-
1
-
-
0036911353
-
Interrogating a high-density SNP map for signatures of natural selection
-
Akey, J. M., Zhang, G., Zhang, K., Jin, L. & Shriver, M. D. Interrogating a high-density SNP map for signatures of natural selection. Genome Res. 12, 1805-1814 (2002).
-
(2002)
Genome Res
, vol.12
, pp. 1805-1814
-
-
Akey, J.M.1
Zhang, G.2
Zhang, K.3
Jin, L.4
Shriver, M.D.5
-
2
-
-
27144491328
-
Adaptive evolution of non-coding DNA in Drosophila
-
Andolfatto, P. Adaptive evolution of non-coding DNA in Drosophila. Nature 437, 1149-1152 (2005).
-
(2005)
Nature
, vol.437
, pp. 1149-1152
-
-
Andolfatto, P.1
-
3
-
-
27144539145
-
-
Bustamante, C. D. et al. Natural selection on protein-coding genes in the human genome. Nature 437, 1153-1157 (2005). This paper reports a genome-wide scan for selection in humans based on a derivative of the MacDonald-Kreitman test.
-
Bustamante, C. D. et al. Natural selection on protein-coding genes in the human genome. Nature 437, 1153-1157 (2005). This paper reports a genome-wide scan for selection in humans based on a derivative of the MacDonald-Kreitman test.
-
-
-
-
4
-
-
33745121154
-
-
Sabeti, P. C. et al. Positive natural selection in the human lineage. Science 312, 1614-1620 (2006). This review contains a comprehensive list of genes that are thought to be under selection in humans.
-
Sabeti, P. C. et al. Positive natural selection in the human lineage. Science 312, 1614-1620 (2006). This review contains a comprehensive list of genes that are thought to be under selection in humans.
-
-
-
-
5
-
-
34347336584
-
Localizing recent adaptive evolution in the human genome
-
Williamson, S. H. et al. Localizing recent adaptive evolution in the human genome. PLoS Genet. 3, e90 (2007).
-
(2007)
PLoS Genet
, vol.3
-
-
Williamson, S.H.1
-
6
-
-
30444460720
-
Global landscape of recent inferred Darwinian selection for Homo sapiens
-
Wang, E. T., Kodama, G., Baldi, P. & Moyzis, R. K. Global landscape of recent inferred Darwinian selection for Homo sapiens. Proc. Natl Acad. Sci. USA 103, 135-140 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 135-140
-
-
Wang, E.T.1
Kodama, G.2
Baldi, P.3
Moyzis, R.K.4
-
9
-
-
24644507039
-
Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans
-
Evans, P. D. et al. Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science 309, 1717-1720 (2005).
-
(2005)
Science
, vol.309
, pp. 1717-1720
-
-
Evans, P.D.1
-
10
-
-
0037158715
-
Molecular evolution of FOXP2, a gene involved in speech and language
-
Enard, W. et al. Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418, 869-872 (2002).
-
(2002)
Nature
, vol.418
, pp. 869-872
-
-
Enard, W.1
-
11
-
-
0037307413
-
Signatures of natural selection in the human genome
-
Bamshad, M. & Wooding, S. P. Signatures of natural selection in the human genome. Nature Rev. Genet. 4, 99A-111A (2003).
-
(2003)
Nature Rev. Genet
, vol.4
-
-
Bamshad, M.1
Wooding, S.P.2
-
12
-
-
0036107903
-
Discovery of regulatory elements by a computational method for phylogenetic footprinting
-
Blanchette, M. & Tompa, M. Discovery of regulatory elements by a computational method for phylogenetic footprinting. Genome Res. 12, 739-748 (2002).
-
(2002)
Genome Res
, vol.12
, pp. 739-748
-
-
Blanchette, M.1
Tompa, M.2
-
13
-
-
23744458086
-
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
-
Siepel, A. et al. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 15, 1034-1050 (2005).
-
(2005)
Genome Res
, vol.15
, pp. 1034-1050
-
-
Siepel, A.1
-
14
-
-
0033611501
-
High genomic deleterious mutation rates in hominids
-
Eyre-Walker, A. & Keightley, P. D. High genomic deleterious mutation rates in hominids. Nature 397, 344-347 (1999).
-
(1999)
Nature
, vol.397
, pp. 344-347
-
-
Eyre-Walker, A.1
Keightley, P.D.2
-
15
-
-
0036900082
-
Quantifying the slightly deleterious model of molecular evolution
-
Eyre-Walker, A., Keightley, P. D., Smith, N. G. C. & Gaffney, D. Quantifying the slightly deleterious model of molecular evolution. Mol. Biol. Evol. 19, 2142-2149 (2002).
