comedication on steady state plasma lamotrigine concentrations in epileptic children: a prospective study with preliminary assessment of correlations with clinical response. Ther Drug Monit 1997; 19: 252-260.
    • (1997) Ther Drug Monit , vol.19 , pp. 252-260
    • Bartoli, A.1    Guerrini, R.2    Belmonte, A.3
  • 79
    • 27844609389 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between oxcarbazepine and lamotrigine
    • Theis JG, Sidhu J, Palmer J, et al. Lack of pharmacokinetic interaction between oxcarbazepine and lamotrigine. Neuropsychopharmacology 2005; 30: 2269-2274.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2269-2274
    • Theis, J.G.1    Sidhu, J.2    Palmer, J.3
  • 80
    • 33644904320 scopus 로고    scopus 로고
    • The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects
    • Sidhu J, Job S, Singh S, et al. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol 2006; 61: 191-199.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 191-199
    • Sidhu, J.1    Job, S.2    Singh, S.3
  • 81
    • 33748684235 scopus 로고    scopus 로고
    • Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    • Contin M, Albani F, Ambrosetto G, et al. Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy. Epilepsia 2006; 47: 1573-1575.
    • (2006) Epilepsia , vol.47 , pp. 1573-1575
    • Contin, M.1    Albani, F.2    Ambrosetto, G.3
  • 82
    • 33748692764 scopus 로고    scopus 로고
    • Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebocontrolled study
    • Harden CL, Herzog AG, Nikolov BG, et al. Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebocontrolled study. Epilepsia 2006; 47: 1447-1451.
    • (2006) Epilepsia , vol.47 , pp. 1447-1451
    • Harden, C.L.1    Herzog, A.G.2    Nikolov, B.G.3
  • 83
    • 33645028734 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of lamotrigine and olanzapine coadministered to healthy subjects
    • Sidhu J, Job S, Bullman J, et al. Pharmacokinetics and tolerability of lamotrigine and olanzapine coadministered to healthy subjects. Br J Clin Pharmacol 2006; 61: 420-426.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 420-426
    • Sidhu, J.1    Job, S.2    Bullman, J.3
  • 84
    • 0025009830 scopus 로고
    • Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine
    • Depot M, Powell JR, Messenheinier JJA, et al. Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine. Clin Pharmacol Ther 1990; 48: 346-355.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 346-355
    • Depot, M.1    Powell, J.R.2    Messenheinier, J.J.A.3
  • 85
    • 23044436564 scopus 로고    scopus 로고
    • Drug interactions between lamotrigine and psychoactive drugs: evidence from a therapeutic drug monitoring service
    • Reimers A, Skogvoll E, Sund JK, et al. Drug interactions between lamotrigine and psychoactive drugs: evidence from a therapeutic drug monitoring service. J Clin Psychopharmacol 2005; 25: 342-348.
    • (2005) J Clin Psychopharmacol , vol.25 , pp. 342-348
    • Reimers, A.1    Skogvoll, E.2    Sund, J.K.3
  • 86
    • 0024335018 scopus 로고
    • Controlled trial of lamotrigine (Lamictal) for refractory partial seizures
    • Jawad S, Richens A, Goodwin G, et al. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989; 30: 356-363.
    • (1989) Epilepsia , vol.30 , pp. 356-363
    • Jawad, S.1    Richens, A.2    Goodwin, G.3
  • 87
    • 0025087187 scopus 로고
    • A randomized double-blind cross-over add-on trial of lamotrigine in patients with treatmentresistant partial seizures
    • Loiseau P, Yuen AWC, Duche B, et al. A randomized double-blind cross-over add-on trial of lamotrigine in patients with treatmentresistant partial seizures. Epilepsy Res 1990; 7: 136-145.
    • (1990) Epilepsy Res , vol.7 , pp. 136-145
    • Loiseau, P.1    Yuen, A.W.C.2    Duche, B.3
  • 88
    • 0025122852 scopus 로고
    • A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy
    • The median seizure reduction, included in Table 43.4, was reported in Richens A, Yuen AWC. Overview of the clinical efficacy of lamotrigine. Epilepsia 1991; 32(Suppl. 2): 13-16.]
    • Sander JWAS, Patsalos PN, Oxley JR, et al. A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy. Epilepsy Res 1990; 6: 221-226. [The median seizure reduction, included in Table 43.4, was reported in Richens A, Yuen AWC. Overview of the clinical efficacy of lamotrigine. Epilepsia 1991; 32(Suppl. 2): 13-16.]
    • (1990) Epilepsy Res , vol.6 , pp. 221-226
    • Sander, J.W.A.S.1    Patsalos, P.N.2    Oxley, J.R.3
  • 89
    • 0029909431 scopus 로고    scopus 로고
    • Bidirectional interaction of valproate and lamotrigine in healthy subjects
    • Anderson GD, Yau MK, Gidal BE, et al. Bidirectional interaction of valproate and lamotrigine in healthy subjects. Clin Pharmacol Ther 1996; 60: 145-156.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 145-156
    • Anderson, G.D.1    Yau, M.K.2    Gidal, B.E.3
  • 90
    • 0032799794 scopus 로고    scopus 로고
    • The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction
    • Pisani F, Oteri G, Russo MF, et al. The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. Epilepsia 1999; 40: 1141-1146.
    • (1999) Epilepsia , vol.40 , pp. 1141-1146
    • Pisani, F.1    Oteri, G.2    Russo, M.F.3
  • 91
    • 0027450234 scopus 로고
    • Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage
    • Hamilton MJ, Cohen AF, Yuen AWC, et al. Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage. Epilepsia 1993; 34: 166-173.
    • (1993) Epilepsia , vol.34 , pp. 166-173
    • Hamilton, M.J.1    Cohen, A.F.2    Yuen, A.W.C.3
  • 92
    • 0026597799 scopus 로고
    • Lamotrigine-induced carbamazepinc toxicity: an interaction with carbamazepine-10,11-epoxide
    • Warner T, Patsalos PN, Prevett M. Lamotrigine-induced carbamazepinc toxicity: an interaction with carbamazepine-10,11-epoxide. Epilepsy Res 1992; 11: 147-150.
    • (1992) Epilepsy Res , vol.11 , pp. 147-150
    • Warner, T.1    Patsalos, P.N.2    Prevett, M.3
  • 93
    • 0031883784 scopus 로고    scopus 로고
    • Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction?
    • Besag FM, Berry DJ, Pool F, et al. Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? Epilepsia 1998; 39: 183-187.
    • (1998) Epilepsia , vol.39 , pp. 183-187
    • Besag, F.M.1    Berry, D.J.2    Pool, F.3
  • 94
    • 0028566506 scopus 로고
    • Single dose pharmacokinctics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy
    • Pisani F, Xiao B, Fazio A, et al. Single dose pharmacokinctics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. Epilepsy Res 1994; 19: 245-248.
    • (1994) Epilepsy Res , vol.19 , pp. 245-248
    • Pisani, F.1    Xiao, B.2    Fazio, A.3
  • 95
    • 0031413729 scopus 로고    scopus 로고
    • No increase in carbamazepine-10,11-epoxide during addition of lamotrigine treatment in children
    • Eriksson A-S, Boreus LO. No increase in carbamazepine-10,11-epoxide during addition of lamotrigine treatment in children. Ther Drug Monit 1997; 19: 499-501.
    • (1997) Ther Drug Monit , vol.19 , pp. 499-501
    • Eriksson, A.-S.1    Boreus, L.O.2
  • 96
    • 0031769482 scopus 로고    scopus 로고
    • Deos percent reduction in seizure frequency correlate with plasma concentration of anticonvulsant drugs?
    • Mahmood I, Tammara VK, Baweja RK. Deos percent reduction in seizure frequency correlate with plasma concentration of anticonvulsant drugs? Clin Pharmacol Ther 1998; 64: 547-552.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 547-552
    • Mahmood, I.1    Tammara, V.K.2    Baweja, R.K.3
  • 97
    • 0022409205 scopus 로고
    • Lamotrigine (BW430C), a potential anticonvulsant: effects on the central nervous system in comparison with phenytoin and diazepam
    • Cohen AF, Ashby L, Crowley D, et al. Lamotrigine (BW430C), a potential anticonvulsant: effects on the central nervous system in comparison with phenytoin and diazepam. Br J Clin Pharmacol 1985; 20: 619-629.
    • (1985) Br J Clin Pharmacol , vol.20 , pp. 619-629
    • Cohen, A.F.1    Ashby, L.2    Crowley, D.3
  • 99
    • 0031038462 scopus 로고    scopus 로고
    • Treatment with high doses of lamotrigine in children and adolescents with refractory seizures
    • Mims J, Panovich P, Ritter F, et al. Treatment with high doses of lamotrigine in children and adolescents with refractory seizures. J Child Neurol 1997; 12: 64-67.
    • (1997) J Child Neurol , vol.12 , pp. 64-67
    • Mims, J.1    Panovich, P.2    Ritter, F.3
  • 100
    • 0031453973 scopus 로고    scopus 로고
    • Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome
    • (Erratum: N Eng J Med 1998; 339: 851-852.)
