-
1
-
-
0034611791
-
Obesity as a medical problem
-
KOPELMAN PG: Obesity as a medical problem. Nature (2000) 404(6778):635-643.
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 635-643
-
-
Kopelman, P.G.1
-
2
-
-
2942716780
-
Modern science versus the stigma of obesity
-
FRIEDMAN JM: Modern science versus the stigma of obesity. Nat. Med. (2004) 10(6):563-569.
-
(2004)
Nat. Med
, vol.10
, Issue.6
, pp. 563-569
-
-
Friedman, J.M.1
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
ZHANG Y, PROENCA R, MAFFEI M, BARONE M, LEOPOLD L, FRIEDMAN JM: Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 372(6505):425-432.
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
4
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
FRIEDMAN JM AND HALAAS JL: Leptin and the regulation of body weight in mammals. Nature (1998) 395(6704):763-770.
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
5
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
FLIER JS: Obesity wars: molecular progress confronts an expanding epidemic. Cell (2004) 116(2):337-350.
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 337-350
-
-
Flier, J.S.1
-
6
-
-
0344512367
-
Minireview: Nutrient sensing and the regulation of insulin action and energy balance
-
OBICI S, ROSSETTI L: Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinologv (2003) 144(12):5172-5178.
-
(2003)
Endocrinology
, vol.144
, Issue.12
, pp. 5172-5178
-
-
Obici, S.1
Rossetti, L.2
-
7
-
-
25144523930
-
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
-
REN D, LI M, DUAN C, RUI L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. (2005) 2(2):95-104.
-
(2005)
Cell Metab
, vol.2
, Issue.2
, pp. 95-104
-
-
Ren, D.1
Li, M.2
Duan, C.3
Rui, L.4
-
8
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
FAROOQI IS, JEBB SA, LANGMACK G et al.: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. (1999) 341(12):879-884.
-
(1999)
N. Engl. J. Med
, vol.341
, Issue.12
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
-
9
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
FAROOQI IS, MATARESE G, LORD GM et al.: Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. (2002) 110(8):1093-1103.
-
(2002)
J. Clin. Invest
, vol.110
, Issue.8
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
-
10
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
MONTAGUE CT, FAROOQI IS, WHITEHEAD JP et al.: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 387(6636):903-908.
-
(1997)
Nature
, vol.387
, Issue.6636
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
11
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
ORAL EA, SIMHA V, RUIZ E et al.: Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. (2002) 346(8):570-578.
-
(2002)
N. Engl. J. Med
, vol.346
, Issue.8
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
-
12
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
-
HEYMSFIELD SB, GREENBERG AS, FUJIOKA K et al.: Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA (1999) 282(16):1568-1575.
-
(1999)
JAMA
, vol.282
, Issue.16
, pp. 1568-1575
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
-
13
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
HALAAS JL, BOOZER C, BLAIR-WESTJ, FIDAHUSEIN N, DENTON DA, FRIEDMAN JM: Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA (1997) 94(16):8878-8883.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, Issue.16
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-west, J.3
Fidahusein, N.4
Denton, D.A.5
Friedman, J.M.6
-
14
-
-
8644243291
-
The Shp-2 tyrosine phosphatase
-
(Arino J and Alexander D, Eds.), Springer-Verlag, Berlin Heidelberg
-
LAI LA, ZHAO C, ZHANG FE, FENG GS: The Shp-2 tyrosine phosphatase. In: Protein phosphatases (Arino J and Alexander D, Eds.), Springer-Verlag, Berlin Heidelberg (2003):275-299.
-
(2003)
Protein Phosphatases
, pp. 275-299
-
-
Lai, L.A.1
Zhao, C.2
Zhang, F.E.3
Feng, G.S.4
-
15
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
NEEL BG, GU H, PAO L: The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. (2003) 28(6):284-293.
-
(2003)
Trends Biochem. Sci
, vol.28
, Issue.6
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
16
-
-
0026630991
-
Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
-
PERKINS LA, LARSEN I, PERRIMON N: Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell (1992) 70(2):225-236.
