메뉴 건너뛰기




Volumn 4, Issue 1, 2006, Pages 19-32

Genetic and pharmacogenetic aspects of alcohol-dependence

Author keywords

CB1 gene; DRD2 receptors; Flushing Syndrome; MAP kinase; Neurotransmitter; Opioids

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACAMPROSATE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANTIDEPRESSANT AGENT; BENZODIAZEPINE; BROMOCRIPTINE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CITALOPRAM; CYTOCHROME P450 2E1; DISULFIRAM; DOPAMINE; ENKEPHALIN DERIVATIVE; FLUOXETINE; GLUTAMIC ACID; MOOD STABILIZER; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALTREXONE; NICOTINE; NORADRENALIN; ONDANSETRON; OPIATE RECEPTOR; RECEPTOR SUBUNIT; RIMONABANT; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; UNINDEXED DRUG; VIQUALINE;

EID: 33646123563     PISSN: 15701603     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016006776055383     Document Type: Review
Times cited : (6)

References (134)
  • 1
    • 2942716700 scopus 로고    scopus 로고
    • A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism
    • Arlinde, C.; Sommer, W.; Bjork, K.; Reimers, M.; Hyytia, P.; Kiianmaa, K. and Heilig, M. (2004) A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. Pharmacogenomics J. 4, 208-218.
    • (2004) Pharmacogenomics J. , vol.4 , pp. 208-218
    • Arlinde, C.1    Sommer, W.2    Bjork, K.3    Reimers, M.4    Hyytia, P.5    Kiianmaa, K.6    Heilig, M.7
  • 5
    • 17344368736 scopus 로고    scopus 로고
    • Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence
    • Bönsch, D.; Lederer, T.; Reulbach, U.; Hothorn, T.; Kornhuber, J. and Bleich, S. (2005) Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Hum. Mol. Genet. 14, 967-971.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 967-971
    • Bönsch, D.1    Lederer, T.2    Reulbach, U.3    Hothorn, T.4    Kornhuber, J.5    Bleich, S.6
  • 6
    • 15944402789 scopus 로고    scopus 로고
    • Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    • Bowers, B. J.; McClure-Begley, T. D.; Keller, J. J.; Paylor, R.; Collins, A. C. and Wehner, J. M. (2005) Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol. Alcohol Clin. Exp. Res. 29, 295-302.
    • (2005) Alcohol Clin. Exp. Res. , vol.29 , pp. 295-302
    • Bowers, B.J.1    McClure-Begley, T.D.2    Keller, J.J.3    Paylor, R.4    Collins, A.C.5    Wehner, J.M.6
  • 7
    • 0030969246 scopus 로고    scopus 로고
    • Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
    • Buck, K. J.; Metten, P.; Belknap, J. K. and Crabbe, J. C. (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci. 17, 3946-3955.
    • (1997) J. Neurosci. , vol.17 , pp. 3946-3955
    • Buck, K.J.1    Metten, P.2    Belknap, J.K.3    Crabbe, J.C.4
  • 8
    • 0347417897 scopus 로고    scopus 로고
    • Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer
    • Chen, S. Y.; Liu, T. Y.; Shun, C. T.; Wu, M. S.; Lu, T. H.; Lin, J. T.; Sheu, J. C.; Santella, R. M. and Chen, C. J. (2004) Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer. Int. J. Cancer. 108, 606-612.
    • (2004) Int. J. Cancer , vol.108 , pp. 606-612
    • Chen, S.Y.1    Liu, T.Y.2    Shun, C.T.3    Wu, M.S.4    Lu, T.H.5    Lin, J.T.6    Sheu, J.C.7    Santella, R.M.8    Chen, C.J.9
  • 10
    • 0038638575 scopus 로고    scopus 로고
    • Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: Rationale and methods
    • COMBINE Study Research Group
    • COMBINE Study Research Group. (2003) Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: rationale and methods. Alcohol. Clin. Exp. Res. 27(7), 1107-22.
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , Issue.7 , pp. 1107-1122
  • 11
    • 0034589734 scopus 로고    scopus 로고
    • Reward deficiency syndrome: Genetic aspects of behavioral disorders
    • Comings, D. E. and Blum, K. (2000) Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog. Brain Res. 126, 325-341.
    • (2000) Prog. Brain Res. , vol.126 , pp. 325-341
    • Comings, D.E.1    Blum, K.2
  • 13
    • 0035139197 scopus 로고    scopus 로고
    • Role of glutamatergic and GABAergic systems in alcoholism
    • Davis, K. M. and Wu, J. Y. (2001) Role of glutamatergic and GABAergic systems in alcoholism. J. Biomed. Sci. 8, 7-19.
    • (2001) J. Biomed. Sci. , vol.8 , pp. 7-19
    • Davis, K.M.1    Wu, J.Y.2
  • 14
    • 23844449355 scopus 로고    scopus 로고
    • Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain
    • Depaz, I. M.; de Las Heras, R.; Kroon, P. A. and Wilce, P. A. (2005) Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain. J. Neurosci. Res. 81, 253-260.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 253-260
    • Depaz, I.M.1    de Las Heras, R.2    Kroon, P.A.3    Wilce, P.A.4
  • 17
    • 15744374040 scopus 로고    scopus 로고
    • Genomic scan for alcohol craving in Mission Indians
    • Ehlers, C. L. and Wilhelmsen, K. C. (2005) Genomic scan for alcohol craving in Mission Indians. Psychiatr. Genet. 15, 71-75.
