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Volumn 54, Issue 5, 2005, Pages 1459-1467

Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: A randomized controlled study

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROLYLTHREONYLASPARAGINYLASPARTYLLYSYLALANYLLYSYLALANYLGLYCYLASPARAGINYLLYS YLPROLINE; PROTEIN; PROTEIN KINASE B; ROSIGLITAZONE; SERINE; UNCLASSIFIED DRUG;

EID: 20944436591     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.5.1459     Document Type: Article
Times cited : (84)

References (49)
  • 1
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI: Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176, 2000
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 2
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J: Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76:149-155, 1985
    • (1985) J Clin Invest , vol.76 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3    Olsson, M.4    Wahren, J.5
  • 3
    • 0034070580 scopus 로고    scopus 로고
    • Use of a novel impermeable biotinylated photolabeiing reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
    • Ryder J, Yang J, Galuska D, Rincon J, Bjornholm M, Krook A, Lund S, Pedersen O, Wallberg-Henriksson H, Zierath J, Holman G: Use of a novel impermeable biotinylated photolabeiing reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients. Diabetes 49:647-654, 2000
    • (2000) Diabetes , vol.49 , pp. 647-654
    • Ryder, J.1    Yang, J.2    Galuska, D.3    Rincon, J.4    Bjornholm, M.5    Krook, A.6    Lund, S.7    Pedersen, O.8    Wallberg-Henriksson, H.9    Zierath, J.10    Holman, G.11
  • 4
    • 0242600806 scopus 로고    scopus 로고
    • 5-Amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes
    • Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H: 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 52:1066-1072, 2003
    • (2003) Diabetes , vol.52 , pp. 1066-1072
    • Koistinen, H.A.1    Galuska, D.2    Chibalin, A.V.3    Yang, J.4    Zierath, J.R.5    Holman, G.D.6    Wallberg-Henriksson, H.7
  • 5
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NlDDM subjects after in vivo insulin stimulation
    • Bjornholm M, Kawano Y, Lehtihet M, Zierath J: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NlDDM subjects after in vivo insulin stimulation. Diabetes 46:524-627, 1997
    • (1997) Diabetes , vol.46 , pp. 524-627
    • Bjornholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.4
  • 6
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim Y-B, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741, 1999
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.-B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 9
    • 0031852665 scopus 로고    scopus 로고
    • Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    • Krook A, Roth R, Jiang X, Zierath J, Wallberg-Henriksson H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47:1281-1286, 1998
    • (1998) Diabetes , vol.47 , pp. 1281-1286
    • Krook, A.1    Roth, R.2    Jiang, X.3    Zierath, J.4    Wallberg-Henriksson, H.5
  • 10
    • 0037381535 scopus 로고    scopus 로고
    • Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: Potential role in insulin resistance
    • Brozinick JT Jr, Roberts BR, Dohm GL: Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes 52:935-941, 2003
    • (2003) Diabetes , vol.52 , pp. 935-941
    • Brozinick Jr., J.T.1    Roberts, B.R.2    Dohm, G.L.3
  • 11
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus
    • DeFronzo RA, Goodman AM, the Multicenter Metformin Study Group: Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 333:541-549, 1995
    • (1995) N Engl J Med , vol.333 , pp. 541-549
    • DeFronzo, R.A.1    Goodman, A.M.2
  • 12
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE: Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333:550-554, 1995
    • (1995) N Engl J Med , vol.333 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 14
    • 0031472452 scopus 로고    scopus 로고
