-
1
-
-
65749103989
-
Regulatory lymphocytes and intestinal inflammation
-
Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009; 27: 313-338
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 313-338
-
-
Izcue, A.1
Coombes, J.L.2
Powrie, F.3
-
3
-
-
0038066531
-
Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-beta expression and prevents allergy in adult life
-
Zemann B, Schwaerzler C, Griot-Wenk M, Nefzger M, Mayer P, Schneider H, de Weck A, Carballido JM, Liehl E. Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-beta expression and prevents allergy in adult life. J Allergy Clin Immunol 2003; 111: 1069-1075
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 1069-1075
-
-
Zemann, B.1
Schwaerzler, C.2
Griot-Wenk, M.3
Nefzger, M.4
Mayer, P.5
Schneider, H.6
de Weck, A.7
Carballido, J.M.8
Liehl, E.9
-
4
-
-
38449109757
-
Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: Possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype
-
Contractor N, Louten J, Kim L, Biron CA, Kelsall BL. Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGFbeta, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype. J Immunol 2007; 179: 2690-2694
-
(2007)
J Immunol
, vol.179
, pp. 2690-2694
-
-
Contractor, N.1
Louten, J.2
Kim, L.3
Biron, C.A.4
Kelsall, B.L.5
-
5
-
-
0036006811
-
The ever-increasing complexity of TGF-beta signaling
-
Roberts AB. The ever-increasing complexity of TGF-beta signaling. Cytokine Growth Factor Rev 2002; 13: 3-5
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 3-5
-
-
Roberts, A.B.1
-
6
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
7
-
-
0027500836
-
Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: Aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype
-
Geiser AG, Letterio JJ, Kulkarni AB, Karlsson S, Roberts AB, Sporn MB. Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc Natl Acad Sci USA 1993; 90: 9944-9948
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9944-9948
-
-
Geiser, A.G.1
Letterio, J.J.2
Kulkarni, A.B.3
Karlsson, S.4
Roberts, A.B.5
Sporn, M.B.6
-
8
-
-
0027531528
-
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
-
Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770-774
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.G.2
Becker, D.3
Geiser, A.4
Lyght, M.5
Flanders, K.C.6
Roberts, A.B.7
Sporn, M.B.8
Ward, J.M.9
Karlsson, S.10
-
9
-
-
0034131557
-
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
-
Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12: 171-181
-
(2000)
Immunity
, vol.12
, pp. 171-181
-
-
Gorelik, L.1
Flavell, R.A.2
-
10
-
-
48449086316
-
TGF-beta: A master of all T cell trades
-
Li MO, Flavell RA. TGF-beta: a master of all T cell trades. Cell 2008; 134: 392-404
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
11
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
12
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, Littman DR. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-1133
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
13
-
-
51649112340
-
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
-
Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 2008; 455: 246-250
-
(2008)
Nature
, vol.455
, pp. 246-250
-
-
Pesu, M.1
Watford, W.T.2
Wei, L.3
Xu, L.4
Fuss, I.5
Strober, W.6
Andersson, J.7
Shevach, E.M.8
Quezado, M.9
Bouladoux, N.10
Roebroek, A.11
Belkaid, Y.12
Creemers, J.13
O'Shea, J.J.14
-
14
-
-
33947265169
-
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
-
Yang Z, Mu Z, Dabovic B, Jurukovski V, Yu D, Sung J, Xiong X, Munger JS. Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol 2007; 176: 787-793
-
(2007)
J Cell Biol
, vol.176
, pp. 787-793
-
-
Yang, Z.1
Mu, Z.2
Dabovic, B.3
Jurukovski, V.4
Yu, D.5
Sung, J.6
Xiong, X.7
Munger, J.S.8
-
15
-
-
0033104503
-
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
-
Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J 1999; 18: 1280-1291
-
(1999)
EMBO J
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
Chen, L.4
Hayman, R.5
Gu, H.6
Roberts, A.B.7
Deng, C.8
-
16
-
-
0029913624
-
Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
-
Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996; 110: 975-984
-
(1996)
Gastroenterology
