-
1
-
-
0027944927
-
Current Concepts: Brain tumors in children
-
Pollack I.F. Current Concepts: Brain tumors in children. N Engl J Med 1994, 331:1500-1507.
-
(1994)
N Engl J Med
, vol.331
, pp. 1500-1507
-
-
Pollack, I.F.1
-
2
-
-
0035843243
-
Brain tumors
-
DeAngelis L.M. Brain tumors. N Engl J Med 2001, 344:114-123.
-
(2001)
N Engl J Med
, vol.344
, pp. 114-123
-
-
DeAngelis, L.M.1
-
3
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
0038278706
-
Mitogenic signaling cascades in glial tumors
-
Kapoor G.S., O'Rourke D.M. Mitogenic signaling cascades in glial tumors. Neurosurgery 2003, 52:1425-1435.
-
(2003)
Neurosurgery
, vol.52
, pp. 1425-1435
-
-
Kapoor, G.S.1
O'Rourke, D.M.2
-
5
-
-
0033559206
-
Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells
-
Yount G.L., Levine K.S., Kuriyama H., Haas-Kogan D.A., Israel M.A. Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. Cancer Res 1999, 59:1362-1365.
-
(1999)
Cancer Res
, vol.59
, pp. 1362-1365
-
-
Yount, G.L.1
Levine, K.S.2
Kuriyama, H.3
Haas-kogan, D.A.4
Israel, M.A.5
-
6
-
-
0027944206
-
Jacks T. p53 status and the efficacy of cancer therapy in vivo
-
Lowe S., Bodis S., McClatchy A., et al. Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science 1994, 266:807-810.
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.1
Bodis, S.2
McClatchy, A.3
-
7
-
-
0035887141
-
Age and TP53 mutation frequency in childhood gliomas. Results in a multi-institutional cohort
-
Pollack I.F., Finkelstein S.D., Burnham J., et al. Age and TP53 mutation frequency in childhood gliomas. Results in a multi-institutional cohort. Cancer Res 2001, 61:7404-7407.
-
(2001)
Cancer Res
, vol.61
, pp. 7404-7407
-
-
Pollack, I.F.1
Finkelstein, S.D.2
Burnham, J.3
-
8
-
-
0026569818
-
Clonal expansion of p53 mutant cells is associated with brain tumor progression
-
Sidransky D., Mikkelsen T., Schechheimer K., Rosenblum M.L., Cavenee W., Vogelstein B. Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature 1992, 355:846-847.
-
(1992)
Nature
, vol.355
, pp. 846-847
-
-
Sidransky, D.1
Mikkelsen, T.2
Schechheimer, K.3
Rosenblum, M.L.4
Cavenee, W.5
Vogelstein, B.6
-
10
-
-
0028879677
-
P53 point mutation and survival in colorectal cancer patients
-
Goh H.-S., Yao J., Smith D.R. p53 point mutation and survival in colorectal cancer patients. Cancer Res 1995, 55:5217-5221.
-
(1995)
Cancer Res
, vol.55
, pp. 5217-5221
-
-
Goh, H.-S.1
Yao, J.2
Smith, D.R.3
-
11
-
-
0037034253
-
Expression of p53 and prognosis in malignant gliomas in children
-
Pollack I.F., Finkelstein S.D., Woods J., et al. Expression of p53 and prognosis in malignant gliomas in children. N Engl J Med 2002, 346:420-427.
-
(2002)
N Engl J Med
, vol.346
, pp. 420-427
-
-
Pollack, I.F.1
Finkelstein, S.D.2
Woods, J.3
-
12
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J., Yen C., Liaw D., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
-
13
-
-
0032403139
-
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
-
Davies M.A., Lu Y., Sano T., et al. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 1998, 58:5285-5290.
-
(1998)
Cancer Res
, vol.58
, pp. 5285-5290
-
-
Davies, M.A.1
Lu, Y.2
Sano, T.3
-
14
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999, 96:4240-4245.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
15
-
-
0023747564
-
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor α and their receptors in human malignant glioma cell lines
-
Nister M., Libermann T.A., Betscholz C., et al. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor α and their receptors in human malignant glioma cell lines. Cancer Res 1988, 48:3910-3918.
-
(1988)
Cancer Res
, vol.48
, pp. 3910-3918
-
-
Nister, M.1
Libermann, T.A.2
Betscholz, C.3
-
16
-
-
0020640259
-
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
-
Waterfield M.D., Scrace G.T., Whittle N., et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 1989, 304:35-39.
-
(1989)
Nature
, vol.304
, pp. 35-39
-
-
Waterfield, M.D.1
Scrace, G.T.2
Whittle, N.3
-
17
-
-
0026045167
-
Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines
-
Nistér M., Claesson-Welch L., Erikssonm A., Heldin C.-H., Westermark B. Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J Biol Chem 1991, 266:16755-16763.
-
(1991)
J Biol Chem
, vol.266
, pp. 16755-16763
-
-
Nistér, M.1
Claesson-welch, L.2
Erikssonm, A.3
Heldin, C.-H.4
Westermark, B.5
-
18
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker N.A., Sullivan C.M., Hollenbach S.J., Israel M.A., Giese N.A. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 2002, 62:3729-3735.
-
(2002)
Cancer Res
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
Sullivan, C.M.2
Hollenbach, S.J.3
Israel, M.A.4
Giese, N.A.5
-
19
-
-
0035003785
-
PDGF-D is a specific, protease-activated ligand for the PDGF beta receptor
-
Bergsten E., Uutela M., Li X., et al. PDGF-D is a specific, protease-activated ligand for the PDGF beta receptor. Nat Cell Biol 2001, 3:512-516.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 512-516
-
-
Bergsten, E.1
Uutela, M.2
Li, X.3
-
20
-
-
0035920172
-
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor
-
Gilbertson D.G., DuffM.E., West J.W., et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem 2001, 276:27406-27414.
-
(2001)
J Biol Chem
, vol.276
, pp. 27406-27414
-
-
Gilbertson, D.G.1
Duff, M.E.2
West, J.W.3
-
21
-
-
0025220468
-
Williams LT. Platelet-derived growth factor (PDGF) autocrine components in human tumor cell lines
-
Harsh G.R., Keating M.T., Escobedo J.A. Williams LT. Platelet-derived growth factor (PDGF) autocrine components in human tumor cell lines. J Neuro-Oncol 1990, 8:1-12.
-
(1990)
J Neuro-Oncol
, vol.8
, pp. 1-12
-
-
Harsh, G.R.1
Keating, M.T.2
Escobedo, J.A.3
-
22
-
-
0025282206
-
Antoniades HN. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance
-
Maxwell M., Naber S.P., Wolfe H.J., Galanopoulos T., Hedley-Whyte E.T., Black P.M. Antoniades HN. Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J Clin Invest 1990, 86:131-140.
-
(1990)
J Clin Invest
, vol.86
, pp. 131-140
-
-
Maxwell, M.1
Naber, S.P.2
Wolfe, H.J.3
Galanopoulos, T.4
Hedley-whyte, E.T.5
Black, P.M.6
-
23
-
-
0026352767
-
Co-expression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas
-
Mauro A., Bulfone A., Turco E., Schiffer D. Co-expression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas. Child's Nerv Syst 1991, 7:432-436.
-
(1991)
Child's Nerv Syst
, vol.7
, pp. 432-436
-
-
Mauro, A.1
Bulfone, A.2
Turco, E.3
Schiffer, D.4
-
24
-
-
0026772431
-
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
-
Hermanson M., Funa K., Hartman M., et al. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res 1992, 52:3213-3219.
-
(1992)
Cancer Res
, vol.52
, pp. 3213-3219
-
-
Hermanson, M.1
Funa, K.2
Hartman, M.3
-
25
-
-
9044248587
-
Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas
-
Hermanson M., Funa K., Koopman J., et al. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. Cancer Res 1996, 56:164-171.
-
(1996)
Cancer Res
, vol.56
, pp. 164-171
-
-
Hermanson, M.1
Funa, K.2
Koopman, J.3
-
26
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors in human glial tumors
-
Fleming T.P., Saxena A., Clark W.C., et al. Amplification and/or overexpression of platelet-derived growth factor receptors in human glial tumors. Cancer Res 1992, 52:4550-4553.
-
(1992)
Cancer Res
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
-
27
-
-
0035425048
-
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
-
Dai C., Celestino J.C., Okada Y., Louis D.N., Fullerm G.N., Holland E.C. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 2001, 15:1913-1925.
-
(2001)
Genes Dev
, vol.15
, pp. 1913-1925
-
-
Dai, C.1
Celestino, J.C.2
Okada, Y.3
Louis, D.N.4
Fullerm, G.N.5
Holland, E.C.6
-
28
-
-
0030001174
-
Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas
-
Black P., Carroll R., Glowacka D. Expression of platelet-derived growth factor transcripts in medulloblastomas and ependymomas. Pediatr Neurosurg 1996, 24:74-78.
-
(1996)
Pediatr Neurosurg
, vol.24
, pp. 74-78
-
-
Black, P.1
Carroll, R.2
Glowacka, D.3
-
29
-
-
0034794796
-
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
-
MacDonald T.J., Brown K.M., LaFleur B., et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nature Genet 2001, 29:143-152.
