Genetics: DISC1 and PDE4B are interacting genetic factors in schizoprenia that regulate cAMP signaling

Science

Volumn 310, Issue 5751, 2005, Pages 1187-1191

  Millar, J Kirsty ^a   Pickard, Benjamin S ^a   Mackie, Shaun ^a   James, Rachel ^a   Christie, Sheila ^a   Buchanan, Sebastienne R ^a   Malloy, M Pat ^a   Chubb, Jennifer E ^a   Huston, Elaine ^b   Baillie, George S ^b   Thomson, Pippa A ^a   Hill, Elaine V ^b   Brandon, Nicholas J ^c   Rain, Jean Christophe ^d   Camargo, L Miguel ^c   Whiting, Paul J ^c   Houslay, Miles D ^b   Blackwood, Douglas H R ^a   Muir, Walter J ^a   Porteous, David J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^d Hybrigenics SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASES; MATHEMATICAL MODELS;

PHOSPHODIESTERASE 4B (PDE4B); SCHIZOPHRENIA; THE DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) GENE;

GENES;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE IV; UNCLASSIFIED DRUG; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CADHERIN; CDH8 PROTEIN, HUMAN; DISC1 PROTEIN, HUMAN; NERVE PROTEIN;

GENETICS;

ARTICLE; DISC1 GENE; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE; GENETIC LINKAGE; GENETIC PREDISPOSITION; HIPPOCAMPUS; HUMAN; HUMAN CELL; MEMORY; MENTAL DISEASE; MOOD; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SECOND MESSENGER; SIGNAL TRANSDUCTION; ADULT; AFFECTIVE PSYCHOSIS; ANIMAL; CELL LINE; CHROMOSOME 1; CHROMOSOME 16; ENZYME ACTIVATION; ENZYMOLOGY; GENE TRANSLOCATION; GENETICS; MALE; METABOLISM; PROTEIN BINDING; RAT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADULT; AFFECTIVE DISORDERS, PSYCHOTIC; ANIMALS; CADHERINS; CELL LINE; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 16; CYCLIC AMP; ENZYME ACTIVATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; NERVE TISSUE PROTEINS; PROTEIN BINDING; RATS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; TRANSLOCATION, GENETIC;

EID: 27944502874     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1112915     Document Type: Article

References (22)

1. P. J. Harrison, D. R. Weinberger, Mol. Psychiatry 10, 40 (2005).
2. J. K. Millar et al., Hum. Mol. Genet. 9, 1415 (2000).
3. D. H. Blackwood et al., Am. J. Hum. Genet. 69, 428 (2001).
4. P. A. Thomson et al., Mol. Psychiatry 10, 616 (2005).
5. L. Ma et al., Genomics 80, 662 (2002).
6. C. P. Austin, L. Ma, B. Ky, J. A. Morris, P. J. Shugrue, Neuroreport 14, 951 (2003).
7. R. James et al., Mol. Cell. Neurosci. 26, 112 (2004).
8. K. Miyoshi et al., Mol. Psychiatry 8, 685 (2003).
9. N. J. Brandon et al., Mol. Cell. Neurosci. 25, 42 (2004).
10. M. A. Hayashi et al., Proc. Natl. Acad. Sci. U.S.A. 102, 3828 (2005).
11. Materials and methods are available as supporting material on Science Online.
12. A. L. Bauman, A. S. Coehring, J. D. Scott, Neuropharmacology 46, 299 (2004).
13. R. L. Davis, J. Cherry, B. Dauwalder, P. L. Han, E. Skoulakis, Mol. Cell. Biochem. 149, 271 (1995).
14. R. Lamprecht, Cell. Mol. Life Sci. 55, 554 (1999).
15. H. T. Zhang et al., Neuropsychopharmacology 27, 587 (2002).
16. J. M. O'Donnell, H. T. Zhang, Trends Pharmacol. Sci. 25, 158 (2004).
17. M. D. Houslay, D. R. Adams, Biochem. J. 370, 1 (2003).
18. S. J. MacKenzie et al., Br. J. Pharmacol. 136, 421 (2002).
19. C. Sette, M. Conti, J. Biol. Chem. 271, 16526 (1996).
20. M. B. Beard et al., J. Biol. Chem. 275, 10349 (2000).
21. A. McCahill et al., Cell. Signal. 17, 1158 (2005).
22. This study was approved by the appropriate local research ethics committee. We thank M. Lai for help with the primary neuronal cultures and S. Cooper for assistance with figure production. Supported by a collaborative research agreement between Merck and Co. and the University of Edinburgh (D.J.P., D.H.R.B, W.J.M., J.K.M., B.S.P.), the Medical Research Council UK (G0100266 to D.J.P., D.H.R.B, W.J.M., G8604010 to M.D.H.) the Stanley Medical Research Institute (01-093 to J.K.M), the Scottish Hospital Endowment Research Trust (RG45/01 to B.S.P. and RG51/01 to J.K.M.), the Wellcome Trust (069300/Z/02/A to J.E.C., J.K.M. and 066717 to D.J.P., D.H.R.B., W.J.M., and others), the Chief Scientist Office of the Scottish Executive (K/MRS/50/ C2789 to D.H.R.B, W.J.M., D.J.P.). W.J.M. was an MRC Clinician Scientist for part of this work.