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Volumn 84, Issue 6, 1996, Pages 1024-1032

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor

Author keywords

7 hydroxystaurosporine; astrocytoma; glioma; growth inhibition; protein kinase C; signal transduction

Indexed keywords

7 HYDROXYSTAUROSPORINE; CARMUSTINE; CISPLATIN; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

EID: 0029938768     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1996.84.6.1024     Document Type: Article
Times cited : (85)

References (43)
  • 1
    • 0026425587 scopus 로고
    • Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models
    • Akinaga S, Gomi K, Morimoto M, et al: Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res 51:4888-4892, 1991
    • (1991) Cancer Res , vol.51 , pp. 4888-4892
    • Akinaga, S.1    Gomi, K.2    Morimoto, M.3
  • 2
    • 0027232037 scopus 로고
    • Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
    • Akinaga S, Nomura K, Gomi K, et al: Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C. Cancer Chemother Pharmacol 32:183-189, 1993
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 183-189
    • Akinaga, S.1    Nomura, K.2    Gomi, K.3
  • 3
    • 0000308252 scopus 로고
    • Synergistic anti-tumor effect of UCN-01, a protein kinase (C) inhibitor, combined with various anti-cancer agents
    • Abstract
    • Akinaga S, Nomura K, Gomi K, et al: Synergistic anti-tumor effect of UCN-01, a protein kinase (C) inhibitor, combined with various anti-cancer agents. Proc Am Assoc Cancer Res 33: 514, 1992 (Abstract)
    • (1992) Proc Am Assoc Cancer Res , vol.33 , pp. 514
    • Akinaga, S.1    Nomura, K.2    Gomi, K.3
  • 4
    • 0027185914 scopus 로고
    • High dose tamoxifen in the treatment of recurrent high grade glioma: A report of clinical stabilization and tumour regression
    • Baltuch G, Shenouda G, Langleben A, et al: High dose tamoxifen in the treatment of recurrent high grade glioma: a report of clinical stabilization and tumour regression. Can J Neurol Sci 20:168-170, 1993
    • (1993) Can J Neurol Sci , vol.20 , pp. 168-170
    • Baltuch, G.1    Shenouda, G.2    Langleben, A.3
  • 5
    • 0027328566 scopus 로고
    • Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen
    • Baltuch GH, Couldwell WT, Villemure JG, et al: Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen. Neurosurgery 33:495-501, 1993
    • (1993) Neurosurgery , vol.33 , pp. 495-501
    • Baltuch, G.H.1    Couldwell, W.T.2    Villemure, J.G.3
  • 6
    • 0025047803 scopus 로고
    • Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia
    • Barry MA, Behnke CA, Eastman A: Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40:2353-2362, 1990
    • (1990) Biochem Pharmacol , vol.40 , pp. 2353-2362
    • Barry, M.A.1    Behnke, C.A.2    Eastman, A.3
  • 7
    • 0026628279 scopus 로고
    • Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1
    • Basu A, Lazo JS: Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1. Cancer Res 52:3119-3124, 1992
    • (1992) Cancer Res , vol.52 , pp. 3119-3124
    • Basu, A.1    Lazo, J.S.2
  • 8
    • 0026638357 scopus 로고
    • Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression
    • Benzil DL, Finkelstein SD, Epstein MH, et al: Expression pattern of α-protein kinase C in human astrocytomas indicates a role in malignant progression. Cancer Res 52:2951-2956, 1992
    • (1992) Cancer Res , vol.52 , pp. 2951-2956
    • Benzil, D.L.1    Finkelstein, S.D.2    Epstein, M.H.3
  • 9
    • 0027510002 scopus 로고
    • Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction
    • Bit RA, Davis PD, Elliott LH, et al: Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. J Med Chem 36:21-29, 1993
    • (1993) J Med Chem , vol.36 , pp. 21-29
    • Bit, R.A.1    Davis, P.D.2    Elliott, L.H.3
  • 10
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 12
    • 0019882480 scopus 로고
    • Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors
    • Chou TC, Talalay P: Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. Eur J Biochem 115:207-216, 1981
    • (1981) Eur J Biochem , vol.115 , pp. 207-216
    • Chou, T.C.1    Talalay, P.2
  • 13
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55, 1984
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 14
    • 0026746408 scopus 로고
    • Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C
    • Couldwell WT, Antel JP, Yong VW: Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery 31:717-724, 1992
    • (1992) Neurosurgery , vol.31 , pp. 717-724
    • Couldwell, W.T.1    Antel, J.P.2    Yong, V.W.3
  • 16
    • 0025790389 scopus 로고
    • Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro
    • Couldwell WT, Uhm JH, Antel JP, et al: Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. Neurosurgery 29:880-887, 1991
    • (1991) Neurosurgery , vol.29 , pp. 880-887
    • Couldwell, W.T.1    Uhm, J.H.2    Antel, J.P.3
  • 17
    • 0027469702 scopus 로고
    • Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen
    • Couldwell WT, Weiss MH, DeGiorgio CM, et al: Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. Neurosurgery 32:485-490, 1993
    • (1993) Neurosurgery , vol.32 , pp. 485-490
    • Couldwell, W.T.1    Weiss, M.H.2    DeGiorgio, C.M.3
  • 18
    • 0024828113 scopus 로고
    • Potent selective inhibitors of protein kinase C
    • Davis PD, Hill CH, Keech E, et al: Potent selective inhibitors of protein kinase C. FEBS Lett 259:61-63, 1989
    • (1989) FEBS Lett , vol.259 , pp. 61-63
    • Davis, P.D.1    Hill, C.H.2    Keech, E.3
  • 19
    • 0022519201 scopus 로고
    • A novel type of phorbol ester-dependent protein phosphorylation in the particulate fraction of mouse epidermis
    • Gschwendt M, Kittstein W, Marks F: A novel type of phorbol ester-dependent protein phosphorylation in the particulate fraction of mouse epidermis. Biochem Biophys Res Commun 137:766-774, 1986
    • (1986) Biochem Biophys Res Commun , vol.137 , pp. 766-774
    • Gschwendt, M.1    Kittstein, W.2    Marks, F.3
  • 20
    • 0028302712 scopus 로고
    • Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis
    • Haimovitz-Friedman A, Balaban N, McLoughlin M, et al: Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res 54:2591-2597, 1994
    • (1994) Cancer Res , vol.54 , pp. 2591-2597
    • Haimovitz-Friedman, A.1    Balaban, N.2    McLoughlin, M.3
  • 21
    • 0023760140 scopus 로고
    • Enhancement of the antiproliferative effect of cis-diamminedichloroplatinum (II) and nitrogen mustard by inhibitors of protein kinase C
    • Hofmann J, Doppler W, Jakob A, et al: Enhancement of the antiproliferative effect of cis-diamminedichloroplatinum (II) and nitrogen mustard by inhibitors of protein kinase C. Int J Cancer 42:382-388, 1988
    • (1988) Int J Cancer , vol.42 , pp. 382-388
    • Hofmann, J.1    Doppler, W.2    Jakob, A.3
  • 22
    • 0024504945 scopus 로고
    • Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C
    • Hofmann J, Ueberall F, Posch L. et al: Synergistic enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by the ether lipid analogue BM41440, an inhibitor of protein kinase C. Lipids 24:312-317, 1989
    • (1989) Lipids , vol.24 , pp. 312-317
    • Hofmann, J.1    Ueberall, F.2    Posch, L.3
  • 23
    • 0023555557 scopus 로고
    • Protein kinase C contains a pseudosubstrate prototype in its regulatory domain
    • House C, Kemp BE: Protein kinase C contains a pseudosubstrate prototype in its regulatory domain. Science 238: 1726-1728, 1987
    • (1987) Science , vol.238 , pp. 1726-1728
    • House, C.1    Kemp, B.E.2
  • 24
    • 0024379951 scopus 로고
    • A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity
    • Meyer T, Regenass U, Fabbro D, et al: A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer 43:851-856, 1989
    • (1989) Int J Cancer , vol.43 , pp. 851-856
    • Meyer, T.1    Regenass, U.2    Fabbro, D.3
  • 25
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-613, 1992
    • (1992) Science , vol.258 , pp. 607-613
    • Nishizuka, Y.1
  • 26
    • 0024565678 scopus 로고
    • Studies and prospectives of the protein kinase C family for cellular regulation
    • Nishizuka Y: Studies and prospectives of the protein kinase C family for cellular regulation. Cancer 63:1892-1903, 1989
    • (1989) Cancer , vol.63 , pp. 1892-1903
    • Nishizuka, Y.1
  • 27
    • 0025241160 scopus 로고
    • Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro
    • Pollack IF, Randall MS, Kristofik MP, et al: Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. Cancer Res 50:7134-7138, 1990
    • (1990) Cancer Res , vol.50 , pp. 7134-7138
    • Pollack, I.F.1    Randall, M.S.2    Kristofik, M.P.3
  • 28
    • 0025780988 scopus 로고
    • Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways
    • Pollack IF, Randall MS, Kristofik MP, et al: Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways. J Neurosurg 75:284-293, 1991
    • (1991) J Neurosurg , vol.75 , pp. 284-293
    • Pollack, I.F.1    Randall, M.S.2    Kristofik, M.P.3
  • 29
    • 0025360434 scopus 로고
    • Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways
    • Pollack IF, Randall MS, Kristofik MP, et al: Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways. J Neurosurg 73:98-105, 1990
    • (1990) J Neurosurg , vol.73 , pp. 98-105
    • Pollack, I.F.1    Randall, M.S.2    Kristofik, M.P.3
  • 31
    • 0026738945 scopus 로고
    • + antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3
    • + antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. J Biol Chem 267:9980-9987, 1992
    • (1992) J Biol Chem , vol.267 , pp. 9980-9987
    • Rajotte, D.1    Haddad, P.2    Haman, A.3
  • 32
    • 0024390830 scopus 로고
    • Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors
    • Reifenberger O, Deckert M, Wechsler W: Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. Acta Neuropathol 78: 166-175, 1989
    • (1989) Acta Neuropathol , vol.78 , pp. 166-175
    • Reifenberger, O.1    Deckert, M.2    Wechsler, W.3
  • 33
    • 0000215699 scopus 로고
    • Comparison of MTT, XTT, and a novel tetrazolium compound MTS for in vitro proliferation and chemosensitivity assays
    • Abstract
    • Riss TL, Moravec RA: Comparison of MTT, XTT, and a novel tetrazolium compound MTS for in vitro proliferation and chemosensitivity assays. Mol Biol Cell 3 (Suppl):184a. 1992 (Abstract)
    • (1992) Mol Biol Cell , vol.3 , Issue.SUPPL.
    • Riss, T.L.1    Moravec, R.A.2
  • 34
    • 0028306807 scopus 로고
    • Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue
    • Seynaeve CM, Kazanietz MG, Blumberg PM, et al: Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol 45:1207-1214, 1994
    • (1994) Mol Pharmacol , vol.45 , pp. 1207-1214
    • Seynaeve, C.M.1    Kazanietz, M.G.2    Blumberg, P.M.3
  • 35
    • 0027157590 scopus 로고
    • Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells
    • Seynaeve CM, Stetler-Stevenson M, Sehers S, et al: Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res 53: 2081-2086, 1993
    • (1993) Cancer Res , vol.53 , pp. 2081-2086
    • Seynaeve, C.M.1    Stetler-Stevenson, M.2    Sehers, S.3
  • 36
    • 0023552288 scopus 로고
    • UCN-01, a selective inhibitor of protein kinase C from streptomyces
    • Letter
    • Takahashi I, Kobayashi E, Asano K, et al: UCN-01, a selective inhibitor of protein kinase C from streptomyces. J Antibiot 40: 1782-1784, 1987 (Letter)
    • (1987) J Antibiot , vol.40 , pp. 1782-1784
    • Takahashi, I.1    Kobayashi, E.2    Asano, K.3
  • 37
    • 0024542411 scopus 로고
    • UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physio-chemical properties, structural determinations, and biological activities
    • Takahashi I, Saitoh Y, Yoshida M, et al: UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physio-chemical properties, structural determinations, and biological activities. J Antibiot 42:571-576, 1989
    • (1989) J Antibiot , vol.42 , pp. 571-576
    • Takahashi, I.1    Saitoh, Y.2    Yoshida, M.3
  • 38
    • 0025942866 scopus 로고
    • Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors
    • Todo T, Shitara N, Nakamura H, et al: Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors. Neurosurgery 29:399-404, 1991
    • (1991) Neurosurgery , vol.29 , pp. 399-404
    • Todo, T.1    Shitara, N.2    Nakamura, H.3
  • 39
    • 0343482373 scopus 로고
    • A dose-escalation study of tamoxifen therapy in patients with recurrent glioblastoma multiforme
    • Abstract
    • Vertosick FT Jr, Selker RG, Arena V: A dose-escalation study of tamoxifen therapy in patients with recurrent glioblastoma multiforme. J Neurosurg 80:385A, 1994 (Abstract)
    • (1994) J Neurosurg , vol.80
    • Vertosick Jr., F.T.1    Selker, R.G.2    Arena, V.3
  • 40
    • 0026672032 scopus 로고
    • The treatment of intracranial malignant gliomas using orally administered lamoxifen therapy: Preliminary results in a series of "failed" patients
    • Vertosick FT Jr, Selker RG, Pollack IF, et al: The treatment of intracranial malignant gliomas using orally administered lamoxifen therapy: preliminary results in a series of "failed" patients. Neurosurgery 30:897-903, 1992
    • (1992) Neurosurgery , vol.30 , pp. 897-903
    • Vertosick Jr., F.T.1    Selker, R.G.2    Pollack, I.F.3
  • 41
    • 0027248964 scopus 로고
    • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
    • Wilkinson SE, Parker PJ, Nixon JS: Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294:335-337, 1993
    • (1993) Biochem J , vol.294 , pp. 335-337
    • Wilkinson, S.E.1    Parker, P.J.2    Nixon, J.S.3
  • 42
    • 0025899138 scopus 로고
    • Programmed cell death: Apoptosis and oncogenesis
    • Williams GT: Programmed cell death: apoptosis and oncogenesis. Cell 65:1097-1098, 1991
    • (1991) Cell , vol.65 , pp. 1097-1098
    • Williams, G.T.1
  • 43
    • 0025062503 scopus 로고
    • A synthetic peptide substrate for selective assay of protein kinase C
    • Yasuda I, Kishimoto A, Tanaka S, et al: A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun 166:1220-1227, 1990
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 1220-1227
    • Yasuda, I.1    Kishimoto, A.2    Tanaka, S.3


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