    • (2005) Psychiatr. Genet. , vol.15 , pp. 71-75
    • Ehlers, C.L.1    Wilhelmsen, K.C.2
  • 18
    • 0032587055 scopus 로고    scopus 로고
    • 5-HT3 receptor over-expression enhances ethanol sensitivity in mice
    • Engel, S. R. and Allan, A. M. (1999) 5-HT3 receptor over-expression enhances ethanol sensitivity in mice. Psychopharmacology 144, 411-415.
    • (1999) Psychopharmacology , vol.144 , pp. 411-415
    • Engel, S.R.1    Allan, A.M.2
  • 19
    • 0031593736 scopus 로고    scopus 로고
    • 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice
    • Engel, S. R.; Lyons, C. R. and Allan, A. M. (1998) 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Psychopharmacology 140, 243-248.
    • (1998) Psychopharmacology , vol.140 , pp. 243-248
    • Engel, S.R.1    Lyons, C.R.2    Allan, A.M.3
  • 20
    • 0042694131 scopus 로고    scopus 로고
    • Pharmacogenomics of alcohol response and addiction
    • Enoch, M A (2003) Pharmacogenomics of alcohol response and addiction. Am. J. Pharmacogenomics 3, 217-232.
    • (2003) Am. J. Pharmacogenomics , vol.3 , pp. 217-232
    • Enoch, M.A.1
  • 21
    • 0035091990 scopus 로고    scopus 로고
    • Molecular cloning and characterization of hNP22: A gene upregulated in human alcoholic brain
    • Fan, L; Jaquet, V.; Dodd, P. R.; Chen, W. and Wilce, P. A. (2001) Molecular cloning and characterization of hNP22: a gene upregulated in human alcoholic brain. J. Neurochem. 76, 1275-1281.
    • (2001) J. Neurochem. , vol.76 , pp. 1275-1281
    • Fan, L.1    Jaquet, V.2    Dodd, P.R.3    Chen, W.4    Wilce, P.A.5
  • 22
    • 0037402997 scopus 로고    scopus 로고
    • Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice
    • Fehr, C.; Rademacher, B. L. and Buck, K. J. (2003) Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 467-472.
    • (2003) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.27 , pp. 467-472
    • Fehr, C.1    Rademacher, B.L.2    Buck, K.J.3
  • 23
    • 12944333124 scopus 로고    scopus 로고
    • Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
    • Feinn, R.; Nellissery, M. and Kranzler, H. R. (2005) Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am. J. Med. Genet. 133, 79-84.
    • (2005) Am. J. Med. Genet. , vol.133 , pp. 79-84
    • Feinn, R.1    Nellissery, M.2    Kranzler, H.R.3
  • 27
    • 0035825221 scopus 로고    scopus 로고
    • Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence
    • Franke, P.; Wang, T.; Nöthen, M.; Knapp, M.; Neidt, H.; Albrecht, S.; Jahnes, E.; Propping, P. and Maier, W. (2001) Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence. Am. J. Med Genet. 105, 114-119.
    • (2001) Am. J. Med Genet. , vol.105 , pp. 114-119
    • Franke, P.1    Wang, T.2    Nöthen, M.3    Knapp, M.4    Neidt, H.5    Albrecht, S.6    Jahnes, E.7    Propping, P.8    Maier, W.9
  • 29
    • 0036894483 scopus 로고    scopus 로고
    • Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: Contribution of antisocial personality disorder in men
    • Fu, Q.; Heath, A. C.; Bucholz, K. K.; Nelson, E.; Goldberg, J.; Lyons, M. J.; True, W. R.; Jacob, T.; Tsuang, M. T. and Eisen, S. A. (2002) Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men. Arch. Gen. Psychiatry 59, 1125-1132.
    • (2002) Arch. Gen. Psychiatry , vol.59 , pp. 1125-1132
    • Fu, Q.1    Heath, A.C.2    Bucholz, K.K.3    Nelson, E.4    Goldberg, J.5    Lyons, M.J.6    True, W.R.7    Jacob, T.8    Tsuang, M.T.9    Eisen, S.A.10
  • 30
  • 31
    • 0032724995 scopus 로고    scopus 로고
    • Genetics of two mu opioid receptor gene (OPRM1) exon 1 polymorphisms: Population studies, and allele frequencies in alcohol- and drug-dependent subjects
    • Gelernter, J.; Kranzler, H. and Cubells, J. (1999) Genetics of two mu opioid receptor gene (OPRM1) exon 1 polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects. Mol. Psychiatry 4, 476-483.
    • (1999) Mol. Psychiatry , vol.4 , pp. 476-483
    • Gelernter, J.1    Kranzler, H.2    Cubells, J.3
  • 32
    • 0034799183 scopus 로고    scopus 로고
    • Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism
    • Gianoulakis, C. (2001) Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. J. Psychiatry Neurosci. 26, 304-318.
    • (2001) J. Psychiatry Neurosci. , vol.26 , pp. 304-318
    • Gianoulakis, C.1
  • 33
    • 0023130467 scopus 로고
    • Polymorphism of aldehyde dehydrogenase and alcohol sensitivity
    • Goedde, H. and Agarwal, D. (1987) Polymorphism of aldehyde dehydrogenase and alcohol sensitivity. Enzyme 37, 29-44.
