The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro

Neuropharmacology

Volumn 39, Issue 11, 2000, Pages 2139-2146

  Cunningham, Mark O ^a   Jones, Roland S G ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Anticonvulsant; Entorhinal cortex; GABA release; Glutamate release; Lamotrigine; Whole cell patch clamp recording

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CALCIUM CHANNEL; GLUTAMIC ACID; LAMOTRIGINE; PHENYTOIN; SODIUM CHANNEL; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENTORHINAL CORTEX; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MEMBRANE CURRENT; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTICONVULSANTS; ENTORHINAL CORTEX; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION; TRIAZINES;

EID: 0033842216     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00051-4     Document Type: Article

References (38)

1. Berretta N., Jones R.S.G. A comparison of spontaneous synaptic EPSCs in layer V and layer II neurones in the rat entorhinal cortex in vitro. J. Neurophysiol. 76:1996;1089-1100.
2. Besag F.M. Use of the "monolog" spike and wave monitor to evaluate lamotrigine for absence seizures. Epilepsia. 32(Suppl):1991;89-90.
3. Binnie C. An overview: efficacy of lamotrigine. Richens A. Clinical Update on Lamotrigine: A Novel Antiepileptic Agent. 1992;81-87 Wells Medical Ltd, Kent.
4. Calabresi P., Centonze D., Marfia G.A., Pisani A., Bernardi G. An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. Brit. J. Pharm. 126:1999;689-696.
5. Cheung M., Kamp D., Marris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res. 13:1992;107-112.
6. TM) in an animal model of anxiety. Brit. J. Pharm. 111:1994;205P.
7. ++ uptake and amino acid neurotransmitter release in vitro. Epilepsia. 28:1987;378-382.
8. Cunningham M.O., Jones R.S.G. Phenytoin modifies spontaneous transmitter release at glutamate terminals in rat medial entorhinal cortex. J. Physiol. 511:1998;126P.
9. Cunningham M.O., Wood S.J., Dhillon A., Jones R.S.G. Reciprocal modulation of glutamate and GABA release may underlie the anticonvulsant effect of phenytoin. Neuroscience. 95:2000;343-351.
10. Cunningham M.O., Wood S.J., Jones R.S.G. Phenytoin enhances spontaneous GABA mediated inhibition in the rat entorhinal cortex. Brit. J. Pharm. 127:1999;49P.
11. Esclapez M., Hirsch J.C., Ben-Ari Y., Bernard C. Newly formed excitatory pathways for hyperexcitability in experimental temporal lobe epilepsy. J. Comp. Neurol. 408:1999;449-460.
12. Frizelle H.P., Moriaty D.C., O'Connor J.J. The combined effects of halothane and lamotrigine on excitatory postsynaptic potentials and use-dependent block in the rat dentate gyrus in vitro. Anesth. Analg. 89:1999;296-501.
13. Goa K.L., Ross S.R., Chrisp P. Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy. Drugs. 46:1993;152-176.
14. Grunze H., Greene R.W., Moller H.J., Meyer T., Walden J. Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current. Brain Res. 791:1998;330-334.
15. Hassel B., Tauboell E., Gjerstad L. Chronic lamotrigine treatment increases hippocampal GABA shunt activity and elevates cerebral taurine levels in rats. Epilpesia. 40(Suppl. 7):1999;16.
16. Hirsch J.C., Agassandian C., Perez-Merchan A., Ben-Ari Y., DeFelipe J., Esclapez M., Bernard C. Deficit of quanta1 release of GABA in experimental models of temporal lobe epilepsy. Nature Neurosci. 2:1999;499-500.
17. Jones R.S.G. Entorhinal-hippocampal connections: a speculative view of their function. Trends Neurosci. 16:1993;58-64.
