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Volumn 111, Issue 4, 2003, Pages 463-468

Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; NOVOLIN R; STREPTOZOCIN;

EID: 0037324750     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16426     Document Type: Article
Times cited : (175)

References (38)
  • 1
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Ader, M., and Bergman, R.N. 1990. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 245:E1020-E1032.
    • (1990) Am. J. Physiol. , vol.245
    • Ader, M.1    Bergman, R.N.2
  • 2
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca, A., et al. 1992. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J. Clin. Invest. 90:1769-1777.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1769-1777
    • Giacca, A.1
  • 3
    • 0031467268 scopus 로고    scopus 로고
    • Indirect effect of insulin to suppress endogeneous glucose production is dominant, even with hyperglucoagonemia
    • Mittelman, S.D., Fu, Y.Y., Rebrin, K., Steil, G.M., and Bergman, R.N. 1997. Indirect effect of insulin to suppress endogeneous glucose production is dominant, even with hyperglucoagonemia. J. Clin. Invest. 100:3121-3130.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3121-3130
    • Mittelman, S.D.1    Fu, Y.Y.2    Rebrin, K.3    Steil, G.M.4    Bergman, R.N.5
  • 4
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar, D.K., Balcom, J.H., Chu, C.A., Neal, D.W., and Cherrington, A.D. 1996. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes. 45:1594-1605.
    • (1996) Diabetes , vol.45 , pp. 1594-1605
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 5
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extra hepatic effects of insulin in humans
    • Lewis, G.F., Zinman, B., Groenwoud, Y., Vranic, M., and Giacca, A. 1996. Hepatic glucose production is regulated both by direct hepatic and extra hepatic effects of insulin in humans. Diabetes. 45:454-462.
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenwoud, Y.3    Vranic, M.4    Giacca, A.5
  • 6
    • 0032972425 scopus 로고    scopus 로고
    • Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes
    • Lewis, G.F., Carpentier, A., Vranic, M., and Giacca, A. 1999. Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes. Diabetes. 48:570-576.
    • (1999) Diabetes , vol.48 , pp. 570-576
    • Lewis, G.F.1    Carpentier, A.2    Vranic, M.3    Giacca, A.4
  • 7
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin, K., Steil, G.M., Getty, L., and Bergman, R.N. 1995. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes. 44:1038-1045.
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 8
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    • Lewis, G.F., Vranic, M., Harley, P., and Giacca, A. 1997. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes. 46:1111-1119.
    • (1997) Diabetes , vol.46 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 9
    • 0030969441 scopus 로고    scopus 로고
    • The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
    • Sindelar, D., Chu, C., Rohlie, M., Neal, D.W., and Swift, L.L. 1997. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes. 46:187-196.
    • (1997) Diabetes , vol.46 , pp. 187-196
    • Sindelar, D.1    Chu, C.2    Rohlie, M.3    Neal, D.W.4    Swift, L.L.5
  • 10
    • 0033826669 scopus 로고    scopus 로고
    • Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin
    • Mittelman, S.D., and Bergman, R.N. 2000. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am. J. Physiol. Endocrinol. Metab. 279:E630-E637.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279
    • Mittelman, S.D.1    Bergman, R.N.2
  • 11
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli, A., Nurjhan, N., Capani, F., and Gerich, J. 1989. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes. 38:550-557.
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.4
  • 12
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
    • Magnusson, I., Rothman, D.L., Katz, L.D., Shulman, R.G., and Shulman, G.I. 1992. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J. Clin. Invest. 90:1323-1327.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 13
    • 0028847792 scopus 로고
    • 13C nuclear magnetic resonance spectroscopy study
    • 13C nuclear magnetic resonance spectroscopy study. J. Clin. Invest. 95:783-787.
    • (1995) J. Clin. Invest. , vol.95 , pp. 783-787
    • Hwang, J.H.1
  • 14
    • 0035011295 scopus 로고    scopus 로고
    • Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
    • Boden, G., Chen, X., and Stein, T.P. 2001. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 280:E23-E30.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.280
    • Boden, G.1    Chen, X.2    Stein, T.P.3
  • 15
    • 0002757550 scopus 로고    scopus 로고
    • Euglycemia acutely restores the direct hepatic effect of insulin on glucose production in depancreatised dogs
    • Abstr.
    • Gupta, N., et al. 1998. Euglycemia acutely restores the direct hepatic effect of insulin on glucose production in depancreatised dogs. Diabetes. 44:A41. (Abstr.)
    • (1998) Diabetes , vol.44
    • Gupta, N.1
  • 16
    • 0023201029 scopus 로고
    • Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog
    • Stevenson, R.W., Williams, P.E., and Cherrington, A.D. 1987. Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia. 30:782-790.
    • (1987) Diabetologia , vol.30 , pp. 782-790
    • Stevenson, R.W.1    Williams, P.E.2    Cherrington, A.D.3
  • 17
    • 0031046709 scopus 로고    scopus 로고
    • Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: Role of glucagon
    • Giacca, A., Fisher, S.J., McCall, R.H., Shi, Z.Q., and Vranic, M. 1997. Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon. Endocrinology. 138:999-1007.
    • (1997) Endocrinology , vol.138 , pp. 999-1007