    • (1987) Enzyme , vol.37 , pp. 29-44
    • Goedde, H.1    Agarwal, D.2
  • 34
    • 0034039782 scopus 로고    scopus 로고
    • Reappraisal of the association between the DRD2 gene, alcoholism and addiction
    • Gorwood, P.; Batel, P.; Gouya, L.; Courtois, F.; Feingold, J. and Ades, J. (2000) Reappraisal of the association between the DRD2 gene, alcoholism and addiction. Eur. Psychiatry 15, 90-96.
    • (2000) Eur. Psychiatry , vol.15 , pp. 90-96
    • Gorwood, P.1    Batel, P.2    Gouya, L.3    Courtois, F.4    Feingold, J.5    Ades, J.6
  • 35
    • 0037219321 scopus 로고    scopus 로고
    • The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure
    • Gorwood, P.; Limosin, F.; Batel, P.; Hamon, M.; Ades, J. and Boni, C. (2003) The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure. Biol. Psychiatry 53, 85-92.
    • (2003) Biol. Psychiatry , vol.53 , pp. 85-92
    • Gorwood, P.1    Limosin, F.2    Batel, P.3    Hamon, M.4    Ades, J.5    Boni, C.6
  • 36
    • 0034663345 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior
    • Gorwood, P.; Batel, P.; Ades, J.; Hamon, M. and Boni, C. (2000) Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol. Psychiatry 48, 259-264.
    • (2000) Biol. Psychiatry , vol.48 , pp. 259-264
    • Gorwood, P.1    Batel, P.2    Ades, J.3    Hamon, M.4    Boni, C.5
  • 37
    • 3543055314 scopus 로고    scopus 로고
    • Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
    • Grant, B. F.; Stinson, F. S.; Dawson, D. A.; Chou, S. P.; Dufour, M. C.; Compton, W.; Pickering, R.P. and Kaplan, K. (2004) Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 61, 807-816.
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 807-816
    • Grant, B.F.1    Stinson, F.S.2    Dawson, D.A.3    Chou, S.P.4    Dufour, M.C.5    Compton, W.6    Pickering, R.P.7    Kaplan, K.8
  • 39
    • 4444369901 scopus 로고    scopus 로고
    • The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: Results of the National Epidemiologic Survey on alcohol and Related Condition on heterogeneity that differ by population subgroup
    • Hasin, D. S. and Grant, B. F. (2004) The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on alcohol and Related Condition on heterogeneity that differ by population subgroup. Arch. Gen. Psychiatry 61, 891-896.
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 891-896
    • Hasin, D.S.1    Grant, B.F.2
  • 40
    • 0141643191 scopus 로고    scopus 로고
    • Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase
    • Hassan, S.; Duong, B.; Kim, K. S. and Miles, M. F. (2003) Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase. J. Biol. Chem. 278, 38860-38869.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38860-38869
    • Hassan, S.1    Duong, B.2    Kim, K.S.3    Miles, M.F.4
  • 41
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1
    • Hayashi, S.; Watanabe, J. and Kawajiri, K. (1991) Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1. J. Biochem. 110, 559-565.
    • (1991) J. Biochem. , vol.110 , pp. 559-565
    • Hayashi, S.1    Watanabe, J.2    Kawajiri, K.3
  • 43
    • 12944300321 scopus 로고    scopus 로고
    • Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women
    • Herman, A. I.; Kaiss, K. M.; Ma, R.; Philbeck, J. W.; Hasan, A.; Dasti, H. and DePetrillo, P. B. (2005) Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women. Am. J. Med. Genet. 133, 74-78.
    • (2005) Am. J. Med. Genet. , vol.133 , pp. 74-78
    • Herman, A.I.1    Kaiss, K.M.2    Ma, R.3    Philbeck, J.W.4    Hasan, A.5    Dasti, H.6    DePetrillo, P.B.7
  • 44
    • 0031037561 scopus 로고    scopus 로고
    • Endogenous opioid systems and alcohol addiction
    • Herz, A. (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology 129, 99-111.
    • (1997) Psychopharmacology , vol.129 , pp. 99-111
    • Herz, A.1
  • 45
    • 4444251068 scopus 로고    scopus 로고
    • Family transmission and heritability of externalizing disorders: A twin-family study
    • Hicks, B. M.; Krueger, R. F.; Iacono, W. G.; McGue, M. and Patrick, C. J. (2004) Family transmission and heritability of externalizing disorders: a twin-family study. Arch. Gen. Psychiatry 61, 922-928.
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 922-928
    • Hicks, B.M.1    Krueger, R.F.2    Iacono, W.G.3    McGue, M.4    Patrick, C.J.5
  • 46
    • 0033009868 scopus 로고    scopus 로고
    • Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
    • Hietala, J. (1999) Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Mol. Psychiatry 4, 286-289.
