Identification of residues critical for metallo-β-lactamase function by codon randomization and selection

Protein Science

Volumn 10, Issue 12, 2001, Pages 2556-2565

  Materon, Isabel C ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Lactam antibiotics; Antibiotic resistance; Carbapenems; Metallo lactamases; Randomization mutagenesis; Structure function

Indexed keywords

AMINO ACID; AMPICILLIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEFALORIDINE; CEFOTAXIME; METAL COMPLEX; NITROCEFIN; PENICILLIN G; ZINC COMPLEX;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CODON; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE LIBRARY; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; AMINO ACIDS; ASPARTIC ACID; BETA-LACTAMASES; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; CODON; DNA; ESCHERICHIA COLI; GENE LIBRARY; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; ZINC;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0035190707     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.ps.40884     Document Type: Article

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