, vol.110
, pp. 975-984
-
-
Babyatsky, M.W.1
Rossiter, G.2
Podolsky, D.K.3
-
17
-
-
0034894059
-
Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001; 108: 601-609
-
(2001)
J Clin Invest
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
McKenzie, C.4
Steer, H.W.5
MacDonald, T.T.6
-
18
-
-
1042266673
-
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation
-
Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R, Alessandroni L, Mann D, Pallone F, MacDonald TT. A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation. J Biol Chem 2004; 279: 3925-3932
-
(2004)
J Biol Chem
, vol.279
, pp. 3925-3932
-
-
Monteleone, G.1
Mann, J.2
Monteleone, I.3
Vavassori, P.4
Bremner, R.5
Fantini, M.6
del Vecchio Blanco, G.7
Tersigni, R.8
Alessandroni, L.9
Mann, D.10
Pallone, F.11
MacDonald, T.T.12
-
19
-
-
33845647693
-
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
-
Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A, Palmieri G, Sanchez M, Strober W, MacDonald TT, Monteleone G. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 2006; 131: 1786-1798
-
(2006)
Gastroenterology
, vol.131
, pp. 1786-1798
-
-
Boirivant, M.1
Pallone, F.2
Di Giacinto, C.3
Fina, D.4
Monteleone, I.5
Marinaro, M.6
Caruso, R.7
Colantoni, A.8
Palmieri, G.9
Sanchez, M.10
Strober, W.11
MacDonald, T.T.12
Monteleone, G.13
-
20
-
-
34247200519
-
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
-
Hong S, Lim S, Li AG, Lee C, Lee YS, Lee EK, Park SH, Wang XJ, Kim SJ. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat Immunol 2007; 8: 504-513
-
(2007)
Nat Immunol
, vol.8
, pp. 504-513
-
-
Hong, S.1
Lim, S.2
Li, A.G.3
Lee, C.4
Lee, Y.S.5
Lee, E.K.6
Park, S.H.7
Wang, X.J.8
Kim, S.J.9
-
21
-
-
0030931156
-
Hepatitis C and hepatocellular carcinoma
-
Di Bisceglie AM. Hepatitis C and hepatocellular carcinoma. Hepatology 1997; 26: 34S-38S
-
(1997)
Hepatology
, vol.26
-
-
Di Bisceglie, A.M.1
-
22
-
-
31344469583
-
Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study
-
Murphy SJ, Anderson LA, Johnston BT, Fitzpatrick DA, Watson PR, Monaghan P, Murray LJ. Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study. World J Gastroenterol 2005; 11: 7290-7295
-
(2005)
World J Gastroenterol
, vol.11
, pp. 7290-7295
-
-
Murphy, S.J.1
Anderson, L.A.2
Johnston, B.T.3
Fitzpatrick, D.A.4
Watson, P.R.5
Monaghan, P.6
Murray, L.J.7
-
23
-
-
31144461664
-
Helicobacter infection and gastric neoplasia
-
Peek RM Jr, Crabtree JE. Helicobacter infection and gastric neoplasia. J Pathol 2006; 208: 233-248
-
(2006)
J Pathol
, vol.208
, pp. 233-248
-
-
Peek Jr., R.M.1
Crabtree, J.E.2
-
24
-
-
59549100166
-
Esophageal adenocarcinoma arising in Barrett esophagus
-
Zhang HY, Spechler SJ, Souza RF. Esophageal adenocarcinoma arising in Barrett esophagus. Cancer Lett 2009; 275: 170-177
-
(2009)
Cancer Lett
, vol.275
, pp. 170-177
-
-
Zhang, H.Y.1
Spechler, S.J.2
Souza, R.F.3
-
25
-
-
0037123274
-
Gastroesophageal reflux, barrett esophagus, and esophageal cancer: Scientific review
-
Shaheen N, Ransohoff DF. Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review. JAMA 2002; 287: 1972-1981
-
(2002)
JAMA
, vol.287
, pp. 1972-1981
-
-
Shaheen, N.1
Ransohoff, D.F.2
-
26
-
-
22144448565
-
Molecular targets for treatment of Barrett's esophagus
-
Feagins LA, Souza RF. Molecular targets for treatment of Barrett's esophagus. Dis Esophagus 2005; 18: 75-86
-
(2005)
Dis Esophagus
, vol.18
, pp. 75-86
-
-
Feagins, L.A.1
Souza, R.F.2
-
27
-
-
0037121243
-
Hallmarks of cancer progression in Barrett's oesophagus
-
Morales CP, Souza RF, Spechler SJ. Hallmarks of cancer progression in Barrett's oesophagus. Lancet 2002; 360: 1587-1589
-
(2002)
Lancet
, vol.360
, pp. 1587-1589
-
-
Morales, C.P.1
Souza, R.F.2
Spechler, S.J.3
-
28
-
-
65649115826
-
Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: Implications for pancreatic carcinogenesis
-
Bhanot UK, Möller P. Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis. Lab Invest 2009; 89: 489-497
-
(2009)
Lab Invest
, vol.89
, pp. 489-497
-
-
Bhanot, U.K.1
Möller, P.2
-
29
-
-
0036093865
-
Inflammation and the development of pancreatic cancer
-
Farrow B, Evers BM. Inflammation and the development of pancreatic cancer. Surg Oncol 2002; 10: 153-169