    • (1999) Mol. Psychiatry , vol.4 , pp. 286-289
    • Hietala, J.1
  • 48
    • 0034703870 scopus 로고    scopus 로고
    • Sequence variability and candidate gene analysis in complex disease: Association of mu opioid receptor gene variation with substance dependence
    • Hoehe, M. R.; Kopke, K.; Wendel, B.; Rohde, K.; Flachmeier, C.; Kidd, K. K; Berrettini, W. H. and Church, G. M. (2000) Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum. Mol. Genet. 9, 2895-2908.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2895-2908
    • Hoehe, M.R.1    Kopke, K.2    Wendel, B.3    Rohde, K.4    Flachmeier, C.5    Kidd, K.K.6    Berrettini, W.H.7    Church, G.M.8
  • 51
    • 12344328265 scopus 로고    scopus 로고
    • An expanded evaluation of the relationship of four alleles to level of response to alcohol and the alcoholism risk
    • Hu, X.; Oroszi, G.; Chun, J.; Smith, T. L.; Goldman, D. and Schuckit, M. A. (2005) An expanded evaluation of the relationship of four alleles to level of response to alcohol and the alcoholism risk. Alcohol Clin. Exp. Res. 29, 8-16.
    • (2005) Alcohol Clin. Exp. Res. , vol.29 , pp. 8-16
    • Hu, X.1    Oroszi, G.2    Chun, J.3    Smith, T.L.4    Goldman, D.5    Schuckit, M.A.6
  • 53
    • 10444259013 scopus 로고    scopus 로고
    • Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors
    • Hungund, B. L. and Basavarajappa, B. S. (2004) Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors. Ann. N. Y. Acad. Sci. 1025, 515-527.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1025 , pp. 515-527
    • Hungund, B.L.1    Basavarajappa, B.S.2
  • 54
    • 0034119109 scopus 로고    scopus 로고
    • Combining ondansetron and naltrexone effectively treats biologically predisposed alcoholics: From hypotheses to preliminary clinical evidence
    • Johnson, B. A.; Ait-Daoud, N. and Prihoda, T. J. (2000) Combining ondansetron and naltrexone effectively treats biologically predisposed alcoholics: from hypotheses to preliminary clinical evidence. Alcohol Clin. Exp. Res. 24, 737-742.
    • (2000) Alcohol Clin. Exp. Res. , vol.24 , pp. 737-742
    • Johnson, B.A.1    Ait-Daoud, N.2    Prihoda, T.J.3
  • 55
    • 10844261674 scopus 로고    scopus 로고
    • Role of the serotonergic system in the neurobiology of alcoholism: Implications for treatment
    • Johnson, B. A. (2004) Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS Drugs 18, 1105-1118.
    • (2004) CNS Drugs , vol.18 , pp. 1105-1118
    • Johnson, B.A.1
  • 56
    • 0030901578 scopus 로고    scopus 로고
    • Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey
    • Kessler, R. C.; Crum, R. M.; Warner, L. A.; Nelson, C. B.; Schulenberg, J. and Anthony, J. C. (1997) Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch. Gen. Psychiatry 54, 313-321.
    • (1997) Arch. Gen. Psychiatry , vol.54 , pp. 313-321
    • Kessler, R.C.1    Crum, R.M.2    Warner, L.A.3    Nelson, C.B.4    Schulenberg, J.5    Anthony, J.C.6
  • 57
    • 14344259393 scopus 로고    scopus 로고
    • Association of polymorphisms in nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4), μ-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients
    • Kim, S. A.; Kim, J. W.; Song, J. Y.; Park, S.; Lee, H. J. and Chung, J. H. (2004) Association of polymorphisms in nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4), μ-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. Alcohol 34, 115-120.
    • (2004) Alcohol , vol.34 , pp. 115-120
    • Kim, S.A.1    Kim, J.W.2    Song, J.Y.3    Park, S.4    Lee, H.J.5    Chung, J.H.6
  • 59
    • 0038036393 scopus 로고    scopus 로고
    • Effects of ondansetron in early - Versus late-onset alcoholics' a prospective, open-label study
    • Kranzler, H. R.; Pierucci-Lagha, A.; Feinn, R. and Hernandez-Avila, C. (2003) Effects of ondansetron in early - versus late-onset alcoholics' a prospective, open-label study. Alcohol Clin. Exp. Res. 27, 1150-1155.
    • (2003) Alcohol Clin. Exp. Res. , vol.27 , pp. 1150-1155
    • Kranzler, H.R.1    Pierucci-Lagha, A.2    Feinn, R.3    Hernandez-Avila, C.4
  • 60
    • 3242675225 scopus 로고    scopus 로고
    • Naltrexone depot for treatment of alcohol dependence: A multicenter, randomized, placebo-controlled clinical trial
    • DrugAbuse Sciences Naltrexone Depot Study Group
    • Kranzler, H. R.; Wesson, D. R. and Billot, L. (2004) DrugAbuse Sciences Naltrexone Depot Study Group. Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial. Alcohol Clin. Exp. Res. 28, 1051-1059.
    • (2004) Alcohol Clin. Exp. Res. , vol.28 , pp. 1051-1059
    • Kranzler, H.R.1    Wesson, D.R.2    Billot, L.3
  • 61
    • 14144253824 scopus 로고    scopus 로고
    • Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments
    • Kreek, M. J.; Bart, G.; Lilly, C.; LaForge, K. S. and Nielsen, D. A. (2005) Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 57, 1-26.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 1-26
    • Kreek, M.J.1    Bart, G.2    Lilly, C.3    LaForge, K.S.4    Nielsen, D.A.5
  • 62
    • 0035857147 scopus 로고    scopus 로고
    • Naltrexone in the treatment of alcohol dependence
    • Veterans Affairs Naltrexone Cooperative Study
    • Krystal, J. H.; Cramer, J. A.; Krol, W. F.; Kirk, G. F. and Rosenheck, R. A. (2001) Veterans Affairs Naltrexone Cooperative Study. Naltrexone in the treatment of alcohol dependence, New Engl. J. Med. 345, 1734-1739.
