CAPECITABINE;
DNA NUCLEOTIDYLEXOTRANSFERASE;
EPIDERMAL GROWTH FACTOR RECEPTOR;
EPIDERMAL GROWTH FACTOR RECEPTOR 2;
LAPATINIB;
LETROZOLE;
PROTEIN TYROSINE KINASE INHIBITOR;
TRASTUZUMAB;
ANOREXIA;
BREAST CARCINOMA;
CANCER INHIBITION;
CARDIOTOXICITY;
CLINICAL TRIAL;
CONSTIPATION;
CORRELATION ANALYSIS;
DIARRHEA;
DRUG EFFICACY;
DRUG POTENCY;
DRUG SCREENING;
DRUG TOLERABILITY;
ENZYME INHIBITION;
FATIGUE;
GASTROINTESTINAL SYMPTOM;
HEAD AND NECK CANCER;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
META ANALYSIS;
NAUSEA;
NICK END LABELING;
PHARMACODYNAMICS;
PHASE 1 CLINICAL TRIAL;
PHASE 2 CLINICAL TRIAL;
PHASE 3 CLINICAL TRIAL;
PRIORITY JOURNAL;
RASH;
REVIEW;
SIDE EFFECT;
SIGNAL TRANSDUCTION;
SOLID TUMOR;
SYSTEMATIC REVIEW;
TREATMENT OUTCOME;
VOMITING;
Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
Amundadottir LT, Leder P. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene 1998;16:737-746.
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
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Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
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Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
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A novel strategy of colon cancer therapy: Targeting both EGFR and ErbB2 receptors
Abstract 5529
Zhou Y, Brattain M. A novel strategy of colon cancer therapy: targeting both EGFR and ErbB2 receptors. Proc Am Assoc Cancer Res 2003; 1267. Abstract 5529.
The characterization of novel, dual erbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
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Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
Xia W, Mullin RJ, Keith BR et al. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene 2002;21:6255-6263.
Safety, clinical efficacy, and biologic assessments from EGF10004: A randomized phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or erbB2
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