Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-β expression and prevents allergy in adult life

Journal of Allergy and Clinical Immunology

Volumn 111, Issue 5, 2003, Pages 1069-1075

  Zemann, Barbara ^a,d   Schwaerzler, Christoph ^a   Griot Wenk, Monika ^b   Nefzger, Marijke ^a   Mayer, Peter ^a   Schneider, Heinz ^b   De Weck, Alain ^c   Carballido, José M ^a   Liehl, Ekke ^a  

^a NOVARTIS RESEARCH INSTITUTE   (Austria)

^b HealthEcon Ltd   (Switzerland)

^c Gerimmun Foundation   (Switzerland)

^d Novartis Research Institute   (Austria)

Author keywords

Allergy; IL 10; Oral tolerance; Regulatory cells; TGF

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC CONJUNCTIVITIS; ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DOG; EOSINOPHILIA; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL TOLERANCE; LUNG LAVAGE; MILK; NEUTROPHILIA; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVOCATION; T LYMPHOCYTE;

EID: 0038066531     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.1411     Document Type: Article

References (27)

1. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 2000;105:860-76.
2. Barnes PJ. Therapeutic strategies for allergic diseases. Nature 1999;402:B31-8.
3. Weiner HL. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J Clin Invest 2000;106:935-7.
4. Friedman A, Weiner H. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A 1994;91:6688-92.
5. Chen Y, Inobe J, Marks R, Gonella, P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995;376:177-80.
6. Garside P, Mowat AM, Khoruts A. Oral tolerance in disease. Gut 1999;44:137-42.
7. Wells HG, Osborne TB. The biological reactions of the vegetable proteins. I. Anaphylaxis. J Infect Dis 1911;8:66-124.
8. Aramaki Y, Fujii Y, Suda H, Suzuki I, Yadomae T, Tsuchiya S. Induction of oral tolerance after feeding of ragweed pollen extract in mice. Immunol Lett 1994;40:21-5.
9. Van Halteren AG, van der Cammen MJ, Biewenga J, Savelkoul HF, Kraal G. IgE and mast cell response on intestinal allergen exposure: a murine model to study the onset of food allergy. J Allergy Clin Immunol 1997;99:94-9.
10. Pecquet S, Pfeifer A, Gauldie S, Fritsche R. Immunoglobulin E suppression and cytokine modulation in mice orally tolerized to beta-lactogtobulin. Immunology 1999;96:278-85.
11. Whitacre CC, Gienapp IE, Meyer A, Cox KL, Javed N. Treatment of autoimmune disease by oral tolerance to autoantigens. Clin Immunol Immunopathol 1996;80:31-9.
12. Fanta C, Bohle B, Hirt W, Siemann U, Horak F, Kraft D, et al. Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol 1999;120:218-24.
13. Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T, Andre C, et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy 1998;53:662-72.
14. Moller C, Dreborg S, Lanner A, Bjorksten B. Oral immunotherapy of children with rhinoconjunctivitis due to birch pollen allergy. A double-blind study. Allergy 1986;41:271-9.
15. de Weck AL, Mayer P, Stumper B, Schiessl B, Pickart L. Dog allergy, a model for allergy genetics. Int Arch Allergy Immunol 1997;113:55-7.
16. de Weck AL. The Carl Prausnitz Memorial Lecture. What can we learn from the allergic zoo? Int Arch Allergy Immunol 1995;107:13-8.
17. Russo M, Nahori MA, Lefort J, Gomes E, de Castro Keller A, Rodriguez D, et al. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am J Respir Cell Mol Biol 2001;24:518-26.
18. Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 2001;167:4245-53.
19. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A, Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683-765.
20. Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nat Rev Immunol 2002;2:46-53.
21. Shevach EM. CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389-400.
22. Tsuji NM, Mizumachi K, Kurisaki J. Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral tolerance. Immunology 2001;103:458-64.
23. Akbari O, deKruyff R, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immun 2001;2:725-31.
24. Thepen T, Van Rooijen N, Kraal G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med 1989;170:499-509.
25. Thepen T, Kraal G, Holt PG. The rote of alveolar macrophages in regulation of lung inflammation. Ann N Y Acad Sci 1994;725:200-6.
26. Thepen T, Hoeben K, Breve J, Kraal G. Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T-cell-dependent, but not T-cell-independent antigens. Immunology 1992;76:60-4.
27. Thepen T, McMenamin C, Girn B, Kraal G, Holt PG. Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen. Clin Exp Allergy 1992;22:1107-14.