    • (2001) New Engl. J. Med. , vol.345 , pp. 1734-1739
    • Krystal, J.H.1    Cramer, J.A.2    Krol, W.F.3    Kirk, G.F.4    Rosenheck, R.A.5
  • 63
    • 0033654978 scopus 로고    scopus 로고
    • Regulation of NMDA receptors by ethanol
    • Kumari, M. and Ticku, M. K. (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res. 54, 152-189.
    • (2000) Prog Drug Res. , vol.54 , pp. 152-189
    • Kumari, M.1    Ticku, M.K.2
  • 64
    • 20444401517 scopus 로고    scopus 로고
    • Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics
    • Kweon, Y. S.; Lee, H. K.; Lee, C. T. and Pae, C. U. (2005) Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics. Psychiatr. Genet. 15, 151-154.
    • (2005) Psychiatr. Genet. , vol.15 , pp. 151-154
    • Kweon, Y.S.1    Lee, H.K.2    Lee, C.T.3    Pae, C.U.4
  • 68
    • 14344259844 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence
    • Le Foll, B. and Goldberg, S. R. (2005) Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J. Pharmacol. Exp. Ther. 312, 875-883.
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 875-883
    • Le Foll, B.1    Goldberg, S.R.2
  • 72
    • 19744380641 scopus 로고    scopus 로고
    • SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism
    • Lin, Z.; Walther, D.; Yu, X. Y.; Li, S.; Drgon, T. and Uhl, G. R. (2005) SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Hum. Mol. Genet. 14, 1393-1404.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1393-1404
    • Lin, Z.1    Walther, D.2    Yu, X.Y.3    Li, S.4    Drgon, T.5    Uhl, G.R.6
  • 73
    • 0033937188 scopus 로고    scopus 로고
    • Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population
    • Loh, E. W.; Higuchi, S.; Matsushita, S.; Murray, R.; Chen, C. K. and Ball, D. (2000) Association analysis of the GABA(A) receptor subunit genes cluster on 5q33-34 and alcohol dependence in a Japanese population. Mol. Psychiatry 5, 301-307.
    • (2000) Mol. Psychiatry , vol.5 , pp. 301-307
    • Loh, E.W.1    Higuchi, S.2    Matsushita, S.3    Murray, R.4    Chen, C.K.5    Ball, D.6
  • 74
    • 13244298667 scopus 로고    scopus 로고
    • Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
    • Lötsch, J. and Geisslinger, G. (2005) Are mu-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol. Med. 11, 82-89.
    • (2005) Trends Mol. Med. , vol.11 , pp. 82-89
    • Lötsch, J.1    Geisslinger, G.2
  • 75
    • 0024535962 scopus 로고
    • Ethanol inhibits NMDA-activated ion current in hippocampal neurons
    • Lovinger, D. M.; White, G. and Weight, F. F. (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243, 1721-1724.
    • (1989) Science , vol.243 , pp. 1721-1724
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 76
    • 0000120613 scopus 로고    scopus 로고
    • Serotonin's role in alcohol's effects on the brain
    • Lovinger, D. M. (1997) Serotonin's role in alcohol's effects on the brain. Alcohol Health & Research World 21, 114-120.
    • (1997) Alcohol Health & Research World , vol.21 , pp. 114-120
    • Lovinger, D.M.1
  • 77
    • 16544374349 scopus 로고    scopus 로고
    • Dopamine transporter network and pathways
    • Maiya, R. and Mayfield, R. D. (2004) Dopamine transporter network and pathways. Int. Rev. Neurobiol. 61, 79-96.
    • (2004) Int. Rev. Neurobiol. , vol.61 , pp. 79-96
    • Maiya, R.1    Mayfield, R.D.2
  • 78
    • 3042515206 scopus 로고    scopus 로고
    • Pharmacotherapy of alcohol dependence: A review of the clinical data
    • Mann, K. (2004) Pharmacotherapy of alcohol dependence: a review of the clinical data. CNS Drugs 18, 485-504.
    • (2004) CNS Drugs , vol.18 , pp. 485-504
    • Mann, K.1
  • 79
    • 1642576316 scopus 로고    scopus 로고
    • The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: Results of a meta-analysis
    • Mann, K.; Lehert, P. and Morgan, M. Y. (2004) The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin. Exp. Res. 28, 51-63.
    • (2004) Alcohol Clin. Exp. Res. , vol.28 , pp. 51-63
    • Mann, K.1    Lehert, P.2    Morgan, M.Y.3
  • 80
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L. A.; Lolait, S. J.; Brownstein, M. J.; Young, A. C. and Bonner, T. I. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 81
    • 0032473367 scopus 로고    scopus 로고
    • Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
    • Michaelis, E. K. (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54, 369-415.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 369-415
    • Michaelis, E.K.1
  • 82
    • 0034809247 scopus 로고    scopus 로고
    • The role of selective serotonin reuptake inhibitors in reducing alcohol consumption
    • Naranjo, C. A. and Knoke, D. M. (2001) The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin. Psychiatry 62, 18-25.
