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Volumn 18, Issue 4, 2000, Pages 904-914

Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY;

EID: 19244366949     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.2000.18.4.904     Document Type: Article
Times cited : (688)

References (41)
  • 1
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • Aaronson SA: Growth factors and cancer. Science 254:1146-1153, 1991
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaronson, S.A.1
  • 2
    • 0023082137 scopus 로고
    • Receptors for epidermal growth factor and other polypeptide mitogens
    • Carpenter G: Receptors for epidermal growth factor and other polypeptide mitogens. Annu Rev Biochem 56:881-914, 1987
    • (1987) Annu Rev Biochem , vol.56 , pp. 881-914
    • Carpenter, G.1
  • 3
    • 0025321157 scopus 로고
    • Epidermal growth factor
    • Carpenter G, Cohen S: Epidermal growth factor. J Biol Chem 265:7709-7712, 1990
    • (1990) J Biol Chem , vol.265 , pp. 7709-7712
    • Carpenter, G.1    Cohen, S.2
  • 4
    • 0024355092 scopus 로고
    • Autocrine interaction between TGF alpha and the EGF-receptor: Quantitative requirements for induction of the malignant phenotype
    • Di Marco E, Pierce JG, Fleming TP, et al: Autocrine interaction between TGF alpha and the EGF-receptor: Quantitative requirements for induction of the malignant phenotype. Oncogene 4:831-838, 1989
    • (1989) Oncogene , vol.4 , pp. 831-838
    • Di Marco, E.1    Pierce, J.G.2    Fleming, T.P.3
  • 5
    • 0026520472 scopus 로고
    • The physiology of transforming growth factor-alpha
    • Derynck R: The physiology of transforming growth factor-alpha. Adv Cancer Res 58:27-52, 1992
    • (1992) Adv Cancer Res , vol.58 , pp. 27-52
    • Derynck, R.1
  • 6
    • 0021958679 scopus 로고
    • Autocrine growth factors and cancer
    • Sporn MB, Todaro GJ: Autocrine growth factors and cancer. Nature 313:747-751, 1985
    • (1985) Nature , vol.313 , pp. 747-751
    • Sporn, M.B.1    Todaro, G.J.2
  • 7
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, et al: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232, 1995
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3
  • 8
    • 0027339486 scopus 로고
    • Immunotherapy of human tumor xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction
    • Modjtahedi H, Eccles S, Box G, et al: Immunotherapy of human tumor xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction. Br J Cancer 67:254-261, 1993
    • (1993) Br J Cancer , vol.67 , pp. 254-261
    • Modjtahedi, H.1    Eccles, S.2    Box, G.3
  • 9
    • 0021363327 scopus 로고
    • Inhibition of human tumor cells in athymic mice by anti-EGF receptor monoclonal antibodies
    • Masui H, Kawamoto T, Sato JD, et al: Inhibition of human tumor cells in athymic mice by anti-EGF receptor monoclonal antibodies. Cancer Res 44:1002-1007, 1984
    • (1984) Cancer Res , vol.44 , pp. 1002-1007
    • Masui, H.1    Kawamoto, T.2    Sato, J.D.3
  • 10
    • 0023279387 scopus 로고
    • Efficacy of antibodies to epidermal growth factor receptor: Immunologically mediated and effector cell-independent effects
    • Rodeck U, Herlyn M, Herlyn D, et al: Efficacy of antibodies to epidermal growth factor receptor: Immunologically mediated and effector cell-independent effects. Cancer Res 47:3692-3696, 1987
    • (1987) Cancer Res , vol.47 , pp. 3692-3696
    • Rodeck, U.1    Herlyn, M.2    Herlyn, D.3
  • 11
    • 0024261027 scopus 로고
    • Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
    • Aboud-Pirak E, Hurwitz E, Pirak ME, et al: Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 80:1605-1611, 1988
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1605-1611
    • Aboud-Pirak, E.1    Hurwitz, E.2    Pirak, M.E.3
  • 12
    • 0026075501 scopus 로고
    • Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site
    • Pellegrini R, Centis F, Martignone S, et al: Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site. Cancer Immunol Immunother 34:37-42, 1991