-
(2002)
Surg Oncol
, vol.10
, pp. 153-169
-
-
Farrow, B.1
Evers, B.M.2
-
30
-
-
26044444704
-
Role of inflammation in pancreatic carcinogenesis and the implications for future therapy
-
Garcea G, Dennison AR, Steward WP, Berry DP. Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology 2005; 5: 514-529
-
(2005)
Pancreatology
, vol.5
, pp. 514-529
-
-
Garcea, G.1
Dennison, A.R.2
Steward, W.P.3
Berry, D.P.4
-
31
-
-
44949137137
-
Helicobacter pylori infection and the pathogenesis of gastric cancer: A paradigm for host-bacterial interactions
-
McNamara D, El-Omar E. Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions. Dig Liver Dis 2008; 40: 504-509
-
(2008)
Dig Liver Dis
, vol.40
, pp. 504-509
-
-
McNamara, D.1
El-Omar, E.2
-
32
-
-
53349153618
-
Inflammatory cytokine gene polymorphisms and gastric cancer
-
Lee DH, Hahm KB. Inflammatory cytokine gene polymorphisms and gastric cancer. J Gastroenterol Hepatol 2008; 23: 1470-1472
-
(2008)
J Gastroenterol Hepatol
, vol.23
, pp. 1470-1472
-
-
Lee, D.H.1
Hahm, K.B.2
-
33
-
-
4043081982
-
Review article: Helicobacter pylori and molecular events in precancerous gastric lesions
-
Nardone G, Rocco A, Malfertheiner P. Review article: helicobacter pylori and molecular events in precancerous gastric lesions. Aliment Pharmacol Ther 2004; 20: 261-270
-
(2004)
Aliment Pharmacol Ther
, vol.20
, pp. 261-270
-
-
Nardone, G.1
Rocco, A.2
Malfertheiner, P.3
-
34
-
-
0042365388
-
Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice
-
Hahm KB, Lee KM, Kim YB, Hong WS, Lee WH, Han SU, Kim MW, Ahn BO, Oh TY, Lee MH, Green J, Kim SJ. Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. Aliment Pharmacol Ther 2002; 16 Suppl 2: 115-127
-
(2002)
Aliment Pharmacol Ther
, vol.16
, Issue.SUPPL. 2
, pp. 115-127
-
-
Hahm, K.B.1
Lee, K.M.2
Kim, Y.B.3
Hong, W.S.4
Lee, W.H.5
Han, S.U.6
Kim, M.W.7
Ahn, B.O.8
Oh, T.Y.9
Lee, M.H.10
Green, J.11
Kim, S.J.12
-
35
-
-
3042599473
-
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation
-
Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004; 287: G7-G17
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
-
-
Itzkowitz, S.H.1
Yio, X.2
-
36
-
-
0042307513
-
The two faces of transforming growth factor beta in carcinogenesis
-
Roberts AB, Wakefield LM. The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA 2003; 100: 8621-8623
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
37
-
-
2642614530
-
Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
-
Tang B, Böttinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ, Wakefield LM. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency. Nat Med 1998; 4: 802-807
-
(1998)
Nat Med
, vol.4
, pp. 802-807
-
-
Tang, B.1
Böttinger, E.P.2
Jakowlew, S.B.3
Bagnall, K.M.4
Mariano, J.5
Anver, M.R.6
Letterio, J.J.7
Wakefield, L.M.8
-
38
-
-
0033565626
-
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
-
Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 1999; 59: 3379-3386
-
(1999)
Cancer Res
, vol.59
, pp. 3379-3386
-
-
Engle, S.J.1
Hoying, J.B.2
Boivin, G.P.3
Ormsby, I.4
Gartside, P.S.5
Doetschman, T.6
-
39
-
-
0028785603
-
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
-
Parsons R, Myeroff LL, Liu B, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 1995; 55: 5548-5550
-
(1995)
Cancer Res
, vol.55
, pp. 5548-5550
-
-
Parsons, R.1
Myeroff, L.L.2
Liu, B.3
Willson, J.K.4
Markowitz, S.D.5
Kinzler, K.W.6
Vogelstein, B.7
-
40
-
-
0034924028
-
Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
-
Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY, Green J, Kim SJ. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001; 49: 190-198
-
(2001)
Gut
, vol.49
, pp. 190-198
-
-
Hahm, K.B.1
Im, Y.H.2
Parks, T.W.3
Park, S.H.4
Markowitz, S.5
Jung, H.Y.6
Green, J.7
Kim, S.J.8
-
41
-
-
0032404111
-
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
-
Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998; 58: 5329-5332
-
(1998)
Cancer Res
, vol.58
, pp. 5329-5332
-
-
Goggins, M.1
Shekher, M.2
Turnacioglu, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
42
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, Velculescu VE, Traverso G, Vogelstein B. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 2001; 28: 184-187
