The initiation step of eukaryotic DNA replication

Sub-Cellular Biochemistry

Volumn 50, Issue , 2010, Pages 79-104

  Pospiech, Helmut ^b   Grosse, Frank ^b   Pisani, Francesca M ^a  

^a CNR   (Italy)

^b NONE

Author keywords

Cdc45; Cell cycle; Checkpoint; Cut5; DNA replication; Dpb11; GINS; Initiation; Sld2; Sld3; TopBP1

Indexed keywords

EUKARYOTA; FUNGI; METAZOA; SCHIZOSACCHAROMYCETACEAE;

ANIMAL; DNA REPLICATION; EUKARYOTIC CELL; HUMAN; MOLECULAR EVOLUTION; PHOSPHORYLATION; REVIEW;

ANIMALS; DNA REPLICATION; EUKARYOTIC CELLS; EVOLUTION, MOLECULAR; HUMANS; PHOSPHORYLATION;

EID: 77953006795     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-90-481-3471-7_5     Document Type: Article

References (129)

1. Alcasabas, A. A., Osborn, A. J., Bachant, J., Hu, F., Werler, P. J., Bousset, K., Furuya, K., Diffley, J. F., Carr, A. M., and Elledge, S. J. (2001) Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol, 3, 958–965
2. Aparicio, O. M., Stout, A. M., and Bell, S. P. (1999) Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci USA, 96, 9130–9135
3. Aparicio, O. M., Weinstein, D. M., and Bell, S. P. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell, 91, 59–69
4. Aparicio, T., Guillou, E., Coloma, J., Montoya, G., and Méndez, J. (2009) The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res, 37, 2087–2095
5. Araki, H., Leem, S. H., Phongdara, A., and Sugino, A. (1995) Dpb11, which interacts with DNA polymerase II (epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci USA, 92, 11791–11795
6. Arata, Y., Fujita, M., Ohtani, K., Kijima, S., and Kato, J. Y. (2000) Cdk2-dependent and -independent pathways in E2F-mediated S phase induction. J Biol Chem, 275, 6337–6345
7. Bachrati, C. Z. and Hickson, I. D. (2008) RecQ helicases: guardian angels of the DNA replication fork. Chromosoma, 117, 219–233
8. Bauerschmidt, C., Pollok, S., Kremmer, E., Nasheuer, H.-P., and Grosse, F. (2007) Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells, 12, 745–758
9. Blow, J. J. and Dutta, A. (2005) Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol, 6, 476–486
10. Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., and Koonin, E. V. (1997) A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FA SEBJ, 11, 68–76
11. Boskovic, J., Coloma, J., Aparicio, T., Zhou, M., Robinson, C., Méndez, J., and Montoya, G. (2007) Molecular architecture of the human GINS complex. EMBO Rep, 8, 678–684
12. Branzei, D. and Foiani, M. (2006) The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation. Exp Cell Res, 312, 2654–2659
13. Callebaut, I. and Mornon, J. P. (1997) From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett, 400, 25–30
14. Calzada, A., Hodgson, B., Kanemaki, M., Bueno, A., and Labib, K. (2005) Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev, 19, 1905–1919
15. Chang, Y. P., Wang, G., Bermudez, V., Hurwitz, J., and Chen, X. S. (2007) Crystal structure of the GINS complex and functional insights into its role in DNA replication. Proc Natl Acad Sci USA, 104, 12685–12690
16. Choi, J. M., Lim, H. S., Kim, J. J., Song, O. K., and Cho, Y. (2007) Crystal structure of the human GINS complex. Genes Dev, 21, 1316–1321
17. Chou, D. M., Petersen, P., Walter, J. C., and Walter, G. (2002) Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex. J Biol Chem, 277, 40520–40527
18. Christensen, T. W. and Tye, B. K. (2003) Drosophila MCM10 interacts with members of the pre-replication complex and is required for proper chromosome condensation. Mol Biol Cell, 14, 2206–2215
19. Costanzo, V., Robertson, K., Ying, C. Y., Kim, E., Avvedimento, E., Gottesman, M., Grieco, D., and Gautier, J. (2000) Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell, 6, 649–659
20. Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K. A., Gottesman, M., and Gautier, J. (2003) An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell, 11, 203–213
21. Dalton, S. and Hopwood, B. (1997) Characterization of Cdc47p-minichromosome maintenance complexes in Saccharomyces cerevisiae: identification of Cdc45p as a subunit. Mol Cell Biol, 17, 5867–5875
22. De Falco, M., Ferrari, E., de Felice, M., Rossi, M., Hübscher, U., and Pisani, F. M. (2007) The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase. EMBO Rep, 99, 99–103
