ATM and ATR check in on origins: A dynamic model for origin selection and activation

Cell Cycle

Volumn 4, Issue 2, 2005, Pages 238-240

  Shechter, David ^a,b,c   Gautier, Jean ^a,c  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c Hammer Health Sciences Center   (United States)

Author keywords

ATM; ATR; Checkpoints; Origin selection; Origins of replication; Replication initiation; Replicon; Xenopus

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 2;

CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CHROMATIN; CHROMATIN STRUCTURE; CHROMOSOME; DNA DAMAGE; DNA REPLICATION; ENZYME INHIBITION; EUKARYOTE; METAZOON; NONHUMAN; PHOSPHORYLATION; PROKARYOTE; REPLICON; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; SOMATIC CELL; XENOPUS LAEVIS; YEAST;

EUKARYOTA; MAMMALIA; METAZOA; PROKARYOTA; SACCHAROMYCES; XENOPUS LAEVIS;

EID: 21444434023     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.2.1466     Document Type: Short Survey

References (40)

1. Diaz-Martinez L, Clarke DJ. Self-regulating model for control of replication origin firing in budding yeast. Cell Cycle 2003; 2:576-8.
2. Lucas I, Chevrier-Miller M, Sogo JM, Hyrien O. Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos. J Mol Biol 2000; 296:769-86.
3. Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 2004; 6:648-55.
4. Marheineke K, Hyrien O. Control of replication origin density and firing time in Xenopus egg extracts: Role of a caffeine-sensitive, ATR-dependent checkpoint. J Biol Chem 2004; In press.
5. Sorensen CS, Syljuasen RG, Lukas J, Bartek J. ATR, claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle 2004; 3:941-5.
6. Miao H, Seiler JA, Burhans WC. Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints. J Biol Chem 2003; 278:4295-304.
7. Gilbert DM. Timeline: In search of the holy replicator. Nat Rev Mol Cell Biol 2004; 5:848-55.
8. Jacob F, Brenner S. [On the regulation of DNA synthesis in bacteria: The hypothesis of the replicon. C R Hebd Seances Acad Sci 1963; 256:298-300.
9. Bell SP. The origin recognition complex: From simple origins to complex functions. Genes Dev 2002; 16:659-72.
10. Housman D, Huberman JA. Changes in the rate of DNA replication fork movement during S phase in mammalian cells. J Mol Biol 1975; 94:173-81.
11. Edenberg HJ, Huberman JA. Eukaryotic chromosome replication. Annu Rev Genet 1975; 9:245-84.
12. Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 2002; 71:333-74.
13. Stinchcomb DT, Struhl K, Davis RW. Isolation and characterisation of a yeast chromosomal replicator. Nature 1979; 282:39-43.
14. Dubey DD, Kim SM, Todorov IT, Huberman JA. Large, complex modular structure of a fission yeast DNA replication origin. Curr Biol 1996; 6:467-73.
15. DePamphilis ML. Eukaryotic DNA replication origins: Reconciling disparate data. Cell 2003; 114:274-5.
16. Hyrien O, Marheineke K, Goldar A. Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem. Bioessays 2003; 25:116-25.
17. Herrick J, Stanislawski P, Hyrien O, Bensimon A. Replication fork density increases during DNA synthesis in X. laevis egg extracts. J Mol Biol 2000; 300:1133-42.
18. Hyrien O, Mechali M. Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos. EMBO J 1993; 12:4511-20.
19. Blumenthal AB, Kriegstein HJ, Hogness DS. The units of DNA replication in Drosophila melanogaster chromosomes. Cold Spring Harb Symp Quant Biol 1974; 38:205-23.
20. Sasaki T, Sawado T, Yamaguchi M, Shinomiya T. Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster. Mol Cell Biol 1999; 19:547-55.
21. Hyrien O, Maric C, Mechali M. Transition in specification of embryonic metazoan DNA replication origins. Science 1995; 270:994-7.
22. Blow JJ, Gillespie PJ, Francis D, Jackson DA. Replication origins in Xenopus egg extract Are 5-15 kilobases apart and are activated in clusters that fire at different times. J Cell Biol 2001; 152:15-25.
23. Hyrien O, Mechali M. Plasmid replication in Xenopus eggs and egg extracts: A 2D gel electrophoretic analysis. Nucleic Acids Res 1992; 20:1463-9.
24. Huberman JA. DNA replication. Choosing a place to begin. Science 1998; 281:929-30.
25. Aladjem MI, Rodewald LW, Kolman JL, Wahl GM. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science 1998; 281:1005-9.
26. Michaelson JS, Ermakova O, Birshtein BK, Ashouian N, Chevillard C, Riblet R, Schildkraut CL. Regulation of the replication of the murine immunoglobulin heavy chain gene locus: Evaluation of the role of the 3′ regulatory region. Mol Cell Biol 1997; 17:6167-74.
27. Dijkwel PA, Wang S, Hamlin JL. Initiation sites are distributed at frequent intervals in the Chinese hamster dihydrofolate reductase origin of replication but are used with very different efficiencies. Mol Cell Biol 2002; 22:3053-65.
28. DePamphilis ML. Replication origins in metazoan chromosomes: Fact or fiction? Bioessays 1999; 21:5-16.
29. Danis E, Brodolin K, Menut S, Maiorano D, Girard-Reydet C, Mechali M. Specification of a DNA replication origin by a transcription complex. Nat Cell Biol 2004; 6:721-30.
30. Harvey KJ, Newport J. Metazoan origin selection: Origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis. J Biol Chem 2003; 278:48524-8.
31. Goren A, Cedar H. Replicating by the clock. Nat Rev Mol Cell Biol 2003; 4:25-32.
32. Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell 1982; 30:675-86.
33. Walter J, Newport JW. Regulation of replicon size in Xenopus egg extracts. Science 1997; 275:993-5.
34. Edwards MC, Tutter AV, Cvetic C, Gilbert CH, Prokhorova TA, Walter JC. MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem 2002; 277:33049-57.
35. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003; 11:203-13.
36. Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell 2000; 6:649-59.
37. Shechter D, Costanzo V, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair 2004; In press.
38. Shechter D, Gautier J. MCM proteins and checkpoint kinases get together at the fork. Proc Natl Acad Sci USA 2004; 101:10845-6.
39. Vogelauer M, Rubbi L, Lucas I, Brewer BJ, Grunstein M. Histone acetylation regulates the time of replication origin firing. Mol Cell 2002; 10:1223-33.
40. Aparicio JG, Viggiani CJ, Gibson DG, Aparicio OM. The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol Cell Biol 2004; 24:4769-80.