-
(2001)
Nature Genet
, vol.29
, pp. 143-152
-
-
MacDonald, T.J.1
Brown, K.M.2
LaFleur, B.3
-
30
-
-
0027952893
-
Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
-
Vassbotn F.S., Ostman A., Langeland N., et al. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J Cell Physiol 1994, 158:381-389.
-
(1994)
J Cell Physiol
, vol.158
, pp. 381-389
-
-
Vassbotn, F.S.1
Ostman, A.2
Langeland, N.3
-
31
-
-
0028911678
-
Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
-
Guha A., Dashner K., Black P.M., Wagner J.A., Stiles C.D. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer 1995, 60:168-173.
-
(1995)
Int J Cancer
, vol.60
, pp. 168-173
-
-
Guha, A.1
Dashner, K.2
Black, P.M.3
Wagner, J.A.4
Stiles, C.D.5
-
32
-
-
0025312789
-
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium
-
Pollack I.F., Randall M.S., Kristofik M.P., Kelly R.H., Selker R.G., Vertosick F.T. Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. J Neurosurg 1990, 73:106-112.
-
(1990)
J Neurosurg
, vol.73
, pp. 106-112
-
-
Pollack, I.F.1
Randall, M.S.2
Kristofik, M.P.3
Kelly, R.H.4
Selker, R.G.5
Vertosick, F.T.6
-
33
-
-
0025780988
-
Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways
-
Pollack I.F., Randall M.S., Kristofik M.P., Kelly R.H., Selker R.G., Vertosick F.T. Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways. J Neurosurg 1991, 75:284-293.
-
(1991)
J Neurosurg
, vol.75
, pp. 284-293
-
-
Pollack, I.F.1
Randall, M.S.2
Kristofik, M.P.3
Kelly, R.H.4
Selker, R.G.5
Vertosick, F.T.6
-
34
-
-
0023874371
-
Growth factors in cultured human glioma cells: differential effects of FGF, EGF, and PDGF
-
Westphal M., Brunken M., Rohde E., Herrmann H.-D. Growth factors in cultured human glioma cells: differential effects of FGF, EGF, and PDGF. Canc Lett 1988, 38:283-296.
-
(1988)
Canc Lett
, vol.38
, pp. 283-296
-
-
Westphal, M.1
Brunken, M.2
Rohde, E.3
Herrmann, H.-D.4
-
35
-
-
0030853215
-
Growth factors in gliomas: Antisense and dominant negative mutant strategies
-
Campbell J., Pollack I.F. Growth factors in gliomas: Antisense and dominant negative mutant strategies. J Neuro-oncol 1997, 35:275-285.
-
(1997)
J Neuro-oncol
, vol.35
, pp. 275-285
-
-
Campbell, J.1
Pollack, I.F.2
-
36
-
-
0028091564
-
Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
-
Kovalenko, M., Gazit, A., Böhmer, A. et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res54, 6106-6114.
-
Cancer Res
, vol.54
, pp. 6106-6114
-
-
Kovalenko, M.1
Gazit, A.2
Böhmer, A.3
-
37
-
-
0027955365
-
Specific inhibition of c-sis protein synthesis and cell proliferation with antisense oligodeoxynucleotides in human glioma cells
-
Nitta T., Sato K. Specific inhibition of c-sis protein synthesis and cell proliferation with antisense oligodeoxynucleotides in human glioma cells. Neurosurgery 1994, 34:309-314.
-
(1994)
Neurosurgery
, vol.34
, pp. 309-314
-
-
Nitta, T.1
Sato, K.2
-
38
-
-
0033119572
-
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
-
Wang D., Huang H.J., Kazlauskas A., Cavenee W.K. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res 1999, 59:1464-1472.
-
(1999)
Cancer Res
, vol.59
, pp. 1464-1472
-
-
Wang, D.1
Huang, H.J.2
Kazlauskas, A.3
Cavenee, W.K.4
-
39
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
40
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
41
-
-
0032562561
-
Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes
-
Shelly M., Pinkas-Kramarski R., Guarino B.C., et al. Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem 1998, 273:10496-10505.
-
(1998)
J Biol Chem
, vol.273
, pp. 10496-10505
-
-
Shelly, M.1
Pinkas-kramarski, R.2
Guarino, B.C.3
-
42
-
-
0029814271
-
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
-
Tzahar E., Waterman H., Chen X., et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996, 16:5276-5287.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5276-5287
-
-
Tzahar, E.1
Waterman, H.2
Chen, X.3
-
43
-
-
0021932240
-
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin
-
Libermann T.A., Nusbaum H.R., Razon N., et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin. Nature 1985, 313:44-147.
-
(1985)
Nature
, vol.313
, pp. 44-147
-
-
Libermann, T.A.1
Nusbaum, H.R.2
Razon, N.3
-
44
-
-
0026710064
-
Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme
-
von Deimling A., Louis D.N., von Ammon K., et al. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg 1993, 77:95-301.
-
(1993)
J Neurosurg
, vol.77
, pp. 95-301
-
-
von Deimling, A.1
Louis, D.N.2
von Ammon, K.3
-
45
-
-
0025790916
-
Genes for epidermal growth factor receptor, transforming growth factor α, and epidermal growth factor and their expression in human gliomas in vivo
-
Ekstrand A.H., James C.D., Cavenee W.K., Seliger B., Petterson R.F., Collins V.P. Genes for epidermal growth factor receptor, transforming growth factor α, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res 1991, 51:2164-2172.
-
(1991)
Cancer Res
, vol.51
, pp. 2164-2172
-
-
Ekstrand, A.H.1
James, C.D.2
Cavenee, W.K.3
Seliger, B.4
Petterson, R.F.5
Collins, V.P.6
-
46
-
-
0025343230
-
Signal transduction by receptor with tyrosine kinase activity
-
Ullrich A., Schlessinger J. Signal transduction by receptor with tyrosine kinase activity. Cell 1990, 61:203-212.
-
(1990)
Cell
, vol.61
, pp. 203-212
-
-
Ullrich, A.1
Schlessinger, J.2
-
47
-
-
0026548240
-
Structural alterations of the epidermal growth factor receptor gene in human gliomas
-
Wong A.J., Ruppert J.M., Bigner S.H., et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 1992, 89:2965-2969.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2965-2969
-
-
Wong, A.J.1
Ruppert, J.M.2
Bigner, S.H.3
-
48
-
-
0029146954
-
EGFR gene amplification-rearrangement in human glioblastomas
-
Schwechheimer K., Huang S., Cavenee W.K. EGFR gene amplification-rearrangement in human glioblastomas. Int J Cancer 1995, 62:145-148.
-
(1995)
Int J Cancer
, vol.62
, pp. 145-148
-
-
Schwechheimer, K.1
Huang, S.2
Cavenee, W.K.3
-
49
-
-
0034163550
-
Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
-
Frederick L., Wang X.-Y., Eley G., James C.D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 2000, 60:1383-1387.
-
(2000)
Cancer Res
, vol.60
, pp. 1383-1387
-
-
Frederick, L.1
Wang, X.-Y.2
Eley, G.3
James, C.D.4
-
50
-
-
0031961980
-
Constitutive activation of phosphatidyl 3-kinase by a naturally occurring mutant epidermal growth factor receptor
-
Moscatello D.K., Holgado-Madruga M., Emlet D.R., et al. Constitutive activation of phosphatidyl 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 1998, 273:200-206.
-
(1998)
J Biol Chem
, vol.273
, pp. 200-206
-
-
Moscatello, D.K.1
Holgado-madruga, M.2
Emlet, D.R.3
-
51
-
-
0030787340
-
Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
-
Chu C.T., Everiss K.D., Wikstrand C.J., et al. Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem J 1997, 324:855-861.
-
(1997)
Biochem J
, vol.324
, pp. 855-861
-
-
Chu, C.T.1
Everiss, K.D.2
Wikstrand, C.J.3
-
52
-
-
0030910239
-
A molecular genetic model of astrocytoma histopathology
-
Louis D.N. A molecular genetic model of astrocytoma histopathology. Brain Pathol 1997, 7:755-764.
-
(1997)
Brain Pathol
, vol.7
, pp. 755-764
-
-
Louis, D.N.1
-
53
-
-
0030017885
-
Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
-
Watanabe K., Tachibana O., Sato K., Yonekawa Y., Kleihues P., Ohgaki H. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996, 6:217-224.
-
(1996)
Brain Pathol
, vol.6
, pp. 217-224
-
-
Watanabe, K.1
Tachibana, O.2
Sato, K.3
Yonekawa, Y.4
Kleihues, P.5
Ohgaki, H.6
-
54
-
-
0027407245
-
Subsets of glioblastoma multiforme defined by molecular genetic analysis
-
von Deimling A., von Ammon K., Schoenfeld D., Wiestler O.D., Seizinger B.R., Louis D.N. Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol 1993, 3:19-26.
-
(1993)
Brain Pathol
, vol.3
, pp. 19-26
-
-
von Deimling, A.1
von Ammon, K.2
Schoenfeld, D.3
Wiestler, O.D.4
Seizinger, B.R.5
Louis, D.N.6
-
55
-
-
0032781105
-
Epidermal growth factor receptor (EGFR) expression in high-grade non-brainstem gliomas of childhood
-
Bredel M., Pollack I.F., Hamilton R.L., James C.D. Epidermal growth factor receptor (EGFR) expression in high-grade non-brainstem gliomas of childhood. Clin Cancer Res 1999, 5:1786-1792.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1786-1792
-
-
Bredel, M.1
Pollack, I.F.2
Hamilton, R.L.3
James, C.D.4
-
56
-
-
0032418416
-
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
-
Holland E.C., Hively W.P., DePinho R.A., Varmus H.E. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 1998, 12:3675-3685.
