SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects

Molecular Psychiatry

Volumn 13, Issue 4, 2008, Pages 385-397

  Lepagnol Bestel, A M ^a   Maussion, G ^a   Boda, B ^b   Cardona, A ^c   Iwayama, Y ^d   Delezoide, A L ^e   Moalic, J M ^a   Muller, D ^b   Dean, B ^f   Yoshikawa, T ^d,g   Gorwood, P ^a   Buxbaum, J D ^h   Ramoz, N ^a   Simonneau, M ^a  

^a INSERM   (France)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c INSTITUT PASTEUR   (France)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^e HÔPITAL ROBERT DEBRÉ   (France)

^f FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cortical parcellation; Dendrite length; Expression pattern; Fetal brain; Gene overexpression; Human embryo; In situ hybridization; SLC25A12

Indexed keywords

CARRIER PROTEIN; PROTEIN; PROTEIN AUTS2; PROTEIN KINASE C BETA; PROTEIN SLC25A12; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTISM; AUTOPSY; BIPOLAR DISORDER; BRAIN CELL; CELL MIGRATION; CEREBELLUM; CONTROLLED STUDY; DENDRITE; FETUS; FRONTAL CORTEX; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GRANULE CELL; HUMAN; HUMAN TISSUE; INTERNEURON; MEDIAN EMINENCE; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; TELENCEPHALON; TEMPORAL CORTEX; UPREGULATION;

EID: 40849142338     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4002120     Document Type: Article

References (63)

