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Volumn 20, Issue 4, 2000, Pages 1448-1459

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

EID: 0033959896     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.4.1448-1459.2000     Document Type: Article
Times cited : (300)

References (59)
  • 2
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B
    • Alessi, D. R., S. R. James, C. P. Downes, A. B. Holmes, P. R. Gaffney, C. B. Reese, and P. Cohen. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B. Curr. Biol. 7:261-269.
    • (1997) Curr. Biol. , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 3
    • 0031577691 scopus 로고    scopus 로고
    • Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential
    • Bardelli, A., P. Longati, D. Gramaglia, M. C. Stella, and P. M. Comoglio. 1997. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene 15:3103-3111.
    • (1997) Oncogene , vol.15 , pp. 3103-3111
    • Bardelli, A.1    Longati, P.2    Gramaglia, D.3    Stella, M.C.4    Comoglio, P.M.5
  • 4
    • 0028040812 scopus 로고
    • Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
    • Batzer, A. G., D. Rotin, J. M. Uren̄a, E. Y. Skolnik, and J. Schlessinger. 1994. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14:5192-5201.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5192-5201
    • Batzer, A.G.1    Rotin, D.2    Urena, J.M.3    Skolnik, E.Y.4    Schlessinger, J.5
  • 5
    • 0025316902 scopus 로고
    • Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation
    • Bjorge, J. D., T. O. Chan, M. Antczak, H. J. Kung, and D. J. Fujita. 1990. Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation. Proc. Natl. Acad. Sci. USA 87:3816-3820.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3816-3820
    • Bjorge, J.D.1    Chan, T.O.2    Antczak, M.3    Kung, H.J.4    Fujita, D.J.5
  • 6
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96:4240-4245.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 7
    • 0031459864 scopus 로고    scopus 로고
    • p62dok: A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
    • Carpino, N., D. Wisniewski, A. Strife, D. Marshak, R. Kobayashi, B. Stillman, and B. Clarkson. 1997. p62dok: a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88:197-204.
    • (1997) Cell , vol.88 , pp. 197-204
    • Carpino, N.1    Wisniewski, D.2    Strife, A.3    Marshak, D.4    Kobayashi, R.5    Stillman, B.6    Clarkson, B.7
  • 8
    • 0032518666 scopus 로고    scopus 로고
    • Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting
    • Falasca, M., S. K. Logan, V. P. Lehto, G. Baccante, M. A. Lemmon, and J. Schlessinger. 1998. Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17:414-422.
    • (1998) EMBO J. , vol.17 , pp. 414-422
    • Falasca, M.1    Logan, S.K.2    Lehto, V.P.3    Baccante, G.4    Lemmon, M.A.5    Schlessinger, J.6
  • 9
    • 0029617615 scopus 로고
    • Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
    • Ferguson, K. M., M. A. Lemmon, J. Schlessinger, and P. B. Sigler. 1995. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83:1037-1046.
    • (1995) Cell , vol.83 , pp. 1037-1046
    • Ferguson, K.M.1    Lemmon, M.A.2    Schlessinger, J.3    Sigler, P.B.4
  • 10
    • 0030839876 scopus 로고    scopus 로고
    • Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
    • Fixman, E. D., M. Holgado-Madruga, L. Nguyen, D. M. Kamikura, T. M. Fournier, A. J. Wong, and M. Park. 1997. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. J. Biol. Chem. 272:20167-20172.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20167-20172
    • Fixman, E.D.1    Holgado-Madruga, M.2    Nguyen, L.3    Kamikura, D.M.4    Fournier, T.M.5    Wong, A.J.6    Park, M.7
  • 11
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke, T. F., D. R. Kaplan, L. C. Cantley, and A. Toker. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665-668.
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 12
    • 0030991386 scopus 로고    scopus 로고
    • High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
    • Frech, M., M. Andjelkovic, E. Ingley, K. K. Reddy, J. R. Falck, and B. A. Hemmings. 1997. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272:8474-8481.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8474-8481
    • Frech, M.1    Andjelkovic, M.2    Ingley, E.3    Reddy, K.K.4    Falck, J.R.5    Hemmings, B.A.6
  • 13
    • 0032238298 scopus 로고    scopus 로고
    • Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
    • Gu, H., J. C. Pratt, S. J. Burakoff, and B. G. Neel. 1998. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell 2:729-740.
    • (1998) Mol. Cell , vol.2 , pp. 729-740
    • Gu, H.1    Pratt, J.C.2    Burakoff, S.J.3    Neel, B.G.4
  • 14
    • 0031835659 scopus 로고    scopus 로고
    • Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
    • Hadari, Y. R., H. Kouhara, I. Lax, and J. Schlessinger. 1998. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol. Cell. Biol. 18:3966-3973.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3966-3973
    • Hadari, Y.R.1    Kouhara, H.2    Lax, I.3    Schlessinger, J.4
  • 15
    • 15144353776 scopus 로고    scopus 로고
    • Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
    • Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and D. Broek. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560.