    • Efficacy of metformin in type II diabetes; results of a double-blind, placebo-controlled, dose-response trial
    • Garber AJ, Duncan TG, Goodman AM, Mills DJ, Rohlf JL: Efficacy of metformin in type II diabetes; results of a double-blind, placebo-controlled, dose-response trial. Am J Med 103:491-497, 1997
    • (1997) Am J Med , vol.103 , pp. 491-497
    • Garber, A.J.1    Duncan, T.G.2    Goodman, A.M.3    Mills, D.J.4    Rohlf, J.L.5
  • 15
    • 0034607438 scopus 로고    scopus 로고
    • Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: A randomized controlled trial
    • Fonseca V, Rosenstock J, Patwardhan R, Salzman A: Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. JAMA 283:1695-1702, 2000
    • (2000) JAMA , vol.283 , pp. 1695-1702
    • Fonseca, V.1    Rosenstock, J.2    Patwardhan, R.3    Salzman, A.4
  • 16
    • 0028129862 scopus 로고
    • Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM
    • Galuska D, Nolte LA, Zierath JE, Wallberg-Henriksson H: Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia 37:826-832, 1994
    • (1994) Diabetologia , vol.37 , pp. 826-832
    • Galuska, D.1    Nolte, L.A.2    Zierath, J.E.3    Wallberg-Henriksson, H.4
  • 17
    • 0036791755 scopus 로고    scopus 로고
    • Metformin enhances insulin signalling in insulin-dependent and -independent pathways in insulin resistant muscle cells
    • Kumar N, Dey CS: Metformin enhances insulin signalling in insulin-dependent and -independent pathways in insulin resistant muscle cells. Br J Pharmacol 137:329-336, 2002
    • (2002) Br J Pharmacol , vol.137 , pp. 329-336
    • Kumar, N.1    Dey, C.S.2
  • 18
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim Y-B, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR, Kahn BB: Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes 51:443-448, 2002
    • (2002) Diabetes , vol.51 , pp. 443-448
    • Kim, Y.-B.1    Ciaraldi, T.P.2    Kong, A.3    Kim, D.4    Chu, N.5    Mohideen, P.6    Mudaliar, S.7    Henry, R.R.8    Kahn, B.B.9
  • 25
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Miyazaki Y, He H, Mandarino LJ, DeFronzo RA: Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes 52:1943-1950, 2003
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    DeFronzo, R.A.4
  • 26
    • 0036723741 scopus 로고    scopus 로고
    • Troglitazone treatment increases protein ktaase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes
    • Meyer MM, Levin K, Grimmsmann T, Perwitz N, Eirich A, Beck-Nielsen H, Klein HH: Troglitazone treatment increases protein ktaase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes. Diabetes 51:2691-2697, 2002
    • (2002) Diabetes , vol.51 , pp. 2691-2697
    • Meyer, M.M.1    Levin, K.2    Grimmsmann, T.3    Perwitz, N.4    Eirich, A.5    Beck-Nielsen, H.6    Klein, H.H.7
  • 27
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • Way JM, Harrington WW, Brown KK, Gottschalk WK, Sundseth SS, Mansfield TA, Ramachandran RK, Willson TM, Kliewer SA: Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142:1269-1277, 2001
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1    Harrington, W.W.2    Brown, K.K.3    Gottschalk, W.K.4    Sundseth, S.S.5    Mansfield, T.A.6    Ramachandran, R.K.7    Willson, T.M.8    Kliewer, S.A.9
  • 29
    • 3042760032 scopus 로고    scopus 로고
    • The effect of pioglitazone on peroxisome proliferator-activated receptor-γ target genes related to lipid storage in vivo
    • Bogacka I, Xie H, Bray GA, Smith SR: The effect of pioglitazone on peroxisome proliferator-activated receptor-γ target genes related to lipid storage in vivo. Diabetes Care 27:1660-1667, 2004
    • (2004) Diabetes Care , vol.27 , pp. 1660-1667
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4
  • 30
    • 0035172839 scopus 로고    scopus 로고
    • Thiazolidinediones (PPAR-γ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes
