The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

Journal of Cell Biology

Volumn 159, Issue 4, 2002, Pages 541-547

  Van Hatten, Ruth A ^a   Tutter, Antonin V ^b   Holway, Antonia H ^a   Khederian, Alyssa M ^a   Walter, Johannes C ^b   Matthew Michael, W ^a  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cdc7; Cell cycle; MCM10; ORC; TopBP1

Indexed keywords

CARRIER PROTEIN; CDC45 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; MUS101 PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; XENOPUS PROTEIN;

ANIMAL; ARTICLE; CHROMATIN; DNA REPLICATION; DNA REPLICATION ORIGIN; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR CLONING; PHYSIOLOGY; SPERMATOZOON; XENOPUS LAEVIS;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMATIN; CLONING, MOLECULAR; DNA REPLICATION; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; HUMANS; MALE; NUCLEAR PROTEINS; REPLICATION ORIGIN; SACCHAROMYCES CEREVISIAE PROTEINS; SPERMATOZOA; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 0037175392     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.200207090     Document Type: Article

References (32)

1. Araki, H., S.H. Leem, A. Phongdara, and A. Sugino. 1995. Dpb11, which interacts with DNA polymerase Il(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc. Natl. Acad. Sci. USA. 92:11791-11795.
2. Bell, S.P., and A. Dutta. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:333-374.
3. Boyd, J.B., M.D. Golino, T.D. Nguyen, and M.M. Green. 1976. Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens. Genetics. 84:485-506.
4. Edwards, M.C., A.V. Tutter, C. Cvetic, C.H. Gilbert, T.A. Prokhorova, and J.C. Walter. 2002. MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J. Biol. Chem. 277:33049-33057.
5. Harlow, E., and D. Lane. 1988. Antibodies, a Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor, NY. 312 pp.
6. Jares, P., and J.J. Blow. 2000. Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. Genes Dev. 14:1528-1540.
7. Kelly, T.J., and G.W. Brown. 2000. Regulation of chromosome replication. Annu. Rev. Biochem. 69:829-880.
8. Labib, K., and J.F. Diffley. 2001. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr. Opin. Genet. Dev. 11:64-70.
9. Makiniemi, M., T. Hillukkala, J. Tuusa, K. Reini, M. Vaara, D. Huang, H. Pospiech, I. Majuri, T. Westerling, T.P. Makela, and J.E. Syvaoja. 2001. BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J. Biol. Chem. 276:30399-30406.
10. Masumoto, H., A. Sugino, and H. Araki. 2000. Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol. Cell. Biol. 20:2809-2817.
11. Michael, W.M., R. Ott, E. Fanning, and J. Newport. 2000. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science. 289:2133-2137.
12. Mimura, S., and H. Takisawa. 1998. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. EMBO J. 17:5699-5707.
13. Mimura, S., T. Masuda, T. Matsui, and H. Takisawa. 2000. Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells. 5:439-452.
14. Orr, W., K. Komitopoulou, and F.C. Kafatos. 1984. Mutants suppressing in trans chorion gene amplification in Drosophila. Proc. Natl. Acad. Sci. USA. 81:3773-3777.
15. Saka, Y., and M. Yanagida. 1993. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell. 74:383-393.
16. Saka, Y., F. Esashi, T. Matsusaka, S. Mochida, and M. Yanagida. 1997. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev. 11:3387-3400.
17. Tada, S., A. Li, D. Maiorano, M. Mechali, and J.J. Blow. 2001. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 3:107-113.
18. Tanaka, T., and K. Nasmyth. 1998. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases. EMBO J. 17:5182-5191.
19. Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 78:67-74.
20. Walter, J.C. 2000. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. J. Biol. Chem. 275:39773-39778.
21. Walter, J., and J. Newport. 1999. Eukaryotic DNA Replication. Oxford Press, Oxford. 201 pp.
22. Walter, J., and J. Newport. 2000. Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell. 5:617-627.
23. Walter, J., L. Sun, and J. Newport. 1998. Regulated chromosomal DNA replication in the absence of a nucleus. Mol. Cell. 1:519-529.
24. Wang, H., and S.J. Elledge. 1999. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 96:3824-3829.
25. Wang, H., and S.J. Elledge. 2002. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics. 160:1295-1304.
26. Wohlschlegel, J.A., B.T. Dwyer, S.K. Dhar, C. Cvetic, J.C. Walter, and A. Dutta. 2000. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science. 290:2309-2312.
27. Wohlschlegel, J.A., S.K. Dhar, T.A. Prokhorova, A. Dutta, and J.C. Walter. 2002. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol. Cell. 9:233-240.
28. Yamamoto, R.R., J.M. Axton, Y. Yamamoto, R.D. Saunders, D.M. Glover, and D.S. Henderson. 2000. The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics. 156:711-721.
29. Yamane, K., M. Kawabata, and T. Tsuruo. 1997. A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur. J. Biochem. 250:794-799.
30. Yamane, K., X. Wu, and J. Chen. 2002. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol. Cell. Biol. 22:555-566.
31. Zou, L., and B. Stillman. 1998. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science. 280:593-596.
32. Zou, L., and B. Stillman. 2000. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol. Cell. Biol. 20:3086-3096.