No increase in carbamazepine-10,11-epoxide during addition of lamotrigine treatment in children

Therapeutic Drug Monitoring

Volumn 19, Issue 5, 1997, Pages 499-501

  Eriksson, Ann Sofie ^a   Boreus, Lars O ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antiepileptic drugs; Carbamazepine; Drug interactions; Lamotrigine

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE;

ADOLESCENT; AGITATION; ANTICONVULSANT THERAPY; ARTICLE; CHILD; CLINICAL ARTICLE; DIPLOPIA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG MONITORING; EPILEPSY; HUMAN; PRIORITY JOURNAL; SEIZURE;

ADOLESCENT; ADULT; ANTICONVULSANTS; CARBAMAZEPINE; CHILD; DRUG INTERACTIONS; DRUG MONITORING; EPILEPSY, GENERALIZED; HUMANS; TRIAZINES;

EID: 0031413729     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199710000-00002     Document Type: Article

References (12)

1. Sillanpää M, Pynnönen S, Laippala P, et al. Carbamazepine in the treatment of partial epilepsy seizures in infants and young children: a preliminary study. Epilepsia 1979;20:563-9.
2. Schoeman JF, Elyas AA, Brett EM, et al. Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. Dev Med Child Neurol 1984;26: 756-64.
3. Tomson T. Side-effects of carbamazepine: drug or metabolite? Lancet 1985;2:1010.
4. Pisani F, Perucca E, Perri R. Clinically relevant antiepileptic drug interactions. J Int Med Res 1990;18:1-15.
5. Korinthenberg R, Haug C, Hannak D. The metabolization of carbamazepine to CBZ-10,11-epoxide in children from newborn age to adolescence. Neuropediatrics 1994;25:214-6.
6. Warner T, Patsalos PN, Prevett M, et al. Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11-epoxide. Epilepsy Res 1992;11:147-50.
7. Graves NM, Ritter FJ, Wagner ML, et al. Effect of lamotrigine on carbamazepine epoxide concentrations. Epilepsia 1991;32(suppl 3):13.
8. Pisani F, Xiao B, Fazio A, et al. Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. Epilepsy Res 1994;19:245-8.
9. Schapel GJ, Dollman W, Beran RG, et al. No effect of lamotrigine on carbamazepine and carbamazepine-epoxide concentrations. Epilepsia 1991;32(suppl 1):58.
10. Forssblad E, Eriksson A-S, Beck O. Liquid chromatographic determination of plasma lamotrigine in pediatric samples. J Pharm Biomed Anal 1996;14:755-8.
11. Rambeck B, Wolf P. Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet 1993;25:433-43.
12. Eriksson A-S, Nergårdh A, Boreus L, et al. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia 1996;37(8):769-73.