    • (2001) J Clin. Psychiatry , vol.62 , pp. 18-25
    • Naranjo, C.A.1    Knoke, D.M.2
  • 83
    • 0033855524 scopus 로고    scopus 로고
    • Social phobia in a population-based female adolescent twin sample: Co-morbidity and associated suicide-related symptoms
    • Nelson, E. C.; Grant, J. D.; Bucholz, K. K.; Glowinski, A.; Madden, P. A. F.; Reich, W. and Heath, A. C. (2000) Social phobia in a population-based female adolescent twin sample: co-morbidity and associated suicide-related symptoms. Psychol. Med. 30, 797-804.
    • (2000) Psychol. Med. , vol.30 , pp. 797-804
    • Nelson, E.C.1    Grant, J.D.2    Bucholz, K.K.3    Glowinski, A.4    Madden, P.A.F.5    Reich, W.6    Heath, A.C.7
  • 85
    • 0029057338 scopus 로고
    • Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism
    • Nevo, I. and Hamon, M. (1995) Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem. Int. 26, 305-336.
    • (1995) Neurochem. Int. , vol.26 , pp. 305-336
    • Nevo, I.1    Hamon, M.2
  • 86
    • 0042163144 scopus 로고    scopus 로고
    • Transcriptional activity of the tandem repeat polymorphism in the 5′-flanking region of the human CYP2E1 gene
    • Nomura, F.; Itoga, S.; Uchimoto, T.; Tomonaga, T.; Nezu, M.; Shimada, H. and Ochiai, T. (2003) Transcriptional activity of the tandem repeat polymorphism in the 5′-flanking region of the human CYP2E1 gene. Alcohol Clin. Exp. Res. 27, 42S-46S.
    • (2003) Alcohol Clin. Exp. Res. , vol.27
    • Nomura, F.1    Itoga, S.2    Uchimoto, T.3    Tomonaga, T.4    Nezu, M.5    Shimada, H.6    Ochiai, T.7
  • 87
    • 11044219969 scopus 로고    scopus 로고
    • Alcoholism: Genes and mechanisms
    • Oroszi, G. and Goldman, D. (2004) Alcoholism. genes and mechanisms. Pharmacogenomics 5, 1037-1048.
    • (2004) Pharmacogenomics , vol.5 , pp. 1037-1048
    • Oroszi, G.1    Goldman, D.2
  • 89
    • 0345713190 scopus 로고    scopus 로고
    • Human chromosomes 11p15 and 4p12 and alcohol dependence: Possible association with the GABRB1 gene
    • Parsian, A. and Zhang, Z. H. (1999) Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene. Am. J. Med. Genet. 98, 533-538.
    • (1999) Am. J. Med. Genet. , vol.98 , pp. 533-538
    • Parsian, A.1    Zhang, Z.H.2
  • 90
    • 0034009163 scopus 로고    scopus 로고
    • Genetic polymorphisms in ethanol metabolism: Issues and goals for physiologically based pharmacokinetic modelling
    • Pastino, G. M.; Flynn, E. J. and Sultatos, L. G. (2000) Genetic polymorphisms in ethanol metabolism: issues and goals for physiologically based pharmacokinetic modelling. Drug Chem. Toxicol. 23, 179-201.
    • (2000) Drug Chem. Toxicol. , vol.23 , pp. 179-201
    • Pastino, G.M.1    Flynn, E.J.2    Sultatos, L.G.3
  • 91
    • 0032437380 scopus 로고    scopus 로고
    • Neuronal signaling systems and ethanol dependence
    • Pandey, S. C. (1998) Neuronal signaling systems and ethanol dependence. Mol. Neurobiol. 17, 1-15.
    • (1998) Mol. Neurobiol. , vol.17 , pp. 1-15
    • Pandey, S.C.1
  • 93
    • 0035886351 scopus 로고    scopus 로고
    • Association between suicide attempts and 5-HTTLPR-S-allete in alcohol-dependent and control subjects: Further evidence from a German alcohol-dependent inpatient sample
    • Preuss, U. W.; Koller, G.; Soyka, M. and Bondy, B. (2001) Association between suicide attempts and 5-HTTLPR-S-allete in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample. Biol. Psychiatry 50, 636-639.
    • (2001) Biol. Psychiatry , vol.50 , pp. 636-639
    • Preuss, U.W.1    Koller, G.2    Soyka, M.3    Bondy, B.4
  • 94
    • 11844262032 scopus 로고    scopus 로고
    • Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster
    • Radel, M.; Vallejo, R. L.; Iwata, N.; Aragon, R.; Long, J. C.; Virkkunen, M. and Goldman, D. (2005) Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. Arch. Gen. Psychiatry 62, 47-55.
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 47-55
    • Radel, M.1    Vallejo, R.L.2    Iwata, N.3    Aragon, R.4    Long, J.C.5    Virkkunen, M.6    Goldman, D.7
  • 97
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch, N. J. (2000) Searching for genetic determinants in the new millennium. Nature 405, 847-856.
