Modeling domino effects in enzymes: Molecular basis of the substrate specificity of the bacterial metallo-β-lactamases IMP-1 and IMP-6

Biochemistry

Volumn 42, Issue 30, 2003, Pages 8945-8956

  Oelschlaeger, Peter ^a,b   Schmid, Rolf D ^a   Pleiss, Juergen ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMICAL ENGINEERING; CATALYST ACTIVITY; COMPUTER SIMULATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS;

METALLOENZYMES;

ENZYME KINETICS;

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFALORIDINE; CEFALOTIN; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORIN; GLYCINE; LYSINE; PROTEIN IMP 1; PROTEIN IMP 6; SERINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CATALYSIS; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SIMULATION; TEMPERATURE DEPENDENCE;

AMINO ACID SUBSTITUTION; BETA-LACTAMASES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ENZYME STABILITY; GLYCINE; HEAT; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PSEUDOMONAS AERUGINOSA; SERINE; SUBSTRATE SPECIFICITY; TEMPERATURE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0042666843     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0300332     Document Type: Article

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