-
(2001)
Nat Genet
, vol.28
, pp. 184-187
-
-
Howe, J.R.1
Bair, J.L.2
Sayed, M.G.3
Anderson, M.E.4
Mitros, F.A.5
Petersen, G.M.6
Velculescu, V.E.7
Traverso, G.8
Vogelstein, B.9
-
43
-
-
0034611611
-
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
-
Xu X, Brodie SG, Yang X, Im YH, Parks WT, Chen L, Zhou YX, Weinstein M, Kim SJ, Deng CX. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 2000; 19: 1868-1874
-
(2000)
Oncogene
, vol.19
, pp. 1868-1874
-
-
Xu, X.1
Brodie, S.G.2
Yang, X.3
Im, Y.H.4
Parks, W.T.5
Chen, L.6
Zhou, Y.X.7
Weinstein, M.8
Kim, S.J.9
Deng, C.X.10
-
44
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271: 350-353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
45
-
-
33745578957
-
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
-
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 2006; 441: 1015-1019
-
(2006)
Nature
, vol.441
, pp. 1015-1019
-
-
Kim, B.G.1
Li, C.2
Qiao, W.3
Mamura, M.4
Kasprzak, B.5
Anver, M.6
Wolfraim, L.7
Hong, S.8
Mushinski, E.9
Potter, M.10
Kim, S.J.11
Fu, X.Y.12
Deng, C.13
Letterio, J.J.14
-
46
-
-
1442332673
-
Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
-
Han SU, Kim HT, Seong DH, Kim YS, Park YS, Bang YJ, Yang HK, Kim SJ. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene 2004; 23: 1333-1341
-
(2004)
Oncogene
, vol.23
, pp. 1333-1341
-
-
Han, S.U.1
Kim, H.T.2
Seong, D.H.3
Kim, Y.S.4
Park, Y.S.5
Bang, Y.J.6
Yang, H.K.7
Kim, S.J.8
-
47
-
-
35848951652
-
Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation
-
Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe EA, Kim SS, Katuri V, Kallakury B, Pishvaian M, Albanese C, Mendelson J, Zasloff M, Rashid A, Fishbein T, Evans SR, Sidawy A, Reddy EP, Mishra B, Johnson LB, Shetty K, Mishra L. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene 2007; 26: 7103-7110
-
(2007)
Oncogene
, vol.26
, pp. 7103-7110
-
-
Kitisin, K.1
Ganesan, N.2
Tang, Y.3
Jogunoori, W.4
Volpe, E.A.5
Kim, S.S.6
Katuri, V.7
Kallakury, B.8
Pishvaian, M.9
Albanese, C.10
Mendelson, J.11
Zasloff, M.12
Rashid, A.13
Fishbein, T.14
Evans, S.R.15
Sidawy, A.16
Reddy, E.P.17
Mishra, B.18
Johnson, L.B.19
Shetty, K.20
Mishra, L.21
more..
-
48
-
-
54449089923
-
Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis
-
Baek HJ, Lim SC, Kitisin K, Jogunoori W, Tang Y, Marshall MB, Mishra B, Kim TH, Cho KH, Kim SS, Mishra L. Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology 2008; 48: 1128-1137
-
(2008)
Hepatology
, vol.48
, pp. 1128-1137
-
-
Baek, H.J.1
Lim, S.C.2
Kitisin, K.3
Jogunoori, W.4
Tang, Y.5
Marshall, M.B.6
Mishra, B.7
Kim, T.H.8
Cho, K.H.9
Kim, S.S.10
Mishra, L.11
-
49
-
-
33745515023
-
Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer
-
Bierie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 2006; 6: 506-520
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
50
-
-
33750311251
-
In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma
-
Rees JR, Onwuegbusi BA, Save VE, Alderson D, Fitzgerald RC. In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res 2006; 66: 9583-9590
-
(2006)
Cancer Res
, vol.66
, pp. 9583-9590
-
-
Rees, J.R.1
Onwuegbusi, B.A.2
Save, V.E.3
Alderson, D.4
Fitzgerald, R.C.5
-
51
-
-
43049103824
-
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601
-
(2008)
Nat Cell Biol
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
Farshid, G.6
Vadas, M.A.7
Khew-Goodall, Y.8
Goodall, G.J.9
-
52
-
-
27744527762
-
Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
-
Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 2005; 129: 1375-1383
-
(2005)
Gastroenterology
, vol.129
, pp. 1375-1383
-
-
Giannelli, G.1
Bergamini, C.2
Fransvea, E.3
Sgarra, C.4
Antonaci, S.5
-
53
-
-
57349137178
-
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism
-
Lee YH, Albig AR, Regner M, Schiemann BJ, Schiemann WP. Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis 2008; 29: 2243-2251
-
(2008)
Carcinogenesis
, vol.29
, pp. 2243-2251
-
-
Lee, Y.H.1
Albig, A.R.2
Regner, M.3
Schiemann, B.J.4
Schiemann, W.P.5
-
54
-
-
33745293286
-
Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy
-