-
(1998)
Genes Dev
, vol.12
, pp. 3675-3685
-
-
Holland, E.C.1
Hively, W.P.2
DePinho, R.A.3
Varmus, H.E.4
-
57
-
-
0030741967
-
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma
-
Gilbertson R.J., Perry R.H., Kelly P.J., Pearson A.D., Lunec J. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res 1997, 57:3272-3280.
-
(1997)
Cancer Res
, vol.57
, pp. 3272-3280
-
-
Gilbertson, R.J.1
Perry, R.H.2
Kelly, P.J.3
Pearson, A.D.4
Lunec, J.5
-
58
-
-
0032170045
-
Expression of the ErbB-neuregulin signaling network during human cerebellar development: Implications for the biology of medulloblastoma
-
Gilbertson R.J., Clifford S.C., Meekin W., et al. Expression of the ErbB-neuregulin signaling network during human cerebellar development: Implications for the biology of medulloblastoma. Cancer Res 1998, 58:3932-3941.
-
(1998)
Cancer Res
, vol.58
, pp. 3932-3941
-
-
Gilbertson, R.J.1
Clifford, S.C.2
Meekin, W.3
-
59
-
-
0035445646
-
Clinical and molecular stratification of disease risk in medulloblastoma
-
Gilbertson R., Wickramasinghe C., Hernan R., et al. Clinical and molecular stratification of disease risk in medulloblastoma. Br J Cancer 2001, 85:705-712.
-
(2001)
Br J Cancer
, vol.85
, pp. 705-712
-
-
Gilbertson, R.1
Wickramasinghe, C.2
Hernan, R.3
-
60
-
-
0036793917
-
ErbB signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
-
Gilbertson R.J., Bentley L., Hernan R., et al. ErbB signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res 2002, 8:3054-3064.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3054-3064
-
-
Gilbertson, R.J.1
Bentley, L.2
Hernan, R.3
-
61
-
-
0030980946
-
Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains
-
O'Rourke D.M., Qian X., Zhang H.T., et al. Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains. Proc Natl Acad Sci USA 1997, 94:3250-3255.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3250-3255
-
-
O'Rourke, D.M.1
Qian, X.2
Zhang, H.T.3
-
62
-
-
0035878746
-
Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor
-
Mishima K., Johns T.G., Luwor R.B., et al. Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. Cancer Res 2001, 61:5349-5354.
-
(2001)
Cancer Res
, vol.61
, pp. 5349-5354
-
-
Mishima, K.1
Johns, T.G.2
Luwor, R.B.3
-
63
-
-
0035878671
-
Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR
-
Luwor R.B., Johns T.G., Murone C., et al. Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Cancer Res 2001, 61:5355-5361.
-
(2001)
Cancer Res
, vol.61
, pp. 5355-5361
-
-
Luwor, R.B.1
Johns, T.G.2
Murone, C.3
-
64
-
-
0037224320
-
ErbB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma
-
Hernan R., Fasheh R., Calabrese C., et al. ErbB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. Cancer Res 2003, 63:140-148.
-
(2003)
Cancer Res
, vol.63
, pp. 140-148
-
-
Hernan, R.1
Fasheh, R.2
Calabrese, C.3
-
65
-
-
0029101707
-
The role of growth factor receptors in central nervous system development and neoplasia
-
Weiner H.L. The role of growth factor receptors in central nervous system development and neoplasia. Neurosurgery 1995, 37:179-194.
-
(1995)
Neurosurgery
, vol.37
, pp. 179-194
-
-
Weiner, H.L.1
-
66
-
-
0027212082
-
How receptors turn Ras on
-
McCormick F. How receptors turn Ras on. Nature 1993, 363:15-16.
-
(1993)
Nature
, vol.363
, pp. 15-16
-
-
McCormick, F.1
-
67
-
-
0028859279
-
Protein modules and signalling networks
-
Pawson T. Protein modules and signalling networks. Nature 1995, 373:573-580.
-
(1995)
Nature
, vol.373
, pp. 573-580
-
-
Pawson, T.1
-
68
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski M.S., McCormick F. Proteins regulating Ras and its relatives. Nature 1993, 366:643-654.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
69
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling
-
Li N., Batzer A., Daly R., et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling. Nature 1993, 363:85-88.
-
(1993)
Nature
, vol.363
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
-
70
-
-
0027294981
-
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
-
Rozakis-Adcock M., Fernley R., Wade J., Pawson T., Bowtell D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 1993, 363:83-85.
-
(1993)
Nature
, vol.363
, pp. 83-85
-
-
Rozakis-adcock, M.1
Fernley, R.2
Wade, J.3
Pawson, T.4
Bowtell, D.5
-
71
-
-
0030057811
-
Genetics of colorectal cancer
-
Peddanna N., Mendis R., Holt S., Verma R.S. Genetics of colorectal cancer. Int J Oncol 1996, 9:327-335.
-
(1996)
Int J Oncol
, vol.9
, pp. 327-335
-
-
Peddanna, N.1
Mendis, R.2
Holt, S.3
Verma, R.S.4
-
72
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos J.L. Ras oncogenes in human cancer: A review. Cancer Res 1989, 49:4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
73
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha A., Feldkamp M.M., Lau N., Boss G., Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene 1997, 15:2755-2765.
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Boss, G.4
Pawson, A.5
-
74
-
-
0026742392
-
Overexpression of multiple oncogenes related to histopathological grade of astrocytic glioma
-
Orian J.M., Vasilopoulos K., Yoshida S., Kaye A.H., Chow C.W., Gonzales M.F. Overexpression of multiple oncogenes related to histopathological grade of astrocytic glioma. Br J Cancer 1992, 66:106-112.
-
(1992)
Br J Cancer
, vol.66
, pp. 106-112
-
-
Orian, J.M.1
Vasilopoulos, K.2
Yoshida, S.3
Kaye, A.H.4
Chow, C.W.5
Gonzales, M.F.6
-
75
-
-
0344946445
-
Proto-oncogene expression and proliferative activity in human malignant gliomas
-
Riccardi A., Danova M., Giordano M., et al. Proto-oncogene expression and proliferative activity in human malignant gliomas. Dev Oncol 1991, 66:81-84.
-
(1991)
Dev Oncol
, vol.66
, pp. 81-84
-
-
Riccardi, A.1
Danova, M.2
Giordano, M.3
-
76
-
-
0029815093
-
Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-SHC-GRB2 pathway
-
Prigent S.A., Nagane M., Lin H., et al. Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-SHC-GRB2 pathway. J Biol Chem 1996, 271:25639-25645.
-
(1996)
J Biol Chem
, vol.271
, pp. 25639-25645
-
-
Prigent, S.A.1
Nagane, M.2
Lin, H.3
-
77
-
-
0033959896
-
A novel positive feedback loop mediated by the docking protein Gab1 and phosphotidylinositol 3-kinase in epidermal growth factor receptor signaling
-
Rodrigues G.A., Falasca M., Zhang Z., Ong S.H., Schlessinger J. A novel positive feedback loop mediated by the docking protein Gab1 and phosphotidylinositol 3-kinase in epidermal growth factor receptor signaling. Molec Cell Biol 2000, 20:1448-1459.
-
(2000)
Molec Cell Biol
, vol.20
, pp. 1448-1459
-
-
Rodrigues, G.A.1
Falasca, M.2
Zhang, Z.3
Ong, S.H.4
Schlessinger, J.5
-
78
-
-
0032478610
-
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
-
Marais R., Light Y., Mason C., Paterson H., Olson M.F., Marshall C.J. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 1998, 280:109-112.
-
(1998)
Science
, vol.280
, pp. 109-112
-
-
Marais, R.1
Light, Y.2
Mason, C.3
Paterson, H.4
Olson, M.F.5
Marshall, C.J.6
-
79
-
-
0024380391
-
Phospholipase C-γ is a substitute for the PDGR and EGF receptor protein-tyrosine kinases in vivo and in vitro
-
Meisenhelder J., Suh P.-G., Rhee S.-G., Hunter T. Phospholipase C-γ is a substitute for the PDGR and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 1989, 57:1109-1122.
-
(1989)
Cell
, vol.57
, pp. 1109-1122
-
-
Meisenhelder, J.1
Suh, P.-G.2
Rhee, S.-G.3
Hunter, T.4
-
80
-
-
0029009762
-
Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling
-
Kauffmann-Zeh A., Thomas G.M.H., Ball A., et al. Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling. Science 1995, 368:1188-1190.
-
(1995)
Science
, vol.368
, pp. 1188-1190
-
-
Kauffmann-zeh, A.1
Thomas, G.M.H.2
Ball, A.3
-
81
-
-
0032938716
-
Regulation of tyrosine kinase cascades by G-protein-coupled receptors
-
Luttrell L.M., Daaka Y., Lefkowitz R.J. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 1999, 11:177-183.
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 177-183
-
-
Luttrell, L.M.1
Daaka, Y.2
Lefkowitz, R.J.3
-
82
-
-
0029907265
-
A role of Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
-
Dikic I., Tokiwa G., Lev S., Courtneidge S.A., Schlessinger J. A role of Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996, 383:547-550.