    • Motte J, Trevathan E, Arvidsson JFV, et al. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Eng J Med 1997; 337: 1807-1812. (Erratum: N Eng J Med 1998; 339: 851-852.)
    • (1997) N Eng J Med , vol.337 , pp. 1807-1812
    • Motte, J.1    Trevathan, E.2    Arvidsson, J.F.V.3
  • 101
    • 0028217246 scopus 로고
    • Lamotrigine in treatment of 120 children with epilepsy
    • Schumberger E, Chavez F, Palacios L, et al. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia 1994; 35: 359-367.
    • (1994) Epilepsia , vol.35 , pp. 359-367
    • Schumberger, E.1    Chavez, F.2    Palacios, L.3
  • 102
    • 0036225896 scopus 로고    scopus 로고
    • Prospective study on concentration-efficacy and concentration-toxicity: correlations with lamotrigine serum levels
    • Froscher W, Keller F, Vogt H, et al. Prospective study on concentration-efficacy and concentration-toxicity: correlations with lamotrigine serum levels. Epileptic Disord 2002; 4: 49-56.
    • (2002) Epileptic Disord , vol.4 , pp. 49-56
    • Froscher, W.1    Keller, F.2    Vogt, H.3
  • 103
    • 9644262385 scopus 로고    scopus 로고
    • Long-term follow-up using a higher target range for lamotrigine monitoring
    • Morris RG, Lee MY, Cleanthous X, et al. Long-term follow-up using a higher target range for lamotrigine monitoring. Ther Drug Monit 2004; 26: 626-632.
    • (2004) Ther Drug Monit , vol.26 , pp. 626-632
    • Morris, R.G.1    Lee, M.Y.2    Cleanthous, X.3
  • 104
    • 45749150011 scopus 로고    scopus 로고
    • Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    • Patsalos PN, Berry DJ, Bourgeois BF, et al. Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008; 49: 1239-1276.
    • (2008) Epilepsia , vol.49 , pp. 1239-1276
    • Patsalos, P.N.1    Berry, D.J.2    Bourgeois, B.F.3
  • 105
    • 0002533196 scopus 로고    scopus 로고
    • Is there a relationship between the occurrence of adverse events from lamotrigine and its serum concentraions?
    • Kanner AM, Chkenkely I, Frey M. Is there a relationship between the occurrence of adverse events from lamotrigine and its serum concentraions? Epilepsia 1998; 39(Suppl. 6): S72-S73.
    • (1998) Epilepsia , vol.39 , Issue.SUPPL. 6
    • Kanner, A.M.1    Chkenkely, I.2    Frey, M.3
  • 106
    • 0029941546 scopus 로고    scopus 로고
    • Concentration-effect and concentration-toxicity relations with lamotrigine: a prospective study
    • Kilpatrick ES, Forrest G, Brodie MJ. Concentration-effect and concentration-toxicity relations with lamotrigine: a prospective study. Epilepsia 1996; 37: 534-538.
    • (1996) Epilepsia , vol.37 , pp. 534-538
    • Kilpatrick, E.S.1    Forrest, G.2    Brodie, M.J.3
  • 107
    • 4644279726 scopus 로고    scopus 로고
    • Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy
    • Hirsch LJ, Weintraub D, Du Y, et al. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology 2004; 63: 1022-1026.
    • (2004) Neurology , vol.63 , pp. 1022-1026
    • Hirsch, L.J.1    Weintraub, D.2    Du, Y.3
  • 108
    • 0027534819 scopus 로고
    • Outcomes of add-on treatment with lamotrigine in partial epilepsy
    • Smith D, Baker G, Davies G. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993; 34: 312-322.
    • (1993) Epilepsia , vol.34 , pp. 312-322
    • Smith, D.1    Baker, G.2    Davies, G.3
  • 109
    • 0024453369 scopus 로고
    • Double-blind cross-over trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy
    • Binnie CD, Debets RMC, Engelsman M, et al. Double-blind cross-over trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989; 4: 222-229.
    • (1989) Epilepsy Res , vol.4 , pp. 222-229
    • Binnie, C.D.1    Debets, R.M.C.2    Engelsman, M.3
  • 110
    • 0029827388 scopus 로고    scopus 로고
    • Controlled trial of lamotrigine (Lamictal®) for treatment-resistant partial seizures
    • Boas J, Dam M, Friis ML, et al. Controlled trial of lamotrigine (Lamictal®) for treatment-resistant partial seizures. Acta Neurol Scand 1996; 94: 247-252.
    • (1996) Acta Neurol Scand , vol.94 , pp. 247-252
    • Boas, J.1    Dam, M.2    Friis, M.L.3
  • 111
    • 0033544351 scopus 로고    scopus 로고
    • A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children Lamictal Pediatric Partial Seizure Study Group
    • Duchowny M, Pellock JM, Graf WD, et al. A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal Pediatric Partial Seizure Study Group. Neurology 1999; 53: 1724-1731.
    • (1999) Neurology , vol.53 , pp. 1724-1731
    • Duchowny, M.1    Pellock, J.M.2    Graf, W.D.3
  • 112
    • 0027491284 scopus 로고
    • Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures
    • Matsuo F, Bergen D, Faught E, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993; 43: 2284-2291.
    • (1993) Neurology , vol.43 , pp. 2284-2291
    • Matsuo, F.1    Bergen, D.2    Faught, E.3
  • 113
    • 0028268250 scopus 로고
    • Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial
    • Messenheimer J, Ramsey RE, Willmore LJ, et al. Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial. Epilepsia 1994; 35: 113-121.
    • (1994) Epilepsia , vol.35 , pp. 113-121
    • Messenheimer, J.1    Ramsey, R.E.2    Willmore, L.J.3
  • 114
    • 35848947010 scopus 로고    scopus 로고
    • Lamotrigine extended-release as adjunctive therapy for partial seizures
    • Naritoku DK, Warnock CR, Messenheimer JA, et al. Lamotrigine extended-release as adjunctive therapy for partial seizures. Neurology 2007; 69: 1610-1618.
    • (2007) Neurology , vol.69 , pp. 1610-1618
    • Naritoku, D.K.1    Warnock, C.R.2    Messenheimer, J.A.3
  • 115
    • 0027254062 scopus 로고
    • Double-blind, placebocontrolled, cross-over study of lamotrigine in treatment resistant partial seizures
    • Schapel GJ, Beran RG, Vajda FJE, et al. Double-blind, placebocontrolled, cross-over study of lamotrigine in treatment resistant partial seizures. J Neurol Neurosurg Psychiatry 1993; 56: 448-453.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , pp. 448-453
    • Schapel, G.J.1    Beran, R.G.2    Vajda, F.J.E.3
  • 116
    • 0003155836 scopus 로고
    • Add-on treatment with lamotrigine for intractable partial epilepsy: a placebo-controlled cross-over trial (abstract)
    • Schmidt D, Reid S, Rapp P. Add-on treatment with lamotrigine for intractable partial epilepsy: a placebo-controlled cross-over trial (abstract). Epilepsia 1993; 34(Suppl. 2): 66.
    • (1993) Epilepsia , vol.34 , Issue.SUPPL. 2 , pp. 66
    • Schmidt, D.1    Reid, S.2    Rapp, P.3
  • 118
    • 0031684166 scopus 로고    scopus 로고
    • An active-control trial of lamotrigine monotherapy for partial seizures
    • Gilliam F, Vazquez B, Sackellares JC, et al. An active-control trial of lamotrigine monotherapy for partial seizures. Neurology 1998; 51: 1018-1025.
    • (1998) Neurology , vol.51 , pp. 1018-1025
    • Gilliam, F.1    Vazquez, B.2    Sackellares, J.C.3
  • 119
    • 0030975686 scopus 로고    scopus 로고
    • Lamotrigine substitution study: evidence for synergism with sodium valproate
    • Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate. Epilepsy Res 1997; 26: 423-432.
    • (1997) Epilepsy Res , vol.26 , pp. 423-432
    • Brodie, M.J.1    Yuen, A.W.2
  • 120
    • 0033758726 scopus 로고    scopus 로고
    • Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine-or valproate-resistant epilepsy
    • Jozwiak S, Terczynski A. Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine-or valproate-resistant epilepsy. Seizure 2000; 9: 486-492.
    • (2000) Seizure , vol.9 , pp. 486-492
    • Jozwiak, S.1    Terczynski, A.2
  • 121
    • 4043175714 scopus 로고    scopus 로고
    • Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy
    • Fakhoury TA, Hammer AE, Vuong A, et al. Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy. Epilepsy Behav 2004; 5: 532-538.
    • (2004) Epilepsy Behav , vol.5 , pp. 532-538
    • Fakhoury, T.A.1    Hammer, A.E.2    Vuong, A.3
  • 122
    • 0034905574 scopus 로고    scopus 로고
    • A comparison of monotherapy with lamotrigine or carbamazepine in patients with newly diagnosed partial epilepsy
    • Nieto-Barrera M, Brozmanova M, Capovilla G, et al. A comparison of monotherapy with lamotrigine or carbamazepine in patients with newly diagnosed partial epilepsy. Epilepsy Res 2001; 46: 145-155.
