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Volumn 89, Issue 3, 2009, Pages

From observation to experimentation: Leptin action in the mediobasal hypothalamus

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 61449129183     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.26788D     Document Type: Conference Paper
Times cited : (79)

References (77)
  • 1
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288:1723-7.
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 2
    • 0028322089 scopus 로고
    • Increasing prevalence of overweight among US adults: The National Health and Nutrition Examination Surveys, 1960 to 1991
    • Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults: the National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 1994;272:205-11.
    • (1994) JAMA , vol.272 , pp. 205-211
    • Kuczmarski, R.J.1    Flegal, K.M.2    Campbell, S.M.3    Johnson, C.L.4
  • 3
    • 0035512787 scopus 로고    scopus 로고
    • Dietary treatment and long-term weight loss and maintenance in type 2 diabetes
    • Hensrud DD. Dietary treatment and long-term weight loss and maintenance in type 2 diabetes. Obes Res 2001;9(suppl 4):348S-53S.
    • (2001) Obes Res , vol.9 , Issue.SUPPL. 4
    • Hensrud, D.D.1
  • 4
    • 76949129342 scopus 로고
    • The glucostatic theory of regulation of food intake and the problem of obesity
    • Mayer J. The glucostatic theory of regulation of food intake and the problem of obesity. Bull New Engl Med Cent 1952;14:43-9.
    • (1952) Bull New Engl Med Cent , vol.14 , pp. 43-49
    • Mayer, J.1
  • 5
    • 0002712310 scopus 로고
    • Glucostatic mechanism of regulation of food intake
    • Mayer J. Glucostatic mechanism of regulation of food intake. N Engl J Med 1953;249:13-6.
    • (1953) N Engl J Med , vol.249 , pp. 13-16
    • Mayer, J.1
  • 6
    • 84961007011 scopus 로고
    • Regulation of energy intake and the body weight: The glucostatic theory and the lipostatic hypothesis
    • Mayer J. Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis. Ann N Y Acad Sci 1955;63:15-43.
    • (1955) Ann N Y Acad Sci , vol.63 , pp. 15-43
    • Mayer, J.1
  • 7
    • 0014080175 scopus 로고
    • Suspension, by change in diet composition, of a 12-hour rhythmic blood glucose concentration fixed by the meal sequence.]
    • in German
    • Muller K, Scharrer E, Zucker H. [Suspension, by change in diet composition, of a 12-hour rhythmic blood glucose concentration fixed by the meal sequence.] Naturwissenschaften 1967;54:201-2 (in German).
    • (1967) Naturwissenschaften , vol.54 , pp. 201-202
    • Muller, K.1    Scharrer, E.2    Zucker, H.3
  • 8
    • 0019197915 scopus 로고    scopus 로고
    • Louis-Sylvestre J, Le Magnen J. Fall in blood glucose level precedes meal onset in free-feeding rats. Neurosci Biobehav Rev 1980;4(suppl 1):13-5.
    • Louis-Sylvestre J, Le Magnen J. Fall in blood glucose level precedes meal onset in free-feeding rats. Neurosci Biobehav Rev 1980;4(suppl 1):13-5.
  • 9
    • 0015850411 scopus 로고
    • Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: Evidence for peripheral glucoreceptors
    • Novin D, VanderWeele DA, Rezek M. Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucoreceptors. Science 1973;181:858-60.
    • (1973) Science , vol.181 , pp. 858-860
    • Novin, D.1    VanderWeele, D.A.2    Rezek, M.3
  • 10
    • 0014593248 scopus 로고
    • Increased feeding in response to decreased glucose utilization in the rat and monkey
    • Smith GP, Epstein AN. Increased feeding in response to decreased glucose utilization in the rat and monkey. Am J Physiol 1969;217:1083-7.
    • (1969) Am J Physiol , vol.217 , pp. 1083-1087
    • Smith, G.P.1    Epstein, A.N.2
  • 11
    • 0018621289 scopus 로고
    • Chronic intra- cerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods SC, Lotter EC, McKay LD, Porte D Jr. Chronic intra- cerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979;282:503-5.
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte Jr., D.4
  • 12
    • 0021473173 scopus 로고
    • Suppression of food intake by intravenous nutrients and insulin in the baboon
    • Woods SC, Stein LJ, McKay LD, Porte D Jr. Suppression of food intake by intravenous nutrients and insulin in the baboon. Am J Physiol 1984; 247:R393-401.
