-
1
-
-
0024453369
-
Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy
-
Binnie CD, Debets RMC, Engelsman M, Meijer JW, Meinardi H, Overweg J, et al. Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989;4:222-9.
-
(1989)
Epilepsy Res
, vol.4
, pp. 222-229
-
-
Binnie, C.D.1
Debets, R.M.C.2
Engelsman, M.3
Meijer, J.W.4
Meinardi, H.5
Overweg, J.6
-
2
-
-
0024335018
-
Controlled trial of lamotrigine (Lamictal) for refractory partial seizures
-
Jawad S, Richens A, Goodwin G, Yuen WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989;30:356-63.
-
(1989)
Epilepsia
, vol.30
, pp. 356-363
-
-
Jawad, S.1
Richens, A.2
Goodwin, G.3
Yuen, W.C.4
-
3
-
-
0025087187
-
A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures
-
Loiseau P, Yuen AWC, Duché B, Ménager T, Arné-Bes MC. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures. Epilepsy Res 1990;7:136-45.
-
(1990)
Epilepsy Res
, vol.7
, pp. 136-145
-
-
Loiseau, P.1
Yuen, A.W.C.2
Duché, B.3
Ménager, T.4
Arné-Bes, M.C.5
-
4
-
-
0025122852
-
A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy
-
Sander JWAS, Patsalos PN, Oxley JR, Hamilton MJ, Yuen WC. A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy. Epilepsy Res 1990;6:221-6.
-
(1990)
Epilepsy Res
, vol.6
, pp. 221-226
-
-
Sander, J.W.A.S.1
Patsalos, P.N.2
Oxley, J.R.3
Hamilton, M.J.4
Yuen, W.C.5
-
5
-
-
0027491284
-
Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures
-
Matsuo F, Bergen D, Faught E, Messenheimer JA, Dren AT, Rudd GD, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993;43:2284-91.
-
(1993)
Neurology
, vol.43
, pp. 2284-2291
-
-
Matsuo, F.1
Bergen, D.2
Faught, E.3
Messenheimer, J.A.4
Dren, A.T.5
Rudd, G.D.6
-
6
-
-
0028268250
-
Lamotrigine therapy for partial seizures: A multicenter, placebo-controlled, double-blind, crossover trial
-
Messenheimer J, Ramsay RE, Willmore LJ, Leroy RF, Zielinski JJ, Mattson R, et al. Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, crossover trial. Epilepsia 1994;35:113-21.
-
(1994)
Epilepsia
, vol.35
, pp. 113-121
-
-
Messenheimer, J.1
Ramsay, R.E.2
Willmore, L.J.3
Leroy, R.F.4
Zielinski, J.J.5
Mattson, R.6
-
7
-
-
0023475125
-
Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans
-
Cohen AF, Land GS, Breimer DD, Yuan WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther 1987;42:535-41.
-
(1987)
Clin Pharmacol Ther
, vol.42
, pp. 535-541
-
-
Cohen, A.F.1
Land, G.S.2
Breimer, D.D.3
Yuan, W.C.4
Winton, C.5
Peck, A.W.6
-
8
-
-
0025879343
-
Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, lamotrigine
-
Doig MV, Clare RA. Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, lamotrigine. J Chromatogr 1991;554:181-9.
-
(1991)
J Chromatogr
, vol.554
, pp. 181-189
-
-
Doig, M.V.1
Clare, R.A.2
-
9
-
-
0025975978
-
Isolation and characterization of a novel quarternary ammonium-linked glucuronide of lamotrigine
-
Sinz MW, Remmel RO. Isolation and characterization of a novel quarternary ammonium-linked glucuronide of lamotrigine. Drug Metab Dispos 1991;19: 149-53.
-
(1991)
Drug Metab Dispos
, vol.19
, pp. 149-153
-
-
Sinz, M.W.1
Remmel, R.O.2
-
10
-
-
0000979733
-
Investigation of the ability of lamotrigine, a novel antiepileptic drug, to induce mixed function oxygenase enzymes
-
Posner J, Webster H, Yuen WC. Investigation of the ability of lamotrigine, a novel antiepileptic drug, to induce mixed function oxygenase enzymes [abstract]. Br J Clin Pharmacol 1991;32:658P.
-
(1991)
Br J Clin Pharmacol
, vol.32
-
-
Posner, J.1
Webster, H.2
Yuen, W.C.3
-
11
-
-
0022885310
-
Acute effects of lamotrigine (BW430C) in persons with epilepsy
-
Binnie CD, van Emde Boas W, Kasteleijn-Nolste-Trenite DGA, de Korte RA, Meijer JW, Meinardi H, et al. Acute effects of lamotrigine (BW430C) in persons with epilepsy. Epilepsia 1986;27:248-54.