-
(1992)
Cell
, vol.70
, Issue.2
, pp. 225-236
-
-
Perkins, L.A.1
Larsen, I.2
Perrimon, N.3
-
17
-
-
0030003293
-
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling
-
HERBST R, CARROLL PM, ALLARD JD, SCHILLING J, RAABE T, SIMON MA, Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell (1996) 85(6):899-909.
-
(1996)
Cell
, vol.85
, Issue.6
, pp. 899-909
-
-
Herbst, R.1
Carroll, P.M.2
Allard, J.D.3
Schilling, J.4
Raabe, T.5
Simon, M.A.6
-
18
-
-
0029984739
-
DOS, a novel pleckmin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
-
RAABE T, RIESGO-ESCOVAR J, LIU X et al.: DOS, a novel pleckmin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell (1996) 85(6):911-920.
-
(1996)
Cell
, vol.85
, Issue.6
, pp. 911-920
-
-
Raabe, T.1
Riesgo-escovar, J.2
Liu, X.3
-
19
-
-
0032548830
-
Crystal structure of the tyrosine phosphatase SHP-2
-
HOF P, PLUSKEY S, DHE-PAGANON S, ECK MJ, SHOELSON SE: Crystal structure of the tyrosine phosphatase SHP-2. Cell (1998) 92(4):441-450.
-
(1998)
Cell
, vol.92
, Issue.4
, pp. 441-450
-
-
Hof, P.1
Pluskey, S.2
Dhe-paganon, S.3
Eck, M.J.4
Shoelson, S.E.5
-
20
-
-
0033989423
-
Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
-
O'REILLY AM, PLUSKEY S, SHOELSON SE, NEEL BG: Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol. Cell. Biol. (2000) 20(1):299-311.
-
(2000)
Mol. Cell. Biol
, vol.20
, Issue.1
, pp. 299-311
-
-
O'reilly, A.M.1
Pluskey, S.2
Shoelson, S.E.3
Neel, B.G.4
-
21
-
-
0032568515
-
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
-
CARPENTER LR, FARRUGGELLA TJ, SYMES A, KAROW ML, YANCOPOULOS GD, STAHL N: Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor, Proc. Natl. Acad. Sci. USA (1998) 95(11):6061-6066.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, Issue.11
, pp. 6061-6066
-
-
Carpenter, L.R.1
Farruggella, T.J.2
Symes, A.3
Karow, M.L.4
Yancopoulos, G.D.5
Stahl, N.6
-
22
-
-
0033578334
-
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
-
LI C, FRIEDMAN JM: Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. USA (1999) 96(17):9677-9682.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.17
, pp. 9677-9682
-
-
Li, C.1
Friedman, J.M.2
-
23
-
-
6344243617
-
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
-
DUAN C, LI M, RUI L: SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol. Chem. (2004) 279(42):43684-43691.
-
(2004)
J Biol. Chem
, vol.279
, Issue.42
, pp. 43684-43691
-
-
Duan, C.1
Li, M.2
Rui, L.3
-
24
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
BJORBAK C, LAVERY HJ, BATES SH et al.: SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. (2000) 275(51).40649-4057.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.51
, pp. 40649-40657
-
-
Bjorbak, C.1
Lavery, H.J.2
Bates, S.H.3
-
25
-
-
0028123457
-
A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
-
LI W, NISHIMURA R, KASHISHIAN A et al.: A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. (1994) 14(1):509-517.
-
(1994)
Mol. Cell. Biol
, vol.14
, Issue.1
, pp. 509-517
-
-
Li, W.1
Nishimura, R.2
Kashishian, A.3
-
26
-
-
0142211311
-
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
-
ARAKI T, NAWA H, NEEL BG: Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. (2003) 278(43):41677-41684.
-
(2003)
J. Biol. Chem
, vol.278
, Issue.43
, pp. 41677-41684
-
-
Araki, T.1
Nawa, H.2
Neel, B.G.3
-
27
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
BJORBAEK C, BUCHHOLZ RM, DAVIS SM et al.: Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Mol. Chem. (2001) 276(7).4747-4755.
-
(2001)
J. Mol. Chem
, vol.276
, Issue.7
, pp. 4747-4755
-
-
Bjorbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
-
28
-
-
0028047349
-
Phosphotyrosine phosphatases with SH2 domains: Regulators of signal transduction
-
FENG GS, PAWSON T: Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet. (1994) 10(2):54-58.
