New antiepileptic drugs: A systematic review of their efficacy and tolerability

British Medical Journal

Volumn 313, Issue 7066, 1996, Pages 1169-1174

  Marson, A G ^a   Kadir, Z A ^a   Chadwick, D W ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN; LAMOTRIGINE; TIAGABINE; TOPIRAMATE; VIGABATRIN; ZONISAMIDE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFICACY; DRUG TOLERABILITY; FOCAL EPILEPSY; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEIZURE;

ACETIC ACIDS; ADOLESCENT; ADULT; AGED; AMINES; ANTICONVULSANTS; CHILD; CROSS-OVER STUDIES; CYCLOHEXANECARBOXYLIC ACIDS; EPILEPSY; FEMALE; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; HUMANS; ISOXAZOLES; MALE; MIDDLE AGED; NIPECOTIC ACIDS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME; TRIAZINES; VIGABATRIN;

EID: 0029822510     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Reynolds EH, Shorvon SD, Galbraith AW. Phenytoin for epilepsy: a long term prospective study, assisted by serum level monitoring in previously untreated patients. Epikpsi? 1981;22;475.
2. Cockereli OC, Johnson AL, Sander JW, Hart YM, Shorvon SD. Remission of epilepsy: results from the national general practice study of epilepsy. Ltfnorrl995;346:140-4.
3. Hauser VA, Kurland LT. The epidemiology of epilepsy in Rochester, Minnesota, 1935 through l967.Epuepsia 1975;I6:l-66.
4. Maison AG, Chadwick DW. Comparing antiepileptic drugs. Cwrr Opin ArmrfI996;9:103-6.
5. Marson AG, Chadwïck DW. How easy are randomized controlled trials in epilepsy to find on Medline? The sensitivity and precision of two Medline searches. Epilepsia 1996j37(4):377-80.
6. Ring HA, Heller AJ, Fair IN, Reynolds EH. Vigabatrin: rational treatment for chronic epilepsy. J Neural Neurosurg Psychiatry I990;53:1051-5.
7. Martson RH, Cramer JA, Collins JF, Smith DB, Delgado-Escueta AV, Browne TR, et al. Comparison of carbamazepine, phénobarbital, phenytoin, and primidone in partial and secondarily generalized ronic-clonic seizures. NEn£J.7,AW1985;313:145-51.
8. Antiplatelet Trialists' Collaboration. Collaborative overview of randomized trials of antiplatelet therapy. Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994;308:81-106-
9. Anhut H, Ashman P, Feuerstein TJ, Sauermann W, Saunders M, Schmidt B. Gabapenrin (Neuronrin) as add-on therapy in patients with partial seizures: a double-blind, placebo-controlled study. The International Gabapentin Study Group. EpUepsia 1994;35:795-801.
10. Sivenius J, Kalviainen R, Ylinen A, Riekkinen P. Double blind study of gabapentin in the treatment of partial seizures. EpUepsia 1991;32:539-42.
11. UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet 1990;335:1114-7.
12. US Gabapentin Study Group No 5. Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallelgroup study. Neurology 1993;43:2292-8.
13. Matsuo F, Bergen D, Faught E, Messenheimer JA, Dren AT, Rudd GD, etal. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. US Lamotrigine Protocol 0.5 Clinical Trial Group. Neurology 1993;43:2284-91.
14. Binnie CD, Debets RM, Engelsman M, Meijer JW, Meinardi H, Overweg J, et al. Double blind crossover trial of lamotrigine (Lamictal) as add on therapy in intractable epilepsy. Ep&psyRa 1989;4:222-9.
15. Jawad S, Richens A, Goodwin G, Yuen WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epüepsia 1989;30:356-63.
16. Loiseau P, Yuen AW, Duché B, Menager T, Arne Bes MC. A randomised double blind placebo controlled crossover add on trial of lamotrigine in patients with treatment resistant partial seizures. EpUcpsy Res 1990;7:13645.
