Positive natural selection in the human lineage

Science

Volumn 312, Issue 5780, 2006, Pages 1614-1620

  Sabeti, P C ^a,b   Schaffner, S F ^a   Fry, B ^a   Lohmueller, J ^a,c   Varilly, P ^a   Shamovsky, O ^a   Palma, A ^a   Mikkelsen, T S ^a   Altshuler, D ^a,b,d   Lander, E S ^a,b,e,f  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROWN UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; DATA REDUCTION; DNA SEQUENCES; GENES; GENETIC ENGINEERING; HUMAN ENGINEERING;

HUMAN LINEAGE; NATURAL SELECTION; POLYMORPHISM; THEORETICAL EXPECTATIONS;

NATURAL SCIENCES;

DNA; GENETIC ANALYSIS; GENETIC STRUCTURE; GENOME; NATURAL SELECTION; POLYMORPHISM;

ALLELE; ANALYTIC METHOD; DNA SEQUENCE; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN GENOME; NATURAL SELECTION; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; EVOLUTION; GENE FREQUENCY; GENETICS, POPULATION; GENOME, HUMAN; HAPLOTYPES; HUMANS; MUTATION; POLYMORPHISM, GENETIC; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

EID: 33745121154     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124309     Document Type: Review

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74. P.C.S. is funded by the Damon Runyon Cancer Fellowship and the L'Oreal for Women in Science Award. We thank C. Bustamante, R. Nielsen, J. Akey, Y. Gilad, and C. Carlson for providing information from their previous publications. We also thank F. Steele, D. Reich, D. Hartl, R. Neilsen, D. Richter, C. Langley, M. Przeworski, A. Clark, J. Fay, S. Myers, T. Farhadian, T. Herrington, A. Foster, P. Sabeti, and four anonymous referees for careful review of our manuscript.