-
(2002)
Mol. Biol. Evol
, vol.19
, pp. 2142-2149
-
-
Eyre-Walker, A.1
Keightley, P.D.2
Smith, N.G.C.3
Gaffney, D.4
-
16
-
-
33745347447
-
The distribution of fitness effects of new deleterious amino acid mutations in humans
-
Eyre-Walker, A., Woolfit, M. & Phelps, T. The distribution of fitness effects of new deleterious amino acid mutations in humans. Genetics 173, 891-900 (2006).
-
(2006)
Genetics
, vol.173
, pp. 891-900
-
-
Eyre-Walker, A.1
Woolfit, M.2
Phelps, T.3
-
17
-
-
34147116715
-
Most rare missense alleles are deleterious in humans: Implications for complex disease and association studies
-
Kryukov, G. V., Pennacchio, L. A. & Sunyaev, S. R. Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Am. J. Hum. Genet. 80, 727-739 (2007).
-
(2007)
Am. J. Hum. Genet
, vol.80
, pp. 727-739
-
-
Kryukov, G.V.1
Pennacchio, L.A.2
Sunyaev, S.R.3
-
18
-
-
0346243805
-
-
Clark, A. G. et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science 302, 1960-1963 (2003). This paper provides a list of genes under positive selection in the human evolutionary lineage based on the ratio of non-synonymous to synonymous mutations.
-
Clark, A. G. et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science 302, 1960-1963 (2003). This paper provides a list of genes under positive selection in the human evolutionary lineage based on the ratio of non-synonymous to synonymous mutations.
-
-
-
-
19
-
-
24344500211
-
-
Consortium, T. C. S. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437, 69-87 (2005).
-
Consortium, T. C. S. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437, 69-87 (2005).
-
-
-
-
20
-
-
20444430245
-
A scan for positively selected genes in the genomes of humans and chimpanzees
-
Nielsen, R. et al. A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol. 3, e170 (2005).
-
(2005)
PLoS Biol
, vol.3
-
-
Nielsen, R.1
-
21
-
-
0034688140
-
Rapid evolution of male reproductive genes in the descent of man
-
Wyckoff, G. J., Wang, W. & Wu, C. I. Rapid evolution of male reproductive genes in the descent of man. Nature 403, 304-309 (2000).
-
(2000)
Nature
, vol.403
, pp. 304-309
-
-
Wyckoff, G.J.1
Wang, W.2
Wu, C.I.3
-
22
-
-
0037230001
-
Pervasive adaptive evolution in mammalian fertilization proteins
-
Swanson, W. J., Nielsen, R. & Yang, Q. Pervasive adaptive evolution in mammalian fertilization proteins. Mol. Biol. Evol. 20, 18-20 (2003).
-
(2003)
Mol. Biol. Evol
, vol.20
, pp. 18-20
-
-
Swanson, W.J.1
Nielsen, R.2
Yang, Q.3
-
23
-
-
0034708031
-
Rapid evolution of reproductive barriers driven by sexual conflict
-
Gavrilets, S. Rapid evolution of reproductive barriers driven by sexual conflict. Nature 403, 886-889 (2000).
-
(2000)
Nature
, vol.403
, pp. 886-889
-
-
Gavrilets, S.1
-
24
-
-
0024372736
-
The hitchhiking effect revisited
-
Kaplan, N. L., Hudson, R. R. & Langley, C. H. The hitchhiking effect revisited. Genetics 123, 887-899 (1989).
-
(1989)
Genetics
, vol.123
, pp. 887-899
-
-
Kaplan, N.L.1
Hudson, R.R.2
Langley, C.H.3
-
25
-
-
0016220238
-
-
Maynard Smith, J. & Haigh, J. The hitch-hiking effect of a favorable gene. Genet. Res. 23, 23-35 (1974). The original paper describing the effect of a selective sweep in a population.
-
Maynard Smith, J. & Haigh, J. The hitch-hiking effect of a favorable gene. Genet. Res. 23, 23-35 (1974). The original paper describing the effect of a selective sweep in a population.
-
-
-
-
26
-
-
0029036829
-
The hitchhiking effect on the site frequency spectrum of DNA polymorphisms
-
Braverman, J. M., Hudson, R. R., Kaplan, N. L., Langley, C. H. & Stephan, W. The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics 140, 783-796 (1995).
-
(1995)
Genetics
, vol.140
, pp. 783-796
-
-
Braverman, J.M.1
Hudson, R.R.2
Kaplan, N.L.3
Langley, C.H.4
Stephan, W.5
-
27
-
-
0031673084
-
The effect of hitch-hiking on neutral genealogies
-
Barton, N. The effect of hitch-hiking on neutral genealogies. Genet. Res. 72, 123-133 (1998).