    • (1998) Science , vol.279 , pp. 558-560
    • Han, J.1    Luby-Phelps, K.2    Das, B.3    Shu, X.4    Xia, Y.5    Mosteller, R.D.6    Krishna, U.M.7    Falck, J.R.8    White, M.A.9    Broek, D.10
  • 16
    • 0028021882 scopus 로고
    • Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
    • Harlan, J. E., P. J. Hajduk, H. S. Yoon, and S. W. Fesik. 1994. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371:168-170.
    • (1994) Nature , vol.371 , pp. 168-170
    • Harlan, J.E.1    Hajduk, P.J.2    Yoon, H.S.3    Fesik, S.W.4
  • 17
    • 0030003293 scopus 로고    scopus 로고
    • Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling
    • Herbst, R., P. M. Carroll, J. D. Allard, J. Schilling, T. Raabe, and M. A. Simon. 1996. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling. Cell 85: 899-909.
    • (1996) Cell , vol.85 , pp. 899-909
    • Herbst, R.1    Carroll, P.M.2    Allard, J.D.3    Schilling, J.4    Raabe, T.5    Simon, M.A.6
  • 18
    • 0030028790 scopus 로고    scopus 로고
    • A Grb2-associated docking protein in EGF- and insulin-receptor signalling
    • Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379:560-564.
    • (1996) Nature , vol.379 , pp. 560-564
    • Holgado-Madruga, M.1    Emlet, D.R.2    Moscatello, D.K.3    Godwin, A.K.4    Wong, A.J.5
  • 19
    • 0030812590 scopus 로고    scopus 로고
    • Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
    • Holgado-Madruga, M., D. K. Moscatello, D. R. Emlet, R. Dieterich, and A. J. Wong. 1997. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. USA 94:12419-12424.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12419-12424
    • Holgado-Madruga, M.1    Moscatello, D.K.2    Emlet, D.R.3    Dieterich, R.4    Wong, A.J.5
  • 20
    • 0026537450 scopus 로고
    • Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
    • Hu, P., B. Margolis, E. Y. Skolnik, R. Lammers, A. Ullrich, and J. Schlessinger. 1992. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 12:981-990.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 981-990
    • Hu, P.1    Margolis, B.2    Skolnik, E.Y.3    Lammers, R.4    Ullrich, A.5    Schlessinger, J.6
  • 21
    • 0028178428 scopus 로고
    • Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110β
    • Hu, P., and J. Schlessinger. 1994. Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110β. Mol. Cell. Biol. 14:2577-2583.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2577-2583
    • Hu, P.1    Schlessinger, J.2
  • 22
    • 0032530384 scopus 로고    scopus 로고
    • Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
    • Isakoff, S. J., T. Cardozo, J. Andreev, Z. Li, K. M. Ferguson, R. Abagyan, M. A. Lemmon, A. Aronheim, and E. Y. Skolnik. 1998. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J. 17:5374-5387.
    • (1998) EMBO J. , vol.17 , pp. 5374-5387
    • Isakoff, S.J.1    Cardozo, T.2    Andreev, J.3    Li, Z.4    Ferguson, K.M.5    Abagyan, R.6    Lemmon, M.A.7    Aronheim, A.8    Skolnik, E.Y.9
  • 23
    • 0029993517 scopus 로고    scopus 로고
    • Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
    • James, S. R., C. P. Downes, R. Gigg, S. J. Grove, A. B. Holmes, and D. R. Alessi. 1996. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochern. J. 315: 709-713.
    • (1996) Biochern. J. , vol.315 , pp. 709-713
    • James, S.R.1    Downes, C.P.2    Gigg, R.3    Grove, S.J.4    Holmes, A.B.5    Alessi, D.R.6
  • 24
    • 0032480321 scopus 로고    scopus 로고
    • The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
    • Jones, N., and D. J. Dumont. 1998. The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene 17:1097-1108.
    • (1998) Oncogene , vol.17 , pp. 1097-1108
    • Jones, N.1    Dumont, D.J.2
  • 25
    • 0030975196 scopus 로고    scopus 로고
    • Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains
    • Klarlund, J. K., A. Guilherme, J. J. Holik, J. V. Virbasius, A. Chawla, and M. P. Czech. 1997. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-1930.