-
(1996)
Nature
, vol.383
, pp. 547-550
-
-
Dikic, I.1
Tokiwa, G.2
Lev, S.3
Courtneidge, S.A.4
Schlessinger, J.5
-
83
-
-
0034981517
-
STAT proteins: Signal transducers and activators of transcription
-
Bromberg J., Chen X. STAT proteins: Signal transducers and activators of transcription. Methods Enzymol 2001, 333:138-151.
-
(2001)
Methods Enzymol
, vol.333
, pp. 138-151
-
-
Bromberg, J.1
Chen, X.2
-
84
-
-
0032547385
-
Signal transduction via platelet-derived growth factor receptors
-
Heldin C.H., Ostman A., Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998, 1378:F79-F113.
-
(1998)
Biochim Biophys Acta
, vol.1378
-
-
Heldin, C.H.1
Ostman, A.2
Ronnstrand, L.3
-
85
-
-
0032576873
-
Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF-beta receptor juxtamembrane and kinase insert domains
-
Valgeirsdottir S., Paukku K., Silvennoinen O., Heldin C.H., Claesson-Welsh L. Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF-beta receptor juxtamembrane and kinase insert domains. Oncogene 1998, 16:505-515.
-
(1998)
Oncogene
, vol.16
, pp. 505-515
-
-
Valgeirsdottir, S.1
Paukku, K.2
Silvennoinen, O.3
Heldin, C.H.4
Claesson-welsh, L.5
-
86
-
-
2542538216
-
Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes
-
Quadros M.R.D., Peruzzi F., Kar C., Rodeck U. Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes. Cancer Res 2004, 64:3934-3939.
-
(2004)
Cancer Res
, vol.64
, pp. 3934-3939
-
-
Quadros, M.R.D.1
Peruzzi, F.2
Kar, C.3
Rodeck, U.4
-
87
-
-
0028349735
-
Stats: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong Z., Wen Z., Darnell J.E. Stats: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994, 264:95-98.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
Wen, Z.2
Darnell, J.E.3
-
88
-
-
0027772891
-
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
-
Shual K., Ziemiecki A., Wilks A.F., et al. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 1993, 366:580-585.
-
(1993)
Nature
, vol.366
, pp. 580-585
-
-
Shual, K.1
Ziemiecki, A.2
Wilks, A.F.3
-
89
-
-
0029811985
-
Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
-
Luo Z., Tzivion G., Belshaw P.J., Vavvas D., Marshall M., Avruch J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 1996, 383:181-185.
-
(1996)
Nature
, vol.383
, pp. 181-185
-
-
Luo, Z.1
Tzivion, G.2
Belshaw, P.J.3
Vavvas, D.4
Marshall, M.5
Avruch, J.6
-
90
-
-
0028073606
-
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
-
Freed E., Symons M., MacDonald S.G., McCormick F., Ruggieri R. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 1994, 265:1713-1716.
-
(1994)
Science
, vol.265
, pp. 1713-1716
-
-
Freed, E.1
Symons, M.2
MacDonald, S.G.3
McCormick, F.4
Ruggieri, R.5
-
91
-
-
0026754369
-
Activation of the MAP kinase pathway by the protein kinase raf
-
Howe L.R., Leevers S.J., Gomez N., Nakielny S., Cohen P., Marshall C.J. Activation of the MAP kinase pathway by the protein kinase raf. Cell 1992, 71:335-342.
-
(1992)
Cell
, vol.71
, pp. 335-342
-
-
Howe, L.R.1
Leevers, S.J.2
Gomez, N.3
Nakielny, S.4
Cohen, P.5
Marshall, C.J.6
-
92
-
-
0027242125
-
Mitogen regulation of c-raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase
-
Kyriakis J.M., Force T.L., Rapp U.R., Bonventre J.V., Avruch J. Mitogen regulation of c-raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem 1993, 268:16009-16019.
-
(1993)
J Biol Chem
, vol.268
, pp. 16009-16019
-
-
Kyriakis, J.M.1
Force, T.L.2
Rapp, U.R.3
Bonventre, J.V.4
Avruch, J.5
-
93
-
-
0028935974
-
Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
-
Derijard B., Raingeaud J., Barrett T., Wu I.-H., Han J., Ulevitch R.J., Davis R.J. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995, 367:682-684.
-
(1995)
Science
, vol.367
, pp. 682-684
-
-
Derijard, B.1
Raingeaud, J.2
Barrett, T.3
Wu, I.-H.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
94
-
-
0027233448
-
Signal transduction via the MAP kinases: proceed at your own RSK
-
Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 1993, 90:5889-5892.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 5889-5892
-
-
Blenis, J.1
-
95
-
-
0028931406
-
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
-
Gille H., Kortenjahn M., Thomae O., et al. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 1995, 14:951-962.
-
(1995)
EMBO J
, vol.14
, pp. 951-962
-
-
Gille, H.1
Kortenjahn, M.2
Thomae, O.3
-
96
-
-
0027297647
-
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
-
Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 1993, 73:381-393.
-
(1993)
Cell
, vol.73
, pp. 381-393
-
-
Marais, R.1
Wynne, J.2
Treisman, R.3
-
97
-
-
0028943245
-
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
-
Lin A., Minden A., Martinetto H., et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 1995, 268:286-290.
-
(1995)
Science
, vol.268
, pp. 286-290
-
-
Lin, A.1
Minden, A.2
Martinetto, H.3
-
98
-
-
0034682264
-
Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
-
Behrens A., Jochum W., Sibilia M., Wagner E.F. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 2000, 19:2657-2663.
-
(2000)
Oncogene
, vol.19
, pp. 2657-2663
-
-
Behrens, A.1
Jochum, W.2
Sibilia, M.3
Wagner, E.F.4
-
99
-
-
0032699144
-
Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes
-
Wu C.J., Qian X., O'Rourke D.M. Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes. DNA Cell Biol 1999, 18:731-741.
-
(1999)
DNA Cell Biol
, vol.18
, pp. 731-741
-
-
Wu, C.J.1
Qian, X.2
O'Rourke, D.M.3
-
100
-
-
0037224587
-
Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors
-
Tsuiki H., Tnani M., Okamoto I., et al. Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors. Cancer Research 2003, 63:250-255.
-
(2003)
Cancer Research
, vol.63
, pp. 250-255
-
-
Tsuiki, H.1
Tnani, M.2
Okamoto, I.3
-
101
-
-
0029912650
-
3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways
-
Ludwig S., Engel K., Hoffmeyer A., et al. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Molec Cell Biol 1996, 16:6687-6697.
-
(1996)
Molec Cell Biol
, vol.16
, pp. 6687-6697
-
-
Ludwig, S.1
Engel, K.2
Hoffmeyer, A.3
-
102
-
-
0030977269
-
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
-
Waskiewicz A.J., Flynn A., Proud C.G., Cooper J.A. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. Embo J 1997, 16:1909-1920.
-
(1997)
Embo J
, vol.16
, pp. 1909-1920
-
-
Waskiewicz, A.J.1
Flynn, A.2
Proud, C.G.3
Cooper, J.A.4
-
103
-
-
0032575714
-
Death receptors: signaling and modulation
-
Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science 1998, 281:1305-1308.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
104
-
-
0027772672
-
Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate
-
Wu J., Dent P., Jelinek T., Wolfman A., Weber M.J., Sturgill T.W. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate. Science 1993, 262:1065-1069.
-
(1993)
Science
, vol.262
, pp. 1065-1069
-
-
Wu, J.1
Dent, P.2
Jelinek, T.3
Wolfman, A.4
Weber, M.J.5
Sturgill, T.W.6
-
105
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., Roy N., Stennicke H.R., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
-
106
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
-
107
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
108
-
-
0032431028
-
PTEN/MMAC1/TEP1 suppressed the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
-
Li D.M., Sun H. PTEN/MMAC1/TEP1 suppressed the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci USA 1998, 95:15406-15411.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15406-15411
-
-
Li, D.M.1
Sun, H.2
-
109
-
-
0027365947
-
Analysis of the functional role of chromosome 10 loss in human glioblastomas
-
Pershouse M.A., Stubblefield E., Hadi A., Killary A.M., Yung W.K., Steck P.A. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res 1993, 53:5043-5050.
-
(1993)
Cancer Res
, vol.53
, pp. 5043-5050
-
-
Pershouse, M.A.1
Stubblefield, E.2
Hadi, A.3
Killary, A.M.4
Yung, W.K.5
Steck, P.A.6
-
110
-
-
0023764824
-
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
-
Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988, 334:661-665.
-
(1988)
Nature
, vol.334
, pp. 661-665
-
-
Nishizuka, Y.1
-
111
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
-
Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992, 258:607-613.
-
(1992)
Science
, vol.258
, pp. 607-613
-
-
Nishizuka, Y.1
-
112
-
-
0024382689
-
EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity
-
Susa M., Olivier A.R., Fabbro D., Thomas G. EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Cell 1989, 57:817-824.
-
(1989)
Cell
, vol.57
, pp. 817-824
-
-
Susa, M.1
Olivier, A.R.2
Fabbro, D.3
Thomas, G.4
-
113
-
-
0025363850
-
Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor
-
Fields A.P., Tyler G., Kraft A.S., May W.S. Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor. J Cell Science 1990, 96:107-114.