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 98
    • 0027305458 scopus 로고
    • The neural basis of drug craving: Anincentiv-sensitization theory od addiction
    • Robinson, T. E. and Berridge, K. C. (1993) The neural basis of drug craving: anincentiv-sensitization theory od addiction. Brain Res. Rev. 18, 247-291.
    • (1993) Brain Res. Rev. , vol.18 , pp. 247-291
    • Robinson, T.E.1    Berridge, K.C.2
  • 99
    • 0034885748 scopus 로고    scopus 로고
    • Genetic analysis of the mu-opioid receptor in alcohol-dependent individuals
    • Rommelspacher, H.; Smolka, M.; Schmidt, L.; Samochowiec, J. and Hoehe, M. R. (2001) Genetic analysis of the mu-opioid receptor in alcohol-dependent individuals. Alcohol 24, 129-135.
    • (2001) Alcohol , vol.24 , pp. 129-135
    • Rommelspacher, H.1    Smolka, M.2    Schmidt, L.3    Samochowiec, J.4    Hoehe, M.R.5
  • 103
    • 0034508242 scopus 로고    scopus 로고
    • Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence
    • Sander, T.; Ostapowicz, A.; Samochowiec, J.; Smolka, M.; Winterer, G. and Schmidt, L. G. (2000) Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence. Psychiatr. Genet. 10, 103-107.
    • (2000) Psychiatr. Genet. , vol.10 , pp. 103-107
    • Sander, T.1    Ostapowicz, A.2    Samochowiec, J.3    Smolka, M.4    Winterer, G.5    Schmidt, L.G.6
  • 104
    • 0031081813 scopus 로고    scopus 로고
    • Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium
    • Sander, T.; Harms, H.; Podschus, J.; Finckh, U.; Nickel, B.; Rolfs, A.; Rommelspacher, H. and Schmidt, L. G. (1997) Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biol. Psychiatry 41, 299-304.
    • (1997) Biol. Psychiatry , vol.41 , pp. 299-304
    • Sander, T.1    Harms, H.2    Podschus, J.3    Finckh, U.4    Nickel, B.5    Rolfs, A.6    Rommelspacher, H.7    Schmidt, L.G.8
  • 106
    • 0031978033 scopus 로고    scopus 로고
    • Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene
    • Schmidt, L. G.; Harms, H.; Kuhn, S.; Rommelspacher, H. and Sander, T. (1998) Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. Am. J. Psychiatry 155, 474-478.
    • (1998) Am. J. Psychiatry , vol.155 , pp. 474-478
    • Schmidt, L.G.1    Harms, H.2    Kuhn, S.3    Rommelspacher, H.4    Sander, T.5
  • 107
    • 0033106106 scopus 로고    scopus 로고
    • Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: A pilot study
    • Schuckit, M. A.; Mazzanti, C.; Smith, T. L.; Ahmed, U.; Radel, M.; Iwata, N. and Goldman, D. (1999) Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol. Psychiatry 45, 647-551.
    • (1999) Biol. Psychiatry , vol.45 , pp. 551-647
    • Schuckit, M.A.1    Mazzanti, C.2    Smith, T.L.3    Ahmed, U.4    Radel, M.5    Iwata, N.6    Goldman, D.7
  • 110
    • 0042243639 scopus 로고    scopus 로고
    • Opioid receptor interactions: Local and nonlocal, symmetric and asymmetric, physical and functional
    • Smith, A. P. and Lee, N. M. (2003) Opioid receptor interactions: Local and nonlocal, symmetric and asymmetric, physical and functional. Life Sciences 73, 1873-1893.
    • (2003) Life Sciences , vol.73 , pp. 1873-1893
    • Smith, A.P.1    Lee, N.M.2
  • 111
    • 12444297474 scopus 로고    scopus 로고
    • The search for candidate genes of alcoholism: Evidence from expression profiling studies
    • Sommer, W. H; Arlinde, C. and Heilig, M. (2005) The search for candidate genes of alcoholism: evidence from expression profiling studies. Addict. Biol. 10, 71-79.
    • (2005) Addict. Biol. , vol.10 , pp. 71-79
    • Sommer, W.H.1    Arlinde, C.2    Heilig, M.3
  • 112
    • 0038698236 scopus 로고    scopus 로고
    • Glutamatergic mechanisms in alcohol dependence and addiction
    • Lodge, D.; Danysz, W. and Parsons, F. P.; Eds.; (Hrsg) Graham Publishing Co
    • Spanagel, R. and Bienkowski, P. (2002) Glutamatergic mechanisms in alcohol dependence and addiction. In Therapeutic Potential of Ionotropic Glutamate Receptor Antagonists and Modulators; Lodge, D.; Danysz, W. and Parsons, F. P.; Eds.; (Hrsg) Graham Publishing Co., pp. 375-403.
    • (2002) Therapeutic Potential of Ionotropic Glutamate Receptor Antagonists and Modulators , pp. 375-403
    • Spanagel, R.1    Bienkowski, P.2
  • 114
    • 0842347937 scopus 로고    scopus 로고
    • Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2
    • Stromberg, P.; Svensson, S.; Berst, K. B.; Plapp, B. V. and Hoog, J. O. (2004) Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2. Biochemistry 43, 1323-1328.
