Linkage of schizophrenia with chromosome 1q loci in Taiwanese families

Molecular Psychiatry

Volumn 8, Issue 4, 2003, Pages 445-452

  Hwu, H G ^a   Liu, C M ^a   Fann, C S J ^b   Ou Yang, W C ^c   Lee, S F C ^d  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c Chia Nan Psychiatric Center   (Taiwan)

^d Taoyuan Psychiatric Center   (Taiwan)

Author keywords

Chromosome 1q; DISC1 gene; Genetic marker; Linkage; Schizophrenia

Indexed keywords

ARTICLE; CAUCASIAN; CHROMOSOME 1Q; CHROMOSOME TRANSLOCATION; CLONING; DISC1 GENE; EVALUATION; FAMILY; FEMALE; GENE; GENE LOCUS; GENETIC LINKAGE; GENETIC MARKER; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE CELL DIFFERENTIATION; PHENOTYPE; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOSIS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; TAIWAN;

ASIAN CONTINENTAL ANCESTRY GROUP; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; FEMALE; GENETIC MARKERS; HUMANS; MALE; MICROSATELLITE REPEATS; PSYCHOTIC DISORDERS; REFERENCE VALUES; SCHIZOPHRENIA; TAIWAN;

EID: 0037953124     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001235     Document Type: Article

References (58)