Becker JC, Muller-Tidow C, Serve H, Domschke W, Pohle T. Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy. World J Gastroenterol 2006; 12: 3297-3305
-
(2006)
World J Gastroenterol
, vol.12
, pp. 3297-3305
-
-
Becker, J.C.1
Muller-Tidow, C.2
Serve, H.3
Domschke, W.4
Pohle, T.5
-
55
-
-
0030639334
-
Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells
-
Park JA, Wang E, Kurt RA, Schluter SF, Hersh EM, Akporiaye ET. Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. Cancer Gene Ther 1997; 4: 42-50
-
(1997)
Cancer Gene Ther
, vol.4
, pp. 42-50
-
-
Park, J.A.1
Wang, E.2
Kurt, R.A.3
Schluter, S.F.4
Hersh, E.M.5
Akporiaye, E.T.6
-
56
-
-
34547187636
-
Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: From preclinical to phase I/II studies
-
Hau P, Jachimczak P, Schlingensiepen R, Schulmeyer F, Jauch T, Steinbrecher A, Brawanski A, Proescholdt M, Schlaier J, Buchroithner J, Pichler J, Wurm G, Mehdorn M, Strege R, Schuierer G, Villarrubia V, Fellner F, Jansen O, Straube T, Nohria V, Goldbrunner M, Kunst M, Schmaus S, Stauder G, Bogdahn U, Schlingensiepen KH. Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 2007; 17: 201-212
-
(2007)
Oligonucleotides
, vol.17
, pp. 201-212
-
-
Hau, P.1
Jachimczak, P.2
Schlingensiepen, R.3
Schulmeyer, F.4
Jauch, T.5
Steinbrecher, A.6
Brawanski, A.7
Proescholdt, M.8
Schlaier, J.9
Buchroithner, J.10
Pichler, J.11
Wurm, G.12
Mehdorn, M.13
Strege, R.14
Schuierer, G.15
Villarrubia, V.16
Fellner, F.17
Jansen, O.18
Straube, T.19
Nohria, V.20
Goldbrunner, M.21
Kunst, M.22
Schmaus, S.23
Stauder, G.24
Bogdahn, U.25
Schlingensiepen, K.H.26
more..
-
57
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S. Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 2008; 177: 137-150
-
(2008)
Recent Results Cancer Res
, vol.177
, pp. 137-150
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
58
-
-
0035877007
-
Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases
-
Leitlein J, Aulwurm S, Waltereit R, Naumann U, Wagenknecht B, Garten W, Weller M, Platten M. Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases. J Immunol 2001; 166: 7238-7243
-
(2001)
J Immunol
, vol.166
, pp. 7238-7243
-
-
Leitlein, J.1
Aulwurm, S.2
Waltereit, R.3
Naumann, U.4
Wagenknecht, B.5
Garten, W.6
Weller, M.7
Platten, M.8
-
59
-
-
0025759209
-
Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: Possible TGF-beta 1-mediated autocrine inhibition
-
Falk LA, De Benedetti F, Lohrey N, Birchenall-Roberts MC, Ellingsworth LW, Faltynek CR, Ruscetti FW. Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: possible TGF-beta 1-mediated autocrine inhibition. Blood 1991; 77: 1248-1255
-
(1991)
Blood
, vol.77
, pp. 1248-1255
-
-
Falk, L.A.1
de Benedetti, F.2
Lohrey, N.3
Birchenall-Roberts, M.C.4
Ellingsworth, L.W.5
Faltynek, C.R.6
Ruscetti, F.W.7
-
60
-
-
0028987267
-
1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells
-
Koli K, Keski-Oja J. 1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells. Cancer Res 1995; 55: 1540-1546
-
(1995)
Cancer Res
, vol.55
, pp. 1540-1546
-
-
Koli, K.1
Keski-Oja, J.2
-
61
-
-
0031469749
-
A novel substance with TGF-beta like activity, diheteropeptin, produced by a fungus, Diheterospora sp
-
Masuoka Y, Shin-ya K, Furihata K, Hayakawa Y, Seto H. A novel substance with TGF-beta like activity, diheteropeptin, produced by a fungus, Diheterospora sp. J Antibiot (Tokyo) 1997; 50: 1058-1060
-
(1997)
J Antibiot (Tokyo)
, vol.50
, pp. 1058-1060
-
-
Masuoka, Y.1
Shin-Ya, K.2
Furihata, K.3
Hayakawa, Y.4
Seto, H.5
-
62
-
-
0033856391
-
Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities
-
Masuoka Y, Shin-Ya K, Kim YB, Yoshida M, Nagai K, Suzuki K, Hayakawa Y, Seto H. Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities. J Antibiot (Tokyo) 2000; 53: 788-792
-
(2000)
J Antibiot (Tokyo)
, vol.53
, pp. 788-792
-
-
Masuoka, Y.1
Shin-Ya, K.2
Kim, Y.B.3
Yoshida, M.4
Nagai, K.5
Suzuki, K.6
Hayakawa, Y.7
Seto, H.8
-
63
-
-
22444444598
-
Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products
-
Lee KH, Nishimura S, Matsunaga S, Fusetani N, Horinouchi S, Yoshida M. Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products. Cancer Sci 2005; 96: 357-364
-
(2005)
Cancer Sci
, vol.96
, pp. 357-364
-
-
Lee, K.H.1
Nishimura, S.2
Matsunaga, S.3
