Concerns regarding lamotrigine and breast-feeding

Epilepsy and Behavior

Volumn 5, Issue 1, 2004, Pages 102-105

  Liporace, Joyce ^a   Kao, Amy ^b   D'Abreu, Anelyssa ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Breast feeding; Epilepsy; Glucuronidation; Lamotrigine

Indexed keywords

CARBAMAZEPINE; CHLORAMPHENICOL; FOLIC ACID; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; VITAMIN; ANTICONVULSIVE AGENT; TRIAZINE DERIVATIVE;

ADULT; ARTICLE; BREAST FEEDING; CASE REPORT; CLINICAL OBSERVATION; CORRELATION ANALYSIS; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG MILK LEVEL; DRUG MONITORING; DRUG POTENTIATION; FEMALE; FOCAL EPILEPSY; GENETIC VARIABILITY; HUMAN; LACTATION; MATERNAL DISEASE; MOTHER CHILD RELATION; NEWBORN; NEWBORN DISEASE; PATIENT COUNSELING; PREGNANCY DISORDER; PUERPERIUM; BLOOD; COMPARATIVE STUDY; EPILEPSY; FOLLOW UP; MALE; PREGNANCY; TIME;

ANTICONVULSANTS; BREAST FEEDING; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; MALE; POSTPARTUM PERIOD; PREGNANCY; TIME FACTORS; TRIAZINES;

EID: 1542348249     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yebeh.2003.11.018     Document Type: Article

References (16)

1. Tennis P. Eldridge R.R. International Lamotrigine Pregnancy registry Scientific Advisory Committee. Preliminary results on pregnancy outcomes in women using lamotrigine Epilepsia 43 10 2002 1161-1167
2. Practice Parameter: Management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Epilepsia 1998 39(12) 1226-31
3. Dickens M. Sawyer D.A. Morley T.J. Parsons D.N. Lamotrigine: chemistry and biotransformation In: Levy R.H. Mattson R.H. Meldrum B.S. editors. Antiepileptic drugs 4th ed. Raven Press New York 1995 871-875
4. Nau H. Kuhnz W. Egger H.J. Rating D. Helge H. Anticonvulsants during pregnancy and lactation: transplacental, maternal, and neonatal pharmacokinetics Clin. Pharmacokinet. 7 1982 508-543
5. Rambeck B. Kurlemann G. Stodieck S.R.G. May T.W. Jurgens U. Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child Eur. J. Clin. Pharmacol. 51 1997 481 484
6. Miners J.O. Mackenzie P.I. Drug glucuronidation in humans Pharmacol. Ther. 51 1999 347-369
7. Coughtrie M.W. Burchell B. Leakey J.E. Hume R. The inadequacy of perinatal glucuronidation: immunoblast analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes Mol. Pharmacol. 34 1988 729-735
8. Perucca E. Drug metabolism in pregnancy, infancy and childhood Pharmacol. Ther. 34 1987 129-143
9. Weiss C. Glazko A.J. Weston J.K. Chloramphenicol in the newborn infant: a physiological explanation of its toxicity when given in excessive doses N. Engl. J. Med. 262 1960 787-794
10. Tomson G. Lunell N.O. Sundwall A. Rane A. Placental passage of oxazepam and its metabolism in mother and newborn Clin. Pharmacol. Ther. 25 1979 74-78
11. Garnett W.R. Lamotrigine: pharmacokinetics J. Child Neurol. 12 S1 1997 10-15
12. Ramsey R.E. Pellock J.M. Garnett W.R. et al Pharmacokinetics and safety of lamotrigine (Lamotrigine) in patients with epilepsy Epilepsy. Res. 10 1991 191-200
13. Tran T. Leppik I.E. Blesi K. Sathanandan S.T. Remmel R. Lamotrigine clearance during pregnancy Neurology 59 2002 251-255
14. Liston H.L. Markowitz J.S. DeVane C.L. Drug glucuronidation in clinical psychopharmacology J. Clin. Psychopharmacol. 21 2001 500-515
15. Bock K.W. Bock-Henning B.S. Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers Biochem. Pharmacol. 37 1988-987
16. Ohman I. Vitols S. Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation Epilepsia 41 2000 709-713