-
(1998)
Genet. Res
, vol.72
, pp. 123-133
-
-
Barton, N.1
-
28
-
-
33646180401
-
The hitchhiking effect on linkage disequilibrium between linked neutral loci
-
Stephan, W., Song, Y. S. & Langley, C. H. The hitchhiking effect on linkage disequilibrium between linked neutral loci. Genetics 172, 2647-2663 (2006).
-
(2006)
Genetics
, vol.172
, pp. 2647-2663
-
-
Stephan, W.1
Song, Y.S.2
Langley, C.H.3
-
29
-
-
0014832106
-
Primary adult lactose intolerance and milking habit - a problem in biologic and cultural interrelations. 2. A culture historical hypothesis
-
Simoons, F. J. Primary adult lactose intolerance and milking habit - a problem in biologic and cultural interrelations. 2. A culture historical hypothesis. Am. J. Dig. Dis. 15, 695-710 (1970).
-
(1970)
Am. J. Dig. Dis
, vol.15
, pp. 695-710
-
-
Simoons, F.J.1
-
30
-
-
0015547172
-
Analytic review: Some current problems of population genetics
-
Cavalli-Sforza, L. Analytic review: some current problems of population genetics. Am. J. Hum. Genet. 25, 82-104 (1973).
-
(1973)
Am. J. Hum. Genet
, vol.25
, pp. 82-104
-
-
Cavalli-Sforza, L.1
-
31
-
-
0345257771
-
Gene-culture coevolution between cattle milk protein genes and human lactase genes
-
Beja-Pereira, A. et al. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nature Genet. 35, 311-313 (2003).
-
(2003)
Nature Genet
, vol.35
, pp. 311-313
-
-
Beja-Pereira, A.1
-
32
-
-
2442677652
-
Genetic signatures of strong recent positive selection at the lactase gene
-
Bersaglieri, T. et al. Genetic signatures of strong recent positive selection at the lactase gene. Am. J. Hum. Genet. 74, 1111-1120 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 1111-1120
-
-
Bersaglieri, T.1
-
33
-
-
34247246180
-
Absence of the lactase-persistence-associated allele in early Neolithic Europeans
-
Burger, J., Kirchner, M., Bramanti, B., Haak, W. & Thomas, M. G. Absence of the lactase-persistence-associated allele in early Neolithic Europeans. Proc. Natl Acad. Sci. USA 104, 3736-3741 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3736-3741
-
-
Burger, J.1
Kirchner, M.2
Bramanti, B.3
Haak, W.4
Thomas, M.G.5
-
34
-
-
2442677652
-
Genetic signatures of strong recent positive selection at the lactase gene
-
Bersaglieri, T. et al. Genetic signatures of strong recent positive selection at the lactase gene. Am. J. Hum. Genet. 74, 1111-1120 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 1111-1120
-
-
Bersaglieri, T.1
-
35
-
-
33845900450
-
-
Tishkoff, S. A. et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nature Genet. 39, 31-40 (2007). A recent paper that demonstrates positive selection acting independently on different lactase alleles that confer lactose tolerance in adults, in African and European populations.
-
Tishkoff, S. A. et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nature Genet. 39, 31-40 (2007). A recent paper that demonstrates positive selection acting independently on different lactase alleles that confer lactose tolerance in adults, in African and European populations.
-
-
-
-
36
-
-
0035919696
-
Haplotype diversity and linkage disequilibrium at human G6PD: Recent origin of alleles that confer malarial resistance
-
Tishkoff, S. A. et al. Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science 293, 455-462 (2001).
-
(2001)
Science
, vol.293
, pp. 455-462
-
-
Tishkoff, S.A.1
-
37
-
-
35348982018
-
Signature of selection at the G6PD locus inferred from patterns of nucleotide variation and linkage disequilibrium in Africans
-
Verrelli, B. C., Argyropoulos, G., Destro-Bisol, G., Williams, S. M. & Tishkoff, S. A. Signature of selection at the G6PD locus inferred from patterns of nucleotide variation and linkage disequilibrium in Africans. Am. J. Hum. Genet. 69, 395-395 (2001).
-
(2001)
Am. J. Hum. Genet
, vol.69
, pp. 395-395
-
-
Verrelli, B.C.1
Argyropoulos, G.2
Destro-Bisol, G.3
Williams, S.M.4
Tishkoff, S.A.5
-
38
-
-
0036963687
-
Nucleotide variability at G6PD and the signature of malarial selection in humans
-
Saunders, M. A., Hammer, M. F. & Nachman, M. W. Nucleotide variability at G6PD and the signature of malarial selection in humans. Genetics 162, 1849-1861 (2002).
-
(2002)
Genetics
, vol.162
, pp. 1849-1861
-
-
Saunders, M.A.1
Hammer, M.F.2
Nachman, M.W.3
-
39
-
-
0037167852
-
Detecting recent positive selection in the human genome from haplotype structure
-
Sabeti, P. C. et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 419, 832-837 (2002).