    • Smith U, Gogg S, Johansson A, Olausson T, Rotter V, Svalstedt B: Thiazolidinediones (PPAR-γ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes. FASEB J 15:215-220, 2001
    • (2001) FASEB J , vol.15 , pp. 215-220
    • Smith, U.1    Gogg, S.2    Johansson, A.3    Olausson, T.4    Rotter, V.5    Svalstedt, B.6
  • 31
    • 0037151026 scopus 로고    scopus 로고
    • A method to identify serine kinase substrates: Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
    • Kane S, Sano H, Liu SCH, Asara JM, Lane WS, Garner CC, Lienhard GE: A method to identify serine kinase substrates: Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem 277:22115-22118, 2002
    • (2002) J Biol Chem , vol.277 , pp. 22115-22118
    • Kane, S.1    Sano, H.2    Liu, S.C.H.3    Asara, J.M.4    Lane, W.S.5    Garner, C.C.6    Lienhard, G.E.7
  • 33
    • 4644300287 scopus 로고    scopus 로고
    • Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160
    • Zeigerer A, McBrayer MK, McGraw TE: Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160. Mol Biol Cell 10:4406-4415, 2004
    • (2004) Mol Biol Cell , vol.10 , pp. 4406-4415
    • Zeigerer, A.1    McBrayer, M.K.2    McGraw, T.E.3
  • 34
    • 0036895990 scopus 로고    scopus 로고
    • Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes
    • Hallsten K, Virtanen KA, Lonnqvist F, Sipila H, Oksanen A, Viljanen T, Ronnemaa T, Viikari J, Knuuti J, Nuutila P: Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes 51: 3479-3485, 2002
    • (2002) Diabetes , vol.51 , pp. 3479-3485
    • Hallsten, K.1    Virtanen, K.A.2    Lonnqvist, F.3    Sipila, H.4    Oksanen, A.5    Viljanen, T.6    Ronnemaa, T.7    Viikari, J.8    Knuuti, J.9    Nuutila, P.10
  • 35
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part I. Diagnosis and classification of diabetes mellitus: Provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part I. Diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabet Med 15:539-553, 1998
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 37
    • 0030718605 scopus 로고    scopus 로고
    • Insulin signaling in human skeletal muscle: Time course and effect of exercise
    • Wojtaszewski JF, Hansen BF, Kiens B, Richter EA: Insulin signaling in human skeletal muscle: time course and effect of exercise. Diabetes 46:1775-1781, 1997
    • (1997) Diabetes , vol.46 , pp. 1775-1781
    • Wojtaszewski, J.F.1    Hansen, B.F.2    Kiens, B.3    Richter, E.A.4
  • 38
    • 20044389885 scopus 로고    scopus 로고
    • Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
    • In press
    • Karlsson HKR, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H: Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. In press
    • Diabetes
    • Karlsson, H.K.R.1    Zierath, J.R.2    Kane, S.3    Krook, A.4    Lienhard, G.E.5    Wallberg-Henriksson, H.6
  • 42
    • 0033123466 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy improves glycaemic control in patients with type 2 diabetes: A twelve-week, randomized, placebo-controlled study
    • Patel J, Anderson RJ, Rappaport EB: Rosiglitazone monotherapy improves glycaemic control in patients with type 2 diabetes: a twelve-week, randomized, placebo-controlled study. Diabetes Obes Metab 1:165-172, 1999
    • (1999) Diabetes Obes Metab , vol.1 , pp. 165-172
    • Patel, J.1    Anderson, R.J.2    Rappaport, E.B.3
  • 48
    • 0035947235 scopus 로고    scopus 로고
    • A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle
    • Mu J, Brozinick JT, Jr, Valladares O, Bucan M, Birnbaum MJ: A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 7:1085-1094, 2001
    • (2001) Mol Cell , vol.7 , pp. 1085-1094
    • Mu, J.1    Brozinick Jr., J.T.2    Valladares, O.3    Bucan, M.4    Birnbaum, M.J.5
  • 49
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LGD, Parbu-Patel A, Carling D: The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277:25226-25232, 2002
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.D.1    Parbu-Patel, A.2    Carling, D.3


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