    • (2001) Epilepsy Res , vol.46 , pp. 145-155
    • Nieto-Barrera, M.1    Brozmanova, M.2    Capovilla, G.3
  • 123
    • 0029866895 scopus 로고    scopus 로고
    • A randomized open multicenter comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy
    • Reunanen OM, Dam M, Yuen AWC. A randomized open multicenter comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy. Epilepsy Res 1996; 23: 149-155.
    • (1996) Epilepsy Res , vol.23 , pp. 149-155
    • Reunanen, O.M.1    Dam, M.2    Yuen, A.W.C.3
  • 124
    • 29044444974 scopus 로고    scopus 로고
    • The LAM-SAFE Study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults
    • Steinhoff BJ, Ueberall MA, Siemes H, et al. The LAM-SAFE Study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults. Seizure 2005; 14: 597-605.
    • (2005) Seizure , vol.14 , pp. 597-605
    • Steinhoff, B.J.1    Ueberall, M.A.2    Siemes, H.3
  • 125
    • 34447279445 scopus 로고    scopus 로고
    • Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy
    • Stephen LJ, Sills GJ, Leach JP, et al. Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. Epilepsy Res 2007; 75: 122-129.
    • (2007) Epilepsy Res , vol.75 , pp. 122-129
    • Stephen, L.J.1    Sills, G.J.2    Leach, J.P.3
  • 126
    • 0032877268 scopus 로고    scopus 로고
    • Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy The UK Lamotrigine Elderly Study Group
    • Brodie MJ, Overstall PW, Giorgi L. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res 1999; 37: 81-87.
    • (1999) Epilepsy Res , vol.37 , pp. 81-87
    • Brodie, M.J.1    Overstall, P.W.2    Giorgi, L.3
  • 127
    • 34548449364 scopus 로고    scopus 로고
    • Monotherapy of lamotrigine versus carbamazepine in patients with poststroke seizures
    • Gilad R, Sadeh M, Rapoport A, et al. Monotherapy of lamotrigine versus carbamazepine in patients with poststroke seizures. Clin Neuropharmacol 2007; 30: 189-195.
    • (2007) Clin Neuropharmacol , vol.30 , pp. 189-195
    • Gilad, R.1    Sadeh, M.2    Rapoport, A.3
  • 128
    • 20444407159 scopus 로고    scopus 로고
    • New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine
    • Rowan AJ, Ramsay RE, Collins JF, et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005; 64: 1868-1873.
    • (2005) Neurology , vol.64 , pp. 1868-1873
    • Rowan, A.J.1    Ramsay, R.E.2    Collins, J.F.3
  • 129
    • 34447319721 scopus 로고    scopus 로고
    • An international multicenter randomized double-blind controlled trial of lamotrigine and sustainedrelease carbamazepine in the treatment of newly diagnosed epilepsy in the elderly
    • Saetre E, Perucca E, Isojarvi J, et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustainedrelease carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia 2007; 48: 1292-1302.
    • (2007) Epilepsia , vol.48 , pp. 1292-1302
    • Saetre, E.1    Perucca, E.2    Isojarvi, J.3
  • 130
    • 0036711702 scopus 로고    scopus 로고
    • Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy
    • Brodie MJ, Chadwick DW, Anhut H, et al. Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy. Epilepsia 2002; 43: 993-1000.
    • (2002) Epilepsia , vol.43 , pp. 993-1000
    • Brodie, M.J.1    Chadwick, D.W.2    Anhut, H.3
  • 131
    • 0029651761 scopus 로고
    • Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy
    • Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet 1995; 345: 476-479.
    • (1995) Lancet , vol.345 , pp. 476-479
    • Brodie, M.J.1    Richens, A.2    Yuen, A.W.C.3
  • 132
    • 0032950428 scopus 로고    scopus 로고
    • Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin
    • Steiner TJ, Dellaportas CI, Findley LJ, et al. Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. Epilepsia 1999; 40: 601-607.
    • (1999) Epilepsia , vol.40 , pp. 601-607
    • Steiner, T.J.1    Dellaportas, C.I.2    Findley, L.J.3
  • 133
    • 33947241772 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblended randomised controlled trial
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblended randomised controlled trial. Lancet 2007; 369: 1000-1015.
    • (2007) Lancet , vol.369 , pp. 1000-1015
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 134
    • 33947228816 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 2007; 369: 1016-1026.
    • (2007) Lancet , vol.369 , pp. 1016-1026
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 135
    • 0032443667 scopus 로고    scopus 로고
    • Double-blind, placebocontrolled, cross-over study of lamotrigine in treatment-resistant generalised epilepsy
    • Beran RG, Berkovic SF, Dunagan FM, et al. Double-blind, placebocontrolled, cross-over study of lamotrigine in treatment-resistant generalised epilepsy. Epilepsia 1998; 39: 1329-1333.
    • (1998) Epilepsia , vol.39 , pp. 1329-1333
    • Beran, R.G.1    Berkovic, S.F.2    Dunagan, F.M.3
  • 136
    • 2642598051 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: a randomized, double-blind, cross-over study
    • Eriksson A-S, Nergardh A, Hoppu K. The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: a randomized, double-blind, cross-over study. Epilepsia 1998; 39: 495-501.
    • (1998) Epilepsia , vol.39 , pp. 495-501
    • Eriksson, A.-S.1    Nergardh, A.2    Hoppu, K.3
  • 137
    • 33645062986 scopus 로고    scopus 로고
    • Double-blind, placebocontrolled study of lamotrigine in primary generalized tonic-clonic seizures
    • Biton V, Sackellares JC, Vuong A, et al. Double-blind, placebocontrolled study of lamotrigine in primary generalized tonic-clonic seizures. Neurology 2005; 65: 1737-1743.
    • (2005) Neurology , vol.65 , pp. 1737-1743
    • Biton, V.1    Sackellares, J.C.2    Vuong, A.3
  • 138
    • 0028915290 scopus 로고
    • Lamotrigine as add-on drug in typical absence seizures
    • Ferrie CD, Robinson RO, Knott C, et al. Lamotrigine as add-on drug in typical absence seizures. Acta Neurol Scand 1995; 91: 200-202.
    • (1995) Acta Neurol Scand , vol.91 , pp. 200-202
    • Ferrie, C.D.1    Robinson, R.O.2    Knott, C.3
  • 139
    • 0033051765 scopus 로고    scopus 로고
    • Lamictal (lamotrigine) monotherapy for typical absence seizures in children
    • Frank LM, Enlow T, Holmes GL, et al. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 1999; 40: 973-979.
    • (1999) Epilepsia , vol.40 , pp. 973-979
    • Frank, L.M.1    Enlow, T.2    Holmes, G.L.3
  • 140
    • 4544220589 scopus 로고    scopus 로고
    • Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study
    • Coppola G, Auricchio G, Federico R, et al. Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study. Epilepsia 2004; 45: 1049-1053.
    • (2004) Epilepsia , vol.45 , pp. 1049-1053
    • Coppola, G.1    Auricchio, G.2    Federico, R.3
  • 141
    • 34447305538 scopus 로고    scopus 로고
    • Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs
    • Gazzola DM, Balcer LJ, French JA. Seizure-free outcome in randomized add-on trials of the new antiepileptic drugs. Epilepsia 2007; 48: 1303-1307.
    • (2007) Epilepsia , vol.48 , pp. 1303-1307
    • Gazzola, D.M.1    Balcer, L.J.2    French, J.A.3
  • 142
    • 0029822510 scopus 로고    scopus 로고
    • New antiepileptic drugs: a systematic review of their efficacy and tolerability
    • Marson AG, Kadir ZA, Chadwick DW. New antiepileptic drugs: a systematic review of their efficacy and tolerability. BMJ 1996; 313: 1169-1174.
    • (1996) BMJ , vol.313 , pp. 1169-1174
    • Marson, A.G.1    Kadir, Z.A.2    Chadwick, D.W.3
  • 143
    • 0030873963 scopus 로고    scopus 로고
    • The new antiepileptic drugs: a systematic review of their efficacy and tolerability
    • Marson AG, Kadir ZA, Hutton JL, et al. The new antiepileptic drugs: a systematic review of their efficacy and tolerability. Epilepsia 1997; 38: 859-880.
    • (1997) Epilepsia , vol.38 , pp. 859-880
    • Marson, A.G.1    Kadir, Z.A.2    Hutton, J.L.3
  • 145
    • 0027753231 scopus 로고
    • Lamotrigine in resistant childhood epilepsy
    • Battino D, Buti D, Croci D, et al. Lamotrigine in resistant childhood epilepsy. Neuropediatrics 1993; 24: 332-336.
    • (1993) Neuropediatrics , vol.24 , pp. 332-336
    • Battino, D.1    Buti, D.2    Croci, D.3
  • 146
    • 0029616551 scopus 로고
    • Lamotrigine for the treatment of epilepsy in childhood
    • Besag FMC, Wallace SJ, Dulac O, et al. Lamotrigine for the treatment of epilepsy in childhood. J Pediatr 1995; 127: 991-997.