Fusetani, N.4
Horinouchi, S.5
Yoshida, M.6
-
64
-
-
0036689042
-
Transforming growth factor beta mimetics: Discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase
-
Glaser KB, Li J, Aakre ME, Morgan DW, Sheppard G, Stewart KD, Pollock J, Lee P, O'Connor CZ, Anderson SN, Mussatto DJ, Wegner CW, Moses HL. Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase. Mol Cancer Ther 2002; 1: 759-768
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 759-768
-
-
Glaser, K.B.1
Li, J.2
Aakre, M.E.3
Morgan, D.W.4
Sheppard, G.5
Stewart, K.D.6
Pollock, J.7
Lee, P.8
O'Connor, C.Z.9
Anderson, S.N.10
Mussatto, D.J.11
Wegner, C.W.12
Moses, H.L.13
-
65
-
-
0035039284
-
High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells
-
Sohn TA, Su GH, Ryu B, Yeo CJ, Kern SE. High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells. Ann Surg 2001; 233: 696-703
-
(2001)
Ann Surg
, vol.233
, pp. 696-703
-
-
Sohn, T.A.1
Su, G.H.2
Ryu, B.3
Yeo, C.J.4
Kern, S.E.5
-
66
-
-
0037085474
-
Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells
-
Park SH, Lee SR, Kim BC, Cho EA, Patel SP, Kang HB, Sausville EA, Nakanishi O, Trepel JB, Lee BI, Kim SJ. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. J Biol Chem 2002; 277: 5168-5174
-
(2002)
J Biol Chem
, vol.277
, pp. 5168-5174
-
-
Park, S.H.1
Lee, S.R.2
Kim, B.C.3
Cho, E.A.4
Patel, S.P.5
Kang, H.B.6
Sausville, E.A.7
Nakanishi, O.8
Trepel, J.B.9
Lee, B.I.10
Kim, S.J.11
-
67
-
-
3542998048
-
Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells
-
Ammanamanchi S, Brattain MG. Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem 2004; 279: 32620-32625
-
(2004)
J Biol Chem
, vol.279
, pp. 32620-32625
-
-
Ammanamanchi, S.1
Brattain, M.G.2
-
68
-
-
0034676340
-
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta
-
Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM. Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. Oncogene 2000; 19: 5525-5533
-
(2000)
Oncogene
, vol.19
, pp. 5525-5533
-
-
Adnane, J.1
Bizouarn, F.A.2
Chen, Z.3
Ohkanda, J.4
Hamilton, A.D.5
Munoz-Antonia, T.6
Sebti, S.M.7
-
69
-
-
0035190076
-
Captopril restores transforming growth factor-beta type II receptor and sensitivity to transforming growth factor-beta in murine renal cell cancer cells
-
Miyajima A, Asano T, Hayakawa M. Captopril restores transforming growth factor-beta type II receptor and sensitivity to transforming growth factor-beta in murine renal cell cancer cells. J Urol 2001; 165: 616-620
-
(2001)
J Urol
, vol.165
, pp. 616-620
-
-
Miyajima, A.1
Asano, T.2
Hayakawa, M.3
-
70
-
-
0035881295
-
Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2
-
Venkatasubbarao K, Ammanamanchi S, Brattain MG, Mimari D, Freeman JW. Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2. Cancer Res 2001; 61: 6239-6247
-
(2001)
Cancer Res
, vol.61
, pp. 6239-6247
-
-
Venkatasubbarao, K.1
Ammanamanchi, S.2
Brattain, M.G.3
Mimari, D.4
Freeman, J.W.5
-
71
-
-
34447509697
-
Vorinostat: A new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma
-
Duvic M, Vu J. Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma. Expert Opin Investig Drugs 2007; 16: 1111-1120
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 1111-1120
-
-
Duvic, M.1
Vu, J.2
-
72
-
-
33750340590
-
Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells
-
Wang H, Han H, Von Hoff DD. Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells. Cancer Res 2006; 66: 9722-9730
-
(2006)
Cancer Res
, vol.66
, pp. 9722-9730
-
-
Wang, H.1
Han, H.2
von Hoff, D.D.3
-
73
-
-
33645735874
-
Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth
-
Park HJ, Partridge E, Cheung P, Pawling J, Donovan R, Wrana JL, Dennis JW. Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res 2006; 66: 3558-3566
-
(2006)
Cancer Res
, vol.66
, pp. 3558-3566
-
-
Park, H.J.1
Partridge, E.2
Cheung, P.3
Pawling, J.4
Donovan, R.5
Wrana, J.L.6
Dennis, J.W.7
-
74
-
-
34247526984
-
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
-
Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 2007; 7: 357-369
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
75
-
-
0037444161
-
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling
-
