Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa)

Clinical Cancer Research

Volumn 8, Issue 11, 2002, Pages 3496-3502

  Heimberger, Amy B ^a   Learn, Chris A ^a   Archer, Gary E ^a   McLendon, Roger E ^a   Chewning, Tracy A ^a   Tuck, Frank L ^a   Pracyk, John B ^a   Friedman, Allan H ^a   Friedman, Henry S ^a   Bigner, Darell D ^a   Sampson, John H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER GRAFT; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CULTURE; CELL STRAIN 3T3; DRUG ANTAGONISM; FLOW CYTOMETRY; METABOLISM; NUCLEOTIDE SEQUENCE; ORAL DRUG ADMINISTRATION; PHOSPHORYLATION; TIME; WESTERN BLOTTING;

3T3 CELLS; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BRAIN NEOPLASMS; DNA MUTATIONAL ANALYSIS; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0036848833     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

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