    • (1995) J Pediatr , vol.127 , pp. 991-997
    • Besag, F.M.C.1    Wallace, S.J.2    Dulac, O.3
  • 147
    • 0034776082 scopus 로고    scopus 로고
    • Efficacy of lamotrigine add-on therapy in severe partial epilepsy in adults with drop seizures and secondary bilateral synchrony on EEG
    • Bisulli F, Baruzzi A, Rosati A, et al. Efficacy of lamotrigine add-on therapy in severe partial epilepsy in adults with drop seizures and secondary bilateral synchrony on EEG. Epileptic Disord 2001; 3: 151-156.
    • (2001) Epileptic Disord , vol.3 , pp. 151-156
    • Bisulli, F.1    Baruzzi, A.2    Rosati, A.3
  • 148
    • 0029146313 scopus 로고
    • The efficacy of lamotrigine on seizure control in 34 children, adolescents and young adults with intellectual and physical disability
    • Buchanan N. The efficacy of lamotrigine on seizure control in 34 children, adolescents and young adults with intellectual and physical disability. Seizure 1995; 4: 233-236.
    • (1995) Seizure , vol.4 , pp. 233-236
    • Buchanan, N.1
  • 149
    • 0029030361 scopus 로고
    • Lamotrigine: clinical experience in 93 patients with epilepsy
    • Buchanan N. Lamotrigine: clinical experience in 93 patients with epilepsy. Acta Neurol Scand 1995; 92: 28-32.
    • (1995) Acta Neurol Scand , vol.92 , pp. 28-32
    • Buchanan, N.1
  • 150
    • 0030846510 scopus 로고    scopus 로고
    • Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial
    • Coppola G, Pascotto A. Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. Brain Dev 1997; 19: 398-402.
    • (1997) Brain Dev , vol.19 , pp. 398-402
    • Coppola, G.1    Pascotto, A.2
  • 151
    • 0031028879 scopus 로고    scopus 로고
    • Lamotrigine adjunctive therapy in childhood epileptic encephalopathy (the Lennox-Gastaut syndrome)
    • Donaldson JA, Glauser TA, Olberding LS. Lamotrigine adjunctive therapy in childhood epileptic encephalopathy (the Lennox-Gastaut syndrome). Epilepsia 1997; 38: 68-73.
    • (1997) Epilepsia , vol.38 , pp. 68-73
    • Donaldson, J.A.1    Glauser, T.A.2    Olberding, L.S.3
  • 152
    • 0030924957 scopus 로고    scopus 로고
    • Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
    • Farrell K, Connolly MB, Munn R, et al. Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy. Pediatr Neurol 1997; 16: 201-205.
    • (1997) Pediatr Neurol , vol.16 , pp. 201-205
    • Farrell, K.1    Connolly, M.B.2    Munn, R.3
  • 153
    • 0033187221 scopus 로고    scopus 로고
    • Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study
    • Gericke CA, Picard F, de Saint-Martin A, et al. Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study. Epileptic Disord 1999; 1: 159-165.
    • (1999) Epileptic Disord , vol.1 , pp. 159-165
    • Gericke, C.A.1    Picard, F.2    de Saint-Martin, A.3
  • 154
    • 0347418145 scopus 로고    scopus 로고
    • Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy
    • Kaminow L, Schimschock JR, Hammer AE, et al. Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy Behav 2003; 4: 659-666.
    • (2003) Epilepsy Behav , vol.4 , pp. 659-666
    • Kaminow, L.1    Schimschock, J.R.2    Hammer, A.E.3
  • 155
    • 22844451397 scopus 로고    scopus 로고
    • Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study
    • Knoester PD, Keyser A, Renier WO, et al. Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study. Epilepsy Res 2005; 65: 93-100.
    • (2005) Epilepsy Res , vol.65 , pp. 93-100
    • Knoester, P.D.1    Keyser, A.2    Renier, W.O.3
  • 156
    • 0344172819 scopus 로고    scopus 로고
    • Lamotrigine as add-on therapy in treatment-resistant epilepsy Portuguese Lamotrigine as Add-on Therapy in Treatment-resistant Epilepsy Study Group
    • Pimentel J, Guimaraes ML, Lima L, et al. Lamotrigine as add-on therapy in treatment-resistant epilepsy. Portuguese Lamotrigine as Add-on Therapy in Treatment-resistant Epilepsy Study Group. J Int Med Res 1999; 27: 148-157.
    • (1999) J Int Med Res , vol.27 , pp. 148-157
    • Pimentel, J.1    Guimaraes, M.L.2    Lima, L.3
  • 157
    • 0025251570 scopus 로고
    • The efficacy and long-term tolerability of lamotrigine in the treatment of severe epilepsy
    • Sander JWAS, Trevisol-Bittencourt PC, Hart YM, et al. The efficacy and long-term tolerability of lamotrigine in the treatment of severe epilepsy. Epilepsy Res 1990; 7: 226-229.
    • (1990) Epilepsy Res , vol.7 , pp. 226-229
    • Sander, J.W.A.S.1    Trevisol-Bittencourt, P.C.2    Hart, Y.M.3
  • 158
    • 0027094188 scopus 로고
    • Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome
    • Timmings PL, Richens A. Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol 1992; 32: 305-307.
    • (1992) Eur Neurol , vol.32 , pp. 305-307
    • Timmings, P.L.1    Richens, A.2
  • 159
    • 0034881643 scopus 로고    scopus 로고
    • Effect of divalproex-lamotrigine combination therapy in frontal lobe seizures
    • McCabe PH, McNew CD, Michel NC. Effect of divalproex-lamotrigine combination therapy in frontal lobe seizures. Arch Neurol 2001; 58: 1264-1268.
    • (2001) Arch Neurol , vol.58 , pp. 1264-1268
    • McCabe, P.H.1    McNew, C.D.2    Michel, N.C.3
  • 160
    • 33747970619 scopus 로고    scopus 로고
    • The effect of lamotrigine on cognitive function in children
    • In: Loiseau P (ed.), International Congress and Symposium Series no. 124. London: Royal Society of Medicine Press Limited
    • Besag F. The effect of lamotrigine on cognitive function in children. In: Loiseau P (ed.). Lamotrigine: A Brighter Future. International Congress and Symposium Series no. 124. London: Royal Society of Medicine Press Limited, 1996: 81-87.
    • (1996) Lamotrigine: A Brighter Future , pp. 81-87
    • Besag, F.1
  • 162
    • 0019464539 scopus 로고
    • Methods of assessment of entiepileptic drugs
    • Milligan N, Richens A. Methods of assessment of entiepileptic drugs. Br J Clin Pharmacol 1981; 11: 35-41.
    • (1981) Br J Clin Pharmacol , vol.11 , pp. 35-41
    • Milligan, N.1    Richens, A.2
  • 163
    • 0032992039 scopus 로고    scopus 로고
    • Efficacy of lamotrigine in refractory neonatal seizures
    • Barr PA, Buettiker VE, Antony JH. Efficacy of lamotrigine in refractory neonatal seizures. Pediatr Neurol 1999; 20: 161-163.
    • (1999) Pediatr Neurol , vol.20 , pp. 161-163
    • Barr, P.A.1    Buettiker, V.E.2    Antony, J.H.3
  • 164
    • 0028126514 scopus 로고
    • Lamotrigine (Lamictal) in infantile spasms
    • Veggiotti P, Cieuta C, Rey E, et al. Lamotrigine (Lamictal) in infantile spasms. Lancet 1994; 344: 1375-1376.
    • (1994) Lancet , vol.344 , pp. 1375-1376
    • Veggiotti, P.1    Cieuta, C.2    Rey, E.3
  • 165
    • 0031898311 scopus 로고    scopus 로고
    • Lamotrigine in Rett syndrome: treatment experience from a pilot study
    • Stenbom Y, Tonnby B, Hagberg B. Lamotrigine in Rett syndrome: treatment experience from a pilot study. Eur Child Adolesc Psychiatry 1998; 7: 49-52.
    • (1998) Eur Child Adolesc Psychiatry , vol.7 , pp. 49-52
    • Stenbom, Y.1    Tonnby, B.2    Hagberg, B.3
  • 166
    • 0033053188 scopus 로고    scopus 로고
    • Lamotrigine therapy in juvenile neuronal ceroid lipofuscinosis
    • Aberg L, Kirveskari E, Santavuori P. Lamotrigine therapy in juvenile neuronal ceroid lipofuscinosis. Epilepsia 1999; 40: 796-799.
    • (1999) Epilepsia , vol.40 , pp. 796-799
    • Aberg, L.1    Kirveskari, E.2    Santavuori, P.3
  • 167
    • 0032841402 scopus 로고    scopus 로고
    • The long-term use of gabapentin, lamotrigine, and vigabatrin in patients with chronic epilepsy
    • Wong IC, Chadwick DW, Fenwick PB, et al. The long-term use of gabapentin, lamotrigine, and vigabatrin in patients with chronic epilepsy. Epilepsia 1999; 40: 1439-1445.
    • (1999) Epilepsia , vol.40 , pp. 1439-1445
    • Wong, I.C.1    Chadwick, D.W.2    Fenwick, P.B.3
  • 168
    • 0034535755 scopus 로고    scopus 로고
    • Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy
    • Lhatoo SD, Wong IC, Polizzi G, et al. Long-term retention rates of lamotrigine, gabapentin, and topiramate in chronic epilepsy. Epilepsia 2000; 41: 1592-1596.