23. Depamphilis, M. L., Blow, J. J., Ghosh, S., Saha, T., Noguchi, K., and Vassilev, A. (2006) Regulating the licensing of DNA replication origins in metazoa. Curr Opin Cell Biol, 18, 231–239
24. Dephoure, N., Zhou, C., Villén, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., and Gygi, S. P. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci USA, 105, 10762–10767
25. Dolan, W. P., Sherman, D. A., and Forsburg, S. L. (2004) Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding. Chromosoma, 113, 145–156
26. Falck, J., Petrini, J. H., Williams, B. R., Lukas, J., and Bartek, J. (2002) The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet, 30, 290–294
27. Feng, D., Tu, Z., Wu, W., and Liang, C. (2003) Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res, 63, 7356–7364
28. Fisher, D. and Méchali, M. (2004) Sleeping policemen for DNA replication? Nat Cell Biol, 6, 576–577
29. Gambus, A., Jones, R. C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R. D., and Labib, K. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol, 8, 358–366
30. Garcia, V., Furuya, K., and Carr, A. M. (2005) Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst), 4, 1227–1239
31. Glover, J. N., Williams, R. S., and Lee, M. S. (2004) Interactions between BRCT repeats and phosphoproteins: tangled up in two. Trends Biochem Sci, 29, 579–585
32. Grabowski, B. and Kelman, Z. (2003) Archeal DNA replication: eukaryal proteins in a bacterial context. Annu Rev Microbiol, 57, 487–516
33. Gregan, J., Lindner, K., Brimage, L., Franklin, R., Namdar, M., Hart, E. A., Aves, S. J., and Kearsey, S. E. (2003) Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding. Mol Biol Cell, 14, 3876–3887
34. Hardy, C. F. (1997) Identification of Cdc45p, an essential factor required for DNA replication. Gene, 187, 239–246
35. Hashimoto, Y. and Takisawa, H. (2003) Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication. EMBO J, 22, 2526–2535
36. Hennessy, K. M., Lee, A., Chen, E., and Botstein, D. (1991) A group of interacting yeast DNA replication genes. Genes Dev, 5, 958–969
37. Hoki, Y., Araki, R., Fujimori, A., Ohhata, T., Koseki, H., Fukumura, R., Nakamura, M., Takahashi, H., Noda, Y., Kito, S., and Abe, M. (2003) Growth retardation and skin abnormalities of the Recql4-deficient mouse. Hum Mol Genet, 12, 2293–2299
38. Homesley, L., Lei, M., Kawasaki, Y., Sawyer, S., Christensen, T., and Tye, B. K. (2000) Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev, 14, 913–926
39. Hopwood, B. and Dalton, S. (1996) Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc Natl Acad Sci USA, 93, 12309–12314
40. Ichikawa, K., Noda, T., and Furuichi, Y. (2002) Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases [Article in Japanese]. Nippon Yakurigaku Zasshi, 119, 219–226
41. Kamada, K., Kubota, Y., Arata, T., Shindo, Y., and Hanaoka, F. (2007) Structure of the human GINS complex and its assembly and functional interface in replication initiation. Nat Struct Mol Biol, 14, 388–396
42. Kamimura, Y., Masumoto, H., Sugino, A., and Araki, H. (1998) Sld2, which interacts with dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol, 18, 6102–6109
43. Kamimura, Y., Tak, Y. S., Sugino, A., and Araki, H. (2001) Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J, 20, 2097–2107
44. Kanemaki, M. and Labib, K. (2006) Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks. EMBO J, 25, 1753–1763
45. Kanemaki, M., Sanchez-Diaz, A., Gambus, A., and Labib, K. (2003) Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature, 423, 720–724
46. Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K., and Shirahige, K. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature, 424, 1078–1083
47. Kim, S., Dallmann, H. G., McHenry, C. S., and Marians, K. J. (1996) Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement. Cell, 84, 643–650
48. Kneissl, M., Putter, V., Szalay, A. A., and Grummt, F. (2003) Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol, 327, 111–128
49. Kong, L., Ueno, M., Itoh, M., Yoshioka, K., and Takakura, N. (2006) Identification and characterization of mouse PSF1-binding protein, SLD5. Biochem Biophys Res Commun, 339, 1204–1207
