Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication

Molecular Cell

Volumn 21, Issue 4, 2006, Pages 581-587

  Pacek, Marcin ^a   Tutter, Antonin V ^a,c   Kubota, Yumiko ^b   Takisawa, Haruhiko ^b   Walter, Johannes C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; BIOTIN; CDC45 PROTEIN; DNA; HELICASE; MCM2 7 PROTEIN; PROTEIN; PROTEIN SUBUNIT; REPLISOME; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; DNA DENATURATION; DNA REPLICATION; DNA STRAND; PLASMID; PROTEIN FUNCTION; PROTEIN LOCALIZATION; XENOPUS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; MACROMOLECULAR SUBSTANCES; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; XENOPUS; XENOPUS PROTEINS;

EUKARYOTA; VERTEBRATA;

EID: 32444450705     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.01.030     Document Type: Article

References (34)

1. O.M. Aparicio, D.M. Weinstein, and S.P. Bell Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase Cell 91 1997 59 69
2. E.E. Arias, and J.C. Walter Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts Genes Dev. 19 2005 114 126
3. J.J. Blow, and A. Dutta Preventing re-replication of chromosomal DNA Nat. Rev. Mol. Cell Biol. 6 2005 476 486
4. A.M. Breier, H.U. Weier, and N.R. Cozzarelli Independence of replisomes in Escherichia coli chromosomal replication Proc. Natl. Acad. Sci. USA 102 2005 3942 3947
5. B.J. Brewer, and W.L. Fangman The localization of replication origins on ARS plasmids in S. cerevisiae Cell 51 1987 463 471
6. E. Danis, K. Brodolin, S. Menut, D. Maiorano, C. Girard-Reydet, and M. Mechali Specification of a DNA replication origin by a transcription complex Nat. Cell Biol. 6 2004 721 730
7. M.C. Edwards, A.V. Tutter, C. Cvetic, C.H. Gilbert, T.A. Prokhorova, and J.C. Walter MCM2-7 complexes bind chromatin in a distributed pattern surrounding ORC in Xenopus egg extracts J. Biol. Chem. 277 2002 33049 33057
8. T. Fukui, K. Yamauchi, T. Muroya, M. Akiyama, H. Maki, A. Sugino, and S. Waga Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts Genes Cells 9 2004 179 191
9. K.J. Harvey, and J. Newport CpG methylation of DNA restricts prereplication complex assembly in Xenopus egg extracts Mol. Cell. Biol. 23 2003 6769 6779
10. Y. Ishimi, Y. Komamura, Z. You, and H. Kimura Biochemical function of mouse minichromosome maintenance 2 protein J. Biol. Chem. 273 1998 8369 8375
11. M. Kanemaki, A. Sanchez-Diaz, A. Gambus, and K. Labib Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo Nature 423 2003 720 724
12. D.L. Kaplan, M.J. Davey, and M. O'Donnell Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex J. Biol. Chem. 278 2003 49171 49182
13. Y. Kubota, Y. Takase, Y. Komori, Y. Hashimoto, T. Arata, Y. Kamimura, H. Araki, and H. Takisawa A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication Genes Dev. 17 2003 1141 1152
14. K. Labib, J.A. Tercero, and J.F. Diffley Uninterrupted MCM2-7 function required for DNA replication fork progression Science 288 2000 1643 1647
15. R.A. Laskey, A.D. Mills, and N.R. Morris Assembly of SV40 chromatin in a cell-free system from Xenopus eggs Cell 10 1977 237 243
16. I. Lucas, M. Chevrier-Miller, J.M. Sogo, and O. Hyrien Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos J. Mol. Biol. 296 2000 769 786
17. M.A. Madine, C.Y. Khoo, A.D. Mills, and R.A. Laskey MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells Nature 375 1995 421 424
18. H.M. Mahbubani, J.P. Chong, S. Chevalier, P. Thommes, and J.J. Blow Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor J. Cell Biol. 136 1997 125 135
19. T. Masuda, S. Mimura, and H. Takisawa CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45 Genes Cells 8 2003 145 161
20. S. Mimura, and H. Takisawa Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk EMBO J. 17 1998 5699 5707
21. S. Mimura, T. Masuda, T. Matsui, and H. Takisawa Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts Genes Cells 5 2000 439 452
22. M. Pacek, and J.C. Walter A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication EMBO J. 23 2004 3667 3676
23. T.A. Prokhorova, and J.J. Blow Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity J. Biol. Chem. 275 2000 2491 2498
24. R.M. Ricke, and A.K. Bielinsky Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha Mol. Cell 16 2004 173 185
25. D. Shechter, C.Y. Ying, and J. Gautier DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process J. Biol. Chem. 279 2004 45586 45593 10.1074/jbc.M407772200 Published online August 23, 2004
26. J.H. Shin, Y. Jiang, B. Grabowski, J. Hurwitz, and Z. Kelman Substrate requirements for duplex DNA translocation by the eukaryal and archaeal minichromosome maintenance helicases J. Biol. Chem. 278 2003 49053 49062
27. T.S. Takahashi, D.B. Wigley, and J.C. Walter Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase Trends Biochem. Sci. 30 2005 437 444
28. Y. Takayama, Y. Kamimura, M. Okawa, S. Muramatsu, A. Sugino, and H. Araki GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast Genes Dev. 17 2003 1153 1165
29. J.A. Tercero, K. Labib, and J.F. Diffley DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p EMBO J. 19 2000 2082 2093
30. S. Waga, T. Masuda, H. Takisawa, and A. Sugino DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts Proc. Natl. Acad. Sci. USA 98 2001 4978 4983
31. J. Walter, and J. Newport Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha Mol. Cell 5 2000 617 627
32. J. Walter, L. Sun, and J. Newport Regulated chromosomal DNA replication in the absence of a nucleus Mol. Cell 1 1998 519 529
33. J.A. Wohlschlegel, S.K. Dhar, T.A. Prokhorova, A. Dutta, and J.C. Walter Xenopus mcm10 binds to origins of DNA replication after mcm2-7 and stimulates origin binding of cdc45 Mol. Cell 9 2002 233 240
34. L. Zou, and B. Stillman Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin Science 280 1998 593 596