Modulation of calcium and potassium currents by lamotrigine

Neuropsychobiology

Volumn 38, Issue 3, 1998, Pages 131-138

  Grunze, Heinz ^a   Von Wegerer, Jörg ^b   Greene, Robert W ^c   Walden, Jörg ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bipolar disorder; Calcium; Carbamazepine; Epilepsy; Lamotrigine; Potassium; Valproate; Verapamil

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID; VALPROIC ACID; VERAPAMIL;

CALCIUM CURRENT; CONFERENCE PAPER; EPILEPSY; FEMALE; MALE; MANIC DEPRESSIVE PSYCHOSIS; MOUSE; NERVE CELL STIMULATION; NEUROMODULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; ANTICONVULSANTS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HIPPOCAMPUS; ION CHANNEL GATING; LINEAR MODELS; MALE; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; TRIAZINES;

EID: 0031783746     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026528     Document Type: Conference Paper

References (38)

1. Messenheimer J: Lamotrigine. Epilepsia 1995; 36:S87 S94.
2. Walden J, Hesslinger B, van Calker D, Berger M: Addition of lamotrigine to valproate may enhance efficacy in the treatment of bipolar affective disorder. Pharmacopsychiatry 1996;29: 193 195.
3. Sporn A, Sachs G: The anticonvulsant lamotrigine in treatment resistant manic-depressive illness. J Clin Psychopharmacol 1997;17:185 189.
4. Calabrese J, Fatemi S, Woyshville M: Antidepressant effects of lamotrigine in rapid cycling bipolar disorder. Am J Psychiatry 1996;153:1236.
5. Leach M, Marden C, Miller A:Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. II. Neurochemical studies on the mechanism of action. Epilepsia 1986;27:490-497.
6. + channels in rat hippocampal neurones. Eur J Physiol 1995;430: 437 446.
7. McGeer E, Zhu S: Lamotrigine protects against kainate but not ibotenate lesions in the rat striatum. Nerosci Lett 1990;112:348 351.
8. Grunze H, Kammerer C, Ackenheil M: The neurobiology of bipolar disorder. J Bipolar Disord 1997;1:2 12.
9. Dubovsky S, Buzan R: Novel alternatives and supplements to lithium and anticonvulsants for bipolar affective disorder. J Clin Psychiatry 1997;58:224 242.
10. Biervert C, Schroeder B, Kubisch C, Berkovic S, Propping P, Jentsch T, Steinlein O: A potassium channel mutation in neonatal human epilepsy. Science 1998;279:403-406.
11. Walden J, Altrup U, Reith H, Speckmann EJ: Effects of valproate on early and late potassium currents of single neurons. Eur Neuropsychopharmacol 1993;3:137 141.
12. Zona C, Tancredi V, Palma E, Pirrone G, Avoli M: Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine. Can J Physiol Pharmacol 1990; 68:545 547.
13. Walden J, Grunze H, Bingmann D, Liu Z, Düsing R: Calcium antagonistic effects of carbamazepine as a mechanism of action in neuropsychiatric disorders: Studies in calcium dependent model epilepsies. Eur Neuropsychopharmacol 1992;2:455-462.
14. Walden J, Grunze H, Mayer A, Düsing R, Schirrmacher K, Liu Z, Bingmann D: Calcium-antagonistic effects of carbamazepine in epilepsies and affective psychoses. Neuropsychobiology 1993;27:171 175.
15. Meldrum B: Action of established and novel anticonvulsant drugs on the basic mechanisms of epilepsy. Epilepsy Res 1996;11:S67-S77.
16. Pohl M, Straub H, Speckmann E: Low-magnesium induced epileptic discharges in guinea pig hippocampal slices: Depression by the organic calcium antagonist verapamil. Brain Res 1986; 577:29 35.
17. Grunze H, Walden J: Reduction of the frequency of occurrence of low magnesium induced field potentials in the hippocampus slice preparation of guinea pigs: A good screening tool for calcium antagonistic effects of anticonvulsant and antipsychotic drugs. Magnesium Res 1997;10:119 126.
18. Wegerer J, Hesslinger B, Berger M, Walden J: A calcium antagonistic effect of the new antiepileptic drug lamotrigine. Eur Neuropsychopharmacol 1997;7:77 81.
19. Blanton M, Lo Turco J, Kriegstein A: Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J Neurosci Methods 1989;30:203 210.
20. Mody I, Lambert JDC, Heinemann U: Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J Neurophysiol 1987;57:869 888.
21. Storm J: Potassium currents in hippocampal pyramidal cells. Prog Brain Res 1990;83:161 187
22. Straub H, Lück A, Köhling R, Moskopp D, Pohl M, Wassmann H, Speckmann E: Low magnesium induced epileptiform activity in the human neocortex maintained in vitro: Suppression by the organic calcium antagonist verapamil. J Epilepsy 1992;5:166 170.
23. Walden J, Pockberger H, Witte O, Speckmann E, Petsche H: Effects of organic calcium antagonists and agonists on invertebrate neurons; in Speckmann EJ, Schulze H, Walden J (eds): Epilepsy and Calcium. Munich. Lirban, & Schwarzenberg, 1986, pp 257 276.
24. Bingmann D, Speckmann, E: Specific suppression of pentylene-tetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil. Exp Brain Res 1988; 74:239 248.
25. Lücke A, Speckmann E: Influence of the organic calcium antagonist verapamil on N-methyl-D-aspartate (NMDA) induced cortical field potentials (neocortical slice, guinea pig). Neurosci Lett 1993;161:179 182.
26. Tappert U, Musshoff U, Madeja M, Lücke A, Speckmann E: Verapamil did not affect GABA and glutamate receptors. Eur J Physiol (Pflügers Arch) 1996;431:SR72.
27. Speckmann E, Schulze H, Walden J (eds): Epilepsy and Calcium. München, Urban & Schwarzenberg, 1986.
28. Dubovsky S: Calcium antagonists in manic-depressive illness. Neuropsychobiology 1993;27: 184-192.
29. Peck A: Clinical pharmacology of lamotrigine. Epilepsia 1991;32:S9 S12.
30. Lees G, Leach M: Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex. Brain Res 1993;612:190 199.
31. Lang D, Wang C: Lamotrigine and phenytoin interactions on ionic channels present in N4TG1 and GH3 clonal cells. Soc Neurosci Abstr 1991;17:1256.
32. Wang S, Huang C, Hsu K, Tsai J, Gean P: Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones. Neuroreport 1996;7:3037 3040.
33. Wang S, Huang C, Hsu K, Tsai J, Gean P: Presynaptic inhibition of excitatory neuro-transmission by lamotrigine in the rat amygdalar neurons. Synapse 1996;24:248-255.
34. Erdelyi L: Zinc modulates A-type potassium currents and neuronal excitability in snail neurons. Cell Mol Neurobiol 1994;14:689 700.
35. Brunet G, Cerlich B, Robert P, Dumas S, Souetre E, Darcourt G: Open trial of a calcium antagonist, nimodipine, in acute mania. Clin Neuropharmacol 1990;13:224 228.
36. Dubovsky SL: Calcium antagonists in manic-depressive illness. Neuropsychobiology 1993;27: 184 192.
37. Pazzaglia P, Post R, Ketter T, George M, Marangell L: Preliminary controlled trial of nimodipine in ultra-rapid cycling affective dysregulation. Psychiatr Res 1993;49:257-272.
38. Walden J, Fritze J, van Calker D, Berger M, Grunze H: A calcium antagonist for the treatment of depressive episodes: Single case reports. J Psychiatr Res 1995;29:71 76.