Selective Platelet-derived Growth Factor Receptor Kinase Blockers Reverse-Transformation

Cancer Research

Volumn 54, Issue 23, 1994, Pages 6106-6114

  Böhmer, Annette ^a   Levitzki, Alexander ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIMETHOXY 2 PHENYLQUINOXALINE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; AG 808; EPIDERMAL GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL TRANSFORMATION; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CATECHOLS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DNA; MICE; NITRILES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; TYRPHOSTINS;

EID: 0028091564     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Ross, R. Platelet-derived growth factor. Lancet, 7: 1179-1182, 1989.
2. Heldin, C.H. Structural and functional studies on platelet-derived growth factor. EMBO J. 77: 4251-4259, 1992.
3. Yarden, Y. Escobedo, J.A. Kuang, W.J. Yang-Feng, T.L. Daniel, T. O. Tremble, P.M. Chen, E.Y. Ando, M.E. Harkins, R.N. Francke, U. Friend, V.A. Ullrich, A. Williams, L.T. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (Lond.), 323: 226-232, 1986.
4. Matsui, T. Heidaran, M. Miki, T. Popescu, N. LaRochelle, W. Kraus, M. Pierce, J. and Aaronson, S. Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science (Washington DC), 243: 800-804, 1989.
5. Claesson-Welsh, L. Eriksson, A. Westermark, B. and Heldin, C.H. cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc. Natl. Acad. Sci. USA, 86: 4917-4921, 1989.
6. Escobedo, J.A. Barr, P.J. and Williams, L.T. Role of tyrosine kinase and membrane-spanning domains in signal transduction by platelet-derived growth factor receptor. Mol. Cell. Biol. 8: 5126-5131, 1988.
7. Ross, R. Mechanisms of atherosclerosis?a review. Adv. Nephrol. Necker Hosp. 19: 79-86, 1990.
8. Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond.), 362: 801-809, 1993.
9. Shaw, R.J. Benedict, S.H. Clark, R.A. and King, T.E. Pathogenesis of pulmonary fibrosis in interstitial lung disease. Alveolar macrophage PDGF(B) gene activation and up-regulation by interferon 7. Am. Rev. Respir. Dis. 143: 167-173, 1991.
10. Gesualdo, L. Ranierei, E. Pannarale, G. Di Paolo, S. and Schena, F.P. Platelet-derived growth factor and proliferative glomerulonephritis. Kidney Int. 43 (Suppl. 39): 86-89, 1993.
11. Rubin, K. Terracio, L. Rönnstrand, L. Heldin, C.H. and Klareskog, L. Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation. Scand. J. Immunol. 27: 285-294, 1988.
12. Waterfield, M.D. Scrace, G.T. Whittle, N. Stroobant, P. Johnson, A. Wasteson, A. Westermark, B. Heldin, C.H. Huang, J.S. and Deuel, T.F. Platelet-derived growth factor is structurally related to the putative transforming protein p. 8sis of simian sarcoma virus. Nature (Lond.), 304: 35-39, 1983.
13. Doolittle, R.F. Hunkapiller, M.W. Hood, L.E. Devare, S.G. Robbins, K.C. Aaronson, S.A. and Antoniades, H.N. Simian sarcoma virus oncogene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (Washington DC), 227: 275-277, 1983.
14. Heldin, C.H. and Westermark, B. Platelet-derived growth factor and autocrine mechanisms of oncogenic processes. CRC Crit. Rev. Oncog. 2: 109-124, 1991.
15. Engström, U. Engstrom, Å. Ernlund, A. Westermark, B. and Heldin, C.H. Identification of a peptide antagonist for platelet-derived growth factor. J. Biol. Chem. 267: 16581-16587, 1992.
16. Vassbotn, F.S. Andersson, M. Westermark, B. Heldin, C.H. and Östman, A. Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant. Mol. Cell. Biol. 13: 4066-4076, 1993.
17. Shaman, S.M. Stiles, C.D. and Guha, A. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol. Cell. Biol. 13: 7203-7212, 1993.
18. Ueno, H. Colbert, H. Escobedo, J.A. and Williams, L.T. Inhibition of PDGFB receptor signal transduction by coexpression of a truncated receptor. Science (Washington DC), 252: 844-848, 1991.
19. Levitzki, A. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J. 6: 3275-3282, 1992.
20. Bilder, G.E. Krawiec, J.A. McVety, K. Gazit, A. Gilon, C. Lyall, R. Zilberstein, A. Levitzki, A. Perrone, M.H. and Schreiber, A.B. Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am. J. Physiol. 260: C721-C730, 1991.
21. Bryckaert, M.C. Eldor, A. Fontanay, M. Gazit, A. Osherov, N. Gilon, C. Levitzki, A. and Tobelem, G. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp. Cell. Res. 799: 255-261, 1992.
22. Westermark, B. Siegbahn, H. Heldin, C.H. and Claesson-Welsh, L. B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. Proc. Natl. Acad. Sci. USA, 87: 128-132, 1990.
23. Eriksson, A. Siegbahn, A. Westermark, B. Heldin, C.H. and Claesson-Welsh, L. PDGF a- and β-receptors activate unique and common signal transduction pathways. EMBO J. 77: 543-550, 1992.
24. Blume-Jensen, P. Claesson-Welsh, L. Siegbahn, A. Zsebo, K.M. Westermark, B. and Heldin, C.H. Activation of the human c-Kit product by ligand-induced dimer-ization mediates circular actin reorganization and chemotaxis. EMBO J. 10: 4121-4128, 1991.