-
(1986)
Epilepsia
, vol.27
, pp. 248-254
-
-
Binnie, C.D.1
Van Emde Boas, W.2
Kasteleijn-Nolste-Trenite, D.G.A.3
De Korte, R.A.4
Meijer, J.W.5
Meinardi, H.6
-
12
-
-
0023574269
-
Lamotrigine: Single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy
-
Jawad S, Yuen WC, Peck AW, Hamilton MJ, Oxley JR, Richens A. Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy. Epilepsy Res 1987;1:194-201.
-
(1987)
Epilepsy Res
, vol.1
, pp. 194-201
-
-
Jawad, S.1
Yuen, W.C.2
Peck, A.W.3
Hamilton, M.J.4
Oxley, J.R.5
Richens, A.6
-
13
-
-
0026005583
-
Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy
-
Ramsay RE, Pellock JM, Garnett WR, Sanchez RM, Valakas AM, Wargin WA, et al. Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy. Epilepsy Res 1991;10:191-200.
-
(1991)
Epilepsy Res
, vol.10
, pp. 191-200
-
-
Ramsay, R.E.1
Pellock, J.M.2
Garnett, W.R.3
Sanchez, R.M.4
Valakas, A.M.5
Wargin, W.A.6
-
14
-
-
0023780144
-
Pharmacologic interactions between valproate and other drugs
-
Bourgeois BFD. Pharmacologic interactions between valproate and other drugs. Am J Med 1988;84(suppl 1A):29-33.
-
(1988)
Am J Med
, vol.84
, Issue.SUPPL. 1A
, pp. 29-33
-
-
Bourgeois, B.F.D.1
-
15
-
-
0026725358
-
In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes
-
Magdalou J, Herber R, Bidault R, Siest G. In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes. J Pharmacol Exp Ther 1992;260:1166-73.
-
(1992)
J Pharmacol Exp Ther
, vol.260
, pp. 1166-1173
-
-
Magdalou, J.1
Herber, R.2
Bidault, R.3
Siest, G.4
-
16
-
-
0021299630
-
Variability in level-dose ratio of valproate: Monotherapy vs polytherapy
-
Levy RH. Variability in level-dose ratio of valproate: monotherapy vs polytherapy. Epilepsia 1984;25(suppl 1):S10-3.
-
(1984)
Epilepsia
, vol.25
, Issue.1 SUPPL.
-
-
Levy, R.H.1
-
17
-
-
0023135810
-
Valproic acid hepatic fatalities: A retrospective review
-
Dreifuss FE, Santilli N, Langer DH, Sweeny KP, Moline KA, Menander KB. Valproic acid hepatic fatalities: a retrospective review. Neurology 1987;37:379-85.
-
(1987)
Neurology
, vol.37
, pp. 379-385
-
-
Dreifuss, F.E.1
Santilli, N.2
Langer, D.H.3
Sweeny, K.P.4
Moline, K.A.5
Menander, K.B.6
-
18
-
-
0021646542
-
The hepatotoxicity of valproic acid and its metabolites in rats; I: Toxicologic, biochemical and histopathologic studies
-
Kesterson JW, Granneman GR, Machinist JM. The hepatotoxicity of valproic acid and its metabolites in rats; I: toxicologic, biochemical and histopathologic studies. Hepatology 1984;4:1143-52.
-
(1984)
Hepatology
, vol.4
, pp. 1143-1152
-
-
Kesterson, J.W.1
Granneman, G.R.2
Machinist, J.M.3
-
19
-
-
0020622593
-
The toxicity of the metabolites of sodium valproate in cultured hepatocytes
-
Kingsley E, Gray PD, Tolman KG, Tweedale R. The toxicity of the metabolites of sodium valproate in cultured hepatocytes. J Clin Pharmacol 1982;23:178-85.
-
(1982)
J Clin Pharmacol
, vol.23
, pp. 178-185
-
-
Kingsley, E.1
Gray, P.D.2
Tolman, K.G.3
Tweedale, R.4
-
21
-
-
0023118253
-
Cytochrome P450 catalyzed formation of Δ-valproate, a toxic metabolite of valproic acid
-
Rettie AE, Rettenmeier AW, Howald WN, Baillie TA. Cytochrome P450 catalyzed formation of Δ-valproate, a toxic metabolite of valproic acid. Science 1987;235: 890-3.
-
(1987)
Science
, vol.235
, pp. 890-893
-
-
Rettie, A.E.1
Rettenmeier, A.W.2
Howald, W.N.3
Baillie, T.A.4
-
22
-
-
0025007782
-
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid
-
Levy RH, Rettenmeier AW, Anderson GD, Wilensky AJ, Friel PN, Baillie TA, et al. Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid. Clin Pharmacol Ther 1990;48: 225-34.
