Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

Oncogene

Volumn 22, Issue 18, 2003, Pages 2812-2822

  Bianco, Roberto ^a   Shin, Incheol ^a   Ritter, Christoph A ^a   Yakes, F Michael ^a   Basso, Andrea ^b   Rosen, Neal ^b   Tsurutani, Junji ^c   Dennis, Phillip A ^c   Mills, Gordon B ^d   Arteaga, Carlos L ^a,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Akt; Epidermal growth factor receptor; PTEN; Tyrosine kinase inhibitors; ZD1839

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BIOLOGICAL FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLECKSTRIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; TERCEVA; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL CYCLE; CELL GROWTH; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG EFFECT; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BLOCKING; RETROVIRUS INFECTION; SIGNAL TRANSDUCTION; TUMOR CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; ENZYME INHIBITORS; GENE DELETION; HUMANS; LUNG NEOPLASMS; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

UNIDENTIFIED RETROVIRUS;

EID: 0037616593     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206388     Document Type: Article

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