    • (2000) Epilepsia , vol.41 , pp. 1592-1596
    • Lhatoo, S.D.1    Wong, I.C.2    Polizzi, G.3
  • 169
    • 0033799649 scopus 로고    scopus 로고
    • A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure
    • Gillham R, Kane K, Bryant-Comstock L, et al. A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure. Seizure 2000; 9: 375-379.
    • (2000) Seizure , vol.9 , pp. 375-379
    • Gillham, R.1    Kane, K.2    Bryant-Comstock, L.3
  • 170
    • 15344344623 scopus 로고    scopus 로고
    • Improved mood states with lamotrigine in patients with epilepsy
    • Cramer JA, Hammer AE, Kustra RP. Improved mood states with lamotrigine in patients with epilepsy. Epilepsy Behav 2004; 5: 702-707.
    • (2004) Epilepsy Behav , vol.5 , pp. 702-707
    • Cramer, J.A.1    Hammer, A.E.2    Kustra, R.P.3
  • 171
    • 0034646342 scopus 로고    scopus 로고
    • When antiepileptic drugs aggravate epilepsy
    • Genton P. When antiepileptic drugs aggravate epilepsy. Brain Dev 2000; 22: 75-80.
    • (2000) Brain Dev , vol.22 , pp. 75-80
    • Genton, P.1
  • 172
    • 33750709381 scopus 로고    scopus 로고
    • Lack of efficacy and potential aggravation of myoclonus with lamotrigine in Unverricht-Lundborg disease
    • Genton P, Gelisse P, Crespel A. Lack of efficacy and potential aggravation of myoclonus with lamotrigine in Unverricht-Lundborg disease. Epilepsia 2006; 47: 2083-2085.
    • (2006) Epilepsia , vol.47 , pp. 2083-2085
    • Genton, P.1    Gelisse, P.2    Crespel, A.3
  • 173
    • 0032773205 scopus 로고    scopus 로고
    • Myoclonic status epilepticus following high-dosage lamotrigine therapy
    • Guerrini R, Belmonte A, Parmeggiani L, et al. Myoclonic status epilepticus following high-dosage lamotrigine therapy. Brain Dev 1999; 21: 420-424.
    • (1999) Brain Dev , vol.21 , pp. 420-424
    • Guerrini, R.1    Belmonte, A.2    Parmeggiani, L.3
  • 174
    • 0031947590 scopus 로고    scopus 로고
    • Lamotrigine and seizure aggravation in severe myoclonic epilepsy
    • Guerrini R, Dravet C, Genton P, et al. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia 1998; 39: 508-512.
    • (1998) Epilepsia , vol.39 , pp. 508-512
    • Guerrini, R.1    Dravet, C.2    Genton, P.3
  • 175
    • 0031883148 scopus 로고    scopus 로고
    • Antiepileptic drugs as a cause of worsening seizures
    • Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia 1998; 39: 5-17.
    • (1998) Epilepsia , vol.39 , pp. 5-17
    • Perucca, E.1    Gram, L.2    Avanzini, G.3
  • 176
    • 3242758971 scopus 로고    scopus 로고
    • Lamotrigine-induced seizure aggravation and negative myclonus in idiopathic rolandic epilepsy
    • Cerminara C, Curatolo P, Seri S. Lamotrigine-induced seizure aggravation and negative myclonus in idiopathic rolandic epilepsy. Neurology 2004; 63: 373-375.
    • (2004) Neurology , vol.63 , pp. 373-375
    • Cerminara, C.1    Curatolo, P.2    Seri, S.3
  • 177
    • 24644444589 scopus 로고    scopus 로고
    • Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies
    • Crespel A, Genton P, Berramdane M, et al. Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology 2005; 65: 762-764.
    • (2005) Neurology , vol.65 , pp. 762-764
    • Crespel, A.1    Genton, P.2    Berramdane, M.3
  • 178
    • 33750689183 scopus 로고    scopus 로고
    • Recurrent absence status epilepticus (spike-and-wave stupor) associated with lamotrigine therapy
    • Haasan M, Lerman-Sagie T, Lev D, et al. Recurrent absence status epilepticus (spike-and-wave stupor) associated with lamotrigine therapy. J Child Neurol 2006; 21: 807-809.
    • (2006) J Child Neurol , vol.21 , pp. 807-809
    • Haasan, M.1    Lerman-Sagie, T.2    Lev, D.3
  • 179
    • 0141961508 scopus 로고    scopus 로고
    • Lamotrigine: a review of its use in bipolar disorder
    • Goldsmith DR, Wagstaff AJ, Ibboston T, et al. Lamotrigine: a review of its use in bipolar disorder. Drugs 2003; 63: 2029-2050.
    • (2003) Drugs , vol.63 , pp. 2029-2050
    • Goldsmith, D.R.1    Wagstaff, A.J.2    Ibboston, T.3
  • 180
    • 4344689028 scopus 로고    scopus 로고
    • The current understanding of lamotrigine as a mood stabilizer
    • Hahn CG, Gyulai L, Baldassano CF, et al. The current understanding of lamotrigine as a mood stabilizer. J Clin Psychiatry 2004; 65: 791-804.
    • (2004) J Clin Psychiatry , vol.65 , pp. 791-804
    • Hahn, C.G.1    Gyulai, L.2    Baldassano, C.F.3
  • 182
    • 0034050859 scopus 로고    scopus 로고
    • The tolerability of lamotrigine in children
    • Messenheimer JA, Giorgi L, Risner ME. The tolerability of lamotrigine in children. Drug Saf 2000; 22: 303-312.
    • (2000) Drug Saf , vol.22 , pp. 303-312
    • Messenheimer, J.A.1    Giorgi, L.2    Risner, M.E.3
  • 183
    • 0031955433 scopus 로고    scopus 로고
    • Safety review of adult clinical trial experience with lamotrigine
    • Messenheimer J, Mullens EL, Giorgi L, et al. Safety review of adult clinical trial experience with lamotrigine. Drug Saf 1998; 18: 281-296.
    • (1998) Drug Saf , vol.18 , pp. 281-296
    • Messenheimer, J.1    Mullens, E.L.2    Giorgi, L.3
  • 184
    • 0027932403 scopus 로고
    • Safety of lamotrigine
    • Richens A. Safety of lamotrigine. Epilepsia 1994; 34(Suppl. 5): S37-S40.
    • (1994) Epilepsia , vol.34 , Issue.SUPPL. 5
    • Richens, A.1
  • 185
    • 0029087362 scopus 로고
    • Lamotrigine: six-month, placebo-controlled safety and tolerance study
    • Schacter S, Leppik I, Matsuo F, et al. Lamotrigine: six-month, placebo-controlled safety and tolerance study. J Epilepsy 1995; 8: 201-210.
    • (1995) J Epilepsy , vol.8 , pp. 201-210
    • Schacter, S.1    Leppik, I.2    Matsuo, F.3
  • 186
    • 0029829941 scopus 로고    scopus 로고
    • Lamotrigine high-dose tolerability and safety in patients with epilepsy: a double-blind, placebo-controlled, eleven-week study
    • Matsuo F, Gay P, Madsen J, et al. Lamotrigine high-dose tolerability and safety in patients with epilepsy: a double-blind, placebo-controlled, eleven-week study. Epilepsia 1996; 37: 857-862.
    • (1996) Epilepsia , vol.37 , pp. 857-862
    • Matsuo, F.1    Gay, P.2    Madsen, J.3
  • 187
    • 0032963219 scopus 로고    scopus 로고
    • Lamotrigine associated with insomnia
    • Sadler M. Lamotrigine associated with insomnia. Epilepsia 1999; 40: 322-325.
    • (1999) Epilepsia , vol.40 , pp. 322-325
    • Sadler, M.1
  • 188
    • 0033556345 scopus 로고    scopus 로고
    • Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults
    • Martin R, Kuzniecky R, Ho S, et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology 1999; 52: 321-327.
    • (1999) Neurology , vol.52 , pp. 321-327
    • Martin, R.1    Kuzniecky, R.2    Ho, S.3
  • 189
    • 0035826962 scopus 로고    scopus 로고
    • Differential cognitive and behavioral effects of carbamazepine and lamotrigine
    • Meador KJ, Loring DW, Ray PG, et al. Differential cognitive and behavioral effects of carbamazepine and lamotrigine. Neurology 2001; 56: 1177-1182.
    • (2001) Neurology , vol.56 , pp. 1177-1182
    • Meador, K.J.1    Loring, D.W.2    Ray, P.G.3
  • 190
    • 0036197191 scopus 로고    scopus 로고
    • Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers
    • Aldenkamp AP, Arends J, Bootsma HP, et al. Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers. Epilepsia 2002; 43: 19-26.