    • (1991) Cancer Immunol Immunother , vol.34 , pp. 37-42
    • Pellegrini, R.1    Centis, F.2    Martignone, S.3
  • 13
    • 0010233988 scopus 로고
    • Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
    • Kawamoto T, Sato JD, Le A, et al: Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci U S A 80:1337-1341, 1983
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 1337-1341
    • Kawamoto, T.1    Sato, J.D.2    Le, A.3
  • 14
    • 0021254542 scopus 로고
    • Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
    • Gill GN, Kawamoto T, Cochet C, et al: Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259: 7755-7760, 1984
    • (1984) J Biol Chem , vol.259 , pp. 7755-7760
    • Gill, G.N.1    Kawamoto, T.2    Cochet, C.3
  • 15
    • 0020933452 scopus 로고
    • Biological effect in vitro of monoclonal antibodies to human EGF receptors
    • Sato JD, Kawamoto T, Le AD, et al: Biological effect in vitro of monoclonal antibodies to human EGF receptors. Mol Biol Med 1:511-529, 1983
    • (1983) Mol Biol Med , vol.1 , pp. 511-529
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3
  • 16
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X, et al: Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 269:27595-27602, 1994
    • (1994) J Biol Chem , vol.269 , pp. 27595-27602
    • Fan, Z.1    Lu, Y.2    Wu, X.3
  • 17
    • 0002350734 scopus 로고
    • Antibodies to growth factors and receptors
    • DeVita VT, Hellman S, Rosenberg SA (eds): Philadelphia, PA, JB Lippincott
    • Mendelsohn J, Baselga J: Antibodies to growth factors and receptors, in DeVita VT, Hellman S, Rosenberg SA (eds): Biologic Therapy of Cancer (ed 2). Philadelphia, PA, JB Lippincott, 1995, pp 607-624
    • (1995) Biologic Therapy of Cancer (Ed 2) , pp. 607-624
    • Mendelsohn, J.1    Baselga, J.2
  • 18
    • 0029670014 scopus 로고    scopus 로고
    • Involvement of p27kip1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • Wu X, Rubin M, Fan Z, et al: Involvement of p27kip1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12:1397-1403, 1996
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3    Et, A.4
  • 19
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces g1 arrest in prostatic cancer cell line DU145
    • Peng D, Fan Z, Lu Y, et al: Anti-epidermal growth factor receptor monoclonal antibody C225 upregulates p27kip1 and induces g1 arrest in prostatic cancer cell line DU145. Cancer Res 56:366-3669, 1996
    • (1996) Cancer Res , vol.56 , pp. 366-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3
  • 20
    • 0030693984 scopus 로고    scopus 로고
    • Reciprocal changes in p27kip1 and p21cip1 in growth inhibition mediated by blockade or overexpression of epidermal growth factor receptors
    • Fan Z, Shang BY, Lu Y, et al: Reciprocal changes in p27kip1 and p21cip1 in growth inhibition mediated by blockade or overexpression of epidermal growth factor receptors. Clin Cancer Res 3:1943-1948, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 1943-1948
    • Fan, Z.1    Shang, B.Y.2    Lu, Y.3
  • 21
    • 0027428571 scopus 로고
    • Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cisdiamminedichloroplatinum on well established A431 cell xenografts
    • Fan Z, Baselga J, Masui H, et al: Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cisdiamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 53:4637-4642, 1993
    • (1993) Cancer Res , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3
  • 22
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga J, Norton L, Masui H, et al: Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 85:1327-1333, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1327-1333
    • Baselga, J.1    Norton, L.2    Masui, H.3
  • 23
    • 0001687355 scopus 로고
    • Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts
    • abstr
    • Baselga J, Norton L, Coplan K, et al: Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts. Proc Am Assoc Cancer Res 35:2262, 1994 (abstr)