-
(2002)
Nature
, vol.419
, pp. 832-837
-
-
Sabeti, P.C.1
-
40
-
-
33644981509
-
-
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in the human genome. PLoS Biol. 4, e72 (2006). This paper provides the result of a genome-wide scan for selective sweeps based on haplotype structure information.
-
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in the human genome. PLoS Biol. 4, e72 (2006). This paper provides the result of a genome-wide scan for selective sweeps based on haplotype structure information.
-
-
-
-
41
-
-
13944278863
-
A common inversion under selection in Europeans
-
Stefansson, H. et al. A common inversion under selection in Europeans. Nature Genet. 37, 129-137 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 129-137
-
-
Stefansson, H.1
-
42
-
-
8844271778
-
CYP3A variation and the evolution of salt-sensitivity variants
-
Thompson, E. E. et al. CYP3A variation and the evolution of salt-sensitivity variants. Am. J. Hum. Genet. 75, 1059-1069 (2004).
-
(2004)
Am. J. Hum. Genet
, vol.75
, pp. 1059-1069
-
-
Thompson, E.E.1
-
43
-
-
18444412585
-
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
-
Osier, M. V. et al. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am. J. Hum. Genet. 1, 84-99 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.1
, pp. 84-99
-
-
Osier, M.V.1
-
44
-
-
0041886501
-
Natural selection on the olfactory receptor gene family in humans and chimpanzees
-
Gilad, Y., Bustamante, C. D., Lancet, D. & Paabo, S. Natural selection on the olfactory receptor gene family in humans and chimpanzees. Am. J. Hum. Genet. 73, 489-501 (2003).
-
(2003)
Am. J. Hum. Genet
, vol.73
, pp. 489-501
-
-
Gilad, Y.1
Bustamante, C.D.2
Lancet, D.3
Paabo, S.4
-
45
-
-
27544482154
-
Genomic regions exhibiting positive selection identified from dense genotype data
-
Carlson, C. S. et al. Genomic regions exhibiting positive selection identified from dense genotype data. Genome Res. 15, 1553-1565 (2005).
-
(2005)
Genome Res
, vol.15
, pp. 1553-1565
-
-
Carlson, C.S.1
-
46
-
-
0024313579
-
-
Tajima, F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123, 585-595 (1989). This paper describes the most common methods for detecting selection based on population genetic data.
-
Tajima, F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123, 585-595 (1989). This paper describes the most common methods for detecting selection based on population genetic data.
-
-
-
-
47
-
-
0033911640
-
Hitchhiking under positive Darwinian selection
-
Fay, J. C. & Wu, C. I. Hitchhiking under positive Darwinian selection. Genetics 155, 1405-1413 (2000).
-
(2000)
Genetics
, vol.155
, pp. 1405-1413
-
-
Fay, J.C.1
Wu, C.I.2
-
48
-
-
13844313862
-
Whole-genome patterns of common DNA variation in three human populations
-
Hinds, D. A. et al. Whole-genome patterns of common DNA variation in three human populations. Science 307, 1072-1079 (2005).
-
(2005)
Science
, vol.307
, pp. 1072-1079
-
-
Hinds, D.A.1
-
49
-
-
27544437635
-
Genomic scans for selective sweeps using SNP data
-
Nielsen, R. et al. Genomic scans for selective sweeps using SNP data. Genome Res. 15, 1566-1575 (2005).
-
(2005)
Genome Res
, vol.15
, pp. 1566-1575
-
-
Nielsen, R.1
-
50
-
-
0037118065
-
Selfish drivers
-
Henikoff, S. & Malik, H. S. Selfish drivers. Nature 417, 227-227 (2002).
-
(2002)
Nature
, vol.417
, pp. 227-227
-
-
Henikoff, S.1
Malik, H.S.2
-
51
-
-
0031450133
-
The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations
-
Charlesworth, B., Nordborg, M. & Charlesworth, D. The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations. Genet. Res. 70, 155-174 (1997).
-
(1997)
Genet. Res
, vol.70
, pp. 155-174
-
-
Charlesworth, B.1
Nordborg, M.2
Charlesworth, D.3
-
52
-
-
0031825318
-
Genetic hitch-hiking in a subdivided population
-
Slatkin, M. & Wiehe, T. Genetic hitch-hiking in a subdivided population. Genet. Res. 71, 155-160 (1998).
-
(1998)
Genet. Res
, vol.71
, pp. 155-160
-
-
Slatkin, M.1
Wiehe, T.2
-
53
-
-
0015879546
-
-
Lewontin, R. C. & Krakauer, J. Distribution of gene frequency as a test of theory of selective neutrality of polymorphisms. Genetics 74, 175-195 (1973). The original paper discussing the effect of selection on measures of population subdivision.