    • (1984) Am J Physiol , vol.247
    • Woods, S.C.1    Stein, L.J.2    McKay, L.D.3    Porte Jr., D.4
  • 13
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 1953;140:578-96.
    • (1953) Proc R Soc Lond B Biol Sci , vol.140 , pp. 578-596
    • Kennedy, G.C.1
  • 14
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973;9:294-8.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 15
    • 0014608866 scopus 로고
    • Effects of parabiosis of normal with genetically diabetic mice
    • Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969;217:1298-304.
    • (1969) Am J Physiol , vol.217 , pp. 1298-1304
    • Coleman, D.L.1    Hummel, K.P.2
  • 17
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 18
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-9.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 20
    • 43049116846 scopus 로고    scopus 로고
    • Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    • Hill JW, Williams KW, Ye C, et al. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest 2008;118:1796-805.
    • (2008) J Clin Invest , vol.118 , pp. 1796-1805
    • Hill, J.W.1    Williams, K.W.2    Ye, C.3
  • 21
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford ML. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997;390:521-5.
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 22
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexi-genic POMC neurons through a neural network in the arcuate nucleus
    • Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexi-genic POMC neurons through a neural network in the arcuate nucleus. Nature 2001;411:480-4.
    • (2001) Nature , vol.411 , pp. 480-484
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3
  • 23
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 2004;7:493-4.
    • (2004) Nat Neurosci , vol.7 , pp. 493-494
    • van den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 24
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • Myers MG, Cowley MA, Munzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008;70:537-56.
    • (2008) Annu Rev Physiol , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 25
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. The leptin receptor. J Biol Chem 1997;272:6093-6.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 26
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 29
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-5.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 31
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A 1996;93:8374-8.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3
  • 33
    • 10544236913 scopus 로고    scopus 로고
    • Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells
    • Rosenblum CI, Tota M, Cully D, et al. Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology 1996;137:5178-81.
    • (1996) Endocrinology , vol.137 , pp. 5178-5181
    • Rosenblum, C.I.1    Tota, M.2    Cully, D.3
  • 35
    • 0031768207 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus of normal rats in vivo
    • McCowen KC, Chow JC, Smith RJ. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 1998;139:4442-7.
    • (1998) Endocrinology , vol.139 , pp. 4442-4447
    • McCowen, K.C.1    Chow, J.C.2    Smith, R.J.3
  • 36
    • 0034909166 scopus 로고    scopus 로고
    • Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve
    • Buyse M, Ovesjo ML, Goiot H, et al. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 2001;14:64-72.
    • (2001) Eur J Neurosci , vol.14 , pp. 64-72
    • Buyse, M.1    Ovesjo, M.L.2    Goiot, H.3
  • 37
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates SH, Stearns WH, Dundon TA, et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003;421:856-9.
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3
  • 38
    • 0033944152 scopus 로고    scopus 로고
    • Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
    • Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000;3:757-8.
    • (2000) Nat Neurosci , vol.3 , pp. 757-758
    • Spanswick, D.1    Smith, M.A.2    Mirshamsi, S.3    Routh, V.H.4    Ashford, M.L.5
  • 39
    • 0030729888 scopus 로고    scopus 로고
    • Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1
    • Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol 1997;504:527-35.
    • (1997) J Physiol , vol.504 , pp. 527-535
    • Harvey, J.1    McKenna, F.2    Herson, P.S.3    Spanswick, D.4    Ashford, M.L.5
  • 40
    • 0035709033 scopus 로고    scopus 로고
    • Glucosensing neurons do more than just sense glucose
    • Levin BE. Glucosensing neurons do more than just sense glucose. Int J Obes Relat Metab Disord 2001;25(suppl 5):S68-72.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , Issue.SUPPL. 5
    • Levin, B.E.1
  • 41
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon H, Zigman JM, Ye C, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203.
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3
  • 42
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 2008;149:2138-48.
    • (2008) Endocrinology , vol.149 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 43
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar N, Coppari R, McMinn J, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004;42:983-91.
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3
  • 44
    • 10744232925 scopus 로고    scopus 로고
    • Essential role of STAT3 in body weight and glucose homeostasis
    • Cui Y, Huang L, Elefteriou F, et al. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 2004;24:258-69.
    • (2004) Mol Cell Biol , vol.24 , pp. 258-269
    • Cui, Y.1    Huang, L.2    Elefteriou, F.3
  • 45
    • 20144389727 scopus 로고    scopus 로고
    • The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    • Choudhury AI, Heffron H, Smith MA, et al. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 2005;115:940-50.