    • Giacca, A.1    Fisher, S.J.2    McCall, R.H.3    Shi, Z.Q.4    Vranic, M.5
  • 18
    • 0030932918 scopus 로고    scopus 로고
    • Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans
    • Lewis, G.F., Vranic, M., and Giacca, A. 1997. Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans. Am. J. Physiol. 272:E371-E378.
    • (1997) Am. J. Physiol. , vol.272
    • Lewis, G.F.1    Vranic, M.2    Giacca, A.3
  • 19
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael, M.D., et al. 2000. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell. 6:87-97.
    • (2000) Mol. Cell. , vol.6 , pp. 87-97
    • Michael, M.D.1
  • 21
    • 0022980751 scopus 로고
    • Metabolic consequences of prolonged hyperinsulinemia in humans. Evidence for induction of insulin insensitivity
    • Marangou, A.G., et al. 1986. Metabolic consequences of prolonged hyperinsulinemia in humans. Evidence for induction of insulin insensitivity. Diabetes. 35:1383-1389.
    • (1986) Diabetes , vol.35 , pp. 1383-1389
    • Marangou, A.G.1
  • 22
    • 0027358624 scopus 로고
    • The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs
    • Radziuk, J., Barron, P., Najm, H., and Davies, J. 1993. The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs. J. Clin. Invest. 92:1713-1721.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1713-1721
    • Radziuk, J.1    Barron, P.2    Najm, H.3    Davies, J.4
  • 23
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning, J.C., et al. 1998. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell. 2:559-569.
    • (1998) Mol. Cell. , vol.2 , pp. 559-569
    • Bruning, J.C.1
  • 24
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase
    • Postic, C., et al. 1999. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274:305-315.
    • (1999) J. Biol. Chem. , vol.274 , pp. 305-315
    • Postic, C.1
  • 25
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • Gerich, J.E., Meyer, C., Woerle, H.J., and Stumvoll, M. 2001. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 24:382-391.
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 26
    • 0035088067 scopus 로고    scopus 로고
    • Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers
    • Moller, N., Rizza, R.A., Ford, G.C., and Nair, K.S. 2001. Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers. Diabetes. 50:747-751.
    • (2001) Diabetes , vol.50 , pp. 747-751
    • Moller, N.1    Rizza, R.A.2    Ford, G.C.3    Nair, K.S.4
  • 27
    • 0025178653 scopus 로고
    • Operation of Randle's cycle in patients with NIDDM
    • Bevilacqua, S., et al. 1990. Operation of Randle's cycle in patients with NIDDM. Diabetes. 39:383-389.
    • (1990) Diabetes , vol.39 , pp. 383-389
    • Bevilacqua, S.1
  • 28
    • 0027368014 scopus 로고
    • Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans
    • Fanelli, C., et al. 1993. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J. Clin. Invest. 92:1617-1622.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1617-1622
    • Fanelli, C.1
  • 29
    • 0027475061 scopus 로고
    • Contribution of muscle and liver to glucosefatty acid cycle in humans
    • Saloranta, C., et al. 1993. Contribution of muscle and liver to glucosefatty acid cycle in humans. Am. J. Physiol. 264:E599-E605.
    • (1993) Am. J. Physiol. , vol.264
    • Saloranta, C.1
  • 30
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden, G., Chen, X., Ruiz, J., White, J.V., and Rossetti, L. 1994. Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93:2438-2446.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 31
    • 0036084279 scopus 로고    scopus 로고
    • Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs
    • Chu, C.A., et al. 2002. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 282:E402-E411.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.282
    • Chu, C.A.1
  • 32
    • 0035082482 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
    • Boden, G., Chen, X., Capulong, E., and Mozzoli, M. 2001. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes. 50:810-816.
    • (2001) Diabetes , vol.50 , pp. 810-816
    • Boden, G.1    Chen, X.2    Capulong, E.3    Mozzoli, M.4
  • 33
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson, J.R., Kreisberg, R.A., and Felts, P.W. 1966. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc. Natl. Acad. Sci. USA. 56:247-254.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 34
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin, M.E., et al. 1999. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48:1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1
  • 35
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • Dresner, A., et al. 1999. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103:253-259.
    • (1999) J. Clin. Invest. , vol.103 , pp. 253-259
    • Dresner, A.1
  • 36
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim, J.K., et al. 2001. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl. Acad. Sci. USA. 98:7522-7527.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7522-7527
    • Kim, J.K.1
  • 37
    • 0002501517 scopus 로고    scopus 로고
    • Mechanism of far induced hepatic insulin resistance
    • Abstr.
    • Samuel, V.T., Yu, C., Chen, Y., Zong, H., and Shulman, G.I. 2002. Mechanism of far induced hepatic insulin resistance. Diabetes. SI(Suppl. 2):A68. (Abstr.)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Samuel, V.T.1    Yu, C.2    Chen, Y.3    Zong, H.4    Shulman, G.I.5
  • 38
    • 0026785891 scopus 로고
    • Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin
    • Yamatani, K., et al. 1992. Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin. Am. J. Physiol. 263:E646-E653.
    • (1992) Am. J. Physiol. , vol.263
    • Yamatani, K.1


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