Suh N, Roberts AB, Birkey Reffey S, Miyazono K, Itoh S, ten Dijke P, Heiss EH, Place AE, Risingsong R, Williams CR, Honda T, Gribble GW, Sporn MB. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Res 2003; 63: 1371-1376
-
(2003)
Cancer Res
, vol.63
, pp. 1371-1376
-
-
Suh, N.1
Roberts, A.B.2
Birkey, R.S.3
Miyazono, K.4
Itoh, S.5
ten Dijke, P.6
Heiss, E.H.7
Place, A.E.8
Risingsong, R.9
Williams, C.R.10
Honda, T.11
Gribble, G.W.12
Sporn, M.B.13
-
76
-
-
0041342109
-
Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
-
Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT. Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci 2003; 44: 3394-3401
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 3394-3401
-
-
Mead, A.L.1
Wong, T.T.2
Cordeiro, M.F.3
Anderson, I.K.4
Khaw, P.T.5
-
77
-
-
0027137485
-
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression
-
Arteaga CL, Hurd SD, Winnier AR, Johnson MD, Fendly BM, Forbes JT. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J Clin Invest 1993; 92: 2569-2576
-
(1993)
J Clin Invest
, vol.92
, pp. 2569-2576
-
-
Arteaga, C.L.1
Hurd, S.D.2
Winnier, A.R.3
Johnson, M.D.4
Fendly, B.M.5
Forbes, J.T.6
-
78
-
-
0036086409
-
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 2002; 109: 1551-1559
-
(2002)
J Clin Invest
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
79
-
-
0036050857
-
Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis
-
Rowland-Goldsmith MA, Maruyama H, Matsuda K, Idezawa T, Ralli M, Ralli S, Korc M. Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis. Mol Cancer Ther 2002; 1: 161-167
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 161-167
-
-
Rowland-Goldsmith, M.A.1
Maruyama, H.2
Matsuda, K.3
Idezawa, T.4
Ralli, M.5
Ralli, S.6
Korc, M.7
-
80
-
-
0037102289
-
Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft
-
Bandyopadhyay A, López-Casillas F, Malik SN, Montiel JL, Mendoza V, Yang J, Sun LZ. Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res 2002; 62: 4690-4695
-
(2002)
Cancer Res
, vol.62
, pp. 4690-4695
-
-
Bandyopadhyay, A.1
López-Casillas, F.2
Malik, S.N.3
Montiel, J.L.4
Mendoza, V.5
Yang, J.6
Sun, L.Z.7
-
81
-
-
0034796457
-
The TGF beta receptor activation process: An inhibitor- to substrate-binding switch
-
Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell 2001; 8: 671-682
-
(2001)
Mol Cell
, vol.8
, pp. 671-682
-
-
Huse, M.1
Muir, T.W.2
Xu, L.3
Chen, Y.G.4
Kuriyan, J.5
Massagué, J.6
-
82
-
-
0032102902
-
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
-
Eyers PA, Craxton M, Morrice N, Cohen P, Goedert M. Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem Biol 1998; 5: 321-328
-
(1998)
Chem Biol
, vol.5
, pp. 321-328
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
83
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002; 62: 65-74
-
(2002)
Mol Pharmacol
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
Nicolás, F.J.2
Callahan, J.F.3
Harling, J.D.4
Gaster, L.M.5
Reith, A.D.6
Laping, N.J.7
Hill, C.S.8
-
84
-
-
4444341835
-
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility
-
Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, Reese ED, Herbstreith MH, Laping NJ, Friedman HS, Bigner DD, Wang XF, Rich JN. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther 2004; 3: 737-745
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 737-745
-
-
Hjelmeland, M.D.1
Hjelmeland, A.B.2
Sathornsumetee, S.3
Reese, E.D.4
Herbstreith, M.H.5
Laping, N.J.6
Friedman, H.S.7
Bigner, D.D.8
Wang, X.F.9
Rich, J.N.10
-
85
-
-
0344496021
-
Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)
-
Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, Corbley MJ, Cheung HK, Arduini RM, Mead JN, Newman MN, Papadatos JL, Bowes S, Josiah S, Ling LE. Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett 2003; 13: 4355-4359
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4355-4359
-
-
Singh, J.1
Chuaqui, C.E.2
Boriack-Sjodin, P.A.3
Lee, W.C.4
Pontz, T.5
Corbley, M.J.6
Cheung, H.K.7
Arduini, R.M.8
Mead, J.N.9
Newman, M.N.10
Papadatos, J.L.11
Bowes, S.12
Josiah, S.13
Ling, L.E.14
-
86
-
-
37149042061
-
Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice
-
Bueno L, de Alwis DP, Pitou C, Yingling J, Lahn M, Glatt S, Trocóniz IF. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice. Eur J Cancer 2008; 44: 142-150