    • (2004) Biochemistry , vol.43 , pp. 1323-1328
    • Stromberg, P.1    Svensson, S.2    Berst, K.B.3    Plapp, B.V.4    Hoog, J.O.5
  • 115
    • 0037780558 scopus 로고    scopus 로고
    • Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors
    • Tabakoff, B.; Bhave, S. V. and Hoffman, P. L. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J. Neurosci. 23, 4491-4498.
    • (2003) J. Neurosci. , vol.23 , pp. 4491-4498
    • Tabakoff, B.1    Bhave, S.V.2    Hoffman, P.L.3
  • 116
    • 0028048215 scopus 로고
    • Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population
    • Takeshita, T.; Morimoto, K.; Mao, X. Q.; Hashimoto, T. and Furuyama, J. (1994) Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Hum. Genet. 94, 217-223.
    • (1994) Hum. Genet. , vol.94 , pp. 217-223
    • Takeshita, T.1    Morimoto, K.2    Mao, X.Q.3    Hashimoto, T.4    Furuyama, J.5
  • 117
    • 12444286735 scopus 로고    scopus 로고
    • Using in vitro models for expression profiling studies on ethanol and drugs of abuse
    • Thibault, C.; Hassan, S. and Miles, M. (2005) Using in vitro models for expression profiling studies on ethanol and drugs of abuse. Addict. Biol. 10, 53-62.
    • (2005) Addict. Biol. , vol.10 , pp. 53-62
    • Thibault, C.1    Hassan, S.2    Miles, M.3
  • 121
    • 0031959272 scopus 로고    scopus 로고
    • The role of glutamatergic neurotransmission in the pathophysiology of alcoholism
    • Tsai, G. and Coyle, J. T. (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Ann. Rev. Med. 49, 173-84.
    • (1998) Ann. Rev. Med. , vol.49 , pp. 173-184
    • Tsai, G.1    Coyle, J.T.2
  • 122
    • 0037764979 scopus 로고    scopus 로고
    • Genetics of Alcoholism and Tobacco Use in Humans
    • Tyndale, R. F. (2003) Genetics of Alcoholism and Tobacco Use in Humans. Ann. of Medicine 35, 94-121.
    • (2003) Ann. of Medicine , vol.35 , pp. 94-121
    • Tyndale, R.F.1
  • 123
    • 0032905099 scopus 로고    scopus 로고
    • A three-pathway psychobiological model of craving for alcohol
    • Verheul, R.; Van Den Brink, W. and Geerlings, P. (1999) A three-pathway psychobiological model of craving for alcohol, Alcohol Alcohol 34, 197-222.
    • (1999) Alcohol Alcohol , vol.34 , pp. 197-222
    • Verheul, R.1    Van Den Brink, W.2    Geerlings, P.3
  • 125
    • 0037225850 scopus 로고    scopus 로고
    • Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians
    • Wall, T. L.; Carr, L. G. and Ehlers, C. L. (2003) Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. Am. J. Psychiatry 160, 41-46.
    • (2003) Am. J. Psychiatry , vol.160 , pp. 41-46
    • Wall, T.L.1    Carr, L.G.2    Ehlers, C.L.3
  • 127
    • 0036149110 scopus 로고    scopus 로고
    • The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade
    • Wand, G. S. McCaul, M.; Yang, X.; Reynolds, J.; Gotjen, D.; Lee, S. and Ali, A. (2002) The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 26, 106-114.
    • (2002) Neuropsychopharmacology , vol.26 , pp. 106-114
    • Wand, G.S.1    McCaul, M.2    Yang, X.3    Reynolds, J.4    Gotjen, D.5    Lee, S.6    Ali, A.7
  • 129
    • 0037110939 scopus 로고    scopus 로고
    • Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population
    • Wernicke, C.; Smolka, M.; Gallinat, J.; Winterer, G.; Schmidt, L. G. and Rommelspacher, H. (2002) Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population. Neurosci. Lett. 15, 45-48.
    • (2002) Neurosci. Lett. , vol.15 , pp. 45-48
    • Wernicke, C.1    Smolka, M.2    Gallinat, J.3    Winterer, G.4    Schmidt, L.G.5    Rommelspacher, H.6
  • 132
    • 0043166866 scopus 로고    scopus 로고
    • Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats
    • Witzmann, F. A.; Li, J.; Strother, W. N.; McBride, W. J.; Hunter, L.; Crabb, D. W.; Lumeng, L. and Li, T. K. (2003) Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats. Proteomics 3, 1335-1344.
    • (2003) Proteomics , vol.3 , pp. 1335-1344
    • Witzmann, F.A.1    Li, J.2    Strother, W.N.3    McBride, W.J.4    Hunter, L.5    Crabb, D.W.6    Lumeng, L.7    Li, T.K.8
  • 134
    • 0037076671 scopus 로고    scopus 로고
    • Betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption
    • Yao, L.; Arolfo, M. P.; Dohrman, D. P.; Jiang, Z.; Fan, P.; Fuchs, S.; Janak, P. H.; Gordon, A. S. and Diamond, I. (2002) betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109, 733-743.
    • (2002) Cell , vol.109 , pp. 733-743
    • Yao, L.1    Arolfo, M.P.2    Dohrman, D.P.3    Jiang, Z.4    Fan, P.5    Fuchs, S.6    Janak, P.H.7    Gordon, A.S.8    Diamond, I.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.