    • (2002) Epilepsia , vol.43 , pp. 19-26
    • Aldenkamp, A.P.1    Arends, J.2    Bootsma, H.P.3
  • 191
    • 33645530397 scopus 로고    scopus 로고
    • Distinct cognitive neurophysiologic profiles for lamotrigine and topiramate
    • Smith ME, Gevins A, McEvoy LK, et al. Distinct cognitive neurophysiologic profiles for lamotrigine and topiramate. Epilepsia 2006; 47: 695-703.
    • (2006) Epilepsia , vol.47 , pp. 695-703
    • Smith, M.E.1    Gevins, A.2    McEvoy, L.K.3
  • 192
    • 33747068234 scopus 로고    scopus 로고
    • Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy
    • Blum D, Meador K, Biton V, et al. Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy. Neurology 2006; 67: 400-406.
    • (2006) Neurology , vol.67 , pp. 400-406
    • Blum, D.1    Meador, K.2    Biton, V.3
  • 193
    • 33745394411 scopus 로고    scopus 로고
    • Effect of lamotrigine on cognition in children with epilepsy
    • Pressler RM, Binnie CD, Coleshill SG, et al. Effect of lamotrigine on cognition in children with epilepsy. Neurology 2006; 66: 1495-1459.
    • (2006) Neurology , vol.66 , pp. 1495-1459
    • Pressler, R.M.1    Binnie, C.D.2    Coleshill, S.G.3
  • 194
    • 0343607367 scopus 로고    scopus 로고
    • Acute psychological disorders in patients with epilepsy: a nation-wide study
    • Cockerell OC, Moriarty J, Trimble M, et al. Acute psychological disorders in patients with epilepsy: a nation-wide study. Epilepsy Res 1996; 25: 119-131.
    • (1996) Epilepsy Res , vol.25 , pp. 119-131
    • Cockerell, O.C.1    Moriarty, J.2    Trimble, M.3
  • 195
    • 34447645976 scopus 로고    scopus 로고
    • Development of psychosis in patients with epilepsy treated with lamotrigine: report of six cases and review of the literature
    • Brandt C, Fueratsch N, Boehme V, et al. Development of psychosis in patients with epilepsy treated with lamotrigine: report of six cases and review of the literature. Epilepsy Behav 2007; 11: 133-139.
    • (2007) Epilepsy Behav , vol.11 , pp. 133-139
    • Brandt, C.1    Fueratsch, N.2    Boehme, V.3
  • 196
    • 30044436502 scopus 로고    scopus 로고
    • Tourette's symptoms provoked by lamotrigine in a bipolar patient
    • Seemuller F, Dehning S, Grunze H, et al. Tourette's symptoms provoked by lamotrigine in a bipolar patient. Am J Psychiatry 2006; 163: 159.
    • (2006) Am J Psychiatry , vol.163 , pp. 159
    • Seemuller, F.1    Dehning, S.2    Grunze, H.3
  • 197
    • 0031913101 scopus 로고    scopus 로고
    • Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine
    • Beran RG, Gibson RJ. Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine. Epilepsia 1998; 39: 280-282.
    • (1998) Epilepsia , vol.39 , pp. 280-282
    • Beran, R.G.1    Gibson, R.J.2
  • 198
    • 4043128764 scopus 로고    scopus 로고
    • Chorea: non-genetic causes
    • Cardoso F. Chorea: non-genetic causes. Curr Opin Neurol 2004; 17: 433-436.
    • (2004) Curr Opin Neurol , vol.17 , pp. 433-436
    • Cardoso, F.1
  • 199
    • 0041922422 scopus 로고    scopus 로고
    • Unusual side effects of lamotrigine therapy
    • Das KB, Harris C, Smyth DP, et al. Unusual side effects of lamotrigine therapy. J Child Neurol 2003; 18: 479-480.
    • (2003) J Child Neurol , vol.18 , pp. 479-480
    • Das, K.B.1    Harris, C.2    Smyth, D.P.3
  • 200
    • 0035697259 scopus 로고    scopus 로고
    • Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?
    • Zaatreh M, Tennison M, D'Cruz O, et al. Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction? Seizure 2001; 10: 596-599.
    • (2001) Seizure , vol.10 , pp. 596-599
    • Zaatreh, M.1    Tennison, M.2    D'Cruz, O.3
  • 201
    • 17044383070 scopus 로고    scopus 로고
    • Downbeat nystagmus as a result of lamotrigine toxicity
    • Alkawi A, Kattah JC, Wyman K. Downbeat nystagmus as a result of lamotrigine toxicity. Epilepsy Res 2005; 63: 85-88.
    • (2005) Epilepsy Res , vol.63 , pp. 85-88
    • Alkawi, A.1    Kattah, J.C.2    Wyman, K.3
  • 202
    • 0035940616 scopus 로고    scopus 로고
    • Dysgeusia in epileptic patients treated with lamotrigine: report of three cases
    • Avoni P, Contin M, Riva R, et al. Dysgeusia in epileptic patients treated with lamotrigine: report of three cases. Neurology 2001; 57: 1521.
    • (2001) Neurology , vol.57 , pp. 1521
    • Avoni, P.1    Contin, M.2    Riva, R.3
  • 203
    • 0031749077 scopus 로고    scopus 로고
    • Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy
    • Isojarvi JI, Rattya J, Myllyla VV, et al. Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Ann Neurol 1998; 43: 446-451.
    • (1998) Ann Neurol , vol.43 , pp. 446-451
    • Isojarvi, J.I.1    Rattya, J.2    Myllyla, V.V.3
  • 204
    • 0037305116 scopus 로고    scopus 로고
    • Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy: results from a post hoc analysis of a randomized, double-blind clinical trial
    • Biton V, Levisohn P, Hoyler S, et al. Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy: results from a post hoc analysis of a randomized, double-blind clinical trial. J Child Neurol 2003; 18: 133-139.
    • (2003) J Child Neurol , vol.18 , pp. 133-139
    • Biton, V.1    Levisohn, P.2    Hoyler, S.3
  • 205
    • 0034864141 scopus 로고    scopus 로고
    • Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
    • Stephen LJ, Kwan P, Shapiro D, et al. Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy. Epilepsia 2001; 42: 1002-1006.
    • (2001) Epilepsia , vol.42 , pp. 1002-1006
    • Stephen, L.J.1    Kwan, P.2    Shapiro, D.3
  • 206
    • 0038094412 scopus 로고    scopus 로고
    • Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy
    • Morrell MJ, Isojarvi J, Taylor AE, et al. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Res 2003; 54: 189-199.
    • (2003) Epilepsy Res , vol.54 , pp. 189-199
    • Morrell, M.J.1    Isojarvi, J.2    Taylor, A.E.3
  • 207
    • 33645019052 scopus 로고    scopus 로고
    • Effect of lamotrigine on sexual function in patients with epilepsy
    • Gil-Nagel A, Lopez-Munoz F, Serratosa JM, et al. Effect of lamotrigine on sexual function in patients with epilepsy. Seizure 2006; 15: 142-149.
    • (2006) Seizure , vol.15 , pp. 142-149
    • Gil-Nagel, A.1    Lopez-Munoz, F.2    Serratosa, J.M.3
  • 208
    • 33750915455 scopus 로고    scopus 로고
    • Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy
    • Herzog AG, Drislane FW, Schomer DL, et al. Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Epilepsia 2006; 47: 1945-1948.
    • (2006) Epilepsia , vol.47 , pp. 1945-1948
    • Herzog, A.G.1    Drislane, F.W.2    Schomer, D.L.3
  • 209
    • 0034686919 scopus 로고    scopus 로고
    • Hyponatremia associated with lamotrigine in cranial diabetes insipidus
    • Mewasingh L, Aylett S, Kirkham F, et al. Hyponatremia associated with lamotrigine in cranial diabetes insipidus. Lancet 2000; 356: 656.
    • (2000) Lancet , vol.356 , pp. 656
    • Mewasingh, L.1    Aylett, S.2    Kirkham, F.3
  • 210
    • 0034794545 scopus 로고    scopus 로고
    • Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy
    • Guo C-Y, Ronen GM, Atkinson SA. Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. Epilepsia 2001; 42: 1141-1147.
    • (2001) Epilepsia , vol.42 , pp. 1141-1147
    • Guo, C.-Y.1    Ronen, G.M.2    Atkinson, S.A.3
  • 211
    • 0035005123 scopus 로고    scopus 로고
    • Normal growth during lamotrigine monotherapy in pediatric epilepsy patients-a prospective evaluation of 103 children and adolescents
    • Uberall MA. Normal growth during lamotrigine monotherapy in pediatric epilepsy patients-a prospective evaluation of 103 children and adolescents. Epilepsy Res 2001; 46: 63-67.
    • (2001) Epilepsy Res , vol.46 , pp. 63-67
    • Uberall, M.A.1
  • 212
    • 0032879447 scopus 로고    scopus 로고
    • Anticonvulsant-induced cutaneous reactions
    • Ruble J, Matsuo F. Anticonvulsant-induced cutaneous reactions. CNS Drugs 1999; 12: 215-236.
    • (1999) CNS Drugs , vol.12 , pp. 215-236
    • Ruble, J.1    Matsuo, F.2
  • 213
    • 0029950986 scopus 로고    scopus 로고
    • Lamotrigine-induced rash in children
    • Dooley J, Camfield P, Gordon K, et al. Lamotrigine-induced rash in children. Neurology 1996; 46: 240-242.