-
(2008)
Eur J Cancer
, vol.44
, pp. 142-150
-
-
Bueno, L.1
de Alwis, D.P.2
Pitou, C.3
Yingling, J.4
Lahn, M.5
Glatt, S.6
Trocóniz, I.F.7
-
87
-
-
7444226411
-
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, Mangadu R, Liu YW, Platten M, Herrlinger U, Murphy A, Wong DH, Wick W, Higgins LS, Weller M. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 2004; 64: 7954-7961
-
(2004)
Cancer Res
, vol.64
, pp. 7954-7961
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
Weiler, M.4
Ma, J.Y.5
Almirez, R.6
Mangadu, R.7
Liu, Y.W.8
Platten, M.9
Herrlinger, U.10
Murphy, A.11
Wong, D.H.12
Wick, W.13
Higgins, L.S.14
Weller, M.15
-
88
-
-
29644443725
-
The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta
-
Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, Node M, Imamura T. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci 2005; 96: 791-800
-
(2005)
Cancer Sci
, vol.96
, pp. 791-800
-
-
Tojo, M.1
Hamashima, Y.2
Hanyu, A.3
Kajimoto, T.4
Saitoh, M.5
Miyazono, K.6
Node, M.7
Imamura, T.8
-
89
-
-
33645665682
-
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor
-
Gellibert F, de Gouville AC, Woolven J, Mathews N, Nguyen VL, Bertho-Ruault C, Patikis A, Grygielko ET, Laping NJ, Huet S. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. J Med Chem 2006; 49: 2210-2221
-
(2006)
J Med Chem
, vol.49
, pp. 2210-2221
-
-
Gellibert, F.1
de Gouville, A.C.2
Woolven, J.3
Mathews, N.4
Nguyen, V.L.5
Bertho-Ruault, C.6
Patikis, A.7
Grygielko, E.T.8
Laping, N.J.9
Huet, S.10
-
90
-
-
55649112720
-
Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/activin receptor-like kinase-5, on prostate cancer cells
-
Lee GT, Hong JH, Mueller TJ, Watson JA, Kwak C, Sheen YY, Kim DK, Kim SJ, Kim IY. Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/activin receptor-like kinase-5, on prostate cancer cells. J Urol 2008; 180: 2660-2667
-
(2008)
J Urol
, vol.180
, pp. 2660-2667
-
-
Lee, G.T.1
Hong, J.H.2
Mueller, T.J.3
Watson, J.A.4
Kwak, C.5
Sheen, Y.Y.6
Kim, D.K.7
Kim, S.J.8
Kim, I.Y.9
-
91
-
-
67650305810
-
Tranilast inhibits the growth and metastasis of mammary carcinoma
-
Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 2009; 20: 334-345
-
(2009)
Anticancer Drugs
, vol.20
, pp. 334-345
-
-
Chakrabarti, R.1
Subramaniam, V.2
Abdalla, S.3
Jothy, S.4
Prud'homme, G.J.5
-
92
-
-
33846523487
-
Pirfenidone inhibits TGF-beta expression in malignant glioma cells
-
Burghardt I, Tritschler F, Opitz CA, Frank B, Weller M, Wick W. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun 2007; 354: 542-547
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 542-547
-
-
Burghardt, I.1
Tritschler, F.2
Opitz, C.A.3
Frank, B.4
Weller, M.5
Wick, W.6
-
93
-
-
2442481893
-
Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone
-
Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 2004; 279: 15167-15176
-
(2004)
J Biol Chem
, vol.279
, pp. 15167-15176
-
-
Xavier, S.1
Piek, E.2
Fujii, M.3
Javelaud, D.4
Mauviel, A.5
Flanders, K.C.6
Samuni, A.M.7
Felici, A.8
Reiss, M.9
Yarkoni, S.10
Sowers, A.11
Mitchell, J.B.12
Roberts, A.B.13
Russo, A.14
-
94
-
-
23944460074
-
Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-beta in vitro via up-regulation of Smad 7
-
Chen YW, Li DG, Wu JX, Chen YW, Lu HM. Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-beta in vitro via up-regulation of Smad 7. J Ethnopharmacol 2005; 100: 299-305
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 299-305
-
-
Chen, Y.W.1
Li, D.G.2
Wu, J.X.3
Chen, Y.W.4
Lu, H.M.5
-
95
-
-
48049083321
-
Doxorubicin inhibits TGF-beta signaling in human lung carcinoma A549 cells
-
Filyak Y, Filyak O, Souchelnytskyi S, Stoika R. Doxorubicin inhibits TGF-beta signaling in human lung carcinoma A549 cells. Eur J Pharmacol 2008; 590: 67-73
-
(2008)
Eur J Pharmacol
, vol.590
, pp. 67-73
-
-
Filyak, Y.1
Filyak, O.2
Souchelnytskyi, S.3
Stoika, R.4
-
97
-
-
34250162144
-
Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells
-
Xu W, Neckers L. Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells. Clin Cancer Res 2007; 13: 1625-1629
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1625-1629
-
-
Xu, W.1
Neckers, L.2
|