-
(1994)
Trends Genet
, vol.10
, Issue.2
, pp. 54-58
-
-
Feng, G.S.1
Pawson, T.2
-
29
-
-
0033624837
-
CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
-
DRAGATSIS I, ZEITLIN S: CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis (2000) 26(2):133-135.
-
(2000)
Genesis
, vol.26
, Issue.2
, pp. 133-135
-
-
Dragatsis, I.1
Zeitlin, S.2
-
30
-
-
8644268830
-
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
-
ZHANG EE, CHAPEAU E, HAGIHARA K, FENG GS: Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. USA (2004) 101(45):16064-16069.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.45
, pp. 16064-16069
-
-
Zhang, E.E.1
Chapeau, E.2
Hagihara, K.3
Feng, G.S.4
-
31
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
VAISSE C, HALAAS JI, HORVATH CM, DARNELL JE jr, STOFFEL M, FRIEDMAN JM: Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. (1996) 14(l):95-97.
-
(1996)
Nat. Genet
, vol.14
, Issue.1
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.I.2
Horvath, C.M.3
Darnell Jr., J.E.4
Stoffel, M.5
Friedman, J.M.6
-
32
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
BATES SH, STEARNS WH, DUNDON TA et al.: STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 421(6925):856-859.
-
(2003)
Nature
, vol.421
, Issue.6925
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
-
33
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
GAO Q, WOLFGANG MJ, NESCHEN S et al.: Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. USA (2004) 101(13):4661-4666.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.13
, pp. 4661-4666
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
-
34
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
KAMOHARA S, BURCELIN R, HALAAS JL, FRIEDMAN JM, CHARRON MJ: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature (1997) 389(6649):374-377.
-
(1997)
Nature
, vol.389
, Issue.6649
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
Friedman, J.M.4
Charron, M.J.5
-
35
-
-
0029939065
-
Decreased food intake does not completely account for adiposity reduction after ob protein infusion
-
LEVIN N, LEVIN N, NELSON C, GURNEY A, VANDLEN R, DE SAUVAGE F: Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. USA (1996) 93(4):1726-1730.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, Issue.4
, pp. 1726-1730
-
-
Levin, N.1
Levin, N.2
Nelson, C.3
Gurney, A.4
Vandlen, R.5
De Sauvage, F.6
-
36
-
-
0037067570
-
Role: For stearoyl-CoA desaturase-1 in leptin-mediated weight loss
-
COHEN P, MIYAZAKI M, SOCCI ND et al.: Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (2002) 297(5579):240-243.
-
(2002)
Science
, vol.297
, Issue.5579
, pp. 240-243
-
-
Cohen, P.1
Miyazaki, M.2
Socci, N.D.3
-
37
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
HALAAS JL, GAJIWALA KS, MAFFEI M et al.: Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 269(5223):543-546.
-
(1995)
Science
, vol.269
, Issue.5223
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
38
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
PELLEYMOUNTER, MA, CULLEN MJ, BAKER MB et at: Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 269(5223):540-543.
-
(1995)
Science
, vol.269
, Issue.5223
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
-
39
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
SHIMOMURA I, HAMMER RE, IKEMOTO S, BROWN MS, GOLDSTEIN JL: Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature (1999) 401(6748):73-76.
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
Brown, M.S.4
Goldstein, J.L.5
-
40
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
KAHN BB, ALQUIER T, CARLING D, HARDIE DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell. Metab. (2005) 1(1):15-25.
-
(2005)
Cell. Metab
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
41
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
BRUNING JC, GAUTAM D, BURKS DJ et al.: Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 289(5487):2122-2125.
-
(2000)
Science
, vol.289
, Issue.5487
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
-
42
-
-
0027179869
-
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
-
KAZLAUSKAS A, FENG GS, PAWSON T, VALIUS M: The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc. Natl. Acad. Sci. USA (1993) 90(15):6939-6943.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, Issue.15
, pp. 6939-6943
-
-
Kazlauskas, A.1
Feng, G.S.2
Pawson, T.3
Valius, M.4
-
43
-
-
0027432407
-
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
-
LECHLEIDER RJ, SUGIMOTO S, BENNETT AM et al.: Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J. Biol. Chem. (1993) 268(29):21478-21481.
