Influence of concurrent antiepileptic medication on the pharmacokinetics of lamotrigine as add-on therapy in epileptic children

British Journal of Clinical Pharmacology

Volumn 41, Issue 4, 1996, Pages 325-330

  Vauzelle Kervroedan F ^a   Rey, E ^a   Cieuta, C ^a   Pariente Khayat, A ^a   Pons, G ^a   D'Athis, P ^a   Bidault, R ^b   Dulac, O ^a   Olive, G ^a  

^a HÔPITAL SAINT VINCENT DE PAUL   (France)

^b Laboratoire Glaxo Wellcome   (France)

Author keywords

Antiepileptic drugs; Children; Epilepsy; Lamotrigine; Pharmacokinetics

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; LAMOTRIGINE; PHENYTOIN; PROGABIDE; VALPROIC ACID; VIGABATRIN;

AREA UNDER THE CURVE; ARTICLE; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; EPILEPSY; FEMALE; HUMAN; INFANT; MALE; ORAL DRUG ADMINISTRATION; PRESCHOOL CHILD; PRIORITY JOURNAL; STEADY STATE;

EID: 0029983078     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.31610.x     Document Type: Article

References (18)

1. Cheun H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992; 13: 107-112.
2. Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II neurochemical studies on the mechanism of action. Epilepsia 1986; 27: 490-497.
3. Binnie CD, Debets RMC, Engelsman M, et al. Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989; 4: 222-229.
4. Jawad S, Richens A, Goodwin G, Yuen WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989; 30: 356-363.
5. Loiseau P, Yuen AWC, Duché B, Ménager T, Arné-Bès MC. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures. Epilepsy Res 1990; 7: 136-145.
6. Schlumberger E, Chavez F, Dulac O, Moszkowski J. Open study with lamotrigine (LTG) in child epilepsy. Abstract. Seizure 1992; 1 (suppl A): P9/21.
7. Yuen AWC, Rafter JEW. Lamotrigine (Lamictal) as add-on therapy in pediatric patients with treatment-resistant epilepsy. An overview. Abstract. Epilepsia 1992; 33 (suppl 3): 82-83.
8. Yuen AWC, Peck AW. Lamotrigine pharmacokinetics: oral and i.v. infusion in man. Abstract. Br J Clin Pharmacol 1988; 26: 242.
9. Cohen AF, Land GS, Breimer DD, Yuen WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther 1987; 42: 535-541.
10. Ramsay RE, Pellock JM, Garnett WR, et al. Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy. Epilepsy Res 1991; 10: 191-200.
11. Goa KL, Ross SR, Chrisp P. Lamotrigine a review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993; 46: 152-176.
12. Jawad S, Yuen WC, Peck AW, Hamilton MJ, Oxley JR, Richens A. Lamotrigine: single dose pharmacokinetics and initial 1 week experience in refractory epilepsy. Epilepsy Res 1987; 1: 194-201.
13. Binnie CD, Van Emde Boas W, Kasteleijn-Nolste-Trenite DGA, et al. Acute effects of lamotrigine (BW430C) in persons with epilepsy. Epilepsia 1986; 27: 248-254.
14. Wallace SJ. Add-on open trial of lamotrigine in resistant childhood seizures. Abstract. Brain Dev 1990; 12: 734.
15. Pons G, Rey E, Vauzelle F, et al. Pharmacokinetics of lamotrigine in young epileptic children. Abstract. Epilepsia 1993; 34 (suppl 2): 168.
16. Commission on classification and terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981; 22: 489-501.
17. Gex-Fabry M, Balant MP. Considerations on data analysis using computer methods and currently available software for personal computers. In: Handbook of Experimental Pharmacology: Pharmacokinetics of drugs, eds Welling PG, Balant LP. Springer-Verlag, Berlin Heidelberg, 1994: 507-527.
18. Posner J, Cohen AF, Land G, Winton C, Peck AW. The pharmacokinetics of lamotrigine (BW 430C) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's Syndrome). Br J Clin Pharmacol 1989; 28: 117-120.