    • (2005) J Clin Invest , vol.115 , pp. 940-950
    • Choudhury, A.I.1    Heffron, H.2    Smith, M.A.3
  • 46
    • 17844389670 scopus 로고    scopus 로고
    • The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    • Coppari R, Ichinose M, Lee CE, et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 2005;1:63-72.
    • (2005) Cell Metab , vol.1 , pp. 63-72
    • Coppari, R.1    Ichinose, M.2    Lee, C.E.3
  • 47
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • Balthasar N, Dalgaard LT, Lee CE, et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005;123:493-505.
    • (2005) Cell , vol.123 , pp. 493-505
    • Balthasar, N.1    Dalgaard, L.T.2    Lee, C.E.3
  • 48
    • 41549111593 scopus 로고    scopus 로고
    • Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    • van de Wall E, Leshan R, Xu AW, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 2008;149:1773-85.
    • (2008) Endocrinology , vol.149 , pp. 1773-1785
    • van de Wall, E.1    Leshan, R.2    Xu, A.W.3
  • 49
    • 0242300570 scopus 로고    scopus 로고
    • Transgenic neuronal expression of proopiomelanocortin attenuates hyper-phagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
    • Mizuno TM, Kelley KA, Pasinetti GM, Roberts JL, Mobbs CV. Transgenic neuronal expression of proopiomelanocortin attenuates hyper-phagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 2003;52:2675-83.
    • (2003) Diabetes , vol.52 , pp. 2675-2683
    • Mizuno, T.M.1    Kelley, K.A.2    Pasinetti, G.M.3    Roberts, J.L.4    Mobbs, C.V.5
  • 50
    • 0037733115 scopus 로고    scopus 로고
    • Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats
    • Morton GJ, Niswender KD, Rhodes CJ, et al. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology 2003;144:2016-24.
    • (2003) Endocrinology , vol.144 , pp. 2016-2024
    • Morton, G.J.1    Niswender, K.D.2    Rhodes, C.J.3
  • 51
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton LE, Ye CP, Coppari R, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007;449:228-32.
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3
  • 52
    • 0037387207 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels
    • Ibrahim N, Bosch MA, Smart JL, et al. Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 2003;144:1331-40.
    • (2003) Endocrinology , vol.144 , pp. 1331-1340
    • Ibrahim, N.1    Bosch, M.A.2    Smart, J.L.3
  • 53
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004;304:108-10.
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 55
    • 0035950093 scopus 로고    scopus 로고
    • Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001;413:794-5.
    • Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001;413:794-5.
  • 56
    • 0037338694 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL. Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 2003;41:763-7.
    • (2003) Hypertension , vol.41 , pp. 763-767
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 57
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • Xu AW, Ste-Marie L, Kaelin CB, Barsh GS. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 2007;148:72-80.
    • (2007) Endocrinology , vol.148 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 59
    • 0036773262 scopus 로고    scopus 로고
    • Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: Implications for the control of food intake
    • Schwartz GJ, Moran TH. Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake. Endocrinology 2002;143:3779-84.
    • (2002) Endocrinology , vol.143 , pp. 3779-3784
    • Schwartz, G.J.1    Moran, T.H.2
  • 60
    • 33646914929 scopus 로고    scopus 로고
    • Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    • Burdakov D, Jensen LT, Alexopoulos H, et al. Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron 2006;50:711-22.
    • (2006) Neuron , vol.50 , pp. 711-722
    • Burdakov, D.1    Jensen, L.T.2    Alexopoulos, H.3
  • 61
    • 0034710310 scopus 로고    scopus 로고
    • Chemical characterization of leptin-activated neurons in the rat brain
    • Elias CF, Kelly JF, Lee CE, et al. Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol 2000;423:261-81.
    • (2000) J Comp Neurol , vol.423 , pp. 261-281
    • Elias, C.F.1    Kelly, J.F.2    Lee, C.E.3
  • 63
    • 33745034786 scopus 로고    scopus 로고
    • Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour
    • Williams KW, Smith BN. Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. J Physiol 2006;573:395-412.
    • (2006) J Physiol , vol.573 , pp. 395-412
    • Williams, K.W.1    Smith, B.N.2
  • 64
    • 33947413088 scopus 로고    scopus 로고
    • Rapid inhibition ofneurons in the dorsal motor nucleus of the vagus by leptin
    • Williams KW, Zsombok A, Smith BN. Rapid inhibition ofneurons in the dorsal motor nucleus of the vagus by leptin. Endocrinology 2007;148:1868-81.