-
(1993)
J. Biol. Chem
, vol.268
, Issue.29
, pp. 21478-21481
-
-
Lechleider, R.J.1
Sugimoto, S.2
Bennett, A.M.3
-
44
-
-
0001903105
-
Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses
-
OHTANI T, ISHIHARA K, ATSUMI T et al.: Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity (2000) 12(1):95-105.
-
(2000)
Immunity
, vol.12
, Issue.1
, pp. 95-105
-
-
Ohtani, T.1
Ishihara, K.2
Atsumi, T.3
-
45
-
-
0034724677
-
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp 130
-
SCHMITZ J, WEISSENBACH M, HAAN S, HEINRICH PC, SCHAPER F: SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp 130. J. Biol. Chem. (2000) 275(17):12848-12856.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.17
, pp. 12848-12856
-
-
Schmitz, J.1
Weissenbach, M.2
Haan, S.3
Heinrich, P.C.4
Schaper, F.5
-
46
-
-
0037169076
-
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
-
HIGASHI H, TSUTSUMI R, MUTO S et al.: SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2002) 295(5555):683-686.
-
(2002)
Science
, vol.295
, Issue.5555
, pp. 683-686
-
-
Higashi, H.1
Tsutsumi, R.2
Muto, S.3
-
47
-
-
0032980574
-
Shp-2 tyrosine phosphatase functions as a negative regulator in the interferon-stimulated Jak/STAT pathway
-
YOU M, YU DH, FENG GS: Shp-2 tyrosine phosphatase functions as a negative regulator in the interferon-stimulated Jak/STAT pathway. Mol. Cell. Biol. (1999) 19:2416-2424.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 2416-2424
-
-
You, M.1
Yu, D.H.2
Feng, G.S.3
-
48
-
-
0030051779
-
PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation
-
ALI S, CHEN Z, LEBRUN JJ et al.: PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation. EMBO J. (1996) 15(1):135-142.
-
(1996)
EMBO J
, vol.15
, Issue.1
, pp. 135-142
-
-
Ali, S.1
Chen, Z.2
Lebrun, J.J.3
-
49
-
-
0035176070
-
Modulation of the nuclear factor kappaB pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor
-
YOU M, FLICK LM, YU D, FENG GS: Modulation of the nuclear factor kappaB pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor. J. Exp. Med. (2001) 193(1):101-110.
-
(2001)
J. Exp. Med
, vol.193
, Issue.1
, pp. 101-110
-
-
You, M.1
Flick, L.M.2
Yu, D.3
Feng, G.S.4
-
50
-
-
0034729686
-
Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt
-
HAKAK Y, HSU YS, MARTIN GS: Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt. Oncogene (2000) 19(28):3164-3171.
-
(2000)
Oncogene
, vol.19
, Issue.28
, pp. 3164-3171
-
-
Hakak, Y.1
Hsu, Y.S.2
Martin, G.S.3
-
51
-
-
0035921728
-
The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors
-
WU CJ, O'ROURKE DM, FENG GS, JOHNSON GR, WANG Q, GREENE MI: The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene (2001) 20(42):6018-6025,
-
(2001)
Oncogene
, vol.20
, Issue.42
, pp. 6018-6025
-
-
Wu, C.J.1
O'Rourke, D.M.2
Feng, G.S.3
Johnson, G.R.4
Wang, Q.5
Greene, M.I.6
-
52
-
-
1842525884
-
SHP-2 regulates the phosphatidylinositide 3′-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis
-
IVINS ZITO C, KONTARIDIS MI, FORNARO M, FENG GS, BENNETT AM: SHP-2 regulates the phosphatidylinositide 3′-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J. Cell. Physiol. (2004) 199(2):227-236.