    • (1996) Neurology , vol.46 , pp. 240-242
    • Dooley, J.1    Camfield, P.2    Gordon, K.3
  • 214
    • 0031923180 scopus 로고    scopus 로고
    • Lamotrigine hypersensitivity in chidhood epilepsy
    • Iametti P, Raucci U, Zuccaro P, et al. Lamotrigine hypersensitivity in chidhood epilepsy. Epilepsia 1998; 39: 502-507.
    • (1998) Epilepsia , vol.39 , pp. 502-507
    • Iametti, P.1    Raucci, U.2    Zuccaro, P.3
  • 215
    • 0032773248 scopus 로고    scopus 로고
    • Adding lamotrigine to valproate: incidence of rash and other adverse effects Postmarketing Antiepileptic Drug Survey (PADS) Group
    • Faught E, Morris G, Jacobson M, et al. Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. Epilepsia 1999; 40: 1135-1140.
    • (1999) Epilepsia , vol.40 , pp. 1135-1140
    • Faught, E.1    Morris, G.2    Jacobson, M.3
  • 216
    • 0342301745 scopus 로고    scopus 로고
    • Lamotrigine-associated rash: risk/benefit considerations in adults and children
    • Guberman AH, Besag FM, Brodie MJ, et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia 1999; 40: 985-991.
    • (1999) Epilepsia , vol.40 , pp. 985-991
    • Guberman, A.H.1    Besag, F.M.2    Brodie, M.J.3
  • 217
    • 0032860571 scopus 로고    scopus 로고
    • Factors influencing the incidence of lamotrigine-related skin rash
    • Wong IC, Mawer GE, Sander JW. Factors influencing the incidence of lamotrigine-related skin rash. Ann Pharmacother 1999; 33: 1037-1042.
    • (1999) Ann Pharmacother , vol.33 , pp. 1037-1042
    • Wong, I.C.1    Mawer, G.E.2    Sander, J.W.3
  • 218
    • 33645299828 scopus 로고    scopus 로고
    • Predictors of lamotrigine-associated rash
    • Hirsch LJ, Weintraub DB, Buchsbaum R, et al. Predictors of lamotrigine-associated rash. Epilepsia 2006; 47: 318-322.
    • (2006) Epilepsia , vol.47 , pp. 318-322
    • Hirsch, L.J.1    Weintraub, D.B.2    Buchsbaum, R.3
  • 219
    • 0035724561 scopus 로고    scopus 로고
    • Extensive fixed drug eruption due to lamotrigine
    • Hsiao CJ, Lee JY, Wong TW, et al. Extensive fixed drug eruption due to lamotrigine. Br J Dermatol 2001; 144: 1289-1291.
    • (2001) Br J Dermatol , vol.144 , pp. 1289-1291
    • Hsiao, C.J.1    Lee, J.Y.2    Wong, T.W.3
  • 220
    • 0031739980 scopus 로고    scopus 로고
    • Rash in adult and pediatric patients treated with lamotrigine
    • Messenheimer JA. Rash in adult and pediatric patients treated with lamotrigine. Can J Neurol Sci 1998; 25: S14-S18.
    • (1998) Can J Neurol Sci , vol.25
    • Messenheimer, J.A.1
  • 221
    • 0033581457 scopus 로고    scopus 로고
    • Stevens-Johnson syndrome and antiepileptics
    • Dunn N, Wilton L, Shakir S. Stevens-Johnson syndrome and antiepileptics. Lancet 1999; 354: 1033-1034.
    • (1999) Lancet , vol.354 , pp. 1033-1034
    • Dunn, N.1    Wilton, L.2    Shakir, S.3
  • 222
    • 0033763162 scopus 로고    scopus 로고
    • Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid
    • Yalcin B, Karaduman A. Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. J Am Acad Dermatol 2000; 43: 898-899.
    • (2000) J Am Acad Dermatol , vol.43 , pp. 898-899
    • Yalcin, B.1    Karaduman, A.2
  • 223
    • 34447312716 scopus 로고    scopus 로고
    • Idiosyncratic adverse reactions to antiepileptic drugs
    • Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007; 48: 1223-1244.
    • (2007) Epilepsia , vol.48 , pp. 1223-1244
    • Zaccara, G.1    Franciotta, D.2    Perucca, E.3
  • 224
    • 0033606436 scopus 로고    scopus 로고
    • Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study
    • Rzany B, Correia O, Kelly JP, et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study Group of the International Case Control Study on Severe Cutaneous Adverse Reactions. Lancet 1999; 353: 2190-2194.
    • (1999) Lancet , vol.353 , pp. 2190-2194
    • Rzany, B.1    Correia, O.2    Kelly, J.P.3
  • 225
    • 0030198337 scopus 로고    scopus 로고
    • Epidemiology of erythema exsundativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): structure and results of a population-based registry
    • Rzany B, Mockenhaupt M, Baur S, et al. Epidemiology of erythema exsundativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): structure and results of a population-based registry. J Clin Epidemiol 1996; 49: 769-773.
    • (1996) J Clin Epidemiol , vol.49 , pp. 769-773
    • Rzany, B.1    Mockenhaupt, M.2    Baur, S.3
  • 226
    • 0033390357 scopus 로고    scopus 로고
    • Anticonvulsant hypersensitivity syndrome: incidence, prevention and management
    • Knowles SR, Shapiro LE, Shear NH. Anticonvulsant hypersensitivity syndrome: incidence, prevention and management. Drug Saf 1999; 21: 489-501.
    • (1999) Drug Saf , vol.21 , pp. 489-501
    • Knowles, S.R.1    Shapiro, L.E.2    Shear, N.H.3
  • 227
    • 0021275561 scopus 로고
    • Serum anticonvulsant concentrations and the risk of drug induced skin reactions
    • Chadwick D, Shaw MDM, Foy P, et al. Serum anticonvulsant concentrations and the risk of drug induced skin reactions. J Neurol Neurosurg Psychiatry 1984; 47: 642-644.
    • (1984) J Neurol Neurosurg Psychiatry , vol.47 , pp. 642-644
    • Chadwick, D.1    Shaw, M.D.M.2    Foy, P.3
  • 228
    • 16844370521 scopus 로고    scopus 로고
    • Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics
    • Mockenhaupt M, Messenheimer J, Tennis P, et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. Neurology 2005; 64: 1134-1138.
    • (2005) Neurology , vol.64 , pp. 1134-1138
    • Mockenhaupt, M.1    Messenheimer, J.2    Tennis, P.3
  • 229
    • 84989328040 scopus 로고    scopus 로고
    • Successful reintroduction of lamotrigine after initial rash with lamotrigine
    • Besag F, Ng GYT, Pool F. Successful reintroduction of lamotrigine after initial rash with lamotrigine. Seizure 2000; 9: 375-379.
    • (2000) Seizure , vol.9 , pp. 375-379
    • Besag, F.1    Ng, G.Y.T.2    Pool, F.3
  • 230
    • 0028933226 scopus 로고
    • Rechallenge with lamotrigine after initial rash
    • Tavenor SJ, Wong ICK, Newton R, et al. Rechallenge with lamotrigine after initial rash. Seizure 1995; 4: 67-71.
    • (1995) Seizure , vol.4 , pp. 67-71
    • Tavenor, S.J.1    Wong, I.C.K.2    Newton, R.3
  • 231
    • 0026645920 scopus 로고
    • Multiorgan failure and disseminated intravascular coagulation in severe convulsive seizures
    • Yuen AWC, Bihari DJ. Multiorgan failure and disseminated intravascular coagulation in severe convulsive seizures. Lancet 1992; 340: 618.
    • (1992) Lancet , vol.340 , pp. 618
    • Yuen, A.W.C.1    Bihari, D.J.2
  • 232
    • 0030712926 scopus 로고    scopus 로고
    • Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid
    • Chattergoon D. McGuigan M, Koren M, et al. Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid. Neurology 1997; 49: 1142-1144.
    • (1997) Neurology , vol.49 , pp. 1142-1144
    • Chattergoon, D.1    McGuigan, M.2    Koren, M.3
  • 233
    • 0029165177 scopus 로고
    • Fulminant hepatic failure induced by lamotrigine
    • Makin AJ, Fitt S. Williams R, et al. Fulminant hepatic failure induced by lamotrigine. BMJ 1995; 311: 292.
    • (1995) BMJ , vol.311 , pp. 292
    • Makin, A.J.1    Fitt, S.2    Williams, R.3
  • 234
    • 27244454636 scopus 로고    scopus 로고
    • Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (MARS)
    • Mecarelli O, Pulitano P, Mingoia M, et al. Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (MARS). Epilepsia 2005; 46: 1687-1689.
    • (2005) Epilepsia , vol.46 , pp. 1687-1689
    • Mecarelli, O.1    Pulitano, P.2    Mingoia, M.3
  • 235
    • 0036715545 scopus 로고    scopus 로고
    • Fatal progressive hepatic necrosis associated with lamotrigine treatment
    • Overstreet K, Costanza C, Behling C, et al. Fatal progressive hepatic necrosis associated with lamotrigine treatment. Dig Dis Sci 2002; 47: 1921-1925.
