Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 4, 2001, Pages 1151-1161

  Yigit, H ^a   Queenan, A M ^a   Anderson, G J ^a   Domenech Sanchez, A ^a   Biddle, J W ^a   Steward, C D ^a   Alberti, S ^a   Bush, K ^a   Tenover, F C ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZTREONAM; BETA LACTAMASE; CARBAPENEM; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; IMIPENEM; MEROPENEM; MONOBACTAM DERIVATIVE; PENICILLIN DERIVATIVE; PROTEIN KPC 1; PROTEIN SME 1; TAZOBACTAM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CONJUGATION; DNA SEQUENCE; DRUG BINDING; DRUG HYDROLYSIS; ENZYME ACTIVITY; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL OUTER MEMBRANE PROTEINS; BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CLONING, MOLECULAR; ESCHERICHIA COLI; IMIPENEM; KINETICS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THIENAMYCINS; TRANSFORMATION, BACTERIAL;

EID: 0035084032     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.4.1151-1161.2001     Document Type: Article

References (71)

1. A standard numbering scheme for the class A β-lactamases
2. Close evolutionary relationship between the chromosomally encoded β-lactamase gene of Klebsiella pneumoniae and the TEM β-lactamase gene mediated by R plasmids
3. A novel integron-like element carrying the metallo-β-lactamase gene blaIMP
4. Antimicrobial resistance in isolates from inpatients and outpatients in the United States: Increasing importance of the intensive care unit
5. Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems
6. Sequences of β-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other β-lactamases
7. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC β-lactamase, and the loss of an outer membrane protein
8. A functional classification scheme for β-lactamases and its correlation with molecular structure
9. Prevalence of outer membrane porin alteration in β-lactam-antibiotic-resistant Enterobacter aerogenes
10. Imipenem resistance associated with the loss of a 40-kDa outer membrane protein in Enterobacter aerogenes
11. Diffusion of meropenem and imipenem through the outer membrane of Escherichia coli K-12 and correlation with their antibacterial activities
12. Phylogeny of LCR-1 and OXA-5 with class A and class-D β-lactamases
13. Clinical and bacteriological study of nosocomial infections due to Enterobacter aerogenes resistant to imipenem
14. Identification and characterization of a new porin gene of Klebsiella pneumoniae: Its role in β-lactam antibiotic resistance
15. Mechanisms responsible for reduced susceptibility to imipenem in Bacteroides fragilis
16. Emergence of resistance to imipenem in Enterobacter isolates masquerading as Klebsiella pneumoniae during therapy with imipenem/cilastatin
17. Enterobacteriaceae: Introduction and identification
18. Strength and regulation of the different promoters for chromosomal β-lactamases of Klebsiella oxytoca
19. oxy-2
20. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: Project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals
21. Resistance to carbapenems
22. Porin expression in clinical isolates of Klebsiella pneumoniae
23. Enhanced resistance to cefotaxime and imipenem associated with outer membrane protein alterations in Enterobacter aerogenes
24. Sequence of the PSE-1 β-lactamase gene
25. The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family
26. Comparison of the sequences of class A β-lactamases and of the secondary structure elements of penicillin-recognizing proteins
27. CARB-3 gene encoding the carbenicillinase-3 β-lactamase of Pseudomonas aeruginosa
28. Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem
29. Mechanisms of resistance to β-lactam antibiotics
30. Bacterial resistance to carbapenems
31. Identification of a ROB-1 β-lactamase in Haemophilus ducreyi
32. Carbapenem resistance in a clinical isolate of Citrobacter freundii
33. A kinetic study of Nmc-A β-lactamase, an Ambler class A carbapenemase also hydrolyzing cephamycins
34. Roles of β-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae
35. Kinship and diversification of bacterial penicillin-binding proteins and β-lactamases
36. Structural and mechanistic aspects of evolution of β-lactamases and penicillin-binding proteins
37. Identification of β-lactamases by analytical isoelectric focusing: Correlation with bacterial taxonomy
38. Detection of Tn917-like sequences within a Tn916-like conjugative transposon (Tn3872) in erythromycin-resistant isolates of Streptococcus pneumoniae
39. Cloning of SHV-2, OHIO-1, and OXA-6 β-lactamases and cloning and sequencing of SHV-1 β-lactamase
40. Characterization of a LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing β-lactamase Sme-1, and comparison of this regulator with other β-lactamase regulators
41. Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A β-lactamase, Sme-1, from Serratia marcescens S6
42. Analysis of a carbapenem-hydrolyzing class A β-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein
43. Biochemical properties of a carbapenem-hydrolyzing β-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli
44. Trends in β-lactam resistance among Enterobacteriaceae
45. Molecular characterization of an enterobacterial metallo-β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance
46. Precise insertion of antibiotic resistance determinants into Tn21-like transposons: Nucleotide sequence of the OXA-1 β-lactamase gene
47. Cloning and nucleotide sequencing of the gene encoding the β-lactamase from Citrobacter diversus
48. Role of primary structure and disulfide bond formation in β-lactamase secretion
49. Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins
50. In-vitro selection of porin-deficient mutants of two strains of Klebsiella pneumoniae with reduced susceptibilities to meropenem, but not to imipenem
51. Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins
52. A disulfide bridge near the active site of carbapenem-hydrolyzing class A β-lactamases might explain their unusual substrate profile
53. Evolution of extended-spectrum β-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia
54. Characterization of IMI-1 β-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae
55. Carbapenem-hydrolyzing β-lactamases
56. Regulatory sequences involved in the promotion and termination of RNA transcription
57. Nucleotide sequence of a new class A β-lactamase gene from the chromosome of Yersinia enterocolitica: Implications for the evolution of class A β-lactamases
58. Determinant of cistron specificity in bacterial ribosomes
59. Role of ser-237 in the substrate specificity of the carbapenem-hydrolyzing class A β-lactamase Sme-1
60. Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 β-lactamase production and loss of an outer membrane protein
61. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322
62. X-ray analysis of the Nmc-A β-lactamase at 1.64-Å resolution, a class A carbapenemase with broad substrate specificity
63. The classification and terminology, of enzymes that hydrolyze β-lactam antibiotics
64. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria
65. Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus β-lactamase II
66. Permeability to carbapenems of Proteus mirabilis mutants selected for resistance to imipenem or other β-lactams
67. Sequence analysis and enzyme kinetics of the L2 serine β-lactamase from Stenotrophomonas maltophilia