Controlled trial of lamotrigine (Lamictal®) for treatment-resistant partial seizures

Acta Neurologica Scandinavica

Volumn 94, Issue 4, 1996, Pages 247-252

  Boas, J ^a   Dam, M ^b   Friis, M L ^c   Kristensen, O ^c   Pedersen, B ^d   Gallagher, J ^e  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d AALBORG UNIVERSITY HOSPITAL   (Denmark)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antiepileptic drug; Controlled trial; Generalised seizures; Lamotrigine; Partial seizures

Indexed keywords

LAMOTRIGINE; PLACEBO;

ADULT; AGED; ANTICONVULSANT THERAPY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; FOCAL EPILEPSY; HUMAN; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; VERTIGO;

EID: 0029827388     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1996.tb07060.x     Document Type: Article

References (17)

1. MELDRUM B, LEACH M. Rev Contemp Pharmacother 1994: 5: 107-114.
2. BINNIE CD, DEBETS RMC, ENGELSMAN M, et al. Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989: 4: 222-9.
3. SCHMIDT D, RIED S, RAPP P. Add-on treatment with lamotrigine for intractable partial epilepsy: a placebo-controlled crossover trial. Epilepsia 1993: 34 (Suppl 2): 66.
4. JAWAD S, RICHENS A, GOODWIN G, YUEN WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989: 30: 356-63.
5. SANDER JWAS, PATSALOS PN, OXLEY JR, HAMILTON MJ, YUEN WC. A randomised double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy. Epilepsy Res 1990: 6: 221-6.
6. SCHAPEL GJ, BERAN RG, VAJDA FJE, et al. Double-blind, placebo-controlled, crossover study of lamotrigine in treatment resistant partial seizures. J Neurol Neurosurg Psychiatry 1993: 56: 448-53.
7. LOISEAU P, YUEN AWC, DUCHÉ B, MÉ NAGER T, ARNÉ-BÈS MC. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial eizures. Epilepsy Res 1990: 7: 136-45.
8. SMITH D, BAKER G, DAVIES G, DEWEY M, CHADWICK K DW. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993: 34 (2): 312-22.
9. MESSENHEIMER J, RAMSAY RE, WILLMORE LJ, et al. Lamotrigine therapy for partial seizures: A multicenter, placebocontrolled, double-blind, crossover trial. Epilepsia 1994: 35: 113-21.
10. MATSUO F, BERGEN D, FAUGHI E, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures. Neurology 1993: 43: 2284-91.
11. BINNIE CD, VAN EMDE BOAS W, KASTELEIJN-NOLSTETRENITE DGA, et al. Acute effects of lamotrigine (BW430C) in persons with epilepsy. Epilepsia 1986: 27: 248-54.
12. JAWAD S, YUEN WC, PECK AW, et al. Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy. Epilepsy Res 1987: 1: 194-201.
13. DREIFUSS FE. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981: 22: 489-501.
14. TASSINARI CA, MICHELUCCI R, AMBROSETTO G, SALVI F. Double-blind study of vigabatrin in the treatment of drug-resistant epilepsy. Arch Neurol 1987: 44: 907-10.
15. GRAM L, WULFF K, RASMUSSEN KE, et al. Valproate sodium: A controlled clinical trial including monitoring of drug levels. Epilepsia 1997: 18: 141-8.
16. HARDEN CL, ZISFEIN J, ATOS-RADZION EC, TUCHMAN AJ. Combination valproate-carbamazepine therapy in partial epilepsies resistant to carbamazepine monotherapy. J Epilepsy 1993: 6: 91-4.
17. CLIFFORD JS, YUEN AWC, BRODIE MJ and the Lamictal Study Group. Open multicentre trial of lamotrigine in patients with treatment resistant epilepsy withdrawing from add-on to lamotrigine monotherapy. Epilepsia 1994: 35 (Suppl 8):31.