25. Waltenberger, J. Claesson-Welsh, L. Siegbahn, A. Shibuya, M. and Heldin, C.H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. in press, 1994.
26. Wennström, S. Sandstrom, C. and Claesson-Welsh, L. cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF. Growth Factors, 4: 197-208, 1991.
27. Thorn, D. Powell, A.J. Lloyd, C.W. and Rees, D.A. Rapid isolation of plasma membranes in high yield from cultured fibroblasts. Biochem. J. 765: 187-194, 1977.
28. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
29. Rönnstrand, L. Beckman, M.P. Faulders, B. Östman, A. Ek, B. and Heldin, C.H. Purification of the receptor for platelet-derived growth factor from porcine uterus. J. Biol. Chem. 262: 2929-2932, 1987.
30. Cooper, J.A. Esch, F.S. Taylor, S.S. and Hunter, T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J. Biol. Chem. 259: 7835-7841, 1984.
31. Besmer, P. The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Curr. Opin. Cell. Biol. 3: 939-946, 1991.
32. Terman, B.I. Dougher-Vermazen, M. Carrion, M.E. Dimitrov, D. Armellino, D.C. Gospodarowicz, D. and Böhlen, P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Comm. 787: 1579-1586, 1992.
33. Matthews, W. Jordan, C. Gavin, M. Jenkins, N. Copeland, N. and Lemischka, I. A receptor tyrosine kinase cDNA from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-Kit. Proc. Natl. Acad. Sci. USA, 88: 9026-9030, 1991.
34. Millauer, B. Wizigmann-Voos, S. Schnürch, H. Martinez, R. Moeller, N.P.H. Risau, W. and Ullrich, A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell, 72: 835-846, 1993.
35. Quinn, T.P. Peters, K.G. De Vries, C. Ferara, N. and Williams, L.T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA, 90: 7533-7537, 1993.
36. Oelrichs, R.B. Reid, H.H. Bernard, O. Ziemicki, A. and Wilks, A.F. NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepi-thelium is expressed in endothelial cells of the developing embryo. Oncogene, 8: 11-18, 1993.
37. Devare, S.G. Reddy, E.P. Robbins, K.C. Andersen, P.R. Tronick, S.R. and Aaronson, S.A. Nucleotide sequence of the transforming gene of simian sarcoma virus. Proc. Natl. Acad. Sci. USA, 79: 3179-3182, 1982.
38. Beckman, M.P. Betzholz, C. Heldin, C.H. Westermark, B. DiMarco, E. DiFiore, P.P. Robbins, K.C. and Aaronson, S.A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (Washington DC), 241: 1346-1349, 1988.
39. Piwnica-Worms, H. Saunders, K.B. Roberts, T.M. Smith, A.E. and Cheng, S.H. Tyrosine phosphorylation regulated the biochemical and biological properties of pp. 60c-Src. Cell, 49: 75-82, 1987.
40. Reynolds, A.B. Vila, J. Lansing, T.J. Potts, W.M. Weber, M.J. and Parsons, J.T. Activation of the oncogenic potential of the avian cellular Src protein by specific structural alteration of the carboxyl terminus. EMBO J. 6: 2359-2364, 1987.
41. Agbotamou, W.K. Levitzki, A. Jaquemin-Sablon, A. and Pierre, J. Effects of tyrphostins on the activated c-Src protein in NIH 3T3 cells. Mol. Pharmacol. 45: 922-931, 1994.
42. Keating, M.T. and Williams, L.T. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science (Washington DC), 239: 914-916, 1988.
43. Huang, S.S. and Huang, J.S. Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. J. Biol. Chem. 263: 12608-12618, 1988.
44. Cascells, W. Migration of smooth muscle and endothelial cells. Critical events in restenosis. Circulation, 86: 723-729, 1992.
45. Pickering, J.G. Weir, L. Jekanowski, J. Kearney, M.A. and Isner, J.M. Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization. J. Clin. Invest. 91: 1469-1480, 1993.
46. Rensing, B.J. Hermans, W.R. Vos, J.G. Rutch, W. Danchin, N. Heyndrickx, G.R. Mast, E.G. Wijns, W. and Serruys, P.W. Luminal narrowing after percutaneous transluminal coronary angioplasty. A study of clinical, procedural and lesional factors related to long-term angiographic outcome. Coronary artery restenosis prevention on repeated thromboxane antagonism (CARPORT) study group. Circulation, 88: 975-985, 1993.
47. Osherov, N. Gazit, A. Gilon, C. and Levitzki, A. Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrpnostins. J. Biol. Chem. 268: 11134-11142, 1993.
48. Yaish, P. Gazit, A. Gilon, C. and Levitzki, A. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science (Washington DC), 242: 933-935, 1988.
49. Posner, I. Engel, M. Gazit, A. and Levitzki, A. Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program. Mol. Pharmacol. 45: 673-683, 1994.
50. Gazit, A. Yaish, P. Gilon, C. and Levitzki, A. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32: 2344-2352, 1989.
51. Schechter, Y. Yaish, P. Chorev, M. Gilon, C. Braun, S. and Levitzki, A. Inhibition of insulin dependent lipogenesis and antilipolysis by protein tyrosine kinase inhibitors. EMBO J. 8: 1671-1676, 1989.