    • (1997) Science , vol.275 , pp. 1927-1930
    • Klarlund, J.K.1    Guilherme, A.2    Holik, J.J.3    Virbasius, J.V.4    Chawla, A.5    Czech, M.P.6
  • 27
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M. A. Escobedo, and L. T. Williams. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16:4117-4127.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 28
    • 0031015986 scopus 로고    scopus 로고
    • A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
    • Klippel, A., W. M. Kavanaugh, D. Pot, and L. T. Williams. 1997. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17:338-344.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 338-344
    • Klippel, A.1    Kavanaugh, W.M.2    Pot, D.3    Williams, L.T.4
  • 29
    • 0030706168 scopus 로고    scopus 로고
    • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    • Kouhara, H., Y. R. Hadari, T. Spivak-Kroizman, J. Schilling, D. Bar-Sagi, I. Lax, and J. Schlessinger. 1997. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89:693-702.
    • (1997) Cell , vol.89 , pp. 693-702
    • Kouhara, H.1    Hadari, Y.R.2    Spivak-Kroizman, T.3    Schilling, J.4    Bar-Sagi, D.5    Lax, I.6    Schlessinger, J.7
  • 30
    • 0029939448 scopus 로고    scopus 로고
    • PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface
    • Lemmon, M. A., K. M. Ferguson, and J. Schlessinger. 1996. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85:621-624.
    • (1996) Cell , vol.85 , pp. 621-624
    • Lemmon, M.A.1    Ferguson, K.M.2    Schlessinger, J.3
  • 31
    • 0031006326 scopus 로고    scopus 로고
    • Regulatory recruitment of signalling molecules to the cell membrane by pieckstrin-homology domains
    • Lemmon, M. A., M. Falasca, K. M. Ferguson, and J. Schlessinger. 1997. Regulatory recruitment of signalling molecules to the cell membrane by pieckstrin-homology domains. Trends Cell Biol. 7:237-242.
    • (1997) Trends Cell Biol. , vol.7 , pp. 237-242
    • Lemmon, M.A.1    Falasca, M.2    Ferguson, K.M.3    Schlessinger, J.4
  • 32
    • 0030840413 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
    • Logan, S. K., M. Falasca, P. Hu, and J. Schlessinger. 1997. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. Mol. Cell. Biol. 17:5784-5790.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5784-5790
    • Logan, S.K.1    Falasca, M.2    Hu, P.3    Schlessinger, J.4
  • 33
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama, T., and J. E. Dixon. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:13375-13378.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 35
    • 0033020148 scopus 로고    scopus 로고
    • The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the Met receptor tyrosine kinase
    • Maroun, C. R., M. Holgado-Madruga, I. Royal, M. A. Naujokas, T. M. Fournier, A. J. Wong, and M. Park. 1999. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the Met receptor tyrosine kinase. Mol. Cell. Biol. 19:1784-1799.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1784-1799
    • Maroun, C.R.1    Holgado-Madruga, M.2    Royal, I.3    Naujokas, M.A.4    Fournier, T.M.5    Wong, A.J.6    Park, M.7
  • 36
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., A. Lin, F. X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 38
    • 0030843307 scopus 로고    scopus 로고
    • Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
    • Nguyen, L., M. Holgado-Madruga, C. Maroun, E. D. Fixman, D. Kamikura, T. Fournier, A. Charest, M. L. Tremblay, A. J. Wong, and M. Park. 1997. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356. J. Biol. Chem. 272:20811-20819.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20811-20819
    • Nguyen, L.1    Holgado-Madruga, M.2    Maroun, C.3    Fixman, E.D.4    Kamikura, D.5    Fournier, T.6    Charest, A.7    Tremblay, M.L.8    Wong, A.J.9    Park, M.10
  • 39
    • 0032559211 scopus 로고    scopus 로고
    • Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
    • Nimnual, A. S., B. A. Yatsula, and D. Bar-Sagi. 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560-563.
    • (1998) Science , vol.279 , pp. 560-563
    • Nimnual, A.S.1    Yatsula, B.A.2    Bar-Sagi, D.3
  • 40
    • 0342331026 scopus 로고    scopus 로고
    • FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
    • in press
    • Ong, S. H., G. R. Guy, Y. Hadari, S. Laks, N. Gotoh, J. Schlessinger, and I. Lax. 1999. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol. Cell. Biol., in press.
    • (1999) Mol. Cell. Biol.
    • Ong, S.H.1    Guy, G.R.2    Hadari, Y.3    Laks, S.4    Gotoh, N.5    Schlessinger, J.6    Lax, I.7
  • 41
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson, T. 1995. Protein modules and signalling networks. Nature 373:573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 42
    • 0028216712 scopus 로고
    • Identification of c-erbB-3 binding sites for phosphatidylinositol 3́-kinase and SHC using an EGF receptor/cerbB-3 chimera
    • Prigent, S. A., and W. J. Gullick, 1994. Identification of c-erbB-3 binding sites for phosphatidylinositol 3́-kinase and SHC using an EGF receptor/cerbB-3 chimera. EMBO J. 13:2831-2841.
