A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity

American Journal of Human Genetics

Volumn 71, Issue 1, 2002, Pages 84-99

  Osier, Michael V ^a   Pakstis, Andrew J ^a   Soodyall, Himla ^b   Comas, David ^c   Goldman, David ^d   Odunsi, Adekunle ^e   Okonofua, Friday ^f   Parnas, Josef ^g   Schulz, Leslie O ^h   Bertranpetit, Jaume ^c   Bonne Tamir, Batsheva ⁱ   Lu, Ru Band ^j   Kidd, Judith R ^a   Kidd, Kenneth K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

^f UNIVERSITY OF BENIN   (Nigeria)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

^h UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

ⁱ TEL AVIV UNIVERSITY   (Israel)

^j TRI SERVICE GENERAL HOSPITAL   (Taiwan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ARGININE; HISTIDINE; ISOLEUCINE; VALINE;

ALCOHOLISM; ALLELISM; ARTICLE; ASIA; DISEASE ASSOCIATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC DRIFT; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 18444412585     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/341290     Document Type: Article

References (45)

1. High-resolution analysis of human Y-chromosome variation shows a sharp discontinuity and limited gene flow between northwestern African and the Iberian Peninsula
2. Heterogeneity and new molecular forms of human liver alcohol dehydrogenase
3. 2 gene locus
4. 3 gene encoding the human alcohol dehydrogenase β3 subunit
5. Alcohol-metabolizing genes and alcoholism among Taiwanese Han men: Independent effect of ADH2, ADH3, and ALDH2
6. Alu insertion polymorphisms in NW Africa and the Iberian Peninsula: Evidence for a strong genetic boundary through the Gibraltar straits
7. High-resolution haplotype structure in the human genome
8. Regulation of the mammalian alcohol dehydrogenase genes
9. Alcohol dehydrogenases
10. Alcohol dehydrogenase genes: Restriction fragment length polymorphisms for ADH4 (II-ADH) and ADH5 (χ-ADH) and construction of haplotypes among different ADH classes
11. Distribution of ADH2 and ALDH2 genotypes in different populations
12. HAPLO: A program using the EM algorithm to estimate the frequencies of multi-site haplotypes
13. Analyses of cross species polymerase chain reaction products to infer the ancestral state of human polymorphisms
14. Intensely punctate meiotic recombination in the Class II region of the major histocompatibility complex
15. Haplotype tagging for the identification of common disease genes
16. The role of genetic drift in the differentiation of Icelandic and Norwegian cattle
17. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus
18. DRD2 haplotypes containing the TaqI A1 allele: Implications for alcoholism research
19. Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations
20. Prospects for whole-genome linkage disequilibrium mapping of common disease genes
21. The interaction of selection and linkage. I. General considerations: Heterotic models
22. Genetic and environmental influences on alcohol metabolism in humans
23. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
24. Rapid RFLP screening procedure identifies new polymorphisms at albumin and alcohol dehydrogenase loci
25. Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: A pilot study
26. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
27. ALFRED: An allele frequency database for diverse populations and DNA polymorphisms - An update
28. st values for SNPs
29. Patterns of linkage disequilibrium for multisite haplotypes at 14 genetic loci in human populations worldwide
30. Effects of worldwide population subdivision on ALDH2 linkage disequilibrium
31. Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: Implication in alcoholic cirrhosis in white patients
32. Linkage disequilibrium in the human genome
33. Genome-wide search for genes affecting the risk for alcohol dependence
34. Polymorphisms of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism
35. Genetics of human alcohol and aldehyde dehydrogenases
36. Polymorphisms of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men
37. Cladistic structure within the human lipoprotein lipase gene and its implications for phenotypic association studies
38. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders
39. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men
40. Global patterns of linkage disequilibrium at the CD4 locus and modern human origins
41. A global haplotype analysis of the myotonic dystrophy locus: Implications for the evolution of modern humans and for the origin of myotonic dystrophy mutations
42. Alcohol dehydrogenase polymorphisms in native Americans: Identification of the ADH2*3 allele
43. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification
44. Assessing linkage disequilibrium in a complex genetic system. I. Overall deviation from random association