18. Kuzniecky R.I., Martin R., Hetherington H., Gilliam F., Faught E. Effects of topiramate, lamotrigine and gabapentin on cerebral GABA in healthy humans. Epilepsia. 40(Suppl. 7):1999;244.
19. Lees G., Leach M. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex. Brain Res. 612:1993;190-199.
20. Leach M.J., Marsden C.M., Miller A.A. Pharmacological studies of lamotrigine, a novel potential antiepileptic drug. 2. Neurochemical studies on the mechanism of action. Epilepsia. 27:1986;490-497.
21. Mikati M.A., Holmes G.L. Lamotrigine in absence and primary generalized epilepsies. J. Child Neurol. 12(Supp 1):1997;S29-S37.
22. Miller A.A., Wheatley P., Sawyer D.A., Baxter M.G., Roth B. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. 1 Anticonvulsant profile in mice and rats. Epilepsia. 27:1986;483-489.
23. Phillips I., Martin K.F., Thompson K.S.J., Heal D.J. Weak blockade of AMPA receptor-mediated depolarizations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine. Eur. J. Pharmac. 337:1997;189-195.
24. Polselli G.M., Pennisi E.M., Talamanca L.F., Roberti R., Garelli F.F., Bandinelli P.L. Psychotic disorder after lamotrigine. Ital. J. Neurol. Sci. 19:1998;124-125.
25. Salvati P., Maj R., Caccia M.A., Cervini M.G., Fornaretto E., Lamberti P., Peverello G.A., Skeen H.S., Wolf L., Faravelli M., Mazzanti M., Varasi M., Fariello R.G. Biochemical and electrophysiological studies on the mechanism of action of PNU-15 1774E, a novel antiepileptic compound. J. Pharm. Exp. Ther. 288:1999;1151-1159.
26. Shoji Y., Tanaka E., Yamamoto S., Maeda H., Higashi H. Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurones of the kindling rat. J. Neurophysiol. 80:1998;638-646.
27. Squires R.F., Saederup E. A review of evidence for GABAergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of 'functional' psychosis. Neurochem. Res. 16:1991;1099-1111.
28. Stefani A., Spadoni F., Benardi G. Differential inhibition by riluzole, lamotrigine and phenytoin of sodium and calcium currents in cortical neurones: implications for neuroprotective strategies. Exp. Neurol. 147:1997;115-122.
29. Stewart J., Hughes E., Reynolds E.H. Lamotrigine in primary generalised epilepsy. Lancet. 340:1992;1223.
30. Teoh H., Fowler L.J., Bowery N.G. Effect of lamotrigine on the electrically-evoked release of endogenous ammo acids from slices of dorsal horn of the rat spinal cord. Neuropharmacology. 34:1995;1273-1278.
31. Timmings P.L., Richens A. Lamotrigine for generalized epilepsies. Lancet. 339:1992;1300-1301.
32. Upton N. Mechanism of action of new antiepileptic drugs: rational design and serendipitous findings. Trends Neurosci. 15:1994;456-463.
33. Waldmeier P.C., Baumann P.A., Wicki P., Feldtrauer J.-J., Stierlin C., Schmutz M. Similar potency of carbamazepine, oxcarbamazepine and lamotrigine in inhibiting the release of glutamate and other neurotransmitters. Neurology. 45:1995;1907-1913.
34. Waldmeier P.C., Martin P., Stöcklin K., Portet C., Schmutz M. Effect of carbamazepine, oxcarbamazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum. N. S. Arch. Pharm. 354:1996;164-172.
35. Wang S.J., Huang C.C., Hsu K.S., Tsai J.J., Gean P.W. Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neurons. Synapse. 24:1996;248-255.
36. Wang S.J., Huang C.C., Hsu K.S., Tsai J.J., Gean P.W. Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones. Neuroreport. 7:1996;3037-3040.
37. Wood S.J., Jones R.S.G. A comparison of characteristics of spontaneous IPSCs in layers II and V of the rat entorhinal cortex in vitro. J. Physiol. 515:1999;120P.
38. + channels in rat hippocampal neurones. Eur. J. Physiol. 430:1995;437-446.