1. Kanner L. Autistic disturbances of affective contact. Nerv Child 1943; 2: 217-250.
2. Volkmar FR, Pauls D. Autism. Lancet 2003; 362: 1133-1141.
3. Tuchman R, Rapin I. Epilepsy in autism. Lancet Neurol 2002; 1: 352-358.
4. Veenstra-VanderWeele J, Cook Jr EH. Molecular genetics of autism spectrum disorder. Mol Psychiatry 2004; 9: 819-832.
5. Ramoz N, Reichert JG, Smith CJ, Silverman JM, Bespalova IN, Davis KL et al. Related linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Am J Psychiatry 2004; 161: 662-669.
6. Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ, et al., International Molecular Genetic Study of Autism Consortium (IMGSAC). SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. Eur J Hum Genet 2006; 14: 123-126.
7. Segurado R, Conroy J, Meally E, Fitzgerald M, Gill M, Gallagher L. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am J Psychiatry 2005; 162: 2182-2184.
8. Rabionet R, McCauley JL, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS et al. Lack of association between autism and SLC25A12. Am J Psychiatry 2006; 163: 929-931.
9. Turunen J, Tero Ylisaukko-oja T, Kilpine H, Rehnström K, Kempas E, Vanhala R et al. Association Analysis of SLC25A12 and EN2 in the Finnish Families with Autism-Spectrum Disorders. WCPG: Cagliari, Italy, 2006, abstracts.
10. del Arco A, Satrustegui J. Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain. J Biol Chem 1998; 273: 23327-23334.
11. Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 2001; 21: 1133-1145.
12. Elston GN. Pyramidal cells of the frontal lobe: all the more spinous to think with. J Neurosci 2000; 20: RC95.
13. Elston GN. Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function. Cereb Cortex 2003; 13: 1124-1138.
14. Sherwood CC, Stimpson CD, Raghanti MA, Wildman DE, Uddin M, Grossman LI et al. Evolution of increased glia-neuron ratios in the human frontal cortex. Proc Natl Acad Sci USA 2006; 103: 13606-13611.
15. Bauman ML, Kemper TL. Neuroanatomic observations of the brain in autism: a review and future directions. Int J Dev Neurosci 2005; 23: 183-187.
16. Palmen SJ, van Engeland H, Hof PR, Schmitz C. Neuropathological findings in autism. Brain 2004; 127: 2572-2583.
17. Baron-Cohen S, Belmonte MK. Autism: a window onto the development of the social and the analytic brain. Annu Rev Neurosci 2005; 28: 109-126.
18. DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C et al. The developmental neurobiology of autism spectrum disorder. J Neurosci 2006; 26: 6897-6906.
19. Letinic K, Zoncu R, Rakic P. Origin of GABAergic neurons in the human neocortex. Nature 2002; 417: 645-649.
20. Rakic P. Specification of cerebral cortical areas. Science 1988; 241: 170-176.
21. Whitford KL, Dijkhuizen P, Polleux F, Ghosh A. Molecular control of cortical dendrite development. Annu Rev Neurosci 2002; 25: 127-149.
22. Li Z, Okamoto K, Hayashi Y, Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004; 119: 873-887.
23. Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E et al. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology 2007; 32: 1727-1737.
24. 2 genes in schizophrenia. Biol Psychiatry 2005; 57: 382-393.
25. Nakatani N, Hattori E, Ohnishi T, Dean B, Iwayama Y, Matsumoto I et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum Mol Genet 2006; 15: 1949-1962.
26. Al Halabiah H, Delezoide AL, Cardona A, Moalic JM, Simonneau M. Expression pattern of NOGO and NgR genes during human development. Gene Expr Patterns 2005; 5: 561-568.
27. Charpak G, Dominik W, Zaganidis N. Optical imaging of the spatial distribution of beta-particles emerging from surfaces. Proc Natl Acad Sci USA 1989; 86: 1741-1745.
28. Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 2006; 124: 1283-1298.
29. Amano T, Richelson E, Nirenberg M. Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culturecholine acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites). Proc Natl Acad Sci USA 1972; 69: 258-263.
30. Stoppini L, Buchs PA, Muller D. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 199; 37: 173-182.
31. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004; 61: 300-308.
32. Iwamoto K, Bundo M, Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005; 14: 241-253.
33. Sultana R, Yu CE, Yu J, Munson J, Chen D, Hua W et al. Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. Genomics 2002; 80: 129-134.
34. Richler E, Reichert JG, Buxbaum JD, McInnes LA. Autism and ultraconserved non-coding sequence on chromosome 7q. Psychiatr Genet 2006; 16: 19-23.
35. Philippi A, Roschmann E, Tores F, Lindenbaum P, Benajou A, Germain-Leclerc L et al. Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism. Mol Psychiatry 2005; 10: 950-960.
36. Hirono M, Sugiyama T, Kishimoto Y, Sakai I, Miyazawa T, Kishio M et al. Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. J Biol Chem 2001; 276: 45236-45242.
37. Kaufman M. Mouse and human embryonic development: a comparative overview. In: Strachan T, Lindsay S, Wilson DI (eds). Molecular Genetics of Early Human Development. T. BIOS Scientific Publishers Ltd.: Oxford, UK, 1997, pp 77-110.
38. Rakic P, Nowakowski RS. The time of origin of neurons in the hippocampal region of the rhesus monkey. J Comp Neurol 1981; 196: 99-128.
39. Nowakowski RS, Rakic P. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. J Comp Neurol 1981; 196: 129-154.
40. Khazipov R, Esclapez M, Caillard O, Bernard C, Khalilov I, Tyzio R et al. Early development of neuronal activity in the primate hippocampus in utero. J Neurosci 2001; 21: 9770-9781.
41. Whitford KL, Marillat V, Stein E, Goodman CS, Tessier-Lavigne M, Chedotal A et al. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 2002; 33: 47-61.
42. Li Z, Okamoto K, Hayashi Y, Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004; 119: 873-887.
43. Carper RA, Courchesne E. Localized enlargement of the frontal cortex in early autism. Biol Psychiatry 2005; 57: 126-133.
44. Casanova MF, Buxhoeveden DP, Switala AE, Roy E. Minicolumnar pathology in autism. Neurology 2002; 58: 428-432.
45. Luna B, Minshew NJ, Garver KE, Lazar NA, Thulborn KR, Eddy WF et al. Neocortical system abnormalities in autism: an fMRI study of spatial working memory. Neurology 2002; 59: 834-840.
46. Silk TJ, Rinehart N, Bradshaw JL, Tonge B, Egan G, O'Boyle MW et al. Related articles, links visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study. Am J Psychiatry 2006; 163: 1440-1443.
47. McAlonan GM, Cheung V, Cheung C, Suckling J, Lam GY, Tai KS et al. Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain 2005; 128: 268-276.
48. Belmonte MK, Allen G, Beckel-Mitchener A, Boulanger LM, Carper RA, Webb SJ. Autism and abnormal development of brain connectivity. J Neurosci 2004; 24: 9228-9231.
49. Ramos M, del Arco A, Pardo B, Martinez-Serrano A, Martinez-Morales JR, Kobayashi K et al. Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord. Brain Res Dev Brain Res 2003; 143: 33-46.
50. Fougerousse F, Bullen P, Herasse M, Lindsay S, Richard I, Wilson D et al. Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes. Hum Mol Genet 2000; 9: 165-173.
51. Donoghue MJ, Rakic P. Molecular gradients and compartments in the embryonic primate cerebral cortex. Cereb Cortex 1999; 9: 586-600.
52. Sur M, Rubenstein JL. Patterning and plasticity of the cerebral cortex. Science 2005; 310: 805-810.
53. Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci 2004; 27: 169-192.
54. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci 2006; 9: 28-30.
55. Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain 2004; 127: 2703-2716.
56. Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH et al. Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 2005; 8: 519-526.
57. Dent EW, Gertler FB. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 2003; 40: 209-227.
58. Hirokawa N, Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci 2005; 6: 201-214.
59. Lasorsa FM, Pinton P, Palmieri L, Fiermonte G, Rizzuto R, Palmieri F. Recombinant expression of the Ca(2+)-sensitive aspartate/ glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J Biol Chem 2003; 278: 38686-38692.
60. Pardo B, Contreras L, Serrano A, Ramos M, Kobayashi K, Iijima M et al. Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria. J Biol Chem 2006; 281: 1039-1047.
61. Geschwind DH, Levitt P. Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol 2007; 17: 103-111.
62. Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C et al. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet 2003; 33: 396-400.
63. Mager J, Bartolomei MS. Strategies for dissecting epigenetic mechanisms in the mouse. Nat Genet 2005; 37: 1194-1200.