-
Lewontin, R. C. & Krakauer, J. Distribution of gene frequency as a test of theory of selective neutrality of polymorphisms. Genetics 74, 175-195 (1973). The original paper discussing the effect of selection on measures of population subdivision.
-
-
-
-
54
-
-
27544501017
-
Measures of human population structure show heterogeneity among genomic regions
-
Weir, B. S., Cardon, L. R., Anderson, A. D., Nielsen, D. M. & Hill, W. G. Measures of human population structure show heterogeneity among genomic regions. Genome Res. 15, 1468-1476 (2005).
-
(2005)
Genome Res
, vol.15
, pp. 1468-1476
-
-
Weir, B.S.1
Cardon, L.R.2
Anderson, A.D.3
Nielsen, D.M.4
Hill, W.G.5
-
55
-
-
0038586483
-
A genome scan to detect candidate regions influenced by local natural selection in human populations
-
Kayser, M., Brauer, S. & Stoneking, M. A genome scan to detect candidate regions influenced by local natural selection in human populations. Mol. Biol. Evol. 20, 893-900 (2003).
-
(2003)
Mol. Biol. Evol
, vol.20
, pp. 893-900
-
-
Kayser, M.1
Brauer, S.2
Stoneking, M.3
-
56
-
-
79959524146
-
A haplotype map of the human genome
-
The International HapMap Consortium
-
The International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
57
-
-
0029099781
-
Properties of statistical tests of neutrality for DNA polymorphism data
-
Simonsen, K. L., Churchill, G. A. & Aquadro, C. F. Properties of statistical tests of neutrality for DNA polymorphism data. Genetics 141, 413-429 (1995).
-
(1995)
Genetics
, vol.141
, pp. 413-429
-
-
Simonsen, K.L.1
Churchill, G.A.2
Aquadro, C.F.3
-
58
-
-
0033828706
-
A genome-wide departure from the standard neutral model in natural populations of Drosophila
-
Andolfatto, P. & Przeworski, M. A genome-wide departure from the standard neutral model in natural populations of Drosophila. Genetics 156, 257-268 (2000).
-
(2000)
Genetics
, vol.156
, pp. 257-268
-
-
Andolfatto, P.1
Przeworski, M.2
-
59
-
-
0034237204
-
Adjusting the focus on human variation
-
Przeworski, M., Hudson, R. R. & Di Rienzo, A. Adjusting the focus on human variation. Trends Genet. 16, 296-302 (2000).
-
(2000)
Trends Genet
, vol.16
, pp. 296-302
-
-
Przeworski, M.1
Hudson, R.R.2
Di Rienzo, A.3
-
60
-
-
0034809334
-
Statistical tests of selective neutrality in the age of genomics
-
Nielsen, R. Statistical tests of selective neutrality in the age of genomics. Heredity 86, 641-647 (2001).
-
(2001)
Heredity
, vol.86
, pp. 641-647
-
-
Nielsen, R.1
-
61
-
-
10344221021
-
Disentangling the effects of demography and selection in human history
-
Stajich, J. E. & Hahn, M. W. Disentangling the effects of demography and selection in human history. Mol. Biol. Evol. 22, 63-73 (2005).
-
(2005)
Mol. Biol. Evol
, vol.22
, pp. 63-73
-
-
Stajich, J.E.1
Hahn, M.W.2
-
62
-
-
0036743513
-
Testing models of selection and demography in Drosophila simulans
-
Wall, J. D., Andolfatto, P. & Przeworski, M. Testing models of selection and demography in Drosophila simulans. Genetics 162, 203-216 (2002).
-
(2002)
Genetics
, vol.162
, pp. 203-216
-
-
Wall, J.D.1
Andolfatto, P.2
Przeworski, M.3
-
63
-
-
0034086970
-
Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
-
Galtier, N., Depaulis, F. & Barton, N. H. Detecting bottlenecks and selective sweeps from DNA sequence polymorphism. Genetics 155, 981-987 (2000).
-
(2000)
Genetics
, vol.155
, pp. 981-987
-
-
Galtier, N.1
Depaulis, F.2
Barton, N.H.3
-
64
-
-
23344438911
-
Distinguishing between selective sweeps and demography using DNA polymorphism data
-
Jensen, J. D., Kim, Y., DuMont, V. B., Aquadro, C. F. & Bustamante, C. D. Distinguishing between selective sweeps and demography using DNA polymorphism data. Genetics 170, 1401-1410 (2005).
