The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: A randomized, double-blind, crossover study

Epilepsia

Volumn 39, Issue 5, 1998, Pages 495-501

  Eriksson, A S ^a,c   Nergardh A ^a   Hoppu, K ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c National Center for Epilepsy   (Norway)

Author keywords

Children; Efficacy; Epilepsy; Lamotrigine; Lennox Gastaut

Indexed keywords

LAMOTRIGINE; PLACEBO;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MONITORING; DRUG TOLERANCE; ELECTROENCEPHALOGRAPHY; FEMALE; GENERALIZED EPILEPSY; HUMAN; INTRACTABLE EPILEPSY; LENNOX GASTAUT SYNDROME; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; AGE FACTORS; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EPILEPSY, GENERALIZED; FEMALE; HUMANS; MALE; PLACEBOS; TREATMENT OUTCOME; TRIAZINES;

EID: 2642598051     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1998.tb01411.x     Document Type: Article

References (26)

1. Binnie CD, Debets RMC, Engelsman M, et al. Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989;4:222-9.
2. Sander JWAS, Patsalos PN, Oxley JR, Hamilton MJ, Yuen WC. A randomised double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy. Epilepsy Res 1990;6: 221-6.
3. Loiseau P, Yuen AWC, Duché B, Ménager T, Arné-Bès MC. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures. Epilepsy Res 1990;7:136-45.
4. Jawad S, Richens A, Goodwin G, Yuen WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989;30(3);356-63.
5. Messenheimer J, Ramsay RE, Willmore LJ, et al. Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, crossover trial. Epilepsia 1994;35(1);113-21.
6. Smith D, Baker G, Davies G, Dewey M, Chadwick DW. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993;32(2):312-22.
7. Schapel GJ, Beran RG, Vajda FJE, et al. Double-blind, placebocontrolled, crossover study of lamotrigine in treatment-resistant partial seizures. J Neural Neurosurg Psychiatry 1993;56:448-53.
8. Schmidt D, Ried S, Rapp P. Add-on treatment with lamotrigine for intractable partial epilepsy: a placebo-controlled crossover trial. Epilepsia 1993;34(suppl 2):66.
9. Yuen AWC. Lamotrigine: a review of antiepileptic efficacy. Epilepsia 1994;35(suppl 5):33-6.
10. Binnie C. An overview: efficacy of lamotrigine. In: Richens A, ed. Clinical update on lamotrigine: a novel antiepileptic agent. Int Clin Pract Series. Tunbridge Wells: Wells Medical, 1992:31-7.
11. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30(4):389-99.
12. Stewart J, Hughes E, Reynolds EH. Lamotrigine for generalised epilepsies. Lancet 1992;340(14):1223.
13. Schlumberger E, Chavez F, Palacios L, Rey E, Pajot N, Dulac O. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia 1994;35(2);359-67.
14. Gibbs J, Appleton RE, Rosenbloom L, Yuen WC. Lamotrigine for intractable childhood epilepsy: a preliminary communication. Dev Med Child Neurol 1992;34:369-71.
15. Wallace SJ. Add-on open trial of lamotrigine in resistant childhood seizures. Brain Dev 1990;12:734.
16. Besag FMC, Wallace SJ, Dulac O, Alving J, Spencer SC, Hosking G. Lamotrigine for the treatment of epilepsy in childhood. J Pediatrics 1995;:991-7.
17. Donaldson J, Glauser T, Olberding L. Lamotrigine adjunctive therapy in childhood epileptic encephalopathy (the Lennox-Gastaut syndrome). Epilepsia 1997;38(1):68-73.
18. Timmings PL, Richens A. Lamotrigine as add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol 1992;32:305-7.
19. Oller LFV, Russi A, Oiler Daurella L. Lamotrigine in the LennoxGastaut syndrome. Epilepsia 1991;32(suppl 1):58.
20. Gastaut H. The Lennox-Gastaut syndrome: comments on the syndrome's terminology and nosological position amongst the secondary generalized epilepsies of childhood. Electroencephalogr Clin Neurophysiol 1982;(suppl 35):71-84.
21. Forssblad E, Eriksson A-S, Beck O. Liquid Chromatographic determination of plasma lamotrigine in pediatric samples. J Pharm Biomed Anal 1996;14:755-8.
22. Aicardi J. Clinical approach to the management of intractable epilepsy. Dev Med Child Neurol 1988;30:429-40.
23. Shorvon SD, Reynolds EH. Reduction in polypharmacy for epilepsy. Br Med J 1979;2:1023-5.
24. Uvebrant P, Bauziene R. Intractable epilepsy in children: the efficacy of lamotrigine treatment, including non-seizure related benefits. Neuropediatrics 1994;25:284-9.
25. Besag FMC. Lamotrigine: pediatric experience. In: Richens A, ed. Clinical update on lamotrigine: a novel antiepileptic agent. Int Clin Pract Series. Tunbridge Wells: Wells Medical, 1992:53-60.
26. Jawad S, Oxley J, Yuen WC, Richens A. The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. Br J Clin Pharmacol 1986;22:191-3.