1. McGuffin P, Asherson P, Owen M, Farmer A. The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 1994; 164: 593-595.
2. Rish N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990; 46: 222-228.
3. Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 1997; 2: 148-155.
4. Hovatta I, Varilo T, Suvisaari J, Terwilliger TD, Olikainen V, Arajarvi R et al. A genome-wide search for schizophrenia genes in an internal isolate of Finland suggesting multiple susceptibility loci. Am J Med Genet (Neuropsychiatric Genet) 1998; 81: 453-454.
5. Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Olikainen V, Arajarvi R et al. A genome-wide search for schizophrenia genes in an isolated Finnish subpopulation suggesting multiple susceptibility loci. Am J Hum Genet 1999; 65: 1114-1124.
6. Ekelund J, Lichtermann D, Hovatta I, Ellonen P, Suvisaari J, Terwilliger JD et al. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet 2000; 9: 1049-1057.
7. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001; 10: 1611-1617.
8. Millar JK, Christie S, Anderson S, Lawson D, Loh DH-W, Devon RS et al. Genomic structure and localization within a linkage hotspot of disrupted in schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry 2001; 6: 173-178.
9. Millar JK, Wilson-Annan JC, Anderson S, Cristie S, Taylor MS, Semple CAM et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9: 1415-1423.
10. St Clair DM, Blackwood D, Muir W, Carothers A, Walker M, Spowart G et al. Association with a family of a balanced autosomal translocation with major mental illness. Lancet 1990; 336: 13-16.
11. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20: 70-73.
12. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B et al. Genome scan of European-American schizophrenia pedigrees: results of the NIMH genetics initiative and millennium consortium. Am J Med Genet (Neuropsychiatric Genet) 1998; 81: 290-295.
13. Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD et al. NIMH genetics initiative millennium schizophrenia consortium: linkage analysis of African-American pedigrees. Am J Med Genet (Neuropsychiatric Genet) 1998; 81: 282-289.
14. Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kriby A et al. Genomescan of schizophrenia. Am J Psychiatry 1998; 155: 741-750.
15. Shaw SH, Kelly M, Smith AB, Shields G, Hopkins PJ, Loftus J et al. A genome-wide search for schizophrenia susceptibility genes. Am J Med Genet 1998; 81: 364-376.
16. Brzustowicz LM, Hodgkinson KA, Chow EWC, Honer WG, Bassett AS. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000; 288: 678-682.
17. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS et al. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001; 68: 661-673.
18. Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong L-L, Ho T-H et al. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry 1998; 3: 32-37.
19. Wittekindt O, Jauch A, Burgert E, Sharer L. The human small conductance-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 21.3, and shows possible association with schizophrenia. Neurogenetics 1998; 1: 259-265.
20. Morris AG, Gaitonde E, McKenna PJ, Mollon JD, Hunt D. CAG repeat expansion and schizophrenia: association with the disease in females and with early age of onset. Hum Mol Genet 1995; 4: 1957-1961.
21. O'Donovan MC, Guy C, Craddock N, Bowen T, McKeon P. Macedo A et al. Confirmation of association between expanded CAG/CTG repeats both in schizophrenia and bipolar disorder. Psychol Med 1996; 26: 1145-1153.
22. Wittekindt O, Schwab SG, Burgert E, Knapp M, Albus M, Lever B et al. Association between hSCa3 and schizophrenic not confirmed by transmission disequilibria test in 193 offspring/parents trios. Mol Psychiatry 1999; 4: 267-270.
23. Cardno AG, Bowen T, Guy CA, Jones LA, McCarthy G, Williams NM et al. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biol Psychiatry 1999; 45: 1592-1596.
24. Speight G, Guy C, Bowen T, Asherson P, McGuffin P, Craddock N et al. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. Am J Med Genet (Neuropsychiatric Genet) 1997; 74: 204-206.
25. Jones AL, Middle F, Guy C, Spurlock G, Cairns NJ, McGuffin P et al. No evidence for expanded polyglutamine in bipolar disorder and schizophrenia. Mol Psychiatry 1997; 2: 478-482.
26. Li T, Hu X, Chandy KG, Fantino E, Kalman K, Gutman G et al. Transmission disequilibrium analysis of a triplet repeat within the hSKCa3 gene using family trios with schizophrenia. Biochem Biophys Res Commun 1998; 251: 662-665.
27. Hawi Z, Mynett-Johnson L, Murphy V, Straub Kendler KS, Walsh D et al. No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population. Mol Psychiatry 1999; 4:488-491.
28. Meissner B, Purmann S, Schürmann M, Zuhlke C, Lencer R, Arolt V et al. hSKCa3: a candidate gene for schizophrenia? Psychiat Genet 1999; 9: 91-96.
29. Hwu HG, Yang SY. Psychiatric diagnostic assessment: establishment and inter-rater reliability. Chin Psychiatry 1987; 2: 267-278.
30. Hwu HG. Psychiatric diagnostic assessment. In: Hwu HG (ed). Manual of Psychiatric Diagnosis, 2nd edn (printing 2). Publication Committee, College of Medicine, National Taiwan University: Taipei, 1999, pp 7-42.
31. American Psychiatric Association: Diagnostic and Statistical Manual, 4th edn, American Psychiatric Association: Washington, DC, 1994.
32. Lahiri DK, Bye S, Nurnberger Jr JI, Hodes ME, Crisp M. A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested. J Biochem Biophys Methods 1992; 25: 193-205.
33. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985; 230: 1350-1354.
34. Cottingham Jr RW, Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993; 53: 252-263.
35. O'Connel JR, Weeks ED. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nat Genet 1995; 11: 402-408.
36. Kainulainen K, Perola M, Terwilliger JD, Kaprio J, Koskenvuo M, Syvanen AC et al. The rennin - angiotensin-system in essential hypertension: evidence for involvement of the angiotensin receptor type-I gene in Finnish patients. Hypertension 1999; 33: 844-849.
37. Durner M, Vieland VJ, Greenberg DA. Further evidence for the increased power of LOD scores compared with nonparametric methods. Am J Hum Genet 1999; 64: 281-289.
38. Abreu PC, Greenberg SE, Hodge SE. Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. Am J Hum Genet 1999; 65: 847-857.
39. Bierut LJ, Rice JP, Edenberg HJ, Goate A, Foroud T, Cloninger CR et al. Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. Am J Med Genet (Neuropsychiatric Genet) 2000; 90: 299-302.
40. Kruglyak L, Daly MJ, Reeve-Daly MR, Lander ES. Parametric and non-parametric analysis: an unified multipoint approach. Am J Hum Genet 1996; 58: 1347-1363.
41. Clerget-Darpoux F, Bonaiti-pellie C, Hochez J. Effects of misspecifying genetic parameters in lod score analysis. Biometrics 1986; 42: 393-399.
42. Hovatta I, Lichtermann D, Juvonen H, Suvisaari J, Terwilliger JD, Arajarvi R et al. Linkage analysis of putative schizophrenia gene candidate regions on chromosomes 3p, 5q, 6p, 8p, 20p, and 22q in a population-based sampled Finnish family set. Mol Psychiatry 1998; 3: 452-457.
43. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS. Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 1999; 65: 876-884.
44. Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y et al. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry 1999; 4: 254-260.
45. Fananas L, Fuster R, Guillamt R, Miro R. Chromosomal fragile site 1q21 in schizophrenic patients. Am J Psychiatry 1997; 154: 716.
46. Kosower NS, Gerad L, Goldstein M, Parasol N, Zipser Y, Ragolsky M et al. Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia. Am J Med Genet 1995; 60: 133-138.
47. Saha N, Tay JS, Tsoi WF, Kua EH. Association of Duffy blood group with schizophrenia in Chinese. Genet Epidemiol 1990; 7: 303-305.
48. Blackwood DHR, Fordyce A, Walker MT, Drysdale JK, St Clair DM, Porteous DJ et al. Schizophrenia and affective disorders cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 2001; 69: 428-433.
49. Lantz VA, Miller KG. A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of drosophila embryos. J Cell Biol 1998; 140: 897-910.
50. Dillman JF, Dabney LP, Karki S, Paschal BM, Holzbaur EL, Pfister KK. Functional analysis of dynactin and cytoplasmic dynein slow axonal transport. J Neurosci 1996; 16: 6742-6752.
51. Ahmad FJ, Echeverri CJ, Vallee RB, Baas PW. Cytoplasmic dynein and dynactin are required for the transport of microtubules into axon. J Cell Biol 1998; 140: 391-401.
52. Zhang W, Vaazquez L, Apperson M, Kennedy MB. Citron binds to PSD-95 at glutamatergic synapse on inhibitory neurons in the hippocampus. J Neurosci 1999; 19: 96-108.
53. Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K. Mammalian homologue of the Caenorhabditis elesans UNC-76 protein involved in axonal outgrowth is a protein kinase C ζ-interacting protein. J Cell Biol 1999; 144: 403-411.
54. Nagy JI, Proce ML, Staines WA, Lynn BD, Granholm AC. The hyaluronan receptor RHAMAM in noradrenergic fibers contributes to axon growth capacity of locus coeruleus neurons in an intraocular transplant model. Neuroscience 1998; 86: 241-255.
55. Dolnick BJ. Naturally occurring antisense RNA. Pharmacol Ther 1997; 75: 179-184.
56. Knee R, Murphy PR. Regulation of gene expression by natural antisense RNA transcripts. Neurochem Int 1997; 31: 379-392.
57. Kobayashi S, Takashima A, Anzai K. The dendritic translocation of translin protein in the form of BC1 RNA protein particles in developing rat hippocampal neurons in primary culture. Biochem Biophys Res Commun 1998; 253: 448-453.
58. Millar JK, Christie S, Semple CAM, Porteous DJ. Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1 a gene disrupted by a translocation segregating with schizophrenia. Genomics 2000; 67: 69-77.