    • (2002) Dig Dis Sci , vol.47 , pp. 1921-1925
    • Overstreet, K.1    Costanza, C.2    Behling, C.3
  • 236
    • 0028087988 scopus 로고
    • Multisystem adverse reaction to lamotrigine
    • Schaub JE, Williamson PJ, Barnes EW, et al. Multisystem adverse reaction to lamotrigine. Lancet 1994; 344: 481.
    • (1994) Lancet , vol.344 , pp. 481
    • Schaub, J.E.1    Williamson, P.J.2    Barnes, E.W.3
  • 237
    • 0031667163 scopus 로고    scopus 로고
    • Lamotrigine-associated anticonvulsant hypersensitivity syndrome
    • Schlienger RG, Knowles SR, Shear NH. Lamotrigine-associated anticonvulsant hypersensitivity syndrome. Neurology 1998; 51: 1172-1175.
    • (1998) Neurology , vol.51 , pp. 1172-1175
    • Schlienger, R.G.1    Knowles, S.R.2    Shear, N.H.3
  • 238
    • 0031844297 scopus 로고    scopus 로고
    • Drug-induced pseudolymphoma secondary to lamotrigine
    • Pathak P, McLachlan RS. Drug-induced pseudolymphoma secondary to lamotrigine. Neurology 1998; 50: 1509-1510.
    • (1998) Neurology , vol.50 , pp. 1509-1510
    • Pathak, P.1    McLachlan, R.S.2
  • 239
    • 0033134852 scopus 로고    scopus 로고
    • Agranulocytosis associated with lamotrigine
    • de Camargo OA, Bode H. Agranulocytosis associated with lamotrigine. Br Med J 1999; 318: 1179.
    • (1999) Br Med J , vol.318 , pp. 1179
    • de Camargo, O.A.1    Bode, H.2
  • 241
    • 0033977293 scopus 로고    scopus 로고
    • Potential hepatotoxicity of lamotrigine
    • Fayad M, Choueiri R, Mikati M. Potential hepatotoxicity of lamotrigine. Pediatr Neurol 2000; 22: 49-52.
    • (2000) Pediatr Neurol , vol.22 , pp. 49-52
    • Fayad, M.1    Choueiri, R.2    Mikati, M.3
  • 242
    • 0008505703 scopus 로고
    • Incidence of sudden unexplained death in the Lamictal (lamotrigine) clinical development program
    • Leestma JE, Annegers JF, Brodie MJ, et al. Incidence of sudden unexplained death in the Lamictal (lamotrigine) clinical development program. Epilepsia 1994; 35(Suppl. 8): 12.
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 8 , pp. 12
    • Leestma, J.E.1    Annegers, J.F.2    Brodie, M.J.3
  • 243
    • 33846885882 scopus 로고    scopus 로고
    • Lamotrigine in idiopathic epilepsy-increased risk of cardiac death
    • Aurlien D, Tanboll E, Gjerstad L. Lamotrigine in idiopathic epilepsy-increased risk of cardiac death. Act Neurol Scand 2007; 115: 119-203.
    • (2007) Act Neurol Scand , vol.115 , pp. 119-203
    • Aurlien, D.1    Tanboll, E.2    Gjerstad, L.3
  • 244
    • 33750258495 scopus 로고    scopus 로고
    • Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder
    • Herold TJ. Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. CJEM 2006; 8: 361-364.
    • (2006) CJEM , vol.8 , pp. 361-364
    • Herold, T.J.1
  • 245
    • 0027330253 scopus 로고
    • Self-poisoning with lamotrigine (letter)
    • Buckley NA, Whyte IM, Dawson AH. Self-poisoning with lamotrigine (letter). Lancet 1993; 342: 1552-1553.
    • (1993) Lancet , vol.342 , pp. 1552-1553
    • Buckley, N.A.1    Whyte, I.M.2    Dawson, A.H.3
  • 246
    • 13544263591 scopus 로고    scopus 로고
    • Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents
    • Danielsson BR, Lansdell K, Patmore L, et al. Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Epilepsia 2005; 63: 17-25.
    • (2005) Epilepsia , vol.63 , pp. 17-25
    • Danielsson, B.R.1    Lansdell, K.2    Patmore, L.3
  • 247
    • 15244362235 scopus 로고    scopus 로고
    • Lamotrigine and the risk of malformations in pregnancy
    • International Lamotrigine Pregnancy Registry Scientific Advisory Committee.
    • Cunnington M, Tennis P; International Lamotrigine Pregnancy Registry Scientific Advisory Committee. Lamotrigine and the risk of malformations in pregnancy. Neurology 2005; 64: 955-960.
    • (2005) Neurology , vol.64 , pp. 955-960
    • Cunnington, M.1    Tennis, P.2
  • 248
    • 34250775442 scopus 로고    scopus 로고
    • The lamotrigine pregnancy registry
    • GlaxoSmithKlein., interim report (1 September 1992 to 31 March
    • GlaxoSmithKlein. The lamotrigine pregnancy registry, interim report (1 September 1992 to 31 March 2007).
    • (2007)
  • 249
    • 32344440085 scopus 로고    scopus 로고
    • Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register
    • Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006; 77: 193-198.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 193-198
    • Morrow, J.1    Russell, A.2    Guthrie, E.3
  • 251
    • 7044231535 scopus 로고    scopus 로고
    • Evaluation of lamotrigine toxicity reported to poison centers
    • Lofton AL, Klein-Schwartz W. Evaluation of lamotrigine toxicity reported to poison centers. Ann Pharmacother 2004; 38: 1811-1815.
    • (2004) Ann Pharmacother , vol.38 , pp. 1811-1815
    • Lofton, A.L.1    Klein-Schwartz, W.2
  • 252
    • 33847145911 scopus 로고    scopus 로고
    • Lamotrigine-induced seizures in a child: case report and literature review
    • Thundiyil JG, Anderson IB, Stewart PJ, et al. Lamotrigine-induced seizures in a child: case report and literature review. Clin Toxicol (Phila) 2007; 45: 169-172.
    • (2007) Clin Toxicol (Phila) , vol.45 , pp. 169-172
    • Thundiyil, J.G.1    Anderson, I.B.2    Stewart, P.J.3
  • 253
    • 84989316687 scopus 로고    scopus 로고
    • Lamotrigine In: British National Formulary
    • Anonymous.
    • Anonymous. Lamotrigine. In: British National Formulary. London: Royal Pharmaceutical Society of Great Britain, 2001; 42: 229.
    • (2001) London: Royal Pharmaceutical Society of Great Britain , vol.42 , pp. 229
  • 254
    • 0035160282 scopus 로고    scopus 로고
    • Effectiveness of first antiepileptic drug
    • Kwan P, Brodie MJ. Effectiveness of first antiepileptic drug. Epilepsia 2001; 42: 1255-1260.
    • (2001) Epilepsia , vol.42 , pp. 1255-1260
    • Kwan, P.1    Brodie, M.J.2
  • 255
    • 0032861994 scopus 로고    scopus 로고
    • Lamotrigine
    • Matsuo F. Lamotrigine. Epilepsia 1999; 40(Suppl. 5): S30-S36.
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. 5
    • Matsuo, F.1
  • 256
    • 0042853198 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of oral loading with lamotrigine in epilepsy monitoring units
    • Lardizabal DV, Morris HH, Hovinga CA, et al. Tolerability and pharmacokinetics of oral loading with lamotrigine in epilepsy monitoring units. Epilepsia 2003; 44: 536-539.
    • (2003) Epilepsia , vol.44 , pp. 536-539
    • Lardizabal, D.V.1    Morris, H.H.2    Hovinga, C.A.3
  • 257
    • 33750924274 scopus 로고    scopus 로고
    • How to replace lamotrigine with valproate
    • Steinhoff BJ. How to replace lamotrigine with valproate. Epilepsia 2006; 47: 1943-1944.
    • (2006) Epilepsia , vol.47 , pp. 1943-1944
    • Steinhoff, B.J.1
  • 258
    • 33845709780 scopus 로고    scopus 로고
    • Optimizing therapy of seizures in patients with renal or hepatic dysfunction
    • Lacerda G, Krummel T, Sabourdy C, et al. Optimizing therapy of seizures in patients with renal or hepatic dysfunction. Neurology 2006; 67: S28-S33.
    • (2006) Neurology , vol.67
    • Lacerda, G.1    Krummel, T.2    Sabourdy, C.3
  • 259
    • 0032937202 scopus 로고    scopus 로고
    • Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy
    • Grasela TH, Fiedler-Kelly J, Cox E, et al. Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. J Clin Pharmacol 1999; 39: 373-384.
    • (1999) J Clin Pharmacol , vol.39 , pp. 373-384
    • Grasela, T.H.1    Fiedler-Kelly, J.2    Cox, E.3
  • 260
    • 0030968695 scopus 로고    scopus 로고
    • Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data
    • Hussein Z, Posner J. Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data. Br J Clin Pharmacol 1997; 43: 457-465.
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 457-465
    • Hussein, Z.1    Posner, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.