-
(1990)
Clin Pharmacol Ther
, vol.48
, pp. 225-234
-
-
Levy, R.H.1
Rettenmeier, A.W.2
Anderson, G.D.3
Wilensky, A.J.4
Friel, P.N.5
Baillie, T.A.6
-
24
-
-
0026742049
-
Lamotrigine: Preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs
-
Wolf P. Lamotrigine: preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs. J Epilepsy 1992;5:73-9.
-
(1992)
J Epilepsy
, vol.5
, pp. 73-79
-
-
Wolf, P.1
-
25
-
-
0026096152
-
Immunofluorometric assay for lamotrigine (Lamictal) in human plasma
-
Sailstad JM, Findlay JWA. Immunofluorometric assay for lamotrigine (Lamictal) in human plasma. Ther Drug Monit 1991;13:433-42.
-
(1991)
Ther Drug Monit
, vol.13
, pp. 433-442
-
-
Sailstad, J.M.1
Findlay, J.W.A.2
-
26
-
-
0023779477
-
Capillary gas chromatographic assay for valproic acid and its 2-desaturated metabolite in brain and plasma
-
Semmes RLO, Shen DD. Capillary gas chromatographic assay for valproic acid and its 2-desaturated metabolite in brain and plasma. J Chromatogr 1988; 432:185-97.
-
(1988)
J Chromatogr
, vol.432
, pp. 185-197
-
-
Semmes, R.L.O.1
Shen, D.D.2
-
27
-
-
0024549456
-
Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques
-
Rettenmeier AW, Howald WN, Levy RH, Witek DJ, Gordon WP, Porubek DJ, et al. Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques. Biomed Environ Mass Spectrom 1989;18: 192-9.
-
(1989)
Biomed Environ Mass Spectrom
, vol.18
, pp. 192-199
-
-
Rettenmeier, A.W.1
Howald, W.N.2
Levy, R.H.3
Witek, D.J.4
Gordon, W.P.5
Porubek, D.J.6
-
28
-
-
0001078989
-
A package of computer programs for pharmacokinetic modeling
-
Metzler CM, Elfring GL, McEwen AJ. A package of computer programs for pharmacokinetic modeling. Biometrics 1974;30:562.
-
(1974)
Biometrics
, vol.30
, pp. 562
-
-
Metzler, C.M.1
Elfring, G.L.2
McEwen, A.J.3
-
30
-
-
0344003602
-
-
Levy RH, Dreifuss FE, Mattson RH, Meldrum MB, Penry JK, editors. New York: Raven Press
-
Levy RH, Shen DD. In: Levy RH, Dreifuss FE, Mattson RH, Meldrum MB, Penry JK, editors. Antiepileptic drugs. New York: Raven Press, 1989:643-51.
-
(1989)
Antiepileptic Drugs
, pp. 643-651
-
-
Levy, R.H.1
Shen, D.D.2
-
31
-
-
0001921267
-
Valproate: Biotransformation
-
Levy RH, Dreifuss FE, Mattson RH, Meldrum MB, Penry JK, editors. New York: Raven Press
-
Baillie TA, Rettenmeier AW. Valproate: biotransformation. In: Levy RH, Dreifuss FE, Mattson RH, Meldrum MB, Penry JK, editors. Antiepileptic drugs. New York: Raven Press, 1989:601-19.
-
(1989)
Antiepileptic Drugs
, pp. 601-619
-
-
Baillie, T.A.1
Rettenmeier, A.W.2
-
32
-
-
0003027397
-
Effect of valproate on the pharmacokinetics of lamotrigine (Lamictal) at steady state
-
Yau MK, Wargin WA, Wolf KB, Lai AA, Dren AT, Harris SI, et al. Effect of valproate on the pharmacokinetics of lamotrigine (Lamictal) at steady state [abstract]. Epilepsia 1992;33(suppl 3):82.
-
(1992)
Epilepsia
, vol.33
, Issue.3 SUPPL.
, pp. 82
-
-
Yau, M.K.1
Wargin, W.A.2
Wolf, K.B.3
Lai, A.A.4
Dren, A.T.5
Harris, S.I.6
-
34
-
-
0023475125
-
Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans
-
Cohen AF, Land GS, Breimer DD, Yuen WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans. Clin Pharmacol Ther 1987;42:535-41.
-
(1987)
Clin Pharmacol Ther
, vol.42
, pp. 535-541
-
-
Cohen, A.F.1
Land, G.S.2
Breimer, D.D.3
Yuen, W.C.4
Winton, C.5
Peck, A.W.6
-
35
-
-
0025967232
-
Alterations in the renal excretion of valproate and its metabolites after chronic treatment
-
Fisher JE, Nau H, Loscher W. Alterations in the renal excretion of valproate and its metabolites after chronic treatment. Epilepsia 1991;32:146-50.
-
(1991)
Epilepsia
, vol.32
, pp. 146-150
-
-
Fisher, J.E.1
Nau, H.2
Loscher, W.3
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