-
(2005)
Genetics
, vol.170
, pp. 1401-1410
-
-
Jensen, J.D.1
Kim, Y.2
DuMont, V.B.3
Aquadro, C.F.4
Bustamante, C.D.5
-
65
-
-
0742288408
-
Mutations arising in the wave front of an expanding population
-
Edmonds, C. A., Lillie, A. S. & Cavalli-Sforza, L. L. Mutations arising in the wave front of an expanding population. Proc. Natl Acad. Sci. USA 101, 975-979 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 975-979
-
-
Edmonds, C.A.1
Lillie, A.S.2
Cavalli-Sforza, L.L.3
-
66
-
-
33244467305
-
The fate of mutations surfing on the wave of a range expansion
-
Klopfstein, S., Currat, M. & Excoffier, L. The fate of mutations surfing on the wave of a range expansion. Mol. Biol. Evol. 23, 482-490 (2006).
-
(2006)
Mol. Biol. Evol
, vol.23
, pp. 482-490
-
-
Klopfstein, S.1
Currat, M.2
Excoffier, L.3
-
67
-
-
0042991419
-
Correcting for ascertainment biases when analyzing SNP data: Applications to the estimation of linkage disequilibrium
-
Nielsen, R. & Signorovitch, J. Correcting for ascertainment biases when analyzing SNP data: applications to the estimation of linkage disequilibrium. Theor. Popul. Biol. 63, 245-255 (2003).
-
(2003)
Theor. Popul. Biol
, vol.63
, pp. 245-255
-
-
Nielsen, R.1
Signorovitch, J.2
-
68
-
-
11244313872
-
Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data
-
Nielsen, R., Hubisz, M. J. & Clark, A. G. Reconstituting the frequency spectrum of ascertained single-nucleotide polymorphism data. Genetics 168, 2373-2382 (2004).
-
(2004)
Genetics
, vol.168
, pp. 2373-2382
-
-
Nielsen, R.1
Hubisz, M.J.2
Clark, A.G.3
-
69
-
-
34547994117
-
A high-resolution recombination map of the human genome
-
Kong, A. et al. A high-resolution recombination map of the human genome. Nature Genet. 10, 10 (2002).
-
(2002)
Nature Genet
, vol.10
, pp. 10
-
-
Kong, A.1
-
70
-
-
26844482093
-
A fine-scale map of recombination rates and hotspots across the human genome
-
Myers, S., Bottolo, L., Freeman, C., McVean, G. & Donnelly, P. A fine-scale map of recombination rates and hotspots across the human genome. Science 310, 321-324 (2005).
-
(2005)
Science
, vol.310
, pp. 321-324
-
-
Myers, S.1
Bottolo, L.2
Freeman, C.3
McVean, G.4
Donnelly, P.5
-
71
-
-
33744815615
-
How reliable are empirical genomic scans for selective sweeps?
-
Teshima, K. M., Coop, G. & Przeworski, M. How reliable are empirical genomic scans for selective sweeps? Genome Res. 16, 702-712 (2006).
-
(2006)
Genome Res
, vol.16
, pp. 702-712
-
-
Teshima, K.M.1
Coop, G.2
Przeworski, M.3
-
72
-
-
33644778674
-
Directional positive selection on an allele of arbitrary dominance
-
Teshima, K. M. & Przeworski, M. Directional positive selection on an allele of arbitrary dominance. Genetics 172, 713-718 (2006).
-
(2006)
Genetics
, vol.172
, pp. 713-718
-
-
Teshima, K.M.1
Przeworski, M.2
-
73
-
-
33644982060
-
Being positive about selection
-
MacCallum, C. & Hill, E. Being positive about selection. PLoS Biol. 4, 293-295 (2006).
-
(2006)
PLoS Biol
, vol.4
, pp. 293-295
-
-
MacCallum, C.1
Hill, E.2
-
74
-
-
22144496080
-
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
-
Shu, W. et al. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc. Natl Acad. Sci. USA 102, 9643-9648 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 9643-9648
-
-
Shu, W.1
-
76
-
-
0018692402
-
Spandrels of San-Marco and the Panglossian paradigm - a critique of the adaptationist program
-
Gould, S. J. & Lewontin, R. C. Spandrels of San-Marco and the Panglossian paradigm - a critique of the adaptationist program. Proc. R. Soc. London Series B Biol. Sci. 205, 581-598 (1979).
-
(1979)
Proc. R. Soc. London Series B Biol. Sci
, vol.205
, pp. 581-598
-
-
Gould, S.J.1
Lewontin, R.C.2
-
77
-
-
0033910320
-
Gaucher disease: The origins of the Ashkenazi Jewish N370S and 84GG acid β-glucosidase mutations
-
Diaz, G. A. et al. Gaucher disease: The origins of the Ashkenazi Jewish N370S and 84GG acid β-glucosidase mutations. Am. J. Hum. Genet. 66, 1821-1832 (2000).
-
(2000)
Am. J. Hum. Genet
, vol.66
, pp. 1821-1832
-
-
Diaz, G.A.1
-
78
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J. P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
79
-
-
0028855776
-
Molecular-basis of familial cardiomyopathies
-
Schwartz, K., Carrier, L., Guicheney, P. & Komajda, M. Molecular-basis of familial cardiomyopathies. Circulation 91, 532-540 (1995).
