Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells

Cancer Research

Volumn 59, Issue 6, 1999, Pages 1362-1365

  Yount, Garret L ^a,b,c   Levine, Kiera S ^a   Kuriyama, Hiroko ^a   Haas Kogan, Daphne A ^a,c   Israel, Mark A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FAS ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN P53;

ARTICLE; CANCER RADIOTHERAPY; CELL DEATH; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; X IRRADIATION;

ANTIBODIES; ANTIGENS, CD95; APOPTOSIS; BRAIN NEOPLASMS; CERAMIDES; GLIOMA; HUMANS; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0033559206     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Levine, V. A., Gutin, P. H., and Leibel, S. Neoplasms of the central nervous system. In: V. T. DeVita, Jr. and S. A. Rosenberg (eds.), Cancer Principles and Practice of Oncology, pp. 1679-1737. Philadelphia: Lippincott, 1993.
2. Taghian, A., Suit, H., Pardo, F., Gioioso, D., Tomkinson, K., DuBois, W., and Gerweck, L. In vitro intrinsic radiation sensitivity of glioblastoma multiforme. Int. J. Radiat. Oncol. Biol. Phys., 23: 55-62, 1992.
3. Leibel, S. A., and Sheline, G. E., Radiation therapy for neoplasms of the brain. J. Neurosurg., 66: 1-22, 1987.
4. Wyllie, A. H. Apoplosis and carcinogenesis. Eur. J. Cell Biol., 73: 189-197, 1997.
5. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
6. Michael, J. M., Lavin, M. F., and Watters, D. J. Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Res., 57: 3600-3605, 1997.
7. Chmura, S. J., Nodzenski, E., Beckett, M. A., Kufe, D. W., Quintans, J., and Weichselbaum, R. R. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res., 57: 1270-1275, 1997.
8. Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K-M. Activation of CD95 (APO-I/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J., 16: 6200-6208, 1997.
9. Haas-Kogan, D. A., Dazin, P., Hu, L., Deen, D. F., and Israel, M. A. p53-independent apoptosis: a mechanism of radiation-induced cell death of glioblastoma cells. Cancer J. Sci. Am., 2: 114-122, 1996.
10. Gjerset, R. A., Turla, S. T., Sobol, R. E., Scalise, J. J., Mecola, D., Collins, H., and Hopkins, P. J. Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53. Mol. Carcinog., 14: 275-285, 1995.
11. Yount, G. L., Haas-Kogan, D. H., Vidair, C. A., Haas, M., Dewey, W. C., and Israel, M. A. Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res., 56: 500-506, 1996.
12. Weller, M., Malipiero, U., Rensing-Ehl, A., Barr, P. J., and Fontana, A. Fas/APO-I gene transfer for human malignant glioma. Cancer Res., 55: 2936-2944, 1995.
13. Chen, P., Iavarone, A., Fick, J., Edwards, M., Prados, M., and Israel, M. A. Constitutional p53 mutations associated with brain tumors in young adults. Cancer Genet. Cytogenet., 82: 106-115, 1995.
14. Nagata, S., and Golstein, P. The Fas death factor. Science (Washington DC), 267: 1449-1456, 1995.
15. Yarnold, J. Molecular aspects of cellular response to radiotherapy. Radiother. Oncol., 44: 1-7, 1997.
16. Haimovitz-Friedman, A., Kan, C. C., Ehleiter, D., Persaud, R. S., McLoughlin, M., Fuks, Z., and Kolesnick, R. N. Ionizing radiation acts on cellular membranes to generate and initiate apoptosis. J. Exp. Med., 180: 525-535, 1994.
17. Uckun, F. M., Waddick, K. G., Majahan, S., Jun, X., Takata, M., Bolen, J., and Kurosaki, T. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science (Washington DC), 273: 1096-1110, 1996.
18. Mizushima, N., Koike, R., Kohsaka, H., Kushi, Y., Handa, S., Yagita, H., and Miyasaka, N. Ceramide induces apoptosis via CPP32 activation. FEBS Lett., 395: 267-271, 1996.
19. Tachibana, O., Lampe, J., Kleihues, P., and Ohgaki, H. Preferential expression of Fas/AP01 (CD95) and apoptotic cell death in perinecrotic cells of glioblastoma multiforme. Acta Neuropathol., 92: 431-434, 1996.
20. Fisher, D. E. Apoptosis in cancer therapy: crossing the threshold. Cell. 78: 539-542, 1994.