Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos

Genes and Development

Volumn 11, Issue 17, 1997, Pages 2250-2258

  Ohlmeyer, Johanna Talavera ^a   Kalderon, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Cubitus interruptus; Development; Drosophila; Hedgehog; Protein kinase A; Signal transduction

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DROSOPHILA; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CUBITUS; CUBITUS INTERRUPTUS; ERINACEIDAE;

EID: 0030984470     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.17.2250     Document Type: Article

References (54)

1. Alcedo, J., M. Ayzenzon, T. Von Ohlen, M. Noll, and J.E. Hooper. 1996. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86: 221-232.
2. Alexandre, C., A. Jacinto and P.W. Ingham. 1996. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes &. Dev. 10: 2003-2013.
3. Aza-Blanc, P., F.-A. Ramirez-Weber, M.-P. Laget, C., Schwartz, and T.B. Kornberg. 1997. Proteolysis that can be inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89: 1043-1053.
4. Bejsovic, A. and E. Wieschaus. 1993. Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119: 501-517.
5. Chen, Y. and G, Struhl. 1996. Dual roles for patched in sequestering and transducing hedgehog. Cell 87: 553-563.
6. Chou, T.-B., E. Noll, and N. Perrimon. 1993. Autosomal P[o-voD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. Development 119: 1359-1369.
7. Concordet, J.-P., K. Lewis, J. Moore, L.V. Goodrich, R.L. Johnson, M.P. Scott, and P.W. Ingham. 1996. Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122: 2835-2846.
8. Domínguez, M., M. Brunner, E. Hafen, and K. Basler. 1996. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus. Science 272: 1621-1625.
9. Eaton, S. and T.B. Kornberg. 1990. Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes & Dev. 4: 1068-1077.
10. Epstein, D.J., E. Marti, M.P. Scott, and A.P. McMahon. 1996. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122: 2885-2894.
11. Ericson, J., S. Morton, A. Kawakami, H. Roelink, and T.M. Jessell. 1996. Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87: 661-673.
12. Fan, C.-M., J.A. Porter, C. Chiang, D.T. Chang, P.A. Beachy, and M. Tessier-Lavigne. 1995. Long-range sclerotome induction by Sonic hedgehog; direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-465.
13. Forbes, A.J., Y. Nakano, A.M. Taylor, and P.W. Ingham. 1993. Genetic analysis of hedgehog signaling in the Drosophila embryo. Development (Suppl.): 115-124.
14. Freedman, N.J. and R.J. Lefkowitz. 1996, Desensitization of G protein-coupled receptors. Recent Prog. Horm. Res. 51: 319-353.
15. Hammerschmidt, M., M.J. Bitgood, and A.P. McMahon. 1996. Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes & Dev. 10: 647-658.
16. Heemskerk, J. and S. DiNardo. 1994. Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76: 449-460.
17. Hepker, J., Q.-T. Wang, CK. Motzny, R. Holmgren, and T.V. Orenic. 1997. Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124: 549-558.
18. Hidalgo, A. and P.W. Ingham. 1990. Cell patterning in the Drosophila segment: Spatial regulation of the segment polarity gene patched. Development 110: 291-302.
19. Hooper, J. 1994. Distinct pathways for autocrine and paracrine wingless signalling in Drosophila embryos. Nature 372: 461-464.
20. Ingham, P.W. 1993. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366: 560-562.
21. _. 1995. Signaling by hedgehog family proteins in Drosophila and vertebrate development. Curr. Biol. 5: 492-498.
22. Inglese, I., N.J. Freedman, W.J. Koch, and R.J. Lefkowitz. 1993. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 268: 23735-23738.
23. Jiang, J. and G. Struhl. 1995. Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80: 563-572.
24. Johnson, R.L., J.K. Grenier and M.P. Scott. 1995. patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets. Development 121: 4161-4170.
25. Kalderon, D. 1995. Responses to Hedgehog. Curr. Biol. 5: 580-582.
26. Lane, M.E. and D. Kalderon. 1993. Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes & Dev. 7: 1229-1243.
27. _. 1994. RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization. Genes &. Dev. 8: 2986-2995.