-
(1995)
Circulation
, vol.91
, pp. 532-540
-
-
Schwartz, K.1
Carrier, L.2
Guicheney, P.3
Komajda, M.4
-
80
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Saxena, R. et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331-1336 (2007).
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
-
81
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
Steinthorsdottir, V. et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nature Genet. 39, 770-775 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 770-775
-
-
Steinthorsdottir, V.1
-
82
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini, E. et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (2007).
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
-
83
-
-
0036842917
-
Evidence for balancing selection from nucleotide sequence analyses of human G6PD
-
Verrelli, B. C. et al. Evidence for balancing selection from nucleotide sequence analyses of human G6PD. Am. J. Hum. Genet. 71, 1112-1128 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.71
, pp. 1112-1128
-
-
Verrelli, B.C.1
-
84
-
-
0031474610
-
-
Allen, S. J. et al. ?+-thalassemia protects children against disease caused by other infections as well as malaria. Proc. Natl Acad. Sci. USA 94, 14736-14741 (1997).
-
Allen, S. J. et al. ?+-thalassemia protects children against disease caused by other infections as well as malaria. Proc. Natl Acad. Sci. USA 94, 14736-14741 (1997).
-
-
-
-
85
-
-
0029016718
-
Protection against bronchial-asthma by Cftr δ-f508 mutation - a heterozygote advantage in cysticfibrosis
-
Schroeder, S. A., Gaughan, D. M. & Swift, M. Protection against bronchial-asthma by Cftr δ-f508 mutation - a heterozygote advantage in cysticfibrosis. Nature Med. 1, 703-705 (1995).
-
(1995)
Nature Med
, vol.1
, pp. 703-705
-
-
Schroeder, S.A.1
Gaughan, D.M.2
Swift, M.3
-
86
-
-
70349566593
-
Diabetes mellitus: A 'thrifty' genotype rendered detrimental by 'progress'?
-
Neel, J. V. Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am. J. Hum. Genet. 14, 353-362 (1962).
-
(1962)
Am. J. Hum. Genet
, vol.14
, pp. 353-362
-
-
Neel, J.V.1
-
87
-
-
7444227970
-
Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: Evolutionary evidence for differences in molecular effects
-
Thomas, P. D. & Kejariwal, A. Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects. Proc. Natl Acad. Sci. USA 101, 15398-15403 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 15398-15403
-
-
Thomas, P.D.1
Kejariwal, A.2
-
88
-
-
33847180200
-
Multiple mutations responsible for frequent genetic diseases in isolated populations
-
Zlotogora, J. Multiple mutations responsible for frequent genetic diseases in isolated populations. Eur. J. Hum. Genet. 15, 272-278 (2007).
-
(2007)
Eur. J. Hum. Genet
, vol.15
, pp. 272-278
-
-
Zlotogora, J.1
-
89
-
-
0035026704
-
Predicting deleterious amino acid substitutions
-
Ng, P. C. & Henikoff, S. Predicting deleterious amino acid substitutions. Genome Res. 11, 863-874 (2001).
-
(2001)
Genome Res
, vol.11
, pp. 863-874
-
-
Ng, P.C.1
Henikoff, S.2
-
90
-
-
0035869223
-
-
Sunyaev, S. et al. Prediction of deleterious human alleles. Hum. Mol. Genet. 10, 591-597 (2001). This paper describes the most popular bioinformatical method for predicting disease mutations without phenotypic data.
-
Sunyaev, S. et al. Prediction of deleterious human alleles. Hum. Mol. Genet. 10, 591-597 (2001). This paper describes the most popular bioinformatical method for predicting disease mutations without phenotypic data.
-
-
-
-
91
-
-
0037167852
-
Detecting recent positive selection in the human genome from haplotype structure
-
Sabeti, P. C. et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 419, 832-837 (2002).
-
(2002)
Nature
, vol.419
, pp. 832-837
-
-
Sabeti, P.C.1
-
92
-
-
0036851314
-
Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-12q14.1 and paralogous regions on other human chromosomes
-
Fan, Y., Linardopoulou, E., Friedman, C., Williams, E. & Trask, B. J. Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-12q14.1 and paralogous regions on other human chromosomes. Genome Res. 12, 1651-1662 (2002).
-
(2002)
Genome Res
, vol.12
, pp. 1651-1662
-
-
Fan, Y.1
Linardopoulou, E.2
Friedman, C.3
Williams, E.4
Trask, B.J.5
-
93
-
-
0036189827
-
Detecting a local signature of genetic hitchhiking along a recombining chromosome
-
Kim, Y. & Stephan, W. Detecting a local signature of genetic hitchhiking along a recombining chromosome. Genetics 160, 765-777 (2002).