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 2262
    • Baselga, J.1    Norton, L.2    Coplan, K.3
  • 24
    • 0026426157 scopus 로고
    • Phase I and imaging trial of indium-111 labeled anti-EGF receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma
    • Divgi C, Welt C, Kris M, et al: Phase I and imaging trial of indium-111 labeled anti-EGF receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma. J Natl Cancer Inst 83:97-104, 1991
    • (1991) J Natl Cancer Inst , vol.83 , pp. 97-104
    • Divgi, C.1    Welt, C.2    Kris, M.3
  • 25
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, et al: Biological efficacy of a chimeric antibody to the epidermal growth factor in a human tumor xenograft model. Clin Cancer Res 1:1311-1418, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 1311-1418
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3
  • 26
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • Rusch V, Baselga J, Cordon-Cardo C, et al: Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 53:2379-2385, 1993
    • (1993) Cancer Res , vol.53 , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3
  • 27
    • 0028090093 scopus 로고
    • Expression of transforming growth factor-alpha and the epidermal growth factor receptor in human prostate tissues
    • Cohen DW, Simak R, Fair WR, et al: Expression of transforming growth factor-alpha and the epidermal growth factor receptor in human prostate tissues. J Urol 152:2120-2124, 1994
    • (1994) J Urol , vol.152 , pp. 2120-2124
    • Cohen, D.W.1    Simak, R.2    Fair, W.R.3
  • 28
    • 0024513888 scopus 로고
    • Quantitation of mouse monoclonal antibody and human anti-mouse antibody response in serum of patients
    • Khazaeli MB: Quantitation of mouse monoclonal antibody and human anti-mouse antibody response in serum of patients. Hybridoma 8:231-239, 1989
    • (1989) Hybridoma , vol.8 , pp. 231-239
    • Khazaeli, M.B.1
  • 29
    • 0024561212 scopus 로고
    • Quantitative assay of a human monoclonal IgM antibody (HA-1A) in human serum
    • Khazaeli MB, Rogers KJ, LoBuglio AF: Quantitative assay of a human monoclonal IgM antibody (HA-1A) in human serum. J Immunol Methods 117:175-180, 1989
    • (1989) J Immunol Methods , vol.117 , pp. 175-180
    • Khazaeli, M.B.1    Rogers, K.J.2    LoBuglio, A.F.3
  • 30
    • 0027818836 scopus 로고
    • Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies
    • Fan Z, Masui H, Altas I, et al: Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 53:4322-4328, 1993
    • (1993) Cancer Res , vol.53 , pp. 4322-4328
    • Fan, Z.1    Masui, H.2    Altas, I.3
  • 31
    • 0001740170 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor: Studies in head and neck tumors and tumor cell lines after exposure to ligand and receptor tyrosine-kinase inhibitors
    • abstr 2392
    • Baselga J, Cañadas MA, Codony J, et al: Activated epidermal growth factor receptor: Studies in head and neck tumors and tumor cell lines after exposure to ligand and receptor tyrosine-kinase inhibitors. Proc Am Soc Clin Oncol 18:619a, 1999 (abstr 2392)
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Baselga, J.1    Cañadas, M.A.2    Codony, J.3
  • 32
    • 0001680408 scopus 로고    scopus 로고
    • A phase i study of chimerized anti-epidermal growth factor receptor (EGFr) monoclonal antibody, C225, in combination with cisplatin (CDDP) in patients (PTS) with recurrent head and neck squamous cell carcinoma (SCC)
    • abstr 1502
    • Mendelsohn J, Shin DM, Donato N, et al: A phase I study of chimerized anti-epidermal growth factor receptor (EGFr) monoclonal antibody, C225, in combination with cisplatin (CDDP) in patients (PTS) with recurrent head and neck squamous cell carcinoma (SCC). Proc Am Soc Clin Oncol 18:389a, 1999 (abstr 1502)
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Mendelsohn, J.1    Shin, D.M.2    Donato, N.3
  • 33
    • 0028208423 scopus 로고
