sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polα

Molecular Genetics and Genomics

Volumn 265, Issue 6, 2001, Pages 1039-1049

  Uchiyama, M ^a   Arai, K ^a,b   Masai, H ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Cell cycle; DNA polymerase; Fission yeast; Initiation of DNA replication; Prereplicative complex

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; GENE PRODUCT; PROTEIN CDC45; UNCLASSIFIED DRUG; CARRIER PROTEIN; CDC45 PROTEIN, S CEREVISIAE; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE BETA; FUNGAL DNA; FUNGAL PROTEIN; HYDROXYUREA; NUCLEAR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SCHIZOSACCHAROMYCES POMBE PROTEIN; SNA41 PROTEIN, S POMBE;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DNA REPLICATION; GENE MUTATION; GENETIC LINKAGE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; YEAST; CELL CYCLE; CYTOLOGY; DRUG EFFECT; GENETIC COMPLEMENTATION; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; SCHIZOSACCHAROMYCES; TEMPERATURE;

CARRIER PROTEINS; CELL CYCLE; DNA POLYMERASE I; DNA REPLICATION; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; G1 PHASE; GENETIC COMPLEMENTATION TEST; GENOTYPE; HYDROXYUREA; LINKAGE (GENETICS); NUCLEAR PROTEINS; PHENOTYPE; S PHASE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TEMPERATURE;

EID: 0034743174     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380100499     Document Type: Article

References (57)

1. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
2. Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'Start' gene
3. Versatile shuttle vectors and genomic libraries for use with Schizosaccharomyces pombe
4. Mutational effect of fission yeast Pol alpha on cell cycle events
5. Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast
6. The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'Start'
7. The fission yeast homolog of Orc4p binds to replication origin DNA via multiple AT-hooks
8. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
9. The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene product
10. Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint
11. Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene
12. + of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase
13. + gene encodes a member of the MCM family of replication proteins
14. Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype
15. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity
16. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase
17. Identification of Cdc45p, an essential factor required for DNA replication
18. Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication
19. The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair
20. The fission yeast cdc18+ gene product couples S phase to START and mitosis
21. Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha
22. Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein
23. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
24. The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27
25. Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle
26. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk
27. Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe
28. Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family
29. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
30. A kinase from fission yeast responsible for blocking mitosis in S phase
31. cdc18+ regulates initiation of Dna replication in Schizosaccharomyces pombe
32. Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'Start' function of Res2-Cdc10
33. At the heart of the budding yeast cell cycle
34. Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe
35. Putting it all together: Building a prereplicative complex
36. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe
37. Fission yeast Nda 1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins
38. Identification of a predominant replication origin in fission yeast
39. +, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+
40. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
41. Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast
42. Human and Xenopus cDNAs encoding budding yeast cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
43. Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p)
44. Regulation of DNA-replication origins during cell-cycle progression
45. Cell cycle control of DNA replication
46. Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality
47. Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion
48. A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SW14 gene products
49. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
50. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
51. DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p
52. A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis
53. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2
54. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
55. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication