The role of kinases in the Hedgehog signalling pathway

EMBO Reports

Volumn 9, Issue 4, 2008, Pages 330-336

  Aikin, Reid A ^a   Ayers, Katie L ^a   Thérond, Pascal P ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; SONIC HEDGEHOG PROTEIN;

ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; DEVELOPMENT; DROSOPHILA; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; GENE COMPONENTS; HEDGEHOG PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTRANSFERASES; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 48749098903     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2008.38     Document Type: Article

References (50)

1. Alves G, Limbourg-Bouchon B, Tricoire H, Brissard-Zahraoui J, Lamour-Isnard C, Busson D (1998) Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech Dev 78: 17-31
2. Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A (2005) Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol 7: 86-92
3. Ascano M Jr, Robbins DJ (2004) An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Mol. Cell Biol 24: 10397-10405
4. Ascano M Jr, Nybakken KE, Sosinski J, Stegman MA, Robbins DJ (2002) The carboxyl-terminal domain of the protein kinase Fused can function as a dominant inhibitor of Hedgehog signaling. Mol Cell Biol 22 1555-1566
5. Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ (2004) Activity-dependent internalization of Smoothened mediated by β-arrestin 2 and GRK2. Science 306: 2257-2260
6. Chen Y, Gallaher N, Goodman RH, Smolik SM (1998) Protein kinase A directly regulates the activity and proteolysis of Cubitus interruptus. Proc Natl Acad Sci USA 95: 2349-2354
7. Claret S, Sanial M, Plessis A (2007) Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused. Curr Biol 17: 1326-1333
8. Denef N, Neubuser D, Perez L, Cohen SM (2000) Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened. Cell 102: 521-531
9. Dussillol-Godar F, Brissard-Zahraoui J, Limbourg-Bouchon B, Boucher D, Fouix S, Lamour-Isnard C, Plessis A, Busson D (2006) Modulation of the suppressor of Fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dev Biol 291: 53-66
10. Epstein DJ, Marti E, Scott MP, McMahon AP (1996) Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122:2885-2894
11. Fukumoto T, Watanabe-Fukunaga R, Fujisawa K, Nagata S, Fukunaga R (2001) The Fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider2 cells. J Blot Chem 276: 38441-38448
12. Hammerschmidt M, Bitgood MJ, McMahon AP (1996) Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10: 647-658
13. Hooper JE, Scott MP (2005) Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6: 306-317
14. Huangfu D, Anderson KV (2006) Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133: 3-14
15. Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J (2002) Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416: 548-552
16. Jia J, Tong C, Jiang J (2003) Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 17: 2709-2720
17. Jia J, Tong C, Wang B, Luo L, Jiang J (2004) Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432: 1045-1050
18. Jiang J, Struhl G (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496
19. Lefers MA, Wang QT, Holmgren RA (2001) Genetic dissection of the Drosophila Cubitus interruptus signaling complex. Dev Biol 236: 411-420
20. Liu Y, Cao X, Jiang J, Jia J (2007) Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev 21: 1949-1963
21. Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA (2003) Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 12: 1261-1274
22. Malpel S, Claret S, Sanial M, Brigui A, Piolot T, Daviet L, Martin-Lanneree S, Plessis A (2007) The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. Dev Biol 303: 121-133
23. Methot N, Basler K (2000) Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127: 4001-4010
24. Molnar C, Holguin H, Mayor F Jr, Ruiz-Gomez A, de Celis JF (2007) The G-protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci USA 104 7963-7968
25. Monnier V, Dussillol F, Alves G, Lamour-Isnard C, Plessis A (1998) Suppressor of Fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway. Curr Biol 8: 583-586
26. Monnier V, Ho KS, Sanial M, Scott MP, Plessis A (2002) Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol 2 4
27. Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW (2004) Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech Dev 121: 507-518
28. Nybakken K, Vokes SA, Lin TY, McMahon AP, Perrimon N (2005) A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 37: 1323-1332
29. Nybakken KE, Turck CW, Robbins DJ, Bishop JM (2002) Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase Fused. J Biol Chem 277: 24638-24647
30. Ohlmeyer JT, Kalderon D (1998) Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396 749-753
31. Pham A, Therond P, Alves G, Tournier FB, Busson D, Lamour-Isnard C, Bouchon BL, Preat T, Tricoire H (1995) The Suppressor of Fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment. Genetics 140: 587-598
32. Preat T, Therond P, Limbourg-Bouchon B, Pham A, Tricoire H, Busson D, Lamour-Isnard C (1993) Segmental polarity in Drosophila melanogaster genetic dissection of Fused in a Suppressor of Fused background reveals interaction with costal-2. Genetics 135: 1047-1062
33. Price MA (2006) CKI, there's more than one: Casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev 20: 399-410
34. Price MA, Kalderon D (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell 108: 823-835
35. Riobo NA, Manning DR (2007) Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 403: 369-379
36. Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP (1997) Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell 90: 225-234
37. Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond PP (2003) Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 5: 907-913
38. Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, Therond PP (2007) Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal12-Cubitus interruptus complex in Hedgehog signalling. Development 134: 3677-3689
39. Smelkinson MG, Zhou Q, Kalderon D (2007) Regulation of Ci-SCF(Slimb) binding, Ci proteolysis, and Hedgehog pathway activity by Ci phosphorylation. Dev Cell 13: 481-495
40. Tay SY, Ingham PW, Roy S (2005) A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development 132: 625-634
41. Therond PP, Knight JD, Komberg TB, Bishop JM (1996) Phosphorylation of the Fused protein kinase in response to signaling from Hedgehog. Proc Natl Acad Sci USA 93: 4224-4228
42. Tiecke E, Turner R, Sanz-Ezquerro JJ, Warner A, Tickle C (2007) Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling. Dev Biol 305: 312-324
43. Varjosalo M, Li SP, Taipale J (2006) Divergence of Hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-186
44. Wang G, Jiang J (2004) Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Dev Biol 268: 493-505
45. Wang G, Amanai K, Wang B, Jiang J (2006) Interactions with Costal2 and Suppressor of Fused regulate nuclear translocation and activity of Cubitus interruptus. Genes Dev 14: 2893-2905
46. Wolff C, Roy S, Ingham PW (2003) Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Curr Biol 13: 1169-1181
47. Zhang C, Williams EH, Guo Y, Lum L, Beachy PA (2004) Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci USA 101: 17900-17907
48. Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J (2006) A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell 10: 719-729
49. Zhang W, Zhao Y, Tong C, Wang G, Wang B, Jia J, Jiang J (2005) Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell 8: 267-278
50. Zhao Y, Tong C, Jiang J (2007) Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature 450: 252-258