-
(1990)
J Cell Science
, vol.96
, pp. 107-114
-
-
Fields, A.P.1
Tyler, G.2
Kraft, A.S.3
May, W.S.4
-
114
-
-
0032422490
-
The application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors
-
Pollack I.F., Bredel M., ErffM. The application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors. Pediatr Neurosurg 1998, 29:228-244.
-
(1998)
Pediatr Neurosurg
, vol.29
, pp. 228-244
-
-
Pollack, I.F.1
Bredel, M.2
Erff, M.3
-
115
-
-
0010510061
-
Protein kinase C
-
CRC Press, Lyon, D.J. Kerr, P. Workman (Eds.)
-
Basu A., Lazo J.S. Protein kinase C. New Molecular Targets for Cancer Chemotherapy 1994, 121-141. CRC Press, Lyon. D.J. Kerr, P. Workman (Eds.).
-
(1994)
New Molecular Targets for Cancer Chemotherapy
, pp. 121-141
-
-
Basu, A.1
Lazo, J.S.2
-
116
-
-
0027326410
-
Protein kinase Cα activates Raf-1 by direct phosphorylation
-
Kolch W., Heldecker G., Kochs G., et al. Protein kinase Cα activates Raf-1 by direct phosphorylation. Nature 1993, 364:249-252.
-
(1993)
Nature
, vol.364
, pp. 249-252
-
-
Kolch, W.1
Heldecker, G.2
Kochs, G.3
-
117
-
-
0028239183
-
Differential raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium
-
Chao T.-S.O., Foster D.A., Rapp U.R., Rosner M.R. Differential raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J Biol Chem 1994, 269:7337-7341.
-
(1994)
J Biol Chem
, vol.269
, pp. 7337-7341
-
-
Chao, T.-S.O.1
Foster, D.A.2
Rapp, U.R.3
Rosner, M.R.4
-
118
-
-
0023913561
-
Protein kinase C in primary astrocyte cultures: cytoplasmic localization and translocation by a phorbol ester
-
Neary J.T., Norenberg O.B., Norenberg M.D. Protein kinase C in primary astrocyte cultures: cytoplasmic localization and translocation by a phorbol ester. J Neurochem 1988, 50:1179-1184.
-
(1988)
J Neurochem
, vol.50
, pp. 1179-1184
-
-
Neary, J.T.1
Norenberg, O.B.2
Norenberg, M.D.3
-
119
-
-
0024390830
-
Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors
-
Reifenberger G., Deckert M., Wechsler W. Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. Acta Neuropathol 1989, 78:166-175.
-
(1989)
Acta Neuropathol
, vol.78
, pp. 166-175
-
-
Reifenberger, G.1
Deckert, M.2
Wechsler, W.3
-
120
-
-
0026638357
-
Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression
-
Benzil D.L., Finkelstein S.D., Epstein M.H., Finch P.W. Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 1992, 52:2951-2956.
-
(1992)
Cancer Res
, vol.52
, pp. 2951-2956
-
-
Benzil, D.L.1
Finkelstein, S.D.2
Epstein, M.H.3
Finch, P.W.4
-
121
-
-
0025790389
-
Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro
-
Couldwell W.T., Uhm J.H., Antel J.P., Yong V.W. Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. Neurosurg 1991, 29:880-887.
-
(1991)
Neurosurg
, vol.29
, pp. 880-887
-
-
Couldwell, W.T.1
Uhm, J.H.2
Antel, J.P.3
Yong, V.W.4
-
122
-
-
0026746408
-
Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C
-
Couldwell W.T., Antel J.P., Yong V.W. Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery 1992, 31:717-724.
-
(1992)
Neurosurgery
, vol.31
, pp. 717-724
-
-
Couldwell, W.T.1
Antel, J.P.2
Yong, V.W.3
-
123
-
-
0028037048
-
Antisense expression of protein kinase C-alpha inhibits the growth and tumorigenicity of human glioblastoma cells
-
Ahmad S., Mineta T., Martuza R.L., Glazer R.I. Antisense expression of protein kinase C-alpha inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery 1994, 35:904-909.
-
(1994)
Neurosurgery
, vol.35
, pp. 904-909
-
-
Ahmad, S.1
Mineta, T.2
Martuza, R.L.3
Glazer, R.I.4
-
124
-
-
0029938768
-
7-hydroxystaurosporine (UCN-01), a selective protein kinase C inhibitor, exhibits cytotoxicity against cultured glioma cells and potentiates the antiproliferative effects of BCNU and cisplatin
-
Pollack I.F., Kawecki S., Lazo J.S. 7-hydroxystaurosporine (UCN-01), a selective protein kinase C inhibitor, exhibits cytotoxicity against cultured glioma cells and potentiates the antiproliferative effects of BCNU and cisplatin. J Neurosurg 1996, 84:1024-1032.
-
(1996)
J Neurosurg
, vol.84
, pp. 1024-1032
-
-
Pollack, I.F.1
Kawecki, S.2
Lazo, J.S.3
-
125
-
-
0029833019
-
Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-α phosphorothioate oligodeoxynucleotide
-
Yazaki T., Ahmad S., Chahlavi A., et al. Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-α phosphorothioate oligodeoxynucleotide. Molec Pharmacol 1996, 50:236-242.
-
(1996)
Molec Pharmacol
, vol.50
, pp. 236-242
-
-
Yazaki, T.1
Ahmad, S.2
Chahlavi, A.3
-
126
-
-
0032961049
-
Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion
-
Bredel M., Pollack I.F., Freund J.M., Rusnak J., Lazo J.S. Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion. J Neuro-oncol 1999, 41:9-20.
-
(1999)
J Neuro-oncol
, vol.41
, pp. 9-20
-
-
Bredel, M.1
Pollack, I.F.2
Freund, J.M.3
Rusnak, J.4
Lazo, J.S.5
-
127
-
-
0033546315
-
ErbB receptor-induced activation of stat transcription factors in mediated by Src tyrosine kinases
-
Olayioye M.A., Beuvink I., Horsch K., Daly J.M., Hynes N.E. ErbB receptor-induced activation of stat transcription factors in mediated by Src tyrosine kinases. J Biol Chem 1999, 274:17209-17218.
-
(1999)
J Biol Chem
, vol.274
, pp. 17209-17218
-
-
Olayioye, M.A.1
Beuvink, I.2
Horsch, K.3
Daly, J.M.4
Hynes, N.E.5
-
128
-
-
0035907245
-
Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism
-
Bienvenu F., Gascan H., Coqueret O. Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J Biol Chem 2001, 276:16840-16847.
-
(2001)
J Biol Chem
, vol.276
, pp. 16840-16847
-
-
Bienvenu, F.1
Gascan, H.2
Coqueret, O.3
-
129
-
-
85047699589
-
Constitutive activation of Stat3α in brain tumors: Localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
-
Schaefer L.K., Ren Z., Fuller G.N., Schaefer T.S. Constitutive activation of Stat3α in brain tumors: Localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 2002, 21:2058-2065.
-
(2002)
Oncogene
, vol.21
, pp. 2058-2065
-
-
Schaefer, L.K.1
Ren, Z.2
Fuller, G.N.3
Schaefer, T.S.4
-
130
-
-
0032750731
-
Inhibition of Ras and related G-proteins as a novel therapeutic strategy for blocking malignant glioma growth. II. In vivo results in a nude mouse model
-
Pollack I.F., Bredel M., ErffM., Sebti S.M. Inhibition of Ras and related G-proteins as a novel therapeutic strategy for blocking malignant glioma growth. II. In vivo results in a nude mouse model. Neurosurgery 1999, 45:1208-1214.
-
(1999)
Neurosurgery
, vol.45
, pp. 1208-1214
-
-
Pollack, I.F.1
Bredel, M.2
Erff, M.3
Sebti, S.M.4
-
131
-
-
0027361809
-
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
-
Shamah S.M., Stiles C.D., Guha A. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Molec Cell Biol 1993, 13:7203-7212.
-
(1993)
Molec Cell Biol
, vol.13
, pp. 7203-7212
-
-
Shamah, S.M.1
Stiles, C.D.2
Guha, A.3
-
132
-
-
0033392005
-
Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results
-
Huang S.M., Harari P.M. Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Invest New Drugs 1999, 17:259-269.
-
(1999)
Invest New Drugs
, vol.17
, pp. 259-269
-
-
Huang, S.M.1
Harari, P.M.2
-
133
-
-
0034235955
-
Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
-
Overholser J.P., Prewett M.C., Hooper A.T., Waksal H.W., Hicklin D.J. Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 2000, 89:74-82.
-
(2000)
Cancer
, vol.89
, pp. 74-82
-
-
Overholser, J.P.1
Prewett, M.C.2
Hooper, A.T.3
Waksal, H.W.4
Hicklin, D.J.5
-
134
-
-
0031903646
-
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram M.D., Lipton A., Hayes D.F., et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998, 16:2659-2671.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2659-2671
-
-
Pegram, M.D.1
Lipton, A.2
Hayes, D.F.3
-
135
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J., Pfister D., Cooper M.R., et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000, 18:904-914.
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
-
136
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin D.M., Donato N.J., Perez-Soler R., et al. Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 2001, 7:1204-1213.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donato, N.J.2
Perez-soler, R.3
-
137
-
-
0033561522
-
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
-
Huang S.M., Bock J.M., Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999, 59:1935-1940.