    • (1994) EMBO J. , vol.13 , pp. 2831-2841
    • Prigent, S.A.1    Gullick, W.J.2
  • 43
    • 0031929680 scopus 로고    scopus 로고
    • N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains
    • Qian, X. L., W. C. Vass, A. G. Papageorge, P. H. Anborgh, and D. R. Lowy. 1998. N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. Mol. Cell. Biol. 18:771-778.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 771-778
    • Qian, X.L.1    Vass, W.C.2    Papageorge, A.G.3    Anborgh, P.H.4    Lowy, D.R.5
  • 44
    • 0029984739 scopus 로고    scopus 로고
    • DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and RAS1 in Drosophila
    • Raabe, T., J. Riesgo-Escovar, X. D. Liu, B. S. Bausenwein, P. Deak, P. Maröy, and E. Hafen. 1996. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and RAS1 in Drosophila. Cell 85:911-920.
    • (1996) Cell , vol.85 , pp. 911-920
    • Raabe, T.1    Riesgo-Escovar, J.2    Liu, X.D.3    Bausenwein, B.S.4    Deak, P.5    Maröy, P.6    Hafen, E.7
  • 45
    • 0026793456 scopus 로고
    • Growth factor signaling by receptor tyrosine kinases
    • Schlessinger, J., and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron 9:383-391.
    • (1992) Neuron , vol.9 , pp. 383-391
    • Schlessinger, J.1    Ullrich, A.2
  • 47
    • 0028302018 scopus 로고
    • ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
    • Soltoff, S. P., K. L. R. Carraway, S. A. Prigent, W. G. Gullick, and L. C. Cantley. 1994. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol. Cell. Biol. 14:3550-3558.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3550-3558
    • Soltoff, S.P.1    Carraway, K.L.R.2    Prigent, S.A.3    Gullick, W.G.4    Cantley, L.C.5
  • 51
    • 0032499031 scopus 로고    scopus 로고
    • Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase
    • Venkateswarlu, K., P. B. Oatey, J. M. Tavare, and P. J. Cullen. 1998. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr. Biol. 8:463-466.
    • (1998) Curr. Biol. , vol.8 , pp. 463-466
    • Venkateswarlu, K.1    Oatey, P.B.2    Tavare, J.M.3    Cullen, P.J.4
  • 52
    • 0029029892 scopus 로고
    • Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region
    • Voliovitch, H., D. G. Schindler, Y. R. Hadari, S. I. Taylor, D. Accili, and Y. Zick. 1995. Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J. Biol. Chem. 270:18083-18087.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18083-18087
    • Voliovitch, H.1    Schindler, D.G.2    Hadari, Y.R.3    Taylor, S.I.4    Accili, D.5    Zick, Y.6
  • 53
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, and W. Birchmeier. 1996. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384:173-176.
    • (1996) Nature , vol.384 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 55
    • 0031444245 scopus 로고    scopus 로고
    • Identification of the Abl- and ras-GAP-associated 62 kDa protein as a docking protein, Dok
    • Yamanashi, Y., and D. Baltimore. 1997, Identification of the Abl- and ras-GAP-associated 62 kDa protein as a docking protein, Dok. Cell 88:205-211.
    • (1997) Cell , vol.88 , pp. 205-211
    • Yamanashi, Y.1    Baltimore, D.2
  • 56
    • 0029820085 scopus 로고    scopus 로고
    • The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1
    • Yenush, L., K. J. Makati, J. Smith-Hall, O. Ishibashi, M. G. J. Myers, and M. F. White. 1996. The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. J. Biol. Chem. 271:24300-24306.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24300-24306
    • Yenush, L.1    Makati, K.J.2    Smith-Hall, J.3    Ishibashi, O.4    Myers, M.G.J.5    White, M.F.6
  • 57
    • 0031171216 scopus 로고    scopus 로고
    • The IRS-signalling system during insulin and cytokine action
    • Yenush, L., and M. F. White. 1997. The IRS-signalling system during insulin and cytokine action. Bioessays 19:491-500.
    • (1997) Bioessays , vol.19 , pp. 491-500
    • Yenush, L.1    White, M.F.2
  • 59
    • 0032498231 scopus 로고    scopus 로고
    • LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
    • Zhang, W. G., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83-92.
    • (1998) Cell , vol.92 , pp. 83-92
    • Zhang, W.G.1    Sloan-Lancaster, J.2    Kitchen, J.3    Trible, R.P.4    Samelson, L.E.5


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