A randomised open multicentre comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy

Epilepsy Research

Volumn 23, Issue 2, 1996, Pages 149-155

  Reunanen, Mauri ^a   Dam, Mogens ^b   Yuen, Alan W C ^c  

^a UNIVERSITY OF OULU   (Finland)

^b HVIDOVRE HOSPITAL   (Denmark)

^c WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

Carbamazepine; Lamotrigine; Monotherapy; Partial; Tonic clonic seizure

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOCAL EPILEPSY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; TONIC CLONIC SEIZURE;

EID: 0029866895     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(95)00085-2     Document Type: Article

References (8)

1. Brodie, M.J., Richens, A. and Yuen, A.W.C., Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy, Lancet, 345 (1995) 476-479.
2. Chapman, A., Yuen, A.W.C. and 106 Investigators, Lamotrigine (Lamictal) versus carbamazepine as monotherapy in patients with epilepsy, Epilepsia, 35 (suppl. 7) (1994) 69.
3. Commission on Classification and Terminology of the International League Against Epilepsy, Proposal for revised clinical and electroencephalographic classification of epileptic seizures, Epilepsia, 22 (1981) 489-501.
4. Goa, K.L., Ross, S.R. and Chrisp, P., Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy, Drugs, 46 (1) (1993) 152-176.
5. Matsuo, F., et al., Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures, Neurology, 43 (1993) 2284-2291.
6. Richens, A. and Yuen, A.W., Overview of the clinical effects of lamotrigine, Epilepsia, 32 (suppl. 2) (1991) 513-516.
7. Young, D.S., In: Effects of Drugs on Clinical Laboratory Tests, AACC Press, Washington, 1990, Vol. 3, pp. 128-129.
8. Yuen, A.W.C. and Chapman, A., Interim report on an open multicentre lamotrigine (Lamictal) vs carbamazepine monotherapy trial in patients with epilepsy, Can. J. Neurol. Sci., 20 (suppl. 4) (1993) S150.