Thiols as classical and slow-binding inhibitors of IMP-1 and other binuclear metallo-β-lactamases

Biochemistry

Volumn 42, Issue 6, 2003, Pages 1673-1683

  Siemann, Stefan ^a   Clarke, Anthony J ^b   Viswanatha, Thammaiah ^a   Dmitrienko, Gary I ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CURVE FITTING; ENZYME INHIBITION; HYDROLYSIS; ISOMERIZATION; PH EFFECTS; PROTEINS; REACTION KINETICS; SUBSTRATES;

SLOW-BINDING INHIBITORS;

BIOCHEMISTRY;

1,2 ETHANEDITHIOL; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; DELTA (ALPHA AMINOADIPOYL) CYSTEINYLVALINE; DITHIOL DERIVATIVE; ENZYME INHIBITOR; IMP1 INHIBITOR; INOSINE PHOSPHATE; METALLO BETA LACTAMASE INHIBITOR; NITROCEFIN; PROTEIN IMP1; SUCCIMER; SUCCINIC ACID DERIVATIVE; THIOGLYCOLIC ACID DERIVATIVE; THIOGLYCOLIC ACID METHYL ESTER; THIOL DERIVATIVE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BACILLUS CEREUS; BACTEROIDES FRAGILIS; BINDING AFFINITY; CATALYSIS; CHEMICAL BINDING; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; INHIBITION KINETICS; ISOMERISM; MATHEMATICAL COMPUTING; MOLECULAR INTERACTION; MOLECULAR MIMICRY; NONHUMAN; PH; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN STRUCTURE; PROTON TRANSPORT; PSEUDOMONAS AERUGINOSA; STANDARD; STRUCTURE ACTIVITY RELATION; TIME;

BACILLUS CEREUS; BACTERIAL PROTEINS; BETA-LACTAMASES; BINDING, COMPETITIVE; CATALYSIS; CEPHALOSPORINS; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INHIBITORY CONCENTRATION 50; KINETICS; METALLOPROTEINS; PSEUDOMONAS AERUGINOSA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY; SULFHYDRYL COMPOUNDS;

BACILLUS CEREUS; BACTEROIDES; BACTEROIDES FRAGILIS; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 12244297122     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027072i     Document Type: Article

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