50. Kubota, Y., Takase, Y., Komori, Y., Hashimoto, Y., Arata, T., Kamimura, Y., Araki, H., and Takisawa, H. (2003) A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev, 17, 1141–1152
51. Kukimoto, I., Igaki, H., and Kanda, T. (1999) Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. Eur J Biochem, 265, 936–943
52. Kumagai, A. and Dunphy, W. G. (2000) Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell Biol, 6, 839–849
53. Liu, P., Barkley, L. R., Day, T., Bi, X., Slater, D. M., Alexandrow, M. G., Nasheuer, H. P., and Vaziri, C. (2006) The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism. J Biol Chem, 281, 30631–30644
54. Loebel, D., Huikeshoven, H., and Cotterill, S. (2000) Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification. Nucleic Acids Res, 28, 3897–3903
55. Machida, Y. J., Hamlin, J. L., and Dutta, A. (2005) Right place, right time, and only once: replication initiation in metazoans. Cell, 123, 13–24
56. Makarova, K. S., Wolf, Y. I., Mekhedov, S. L., Mirkin, B. G., and Koonin, E. V. (2005) Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res, 33, 4626–4638
57. Mäkiniemi, M., Hillukkala, T., Tuusa, J., Reini, K., Vaara, M., Huang, D., Pospiech, H., Majuri, I., Westerling, T., Makela, T. P., and Syväoja, J. E. (2001) BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J Biol Chem, 276, 30399–30406
58. Mann, M. B., Hodges, C. A., Barnes, E., Vogel, H., Hassold, T. J., and Luo, G. (2005) Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet, 14, 813–825
59. Marinsek, N., Barry, E. R., Makarova, K. S., Dionne, I., Koonin, E. V., and Bell, S. D. (2006) Gins, a central nexus in the archaeal DNA replication fork. EMBO Rep, 7, 539–545
60. Masai, H., Taniyama, C., Ogino, K., Matsui, E., Kakusho, N., Matsumoto, S., Kim, J. M., Ishii, A., Tanaka, T., Kobayashi, T., Tamai, K., Ohtani, K., and Arai, K. (2006) Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J Biol Chem, 281, 39249–39261
61. Masai, H., You, Z., and Arai, K. (2005) Control of DNA replication: regulation and activation of eukaryotic replicative helicase, MCM. IUBMB Life, 57, 323–335
62. Masuda, T., Mimura, S., and Takisawa, H. (2003) CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45. Genes Cells, 8, 145–161
63. Masumoto, H., Muramatsu, S., Kamimura, Y., and Araki, H. (2002) S-Cdk-dependent phospho-rylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature, 415, 651–655
64. Masumoto, H., Sugino, A., and Araki, H. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol, 20, 2809–2817
65. Matsunaga, F., Forterre, P., Ishino, Y., and Myllykallio, H. (2001) In vivo interactions of archaeal Cdc6/Orc1 and minichromosome maintenance proteins with the replication origin. Proc Natl Acad Sci USA, 98, 11152–11157
66. Matsuno, K., Kumano, M., Kubota, Y., Hashimoto, Y., and Takisawa, H. (2006) The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication. Mol Cell Biol, 26, 4843–4852
67. Mimura, S., Masuda, T., Matsui, T., and Takisawa, H. (2000) Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells, 5, 439–452
68. Mimura, S. and Takisawa, H. (1998) Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase cdk. EMBO J, 17, 5699–5707
69. Miyake, S. and Yamashita, S. (1998) Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe. Genes Cells, 3, 157–166
70. Moir, D., Stewart, S. E., Osmond, B. C., and Botstein, D. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics, 100, 547–563
71. Mordes, D. A., Nam, E. A., and Cortez, D. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci USA, 105, 18730–18734
72. Moyer, S. E., Lewis, P. W., and Botchan, M. R. (2006) Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci USA, 103, 10236–10241
73. Nakajima, R. and Masukata, H. (2002) SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast. Mol Biol Cell, 13, 1462–1472
74. Navadgi-Patil, V. M. and Burgers, P. M. (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem, 283, 35853–35859
75. Nasheuer, H. P., Pospiech, H., and Syväoja, J. (2007) Progress towards the anatomy of the eukaryotic DNA replication fork. In: Lankenau, D. H. (Ed.) Genome Integrity: Facets and Perspectives, Genome Dynamics & Stability, Vol. 1, Springer, Berlin, Heidelberg, New York, pp. 27–68
