Primate-accelerated evolutionary genes: Novel routes to drug discovery in psychiatric disorders

Current Medicinal Chemistry

Volumn 17, Issue 13, 2010, Pages 1300-1316

  Moalic, J M ^a   Le Strat, Y ^a   Lepagnol Bestel, A M ^a   Ramoz, N ^a   Loe Mie, Y ^a   Maussion, G ^a   Gorwood, P ^a,b   Simonneau, M ^a  

^a INSERM   (France)

^b CENTRE HOSPITALIER SAINTE ANNE   (France)

Author keywords

Alcoholism; Autism; Drugable targets; Positive selection; Primate accelerated evolution; Psychiatric diseases; Schizophrenia; Synaptic transmission

Indexed keywords

ADRENALIN; BIOGENIC AMINE; CADHERIN; DOPAMINE; HISTAMINE; MICRORNA; NORADRENALIN; PROTOCADHERIN; SEROTONIN; UNCLASSIFIED DRUG;

ALCOHOLISM; AUTISM; BRAIN DEVELOPMENT; CELL LINEAGE; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG SYNTHESIS; EVOLUTION; GABRB2 GENE; GENE; GENE IDENTIFICATION; GENETIC POLYMORPHISM; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; MARK 1 GENE; MENTAL DISEASE; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; NONHUMAN; PRIMATE; REVIEW; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTIPSYCHOTIC AGENTS; DRUG DISCOVERY; EVOLUTION, MOLECULAR; HUMANS; NEUROPHYSINS; PRIMATES; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; PSYCHOTIC DISORDERS; RECEPTORS, DOPAMINE D4; RECEPTORS, GABA-A; RNA INTERFERENCE; VASOPRESSINS;

EID: 77950676975     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790936338     Document Type: Review

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