-
(1999)
Cancer Res
, vol.59
, pp. 1935-1940
-
-
Huang, S.M.1
Bock, J.M.2
Harari, P.M.3
-
138
-
-
0028273552
-
Efficacy of direct intratumoral therapy with targeted protein toxins for solid human tumors in nude mice
-
Laske D.W., Ilercil O., Akbasak A., Youle R.J., Oldfield E.H. Efficacy of direct intratumoral therapy with targeted protein toxins for solid human tumors in nude mice. J Neurosurg 1994, 80:520-526.
-
(1994)
J Neurosurg
, vol.80
, pp. 520-526
-
-
Laske, D.W.1
Ilercil, O.2
Akbasak, A.3
Youle, R.J.4
Oldfield, E.H.5
-
139
-
-
0031451777
-
Tumor regression with regional distribution of targeted toxin TF-CRM107 in patients with malignant brain tumors
-
Laske D.W., Youle R.J., Oldfield E.H. Tumor regression with regional distribution of targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med 1997, 3:1362-1368.
-
(1997)
Nature Med
, vol.3
, pp. 1362-1368
-
-
Laske, D.W.1
Youle, R.J.2
Oldfield, E.H.3
-
140
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker B.J., Tamura S., Buchdunger E., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996, 2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
141
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker B.J., Sawyers C.L., Kantarjian H., et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001, 344:1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
142
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
143
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results in a phase II study
-
Sawyers C.L., Hochhaus A., Feldman E., et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results in a phase II study. Blood 2002, 99:3530-3539.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
144
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. New Engl J Med 2003, 348:994-1004.
-
(2003)
New Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
145
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
Hughes T.P., Kaeda J., Branford S., et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. New Engl J Med 2003, 349:1423-1432.
-
(2003)
New Engl J Med
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
Kaeda, J.2
Branford, S.3
-
146
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre M.E., Mohammed M., Ellwood K., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001, 293:876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
147
-
-
10744232328
-
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
-
Branford S., Rudzki Z., Walsh S., et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003, 102:276-283.
-
(2003)
Blood
, vol.102
, pp. 276-283
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
148
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
Heinrich M.C., Griffith D.J., Druker B.J., Wait C.L., Ott K.A., Zigler A.J. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000, 96:925-932.
-
(2000)
Blood
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
Griffith, D.J.2
Druker, B.J.3
Wait, C.L.4
Ott, K.A.5
Zigler, A.J.6
-
149
-
-
0035810148
-
Effect of the tyrosine kinase inhibitor STTI571 in a patient with a metastatic gastrointestinal stromal tumor
-
Joensuu H., Roberts P.J., Sarlomo-Rikala M., et al. Effect of the tyrosine kinase inhibitor STTI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001, 344:1052-1056.
-
(2001)
N Engl J Med
, vol.344
, pp. 1052-1056
-
-
Joensuu, H.1
Roberts, P.J.2
Sarlomo-rikala, M.3
-
150
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E., CioffiC.L., Law N., et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exper Ther 2000, 295:139-145.
-
(2000)
J Pharmacol Exper Ther
, vol.295
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
151
-
-
0033986415
-
Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
-
Uhrbom L., Hesselager G., Ostman A., Nister M., Westermark B. Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells. Int J Cancer 2000, 85:398-406.
-
(2000)
Int J Cancer
, vol.85
, pp. 398-406
-
-
Uhrbom, L.1
Hesselager, G.2
Ostman, A.3
Nister, M.4
Westermark, B.5
-
152
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T., Alberta J.A., Zdunek P.R., et al. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res 2000, 60:143-150.
-
(2000)
Cancer Res
, vol.60
, pp. 143-150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
-
153
-
-
0035297541
-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K., Ostman A., Sjoquist M., et al. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 2001, 61:2929-2934.
-
(2001)
Cancer Res
, vol.61
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
-
154
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperly J.F., Gardembas M., Melo J.V., et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. New Engl J Med 2002, 347:481-487.
-
(2002)
New Engl J Med
, vol.347
, pp. 481-487
-
-
Apperly, J.F.1
Gardembas, M.2
Melo, J.V.3
-
155
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K., Rubin K., Sjoblom T., et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Canc Res 2002, 62:5476-5484.
-
(2002)
Canc Res
, vol.62
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
Sjoblom, T.3
-
156
-
-
16844382189
-
Multicentre phase II study of imatinib mesylate in patients with recurrent glioblastoma: An EORTC:NDDG/BTG intergroup study
-
Raymond E., Brandes A., Van Oosterom A., et al. Multicentre phase II study of imatinib mesylate in patients with recurrent glioblastoma: An EORTC:NDDG/BTG intergroup study. Proc ASCO 2004, 107.
-
(2004)
Proc ASCO
, pp. 107
-
-
Raymond, E.1
Brandes, A.2
Van Oosterom, A.3
-
157
-
-
17444384384
-
Imatinib (STI 571) is active in patients with high-grade gliomas progressing on standard therapy
-
Katz A., Barrios C.H., AbramoffR., Simon S.D., Tabacof J., Gansl R.C. Imatinib (STI 571) is active in patients with high-grade gliomas progressing on standard therapy. Proc ASCO 2004, 117.
-
(2004)
Proc ASCO
, pp. 117
-
-
Katz, A.1
Barrios, C.H.2
Abramoff, R.3
Simon, S.D.4
Tabacof, J.5
Gansl, R.C.6
-
158
-
-
5444224787
-
Imatinib (STI571) plus hydroxyurea: Safety and efficacy in pretreated progressive glioblastoma multiforme patients
-
Dresemann G. Imatinib (STI571) plus hydroxyurea: Safety and efficacy in pretreated progressive glioblastoma multiforme patients. Proc ASCO 2004, 119.
-
(2004)
Proc ASCO
, pp. 119
-
-
Dresemann, G.1
-
159
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F., Caputo R., Bianco R., et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 2001, 7:1459-1465.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
-
160
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardello F., Caputo R., Bianco R., et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 2000, 6:2053-2063.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2053-2063
-
-
Ciardello, F.1
Caputo, R.2
Bianco, R.3
-
161
-
-
0033763084
-
ZD1839 ('Iressa') as an anticancer agent
-
Baselga J., Averbuch S.D. ZD1839 ('Iressa') as an anticancer agent. Drugs 2000, 60(suppl 1):33-40.
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 33-40
-
-
Baselga, J.1
Averbuch, S.D.2
-
162
-
-
0037109014
-
ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
-
Wakeling A.E., Guy S.P., Woodburn J.R., et al. ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res 2002, 62:5749-5754.
-
(2002)
Cancer Res
, vol.62
, pp. 5749-5754
-
-
Wakeling, A.E.1
Guy, S.P.2
Woodburn, J.R.3
-
163
-
-
0035023187
-
Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers
-
Swaisland H., Laight A., Stafford L., et al. Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers. Clin Pharmacokinetics 2001, 40:297-306.
-
(2001)
Clin Pharmacokinetics
, vol.40
, pp. 297-306
-
-
Swaisland, H.1
Laight, A.2
Stafford, L.3
-
164
-
-
0033757709
-
Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy
-
Raymond E., Faivre S., Armand J.P. Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy. Drugs 2000, 60(Suppl 1):15-23.
-
(2000)
Drugs
, vol.60
, Issue.SUPPL.1
, pp. 15-23
-
-
Raymond, E.1
Faivre, S.2
Armand, J.P.3
-
165
-
-
0037297362
-
Phase I studies of ZD1839 in patients with common solid tumors
-
Lorusso P.M. Phase I studies of ZD1839 in patients with common solid tumors. Sem Oncol 2003, 30(Suppl 1):21-29.
-
(2003)
Sem Oncol
, vol.30
, Issue.SUPPL.1
, pp. 21-29
-
-
Lorusso, P.M.1
-
166
-
-
0036139727
-
Pharmacokinetic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histological and molecular consequences of receptor inhibition
-
Albanell J., Royo F., Auerbach S., et al. Pharmacokinetic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histological and molecular consequences of receptor inhibition. J Clin Oncol 2002, 20:110-124.
-
(2002)
J Clin Oncol
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Royo, F.2
Auerbach, S.3
-
167
-
-
0036842170
-
Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
Baselga J., Rischin D., Ranson M., et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 2002, 20:4292-4302.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
-
168
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M., Yano S., Giaccone G., et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003, 21:2237-2246.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
169
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with nonsmall cell lung cancer: a randomized trial
-
Kris M.G., Natale R.B., Herbst R.S., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with nonsmall cell lung cancer: a randomized trial. JAMA 2003, 290:2149-2158.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
170
-
-
1542713370
-
Gefinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-Intact 2
-
Herbst R.S., Giaccone G., Schiller J.H., Natale R.B., Miller V., Manegold C., et al. Gefinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-Intact 2. J Clin Oncol 2004, 22:785-794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
-
171
-
-
1542503746
-
Gefinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-Intact 1
-
Giaccone G., Herbst R.S., Manegold C., Scagliotti G., Rosell R., Miller V., et al. Gefinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-Intact 1. J Clin Oncol 2004, 22:777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
-
172
-
-
0038501053
-
Targeting epidermal growth factor receptor - are we missing the mark
-
Dancey J.E., Freidlin B. Targeting epidermal growth factor receptor - are we missing the mark. Lancet 2003, 362:62-64.
-
(2003)
Lancet
, vol.362
, pp. 62-64
-
-
Dancey, J.E.1
Freidlin, B.2
-
173
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New Engl J Med 2004, 350:2129-2139.