    • (2007) Endocrinology , vol.148 , pp. 1868-1881
    • Williams, K.W.1    Zsombok, A.2    Smith, B.N.3
  • 65
    • 0033695676 scopus 로고    scopus 로고
    • Addiction, dopamine, and the molecular mechanisms of memory
    • Berke JD, Hyman SE. Addiction, dopamine, and the molecular mechanisms of memory. Neuron 2000;25:515-32.
    • (2000) Neuron , vol.25 , pp. 515-532
    • Berke, J.D.1    Hyman, S.E.2
  • 66
    • 27644454882 scopus 로고    scopus 로고
    • Neural systems of reinforcement for drug addiction: From actions to habits to compulsion
    • Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 2005;8:1481-9.
    • (2005) Nat Neurosci , vol.8 , pp. 1481-1489
    • Everitt, B.J.1    Robbins, T.W.2
  • 67
    • 0035798931 scopus 로고    scopus 로고
    • Wang GJ, Volkow ND, Logan J, et al. Brain dopamine and obesity. Lancet 2001;357:354-7.
    • Wang GJ, Volkow ND, Logan J, et al. Brain dopamine and obesity. Lancet 2001;357:354-7.
  • 68
    • 33847614268 scopus 로고    scopus 로고
    • Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    • Dalley JW, Fryer TD, Brichard L, et al. Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 2007;315:1267-70.
    • (2007) Science , vol.315 , pp. 1267-1270
    • Dalley, J.W.1    Fryer, T.D.2    Brichard, L.3
  • 69
    • 0034063046 scopus 로고    scopus 로고
    • Dopamine is required for hyperphagia in Lep(ob/ob) mice
    • Szczypka MS, Rainey MA, Palmiter RD. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 2000;25:102-4.
    • (2000) Nat Genet , vol.25 , pp. 102-104
    • Szczypka, M.S.1    Rainey, M.A.2    Palmiter, R.D.3
  • 70
    • 2542460250 scopus 로고    scopus 로고
    • Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats
    • Figlewicz DP, Bennett J, Evans SB, Kaiyala K, Sipols AJ, Benoit SC. Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behav Neurosci 2004;118:479-87.
    • (2004) Behav Neurosci , vol.118 , pp. 479-487
    • Figlewicz, D.P.1    Bennett, J.2    Evans, S.B.3    Kaiyala, K.4    Sipols, A.J.5    Benoit, S.C.6
  • 71
    • 0019949841 scopus 로고
    • Attenuation by haloperidol of place preference conditioning using food reinforcement
    • Spyraki C, Fibiger HC, Phillips AG. Attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology (Berl) 1982;77:379-82.
    • (1982) Psychopharmacology (Berl) , vol.77 , pp. 379-382
    • Spyraki, C.1    Fibiger, H.C.2    Phillips, A.G.3
  • 72
    • 33748540764 scopus 로고    scopus 로고
    • Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    • Hommel JD, Trinko R, Sears RM, et al. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006;51:801-10.
    • (2006) Neuron , vol.51 , pp. 801-810
    • Hommel, J.D.1    Trinko, R.2    Sears, R.M.3
  • 73
    • 27744436291 scopus 로고    scopus 로고
    • Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    • Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 2005;493:63-71.
    • (2005) J Comp Neurol , vol.493 , pp. 63-71
    • Elmquist, J.K.1    Coppari, R.2    Balthasar, N.3    Ichinose, M.4    Lowell, B.B.5
  • 75
    • 61449095573 scopus 로고    scopus 로고
    • Leptin at 14 y of age: An ongoing story
    • Friedman JM. Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 2009;89(suppl):973S-9S.
    • (2009) Am J Clin Nutr , vol.89 , Issue.SUPPL.
    • Friedman, J.M.1
  • 76
    • 61449105725 scopus 로고    scopus 로고
    • Leptin: A pivotal regulator of human energy homeostasis
    • Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009;89(suppl):980S-4S.
    • (2009) Am J Clin Nutr , vol.89 , Issue.SUPPL.
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 77
    • 61449257382 scopus 로고    scopus 로고
    • Blüher S, Mantzoros CS. Leptin in humans: lessons from translational research. Am J Clin Nutr 2009;89(suppl):991S-7S.
    • Blüher S, Mantzoros CS. Leptin in humans: lessons from translational research. Am J Clin Nutr 2009;89(suppl):991S-7S.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.