28. Lawrence, P.A. and G. Struhl. 1996. Morphogens, compartments and pattern: Lessons from Drosophila? Cell 85: 951-961.
29. Lepage, T., S.M. Cohen, F.J. Diaz-Benjumea, and S.M. Parkhurst. 1995. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373: 711-715.
30. Li, W., J.T. Ohlmeyer, M.E. Lane, and D. Kalderon. 1995. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginai disc development. Cell 80: 553-562.
31. Ma, C., Y. Zhou, P.A. Beachy, and K. Moses. 1993. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75: 927-938.
32. Marigo, V., R.A. Davey, Y. Zuo, J.A. Cunningham, and C.J. Tabin. 1996. Biochemical evidence that Patched is the Hedgehog receptor. Nature 384: 176-179.
33. Motzny, C.K. and R. Holmgren. 1995. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52: 137-150.
34. Orellana, S.A. and G.S. McKnight. 1992. Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity. Proc. Natl. Acad. Sci. 89: 4726-4730.
35. Orenic, T.V., D.C. Slusarski, K.L. Kroll, and R.A. Holmgren. 1990. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes &. Dev. 4: 1053-1067.
36. Pan, D. and G.M. Rubin. 1995. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription m Drosophila imaginai discs. Cell 80: 543-552.
37. Patel, N.H., E. Martin-Blanco, K.G. Coleman, S.J. Poole, M.C. Ellis, T.B. Kornberg, and C.S. Goodman. 1989. Expression of engrailed proteins in arthropods, annelids and chordates. Cell 58: 955-968.
38. Peifer, M. and A. Bejsovic. 1992. Knowing your neighbors: Cell interactions determine intrasegmental patterning in Drosophila. Trends Genet. 8: 243-249.
39. Porter, J.A., K.E. Young, and P.A. Beachy. 1996. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255-259.
40. Préat, T. 1992. Characterization of Supressor of fused, a complete supressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132: 725-736.
41. Préat, T., R. Thérond, C. Lamour-Isnard, B. Limbourg-Bouchon, H. Tricoire, I. Erk, M.C. Mariol, and D. Busson. 1990. A putative serine threonine protein-kinase encoded by the segment-polarity fused gene of Drosophila. Nature 347: 87-89.
42. Roelink, H., J.A. Porter, C. Chiang, Y. Tanabe, D.T. Chang, P.A. Beachy, and T.M. Jessell. 1995. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445-456.
43. Sánchez-Herrero, E., J.P. Couso, J. Capdevila, and I. Guerrero. 1996. The fu gene discriminates between pathways to control dpp expresson in Drosophila imaginai discs. Mech. Dev. 55: 159-170.
44. Slusarski, D.C., C.K. Motzny, and R. Holmgren. 1995. Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics 139: 229-2404.
45. Stone, D.M., M. Hynes, M. Armanini, T.A. Swanson, Q. Gu, R.L. Johnson, M.P. Scott, D. Pennica, A. Goddard, H. Phillips, M. Noll, J.E. Hooper, F. de Sauvage, and A. Rosenthal, 1996. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134.
46. Struhl, G., D.A. Barbash, and P.A. Lawrence. 1997. Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen. Development 124: 2155-2165.
47. Strutt, D.I., V. Wiersdorff, and M. Mlodzik. 1995. Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373: 705-708.
48. Tabata, T. and T.B. Kornberg. 1994. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76: 89-102.
49. Thérond, P., G. Alves, B. Limbourg-Bouchon, H. Tricoire, E. Guillemet, J. Brissard-Zahraoui, C. Lamour-Isnard, and D. Busson. 1996a. Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila. Genetics 142: 1181-1198.
50. Thérond, P.P., J.D. Knight, T. Kornberg, and J.M. Bishop. 1996b. Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl Acad. Sci. 93: 4224-4228.
51. Ungar, A.R. and R.T. Moon. 1996. Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. Dev. Biol. 178: 186-191.
52. van den Heuvel, M. and P.W. Ingham. 1996. smoothened encodes a receptor-like serpentine protein required for hedgehog signaling. Nature 382: 547-551.
53. Von Ohlen, T., D. Lessing, R. Nusse, and J.E. Hooper. 1997. Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. 94: 2404-2409.
54. Yoffe, K.B., A.S. Manoukian, E.L. Wilder, A.M. Brand, and N. Perrimon. 1995. Evidence for engrailed-independent wingless autoregulation in Drosophila. Dev. Biol. 170: 636-650.