76. Nasheuer, H. P., Smith, R., Bauerschmidt, C., Grosse, F., and Weisshart, K. (2002) Initiation of eukaryotic DNA replication: regulation and mechanisms. Prog Nucleic Acid Res Mol Biol, 72, 41–94
77. Nitani, N., Nakamura, K., Nakagawa, C., Masukata, H., and Nakagawa, T. (2006) Regulation of DNA replication machinery by Mrc1 in fission yeast. Genetics, 174, 155–165
78. Noguchi, E., Shanahan, P., Noguchi, C., and Russell, P. (2002) CDK phosphorylation of Drc1 regulates DNA replication in fission yeast. Curr Biol, 12, 599–605
79. Oehlmann, M., Mahon, C., and Nasheuer, H. P. (2007) Comparison of DNA replication in Xenopus laevis and Simian Virus 40. Adv Exp Med Biol, 604, 3–16
80. Osborn, A. J. and Elledge, S. J. (2003) Mrc1 is a replication fork component whose phosphoryla-tion in response to DNA replication stress activates Rad53. Genes Dev, 17, 1755–1767
81. Owens, J. C., Detweiler, C. S., and Li, J. J. (1997) CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci USA, 94, 12521–12526
82. Pacek, M., Tutter, A. V., Kubota, Y., Takisawa, H., and Walter, J. C. (2006) Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell, 21, 581–587
83. Pacek, M. and Walter, J. C. (2004) A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J, 23, 3667–3676
84. Petersen, P., Chou, D. M., You, Z., Hunter, T., Walter, J. C., and Walter, G. (2006) Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol, 26, 1997–2011
85. Pollok, S., Bauerschmidt, C., Sänger, J., Nasheuer, H.-P., and Grosse, F. (2007) Human Cdc45 is a proliferation-associated antigen. FEBS J, 274, 3669–3684
86. Pollok, S. and Grosse, F. (2007) Cdc45 degradation during differentiation and apoptosis. Biochem Biophys Res Commun, 362, 910–915
87. Pollok, S., Stoepel, J., Bauerschmidt, C., Kremmer, E., and Nasheuer, H. P. (2003) Regulation of eukaryotic DNA replication at the initiation step. Biochem Soc Trans, 31, 266–269
88. Pulliam, K. F., Fasken, M. B., McLane, L. M., Pulliam, J. V., and Corbett, A. H. (2009) The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae. Genetics, 181, 105–118
89. Ramachandran, N., Hainsworth, E., Bhullar, B., Eisenstein, S., Rosen, B., Lau, A. Y., Walter, J. C., and Labaer, J. (2004) Self-assembling protein microarrays. Science, 305, 86–90
90. Reid, R. J., Fiorani, P., Sugawara, M., and Bjornsti, M. A. (1999) CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage. Proc Natl Acad Sci USA, 96, 11440–11445
91. Rodriguez, M. C. and Songyang, Z. (2008) BRCT domains: phosphopeptide binding and signaling modules. Front Biosci, 13, 5909–5915
92. Saha, P., Thome, K. C., Yamaguchi, R., Hou, Z., Weremowicz, S., and Dutta, A. (1998) The human homolog of Saccharomyces cerevisiae CDC45. J Biol Chem, 273, 18205–18209
93. Saka, Y., Fantes, P., Sutani, T., McInerny, C., Creanor, J., and Yanagida, M. (1994) Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J, 13, 5319–5329
94. Saka, Y. and Yanagida, M. (1993) Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell, 74, 383–393
95. Sangrithi, M. N., Bernal, J. A., Madine, M., Philpott, A., Lee, J., Dunphy, W. G., and Venkitaraman, A. R. (2005) Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell, 121, 887–898
96. Sawyer, S. L., Cheng, I. H., Chai, W., and Tye, B. K. (2004) Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. J Mol Biol, 340, 195–202
97. Schmidt, U., Wollmann, Y., Franke, C., Grosse, F., Saluz, H.-P., and Hänel, F. (2008) Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein. Biochem J, 409, 169–177
98. Sclafani, R. A. and Holzen, T. M. (2007) Cell cycle regulation of DNA replication. Annu Rev Genet, 41, 237–280
99. Shaikh, T. H., Gottlieb, S., Sellinger, B., Chen, F., Roe, B. A., Oakey, R. J., Emanuel, B. S., and Budarf, M. L. (1999) Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. Mamm Genome, 10, 322–326
100. Shechter, D., Costanzo, V., and Gautier, J. (2004) Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst), 3, 901–908
101. Shechter, D. and Gautier, J. (2005) ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle, 4, 235–238
102. Sherr, C. J. and Roberts, J. M. (2004) Living with or without cyclins and cyclin-dependent kinases. Genes Dev, 18, 2699–2711