-
(2004)
New Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
174
-
-
0036848833
-
Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa)
-
Heimberger A.B., Learn C.A., Archer G.E., McLendon R.E., Chewning T.A., Tuck F.L., et al. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res 2002, 8:3496-3502.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3496-3502
-
-
Heimberger, A.B.1
Learn, C.A.2
Archer, G.E.3
McLendon, R.E.4
Chewning, T.A.5
Tuck, F.L.6
-
175
-
-
0242442483
-
Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas
-
Li B., Chang C.-M., Yuan M., McKenna G., Shu H.-K. Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas. Cancer Res 2003, 63:7443-7450.
-
(2003)
Cancer Res
, vol.63
, pp. 7443-7450
-
-
Li, B.1
Chang, C.-M.2
Yuan, M.3
McKenna, G.4
Shu, H.-K.5
-
176
-
-
0037616593
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
-
Bianco R., Shin I., Ritter C.A., et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 2003, 22:2812-2822.
-
(2003)
Oncogene
, vol.22
, pp. 2812-2822
-
-
Bianco, R.1
Shin, I.2
Ritter, C.A.3
-
177
-
-
23944481895
-
NABTC phase I/II trial of ZD-1839 for recurrent malignant gliomas and unresectable meningiomas
-
Lieberman F.S., Cloughesy T., Fine H., Kuhn J., Lamborn K., Malkin M., et al. NABTC phase I/II trial of ZD-1839 for recurrent malignant gliomas and unresectable meningiomas. Proc ASCO 2004, 109.
-
(2004)
Proc ASCO
, pp. 109
-
-
Lieberman, F.S.1
Cloughesy, T.2
Fine, H.3
Kuhn, J.4
Lamborn, K.5
Malkin, M.6
-
178
-
-
23944478922
-
Phase II study of ZD 1839 in patients with newly diagnosed grade 4 astrocytomas
-
Uhm J.H., Ballman K.V., Giannini C., et al. Phase II study of ZD 1839 in patients with newly diagnosed grade 4 astrocytomas. Proc ASCO 2004, 108.
-
(2004)
Proc ASCO
, pp. 108
-
-
Uhm, J.H.1
Ballman, K.V.2
Giannini, C.3
-
179
-
-
5444255629
-
Phase I study of ZD1839 plus temozolomide in patients with malignant glioma
-
Prados M., Yung W., Wen P., et al. Phase I study of ZD1839 plus temozolomide in patients with malignant glioma. Proc ASCO 2004, 108.
-
(2004)
Proc ASCO
, pp. 108
-
-
Prados, M.1
Yung, W.2
Wen, P.3
-
180
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer J.D., Barbacci EG., Iwata K.K., et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 1997, 57:4838-4848.
-
(1997)
Cancer Res
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
-
181
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774. Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
-
Pollack V.A., Savage D., Baker D., et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774. Dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 1999, 291:739-748.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.2
Baker, D.3
-
182
-
-
12444259660
-
Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients
-
Malik S.N., Siu L.L., Rowinsky E.K., et al. Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients. Clin Cancer Res 2003, 9:2478-2486.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2478-2486
-
-
Malik, S.N.1
Siu, L.L.2
Rowinsky, E.K.3
-
183
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M., Siu L.L., Nemunaitis J., et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001, 19:3267-3279.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
-
184
-
-
0002114422
-
Dose-schedule-finding, pharmacokinetic, biologic, and functional imaging studies of OSI-774, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor
-
(abstract 5)
-
Rowinsky E.K., Hammond L., Siu L., et al. Dose-schedule-finding, pharmacokinetic, biologic, and functional imaging studies of OSI-774, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. Proc Am Soc Clin Oncol 2001, 20:2a. (abstract 5).
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Rowinsky, E.K.1
Hammond, L.2
Siu, L.3
-
185
-
-
0000329007
-
A phase II trial of the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients with advanced, EGFR-expressing non-small cell lung cancer
-
abstract 1235
-
Perez-Soler R., Chachoua A., Huberman M., et al. A phase II trial of the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients with advanced, EGFR-expressing non-small cell lung cancer. Proc Am Soc Clin Oncol 2001, 20:310a. abstract 1235.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Perez-soler, R.1
Chachoua, A.2
Huberman, M.3
-
186
-
-
0001069404
-
Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian cancer
-
abstract 831
-
Finkler N., Gordon A., Crozier M., et al. Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian cancer. Proc Am Soc Clin Oncol 2001, 20:208a. abstract 831.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Finkler, N.1
Gordon, A.2
Crozier, M.3
-
187
-
-
0003264493
-
Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced squamous cell carcinoma of the head and neck
-
abstract 6
-
Senzer N.N., Soulieres D., Siu L., et al. Phase 2 evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 2001, 20:2a. abstract 6.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Senzer, N.N.1
Soulieres, D.2
Siu, L.3
-
188
-
-
3042619127
-
The role of erlotinib (Tarceva, OSI 774) in the treatment of non-small cell lung cancer
-
Perez-Soler R. The role of erlotinib (Tarceva, OSI 774) in the treatment of non-small cell lung cancer. Clinical Cancer Research 2004, 10:4238s-4240s.
-
(2004)
Clinical Cancer Research
, vol.10
-
-
Perez-soler, R.1
-
189
-
-
0242286359
-
Phase I study of OSI-774 alone or with temozolomide in patients with malignant glioma
-
Abstract 394
-
Prados M., Chang S., Burton E., et al. Phase I study of OSI-774 alone or with temozolomide in patients with malignant glioma. Proc ASCO 2003, Abstract 394.
-
(2003)
Proc ASCO
-
-
Prados, M.1
Chang, S.2
Burton, E.3
-
190
-
-
16844384784
-
A phase II trial of erlotinib (OSI-774) in patients with recurrent malignant gliomas not on EIACDs
-
Raizer J.J., Abrey L.E., Wen P., Cloughesy T., Robins I.A., Fine H.A., et al. A phase II trial of erlotinib (OSI-774) in patients with recurrent malignant gliomas not on EIACDs. Proc ASCO 2004, 107.
-
(2004)
Proc ASCO
, pp. 107
-
-
Raizer, J.J.1
Abrey, L.E.2
Wen, P.3
Cloughesy, T.4
Robins, I.A.5
Fine, H.A.6
-
191
-
-
16844383318
-
Phase II trial of the EGFR tyrosine kinase inhibitor erlotinib for single agent therapy of recurrent glioblastoma multiforme: Interim results
-
Vogelbaum M.A., Peereboom D., Stevens G., Barnett G., Brewer C. Phase II trial of the EGFR tyrosine kinase inhibitor erlotinib for single agent therapy of recurrent glioblastoma multiforme: Interim results. Proc ASCO 2004, 121.
-
(2004)
Proc ASCO
, pp. 121
-
-
Vogelbaum, M.A.1
Peereboom, D.2
Stevens, G.3
Barnett, G.4
Brewer, C.5
-
192
-
-
16844369376
-
Erlotinib HCL for glioblastoma multiforme in first relapse, a phase II trial
-
Yung A., Vredenburgh J., Cloughesy T., Klencke B.J., Mischel P.S., Bigner D.D., et al. Erlotinib HCL for glioblastoma multiforme in first relapse, a phase II trial. Proc ASCO 2004, 120.
-
(2004)
Proc ASCO
, pp. 120
-
-
Yung, A.1
Vredenburgh, J.2
Cloughesy, T.3
Klencke, B.J.4
Mischel, P.S.5
Bigner, D.D.6
-
193
-
-
0031981553
-
A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo
-
Lydon N.B., Mett H., Mueller M., et al. A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo. Int J Cancer 1998, 76:154-163.
-
(1998)
Int J Cancer
, vol.76
, pp. 154-163
-
-
Lydon, N.B.1
Mett, H.2
Mueller, M.3
-
194
-
-
2942592008
-
Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ErbB-2 inhibitor lapitinib
-
Burris H.A. Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ErbB-2 inhibitor lapitinib. The Oncologist 2004, 9(suppl 3):10-15.
-
(2004)
The Oncologist
, vol.9
, Issue.SUPPL. 3
, pp. 10-15
-
-
Burris, H.A.1
-
195
-
-
0035476866
-
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer
-
Rusnak D.W., Affleck K., Cockerill S.G., et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Res 2001, 61:7196-7203.
-
(2001)
Cancer Res
, vol.61
, pp. 7196-7203
-
-
Rusnak, D.W.1
Affleck, K.2
Cockerill, S.G.3
-
196
-
-
0035863314
-
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxy-camptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux
-
Erlichman C., Boerner S.A., Hallgren C.G., et al. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxy-camptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res 2001, 61:739-748.