17. Messenheimer J, Ramsay RE, Willmore LJ, Leroy RF, Zielinski JJ, Mattson R, et al. Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial. Epikpsia 1994;35:113-21.
18. Schapel GJ, Beran RG, Vajda FJ, Berkovic SF, Mashford ML, Dunagan FM, et al. Double blind, placebo controlled, crossover study of lamotrigine in treatment resistant partial seizures, jf Neural Neurosurg Psychiatry 1993;56:448-53.
19. Smith D, Baker G, Davies G, Dewey M, Chadwick DW. Outcomes of add on treatment with lamotrigine in partial epilepsy. EpUepsia 1993;34:312-22.
20. Tassinari CA, Michelucct R, Chauvel P, Chodiewicz J, Shorvon S, Henriksen O, et aï. Double blind placebo controlled trial of topiramate (600 mg daily) for the treatment of refractory partial epilepsy. EpUepsia 1996;37:763-8
21. Ben-Menachem E, Henriksen O, Dam M, Schmidt D. Double blind placebo controlled trial of topiramate as add-on treatment in patients with refractory partial epilepsy. Epüepsia I996;36:539-43
22. Faught E, Wilder BJ, Ramsay E, Reife R, Kramer L, Pledger G, et al. Topîramate controlled dose ranging trial in refractory partial epilepsy using 200,400 and 600 mg daily dosages. Neurology 1996-46:1684-90.
23. Privirera M, Fincham R, Renry J, Reife R, Kramer L, Pledger G, et al. Topiramate placebo controlled trial in refractory partial epilepsy using 600,800 and 1000 mg daily dosages. Neurology I996;46:1678-83.
24. French JA, Mosier M, Walker S, Somerville K, Sussman N, the Vigabatrin Protocol 024 Investigative Cohort. A double-blind, placebo controlled study of vigabatrin 3g/day in patients with uncontrolled complex partial seizures. Neurology 1996;46:54-61.
25. Grunewald RA, Thompson PJ, Corcoran R, Corden Z, Jackson GD, Duncan JS. Effects of vigabatrin on partial seizures and cognitive function. J Neurol Neurosurg Psychiatry 1994;57:1057-63.
26. Penry JK, Wilder BJ, Sachdeo RC, Vaughan LV, Ahlbrandt RA, Sommerville KW, et al. Multicenter dose-response study of vigabatrin in adults with focal (partial) epilepsy [abstract]. Epüepsia 1993;34(suppl 6):67.
27. Schmidt D, Jacob R, Loiseau P, Deisenhammer E, Klinger D, Despland A, et cd. Zonisamide for add on treatment of refractory partial epilepsy: a European double blind trial. Epi!cpsy Res 1993;I5:67-73.
28. Wilder BJ, Ramsay RE, Guterman A. A double-blind midticenter placebo-controlled study of the efficacy and safety ofzonisamide in the treatment of complex partial seizures in jnedicaUy refractory patients. Internal report of the Dianippon Pharmaceutical Co. 1986.
29. Spilker B, Segreti A. Validation of the phenomenon of regression of seizure " frequency in epilepsy. Epüepsia 1984;25:443-9.
30. Mattson RH, Cramer JA, CoIIins JF. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No 264 Group. N Engl J Aled 1992;327:765-7I.
31. Richens A, Davidson DL, Cartlidge NE, Easter DJ. A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group. J Neurol Neurosurg Psychiatry 1994;57:682-7. -
32. Verity CM, Hosking G, Easter DJ. A multicentre comparative trial of sodium valproate and carbamazepine in paediatric epilepsy. The Paediatric EPITEG Collaborative Group. DevMedChüdNeurol I995;37:97-108.
33. Willmore JL, Shu V, Wallin B, the M88-194 Study Group. Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures. Neurol I996;46:49-53.
34. Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet 1995;34S:476-9.
35. Chadwick D, Marson AG, Kadir ZA. The clinical use of new antiepileptic drugs: an overview of safety and efficacy. Epüepsia (in press).
36. Commission on Antiepileptic Drugs of the International League Against Epilepsy. Guidelines for antiepileptic drug trials in children. Epüepsia 1994;3S:94-100.