-
(2004)
J. Cell. Physiol.
, vol.199
, Issue.2
, pp. 227-236
-
-
Ivins Zito, C.1
Kontaridis, M.I.2
Fornaro, M.3
Feng, G.S.4
Bennett, A.M.5
-
53
-
-
3543036342
-
Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion
-
YU DH, QU CK, HENEGARIU O, LU X, FENG GS: Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion. J. Biol. Chem. (1998) 273:21125-21131.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21125-21131
-
-
Yu, D.H.1
Qu, C.K.2
Henegariu, O.3
Lu, X.4
Feng, G.S.5
-
54
-
-
0032932203
-
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
-
OH ES, GU H, SAXTON TM et al.: Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol. Cell. Biol. (1999) 19(4):3205-3215.
-
(1999)
Mol. Cell. Biol.
, vol.19
, Issue.4
, pp. 3205-3215
-
-
Oh, E.S.1
Gu, H.2
Saxton, T.M.3
-
55
-
-
0033785409
-
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
-
MIAO H, BURNETT E, KINCH M, SIMON E, WANG B: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. (2000) 2(2):62-69.
-
(2000)
Nat. Cell Biol.
, vol.2
, Issue.2
, pp. 62-69
-
-
Miao, H.1
Burnett, E.2
Kinch, M.3
Simon, E.4
Wang, B.5
-
56
-
-
0035798647
-
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain
-
TONG J, KILLEEN M, STEVEN I, BINNS KL, CULOTTI J, PAWSON T: Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain. J. Biol. Chem. (2001) 276(44):40917-40925.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.44
, pp. 40917-40925
-
-
Tong, J.1
Killeen, M.2
Steven, I.3
Binns, K.L.4
Culotti, J.5
Pawson, T.6
-
57
-
-
0036068404
-
Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1
-
TAKAI S. YAMADA M, ARAKI T, KOSHIMIZU H, NAWA H, HATANAKA H: Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1. Neurochem. (2002) 82(2):353-3564.
-
(2002)
Neurochem
, vol.82
, Issue.2
, pp. 353-3564
-
-
Takai, S.1
Yamada, M.2
Araki, T.3
Koshimizu, H.4
Nawa, H.5
Hatanaka, H.6
-
58
-
-
13444292906
-
Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity
-
RUSANESCU G, YANG W, BAI A, NEEL BG, FEIG LA: Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity. EMBO. J. (2005) 24(2):305-314.
-
(2005)
EMBO. J.
, vol.24
, Issue.2
, pp. 305-314
-
-
Rusanescu, G.1
Yang, W.2
Bai, A.3
Neel, B.G.4
Feig, L.A.5
-
59
-
-
18344385476
-
Mutations in PTPN 11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
-
TARTAGLIA M, MEHLER EL, GOLDBERG R et al.: Mutations in PTPN 11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat. Genet. (2001) 29(4):465-468.
-
(2001)
Nat. Genet.
, vol.29
, Issue.4
, pp. 465-468
-
-
Tartaglia, M.1
Mehler, E.L.2
Goldberg, R.3
-
60
-
-
24744465207
-
Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes
-
KEILHACK H, DAVID FS, MCGREGOR M, CANTLEY LC, NEEL BG: Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J. Biol. Chem. (2005) 280(35):30984-30993.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.35
, pp. 30984-30993
-
-
Keilhack, H.1
David, F.S.2
Mcgregor, M.3
Cantley, L.C.4
Neel, B.G.5
-
61
-
-
4043056497
-
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
-
ARAKI T, MOHI MG, ISMAT FA et al.: Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat. Med. (2004) 10(8):849-857.
-
(2004)
Nat. Med.
, vol.10
, Issue.8
, pp. 849-857
-
-
Araki, T.1
Mohi, M.G.2
Ismat, F.A.3
-
62
-
-
0038278866
-
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
-
TARTAGLIA M, NIEMEYER CM, FRAGALE A et al.: Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat. Genet. (2003) 34(2):148-150.
-
(2003)
Nat. Genet.
, vol.34
, Issue.2
, pp. 148-150
-
-
Tartaglia, M.1
Niemeyer, C.M.2
Fragale, A.3
-
63
-
-
0037458728
-
Crystal structure of human protein-tyrosine phosphatase SHP-1
-
YANG J, LIU L, HE D et al.: Crystal structure of human protein-tyrosine phosphatase SHP-1. J. Biol. Chem. (2003) 278(8):6516-6520.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.8
, pp. 6516-6520
-
-
Yang, J.1
Liu, L.2
He, D.3
|