A brain-liver circuit regulates glucose homeostasis

Cell Metabolism

Volumn 1, Issue 1, 2005, Pages 53-61

  Pocai, Alessandro ^a   Obici, Silvana ^a   Schwartz, Gary J ^a   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; POTASSIUM CHANNEL; OXYGEN; PHOSPHATASE; POTASSIUM; PROTEIN C FOS;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN STEM; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HYPERGLYCEMIA; HYPOTHALAMUS NUCLEUS; LIPID METABOLISM; LIPID OXIDATION; LIVER FUNCTION; MALE; MOTONEURON NUCLEUS; NEGATIVE FEEDBACK; NONHUMAN; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SOLITARY TRACT NUCLEUS; VAGUS NERVE NUCLEUS; ANIMAL; BIOLOGICAL MODEL; BRAIN; CENTRAL NERVOUS SYSTEM; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; KINETICS; LIVER; METABOLISM; NERVE CELL; PANCREAS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; VAGUS NERVE; VASCULARIZATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; HYPERGLYCEMIA; KINETICS; LIPID METABOLISM; LIVER; MALE; MODELS, BIOLOGICAL; NEURONS; OXYGEN; PANCREAS; PHOSPHORIC MONOESTER HYDROLASES; POTASSIUM; POTASSIUM CHANNELS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VAGUS NERVE;

EID: 16244383657     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2004.11.001     Document Type: Article

References (43)

1. Berthoud H.R., Fox E.A., and Powley T.L. Localization of vagal preganglionics that stimulate insulin and glucagon secretion. Am. J. Physiol. 258 (1990) R160-R168
2. Berthoud H.R., Carlson N.R., and Powley T.L. Topography of efferent vagal innervation of the rat gastrointestinal tract. Am. J. Physiol. 260 (1991) R200-R207
3. Emond M., Ladenheim E.E., Schwartz G.J., and Moran T.H. Leptin amplifies the feeding inhibition and neural activation arising from a gastric nutrient preload. Physiol. Behav. 72 (2001) 123-128
4. Emond M., Schwartz G.J., and Moran T.H. Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R1315-R1321
5. Evans M.L., and Sherwin R.S. Brain glucose metabolism and hypoglycaemia. Diabetes Nutr. Metab. 15 (2002) 294-296
6. Flier J.S. Diabetes. The missing link with obesity?. Nature 409 (2001) 292-293
7. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
8. Friedman J.M. Obesity in the new millennium. Nature 404 (2000) 632-634
9. Giannessi F., Pessotto P., Tassoni E., Chiodi P., Conti R., De Angelis F., Dell'Uomo N., Catini R., Deias R., Tinti M.O., et al. Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity. J. Med. Chem. 46 (2003) 303-309
10. Gribble F.M., Proks P., Corkey B.E., and Ashcroft F.M. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J. Biol. Chem. 273 (1998) 26383-26387
11. Grill H.J., Schwartz M.W., Kaplan J.M., Foxhall J.S., Breininger J., and Baskin D.G. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143 (2002) 239-246
12. Grundy S.M. Inflammation, hypertension, and the metabolic syndrome. JAMA 290 (2003) 3000-3002
13. Kahn B.B., and Flier J.S. Obesity and insulin resistance. J. Clin. Invest. 106 (2000) 473-481
14. Kopelman P.G. Obesity as a medical problem. Nature 404 (2000) 635-643
15. la Fleur S.E., Ji H., Manalo S.L., Friedman M.I., and Dallman M.F. The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. Diabetes 52 (2003) 2321-2330
16. Larsson O., Deeney J.T., Branstrom R., Berggren P.O., and Corkey B.E. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J. Biol. Chem. 271 (1996) 10623-10626
17. Liu L., Karkanias G.B., Morales J.C., Hawkins M., Barzilai N., Wang J., and Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J. Biol. Chem. 273 (1998) 31160-31167
18. Loftus T.M., Jaworsky D.E., Frehywot G.L., Townsend C.A., Ronnett G.V., Lane M.D., and Kuhajda F.P. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 (2000) 2379-2381
19. Matsuhisa M., Yamasaki Y., Shiba Y., Nakahara I., Kuroda A., Tomita T., Iida M., Ikeda M., Kajimoto Y., Kubota M., and Hori M. Important role of the hepatic vagus nerve in glucose uptake and production by the liver. Metabolism 49 (2000) 11-16
20. McGarry J.D., Mannaerts G.P., and Foster D.W. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60 (1977) 265-270
21. Mistry A.M., Helferich W., and Romsos D.R. Elevated neuronal c-Fos-like immunoreactivity and messenger ribonucleic acid (mRNA) in genetically obese (ob/ob) mice. Brain Res. 666 (1994) 53-60
22. Moller D.E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414 (2001) 821-827
23. Moore M.C., Shulman G.I., Giaccari A., Pagliassotti M.J., Cline G., Neal D., Rossetti L., and Cherrington A.D. Effect of hepatic nerves on disposition of an intraduodenal glucose load. Am. J. Physiol. 265 (1993) E487-E496
24. Moran T.H., Ladenheim E.E., and Schwartz G.J. Within-meal gut feedback signaling. Int. J. Obes. Relat. Metab. Disord. 25 (2001) S39-S41
25. Morgan K., Obici S., and Rossetti L. Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J. Biol. Chem. 279 (2004) 31139-31148
26. Norgren R., and Smith G.P. A method for selective section of vagal afferent or efferent axons in the rat. Am. J. Physiol. 267 (1994) R1136-R1141
27. Obici S., and Rossetti L. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144 (2003) 5172-5178
28. Obici S., Feng Z., Tan J., Liu L., Karkanias G., and Rossetti L. Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108 (2001) 1079-1085
29. Obici S., Feng Z., Karkanias G., Baskin D.G., and Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5 (2002) 566-572
30. Obici S., Feng Z., Morgan K., Stein D., Karkanias G., and Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51 (2002) 271-275
31. Obici S., Zhang B.B., Karkanias G., and Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8 (2002) 1376-1382
32. Obici S., Feng Z., Arduini A., Conti R., and Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat. Med. 9 (2003) 756-761
33. Rossetti L., Giaccari A., Barzilai N., Howard K., Sebel G., and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J. Clin. Invest. 92 (1993) 1126-1134
34. Ruderman N.B., Saha A.K., Vavvas D., Heydrick S.J., and Kurowski T.G. Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann. N Y Acad. Sci. 827 (1997) 221-230
35. Schwartz G.J., Salorio C.F., Skoglund C., and Moran T.H. Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression. Am. J. Physiol. 276 (1999) R1623-R1629
36. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
37. Sclafani A., Ackroff K., and Schwartz G.J. Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. Physiol. Behav. 78 (2003) 285-294
38. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., and Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390 (1997) 521-525
39. Spanswick D., Smith M.A., Mirshamsi S., Routh V.H., and Ashford M.L. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat. Neurosci. 3 (2000) 757-758
40. Tracey K.J. The inflammatory reflex. Nature 420 (2002) 853-859
41. Wang J., Obici S., Morgan K., Barzilai N., Feng Z., and Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50 (2001) 2786-2791
42. Xue C., Aspelund G., Sritharan K.C., Wang J.P., Slezak L.A., and Andersen D.K. Isolated hepatic cholinergic denervation impairs glucose and glycogen metabolism. J. Surg. Res. 90 (2000) 19-25
43. Zimmet P., Alberti K.G., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 (2001) 782-787