103. Stevens, R., Grelon, M., Vezon, D., Oh, J., Meyer, P., Perennes, C., Domenichini, S., and Bergounioux, C. (2004) A CDC45 homolog in Arabidopsis is essential for meiosis, as shown by RNA interference-induced gene silencing. Plant Cell, 16, 99–113
104. Tak, Y. S., Tanaka, Y., Endo, S., Kamimura, Y., and Araki, H. (2006) A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11. EMBO J, 25, 1987–1996
105. Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., and Araki, H. (2003) Gins, a novel mulTiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev, 17, 1153–1165
106. Tanaka, S., Tak, Y. S., and Araki, H. (2007a) The role of CDK in the initiation step of DNA replication in eukaryotes. Cell Div, 2, 16
107. Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y., and Araki, H. (2007b) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature, 445, 328–332
108. Tercero, J. A., Labib, K., and Diffley, J. F. (2000) DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. EMBO J, 19, 2082–2093
109. Tourrière, H. and Pasero, P. (2007) Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst), 6, 900–913
110. Tourrière, H., Versini, G., Cordon-Preciado, V., Alabert, C., and Pasero, P. (2005) Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53. Mol Cell, 19, 699–706
111. Uchiyama, M., Arai, K., and Masai, H. (2001a) Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha. Mol Genet Genomics, 265, 1039–1049
112. Uchiyama, M., Griffiths, D., Arai, K., and Masai, H. (2001b) Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast. J Biol Chem, 276, 26189–26196
113. Ueno, M., Itoh, M., Kong, L., Sugihara, K., Asano, M., and Takakura, N. (2005) PSF1 is essential for early embryogenesis in mice. Mol Cell Biol, 25, 10528–10532
114. Ueno, M., Itoh, M., Sugihara, K., Asano, M., and Takakura, N. (2009) Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration. Blood, 113, 555–562
115. van Hatten, R. A., Tutter, A. V., Holway, A. H., Khederian, A. M., Walter, J. C., and Michael, W. M. (2002) The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol, 159, 541–547
116. Vogelauer, M., Rubbi, L., Lucas, I., Brewer, B. J., and Grunstein, M. (2002) Histone acetylation regulates the time of replication origin firing. Mol Cell, 10, 1223–1233
117. Wang, H. and Elledge, S. J. (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci USA, 96, 3824–3829
118. Weinreich, M. and Stillman, B. (1999) Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J, 18, 5334–5346
119. Wollmann, Y., Schmidt, U., Wieland, G. D., Zipfel, P. F., Saluz, H.-P., and Hänel, F. (2007) The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (ADP-ribose) polymerase (PARP-1). J Cell Biochem, 102, 171–182
120. Xu, X. and Liu, Y. (2009) Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. EMBO J, Epub ahead of print, doi: 10.1038/emboj
121. Yabuuchi, H., Yamada, Y., Uchida, T., Sunathvanichkul, T., Nakagawa, T., and Masukata, H. (2006) Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J, 25, 4663–4674
122. Yamada, Y., Nakagawa, T., and Masukata, H. (2004) A novel intermediate in initiation complex assembly for fission yeast DNA replication. Mol Biol Cell, 15, 3740–3750
123. Yamane, K. and Tsuruo, T. (1999) Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene, 18, 5194–5203
124. Yoshida, K., Kuo, F., George, E. L., Sharpe, A. H., and Dutta, A. (2001) Requirement of CDC45 for postimplantation mouse development. Mol Cell Biol, 21, 4598–4603
125. Yoshimochi, T., Fujikane, R., Kawanami, M., Matsunaga, F., and Ishino, Y. (2008) The GINS complex from Pyrococcus furiosus stimulates the MCM helicase activity. J Biol Chem, 283, 1601–1609
126. Zegerman, P. and Diffley, J. F. (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature, 445, 281–285
127. Zhu, W., Ukomadu, C., Jha, S., Senga, T., Dhar, S. K., Wohlschlegel, J. A., Nutt, L. K., Kornbluth, S., and Dutta, A. (2007) Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. Genes Dev, 21, 2288–2299
128. Zou, L., Mitchell, J., and Stillman, B. (1997) CDC45, a novel yeast gene that functions with the origin recognition complex and MCM proteins in initiation of DNA replication. Mol Cell Biol, 17, 553–563
129. Zou, L. and Stillman, B. (2000) Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol, 20, 3086–3096.