-
(2001)
Cancer Res
, vol.61
, pp. 739-748
-
-
Erlichman, C.1
Boerner, S.A.2
Hallgren, C.G.3
-
197
-
-
0001357911
-
A phase I and pharmacokinetic study of CI-1033, a pan-ErbB tyrosine kinase inhibitor, given orally on days 1, 8, 15, every 28 days to patients with solid tumors
-
abstract 283
-
Garrison M., Tolcher A., McCreery H. A phase I and pharmacokinetic study of CI-1033, a pan-ErbB tyrosine kinase inhibitor, given orally on days 1, 8, 15, every 28 days to patients with solid tumors. Proc Am Soc Clin Oncol 2001, 20:72a. abstract 283.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Garrison, M.1
Tolcher, A.2
McCreery, H.3
-
198
-
-
0002353789
-
A phase I clinical and biomarker study of CI-1033, a novel pan-ErbB tyrosine kinase inhibitor in patients with solid tumors
-
abstract 324
-
Shin D., Nemunaitis J., Zinner R. A phase I clinical and biomarker study of CI-1033, a novel pan-ErbB tyrosine kinase inhibitor in patients with solid tumors. Proc Am Soc Clin Oncol 2001, 20:82a. abstract 324.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Shin, D.1
Nemunaitis, J.2
Zinner, R.3
-
199
-
-
0000453534
-
EKB-569: a new irreversible inhibitor of EGFR tyrosine kinase for the treatment of cancer
-
Greenberger L.M., Discafani C., Wang Y-F., et al. EKB-569: a new irreversible inhibitor of EGFR tyrosine kinase for the treatment of cancer. Clin Cancer Res 2000, 6:4544s.
-
(2000)
Clin Cancer Res
, vol.6
-
-
Greenberger, L.M.1
Discafani, C.2
Wang, Y.-F.3
-
200
-
-
0033827119
-
Combinatorial chemoprevention of intestinal neoplasia
-
Torrance, C. J., Jackson, P. E., Montgomery, E. et al. Combinatorial chemoprevention of intestinal neoplasia. Nat Med6, 1024-1028.
-
Nat Med
, vol.6
, pp. 1024-1028
-
-
Torrance, C.J.1
Jackson, P.E.2
Montgomery, E.3
-
201
-
-
0028941001
-
Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF
-
Tsai J.C., Goldman C.K., Gillespie G.Y. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 1995, 82:864-873.
-
(1995)
J Neurosurg
, vol.82
, pp. 864-873
-
-
Tsai, J.C.1
Goldman, C.K.2
Gillespie, G.Y.3
-
202
-
-
0034667464
-
Epidermal growth factor transcriptionally up-regulated vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia
-
Maity A., Pore N., Lee J., Solomon D., O'Rourke D.M. Epidermal growth factor transcriptionally up-regulated vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia. Cancer Res 2000, 60:5879-5886.
-
(2000)
Cancer Res
, vol.60
, pp. 5879-5886
-
-
Maity, A.1
Pore, N.2
Lee, J.3
Solomon, D.4
O'Rourke, D.M.5
-
203
-
-
0035906852
-
Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulinlike growth factor-1 by a PI3 kinase dependent pathway
-
Clark K., Smith K., Gullick W.J., Harris A.J. Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulinlike growth factor-1 by a PI3 kinase dependent pathway. Br J Cancer 2001, 84:1322-1329.
-
(2001)
Br J Cancer
, vol.84
, pp. 1322-1329
-
-
Clark, K.1
Smith, K.2
Gullick, W.J.3
Harris, A.J.4
-
204
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis
-
Viloria-Petit A., Crombet T., Jothy S., et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001, 61:5090-5101.
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-petit, A.1
Crombet, T.2
Jothy, S.3
-
205
-
-
0036681995
-
Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
-
Huang S.-M., Li E., Armstrong E.A., Harari P.M. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res 2002, 62:4300-4306.
-
(2002)
Cancer Res
, vol.62
, pp. 4300-4306
-
-
Huang, S.-M.1
Li, E.2
Armstrong, E.A.3
Harari, P.M.4
-
206
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J., Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000, 407:242-248.
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
Rudge, J.S.4
Wiegand, S.J.5
Holash, J.6
-
207
-
-
0032005359
-
Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review
-
Jensen R.L. Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review. Surg Neurol 1998, 49:189-195.
-
(1998)
Surg Neurol
, vol.49
, pp. 189-195
-
-
Jensen, R.L.1
-
208
-
-
0036570203
-
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
-
Hirata A., Ogawa S.-I., Kometani T., et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 2002, 62:2554-2560.
-
(2002)
Cancer Res
, vol.62
, pp. 2554-2560
-
-
Hirata, A.1
Ogawa, S.-I.2
Kometani, T.3
-
209
-
-
0030888746
-
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells
-
Kondapaka, S. B., Fridman, R., and Reddy, K. B. Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. Int J Cancer17, 722-726.
-
Int J Cancer
, vol.17
, pp. 722-726
-
-
Kondapaka, S.B.1
Fridman, R.2
Reddy, K.B.3
-
210
-
-
0037096945
-
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion
-
Lal A., Glazer C.A., Martinson H.M., et al. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res 2002, 62:3335-3339.
-
(2002)
Cancer Res
, vol.62
, pp. 3335-3339
-
-
Lal, A.1
Glazer, C.A.2
Martinson, H.M.3
-
211
-
-
0032904485
-
Antitumor activity of sequential treatment with topotecan and antiepidermal growth factor receptor monoclonal antibody C225
-
Ciardiello F., Bianco R., Damiano V., et al. Antitumor activity of sequential treatment with topotecan and antiepidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res 1999, 5:909-916.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 909-916
-
-
Ciardiello, F.1
Bianco, R.2
Damiano, V.3
-
212
-
-
18844473781
-
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
-
Bruns C.J., Harbison M.T., Davis D.W., et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000, 6:1936-1948.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
-
213
-
-
0034489116
-
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
-
Inoue K., Slaton J.W., Perrotte P., et al. Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clin Cancer Res 2000, 6:4874-4884.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4874-4884
-
-
Inoue, K.1
Slaton, J.W.2
Perrotte, P.3
-
214
-
-
0037295398
-
Studies with ZD1839 in preclinical models
-
Sirotnak F.M. Studies with ZD1839 in preclinical models. Sem Oncol 2003, 30(Suppl 1):12-20.
-
(2003)
Sem Oncol
, vol.30
, Issue.SUPPL.1
, pp. 12-20
-
-
Sirotnak, F.M.1
-
215
-
-
0034329308
-
Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers
-
Bonner J.A., Raisch K.P., Trummell H.Q., et al. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol 2000, 18:47S-53S.
-
(2000)
J Clin Oncol
, vol.18
-
-
Bonner, J.A.1
Raisch, K.P.2
Trummell, H.Q.3
-
216
-
-
0033966576
-
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
-
Milas L., Mason K., Hunter N. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Canc Res 2000, 6:323-325.
-
(2000)
Clin Canc Res
, vol.6
, pp. 323-325
-
-
Milas, L.1
Mason, K.2
Hunter, N.3
-
217
-
-
0035398021
-
Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
-
Robert F., Ezekiel M.P., Spencer S.A., et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 2001, 19:3234-3243.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3234-3243
-
-
Robert, F.1
Ezekiel, M.P.2
Spencer, S.A.3
-
218
-
-
0032168534
-
Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells
-
O'Rourke D.M., Kao G.D., Singh N., et al. Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells. Proc Natl Acad Sci USA 1998, 95:10842-10847. 18.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10842-10847
-
-
O'Rourke, D.M.1
Kao, G.D.2
Singh, N.3
-
219
-
-
0036795061
-
Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa)
-
Bianco C., Tortora G., Bianco R., et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res 2002, 8:3250-3258.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3250-3258
-
-
Bianco, C.1
Tortora, G.2
Bianco, R.3
-
220
-
-
0037276771
-
Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: Radiosensitization
-
Gee J.M., Nicholson R.I. Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: Radiosensitization. Breast Cancer Res 2003, 5:126-129.
-
(2003)
Breast Cancer Res
, vol.5
, pp. 126-129
-
-
Gee, J.M.1
Nicholson, R.I.2
-
221
-
-
0347928791
-
EGFR blockade with ZD1839 (Iressa) potentiates the antitumor effects of single and multiple fractions of ionizing irradiation in human A431 squamous cell carcinoma
-
Solomon B., Hagekyriakou J., Trivett M.K., Stacker S.A., McArthur G.A., Cullinane C. EGFR blockade with ZD1839 (Iressa) potentiates the antitumor effects of single and multiple fractions of ionizing irradiation in human A431 squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2003, 55:713-723.
-
(2003)
Int J Radiat Oncol Biol Phys
, vol.55
, pp. 713-723
-
-
Solomon, B.1
Hagekyriakou, J.2
Trivett, M.K.3
Stacker, S.A.4
McArthur, G.A.5
Cullinane, C.6
-
222
-
-
0034330931
-
Efficacy of STI571, and abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells
-
Thiesing J.T., Ohno-Jones S., Kolibaba K.S., Druker B.J. Efficacy of STI571, and abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells. Blood 2000, 96:3195-3199.
-
(2000)
Blood
, vol.96
, pp. 3195-3199
-
-
Thiesing, J.T.1
Ohno-jones, S.2
Kolibaba, K.S.3
Druker, B.J.4
-
223
-
-
0035313251
-
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemia agents
-
Kano Y., Akutsu M., Tsunoda S., et al. In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemia agents. Blood 2001, 97:1999-2007.
-
(2001)
Blood
, vol.97
, pp. 1999-2007
-
-
Kano, Y.1
Akutsu, M.2
Tsunoda, S.3
-
224
-
-
0035080416
-
Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on the BCR-ABL-positive chronic myelogenous leukemia cells
-
Topaly J., Zeller W.J., Fruehauf S. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on the BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 2001, 15:342-347.
-
(2001)
Leukemia
, vol.15
, pp. 342-347
-
-
Topaly, J.1
Zeller, W.J.2
Fruehauf, S.3
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