    • Tumor epidermal growth factor receptor studies in patients with non-small-cell lung cancer or head and neck cancer treated with monoclonal antibody rg 83852
    • published erratum appears in J Clin Oncol 12:1526, 1994
    • Perez-Soler R, Donato NJ, Shin DM, et al: Tumor epidermal growth factor receptor studies in patients with non-small-cell lung cancer or head and neck cancer treated with monoclonal antibody RG 83852. J Clin Oncol 12:730-739, 1994 (published erratum appears in J Clin Oncol 12:1526, 1994)
    • (1994) J Clin Oncol , vol.12 , pp. 730-739
    • Perez-Soler, R.1    Donato, N.J.2    Shin, D.M.3
  • 34
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and erbb-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al: Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523-1530, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 35
    • 0343205079 scopus 로고    scopus 로고
    • Chimeric Monoclonal antibody (Mab) C225 to the Epidermal Growth Factor Receptor (EGF-R) antibody inhibits angiogenesis in human transitional cell carcinoma (TCC)
    • abstr
    • Perrotte P, Matsumoto T, Inoue K, et al: Chimeric monoclonal antibody (Mab) C225 to the epidermal growth factor receptor (EGF-R) antibody inhibits angiogenesis in human transitional cell carcinoma (TCC). Proc Am Assoc Cancer Res 39:316, 1998 (abstr)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 316
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 36
    • 0031409362 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy
    • Mendelsohn J: Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy. Clin Cancer Res 3:2703-2707, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 2703-2707
    • Mendelsohn, J.1
  • 37
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with patients with HER2/neu-overexpressing metastatic breast cancer
    • Baselga J, Tripathy D, Mendelsohn J, et al: Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 14:737-744, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 38
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF, et al: Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 16:2659-2671, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3
  • 39
    • 0000405942 scopus 로고    scopus 로고
    • Addition of herceptin[tm] (humanized anti-HER2 antibody) to first line chemotherapy for HER2 overexpressing metastatic breast cancer (HER2+/MBC) markedly increases anticancer activity: A randomized, multinational, controlled phase III trial
    • abstr
    • Slamon D, Leyland-Jones B, Shak S, et al: Addition of Herceptin[tm] (humanized anti-HER2 antibody) to first line chemotherapy for HER2 overexpressing metastatic breast cancer (HER2+/MBC) markedly increases anticancer activity: A randomized, multinational, controlled phase III trial. Proc Am Soc Clin Oncol 17:377, 1998 (abstr)
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 377
    • Slamon, D.1    Leyland-Jones, B.2    Shak, S.3
  • 40
    • 0028200221 scopus 로고
    • Antibody to HER-2/ neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
    • Pietras RJ, Fendly BM, Chazin VR, et al: Antibody to HER-2/ neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogcne 9:1829-1838, 1994
    • (1994) Oncogcne , vol.9 , pp. 1829-1838
    • Pietras, R.J.1    Fendly, B.M.2    Chazin, V.R.3
  • 41
    • 0028167813 scopus 로고
    • P185c-erbB-2 signaling enhances cisplatin-induced cytotoxicity in human breast carcinoma cells: Association between an oncogenic receptor tyrosine kinase and drug-induced DNA repair
    • Arteaga CL, Winnier AR, Poirier MC, et al: p185c-erbB-2 signaling enhances cisplatin-induced cytotoxicity in human breast carcinoma cells: Association between an oncogenic receptor tyrosine kinase and drug-induced DNA repair. Cancer Res 54:3758-3765, 1994
    • (1994) Cancer Res , vol.54 , pp. 3758-3765
    • Arteaga, C.L.1    Winnier, A.R.2    Poirier, M.C.3


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