-
(2002)
Genetics
, vol.160
, pp. 765-777
-
-
Kim, Y.1
Stephan, W.2
-
94
-
-
0023339852
-
-
Hudson, R. R., Kreitman, M. & Aguade, M. A test of neutral molecular evolution based on nucleotide data. Genetics 116, 153-159 (1987). The original paper describing the combined use of divergence and diversity data to detect selection.
-
Hudson, R. R., Kreitman, M. & Aguade, M. A test of neutral molecular evolution based on nucleotide data. Genetics 116, 153-159 (1987). The original paper describing the combined use of divergence and diversity data to detect selection.
-
-
-
-
95
-
-
0031940694
-
Localisation of a gene implicated in a severe speech and language disorder
-
Fisher, S. E., Vargha-Khadem, F., Watkins, K. E., Monaco, A. P. & Pembrey, M. E. Localisation of a gene implicated in a severe speech and language disorder. Nature Genet. 18, 168-170 (1998).
-
(1998)
Nature Genet
, vol.18
, pp. 168-170
-
-
Fisher, S.E.1
Vargha-Khadem, F.2
Watkins, K.E.3
Monaco, A.P.4
Pembrey, M.E.5
-
96
-
-
0033865944
-
The SPCH1 region on human 7q31: Genomic characterization of the critical interval and localization of translocations associated with speech and language disorder
-
Lai, C. S. et al. The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. Am. J. Hum. Genet. 67, 357-368 (2000).
-
(2000)
Am. J. Hum. Genet
, vol.67
, pp. 357-368
-
-
Lai, C.S.1
-
97
-
-
0035807360
-
A forkhead-domain gene is mutated in a severe speech and language disorder
-
Lai, C. S., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F. & Monaco, A. P. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413, 519-523 (2001).
-
(2001)
Nature
, vol.413
, pp. 519-523
-
-
Lai, C.S.1
Fisher, S.E.2
Hurst, J.A.3
Vargha-Khadem, F.4
Monaco, A.P.5
-
98
-
-
0036959262
-
Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
-
Zhang, J., Webb, D. M. & Podlaha, O. Accelerated protein evolution and origins of human-specific features: Foxp2 as an example. Genetics 162, 1825-1835 (2002).
-
(2002)
Genetics
, vol.162
, pp. 1825-1835
-
-
Zhang, J.1
Webb, D.M.2
Podlaha, O.3
-
99
-
-
24644454655
-
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
-
Mekel-Bobrov, N. et al. Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science 309, 1720-1722 (2005).
-
(2005)
Science
, vol.309
, pp. 1720-1722
-
-
Mekel-Bobrov, N.1
-
100
-
-
33746456056
-
Comment on 'Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens' and 'Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans'
-
Currat, M. et al. Comment on 'Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens' and 'Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans'. Science 313, 172 (2006).
-
(2006)
Science
, vol.313
, pp. 172
-
-
Currat, M.1
-
101
-
-
34247520904
-
Comment on 'Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens'
-
Yu, F. L. et al. Comment on 'Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens'. Science 316, 367 (2007).
-
(2007)
Science
, vol.316
, pp. 367
-
-
Yu, F.L.1
-
102
-
-
34247123696
-
The ongoing adaptive evolution of ASPM and microcephalin is not explained by increased intelligence
-
Mekel-Bobrov, N. et al. The ongoing adaptive evolution of ASPM and microcephalin is not explained by increased intelligence. Hum. Mol. Genet. 16, 600-608 (2007).
-
(2007)
Hum. Mol. Genet
, vol.16
, pp. 600-608
-
-
Mekel-Bobrov, N.1
-
103
-
-
0033965571
-
Estimation of population parameters and recombination rates from single nucleotide polymorphisms
-
Nielsen, R. Estimation of population parameters and recombination rates from single nucleotide polymorphisms. Genetics 154, 931-942 (2000).
-
(2000)
Genetics
, vol.154
, pp. 931-942
-
-
Nielsen, R.1
-
104
-
-
27544474337
-
Ascertainment bias in studies of human genome-wide polymorphism
-
Clark, A. G., Hubisz, M. J., Bustamante, C. D., Williamson, S. H. & Nielsen, R. Ascertainment bias in studies of human genome-wide polymorphism. Genome Res. 15, 1496-1502 (2005).
-
(2005)
Genome Res
, vol.15
, pp. 1496-1502
-
-
Clark, A.G.1
Hubisz, M.J.2
Bustamante, C.D.3
Williamson, S.H.4
Nielsen, R.5
-
105
-
-
0036184745
-
Generating samples under a Wright-Fisher neutral model of genetic variation
-
Hudson, R. R. Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18, 337-338 (2002).
-
(2002)
Bioinformatics
, vol.18
, pp. 337-338
-
-
Hudson, R.R.1
|