Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism

Molecular and Cellular Biology

Volumn 19, Issue 8, 1999, Pages 5495-5503

  Fajas, Lluis ^a,d   Schoonjans, Kristina ^a   Gelman, Laurent ^a   Kim, Jae B ^b   Najib, Jamila ^a   Martin, Genevieve ^a   Fruchart, Jean Charles ^a   Briggs, Michael ^c,e   Spiegelman, Bruce M ^b   Auwerx, Johan ^a  

^a INSERM   (France)

^b HARVARD MEDICAL SCHOOL   (United States)

^c LIGAND PHARMACEUTICALS INC   (United States)

^d INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; GENE EXPRESSION REGULATION; LIPID METABOLISM; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL;

ANIMALIA;

EID: 0032793068     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.8.5495     Document Type: Article

References (58)

1. Alaupovic, P., T. Heinonen, L. Shurzinske, and D. M. Black. 1997. Effect of a new HMG-CoA reductase inhibitor, atorvastatin, on lipids, apolipoproteins and lippprotein particles in patients with elevated serum cholesterol and triglyceride levels. Atherosclerosis 133:123-133.
2. Amri, E.-Z., B. Bertrand, G. Ailhaud, and P. Grimaldi. 1991. Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression. J. Lipid Res. 32:1449-1456.
3. Aubert, J., G. Ailhaud, and R. Negrel. 1996. Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells. FEBS Lett. 397:117-121.
4. Bennet, M. K., J. M. Lopez, H. B. Sanchez, and T. F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter:coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270:25578-25583.
5. Berger, J., P. Bailey, C. Biswas, C. A. Cullinan, T. W. Doebber, N. S. Hayes, R. Saperstein, R. G. Smith, and M. D. Leibowitz. 1996. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-γ: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology 137:4189-4195.
6. Brun, R. P., J. B. Kim, E. Hu, and B. M. Spiegelman. 1997. Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. Curr. Opin. Lipidol. 8:212-218.
7. Chawla, A., and M. A. Lazar. 1994. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc. Natl. Acad. Sci. USA 91:1786-1790.
8. Christy, R. J., V. W. Yang, J. M. Ntambi, D. E. Geiman, W. H. Landschulz, A. D. Friedman, Y. Nakabeppu, T. J. Kelly, and M. D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1323-1335.
9. Cornelius, P., O. A. MacDougald, and M. D. Lane. 1994. Regulation of adipocyte development. Annu. Rev. Nutr. 14:99-129.
10. Ericsson, J., S. M. Jackson, J. B. Kim, B. M. Spiegelman, and P. A. Edwards. 1997. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J. Biol. Chem. 272:7298-7305.
11. Fajas, L., D. Auboeuf, E. Raspe, K. Schoonjans, A. M. Lefebvre, R. Saladin, J. Najib, M. Laville, J. C. Fruchart, S. Deeb, A. Vidal-Puig, J. Flier, M. R. Briggs, B. Staels, H. Vidal, and J. Auwerx. 1997. Organization, promoter analysis and expression of the human PPARγ gene. J. Biol. Chem. 272: 18779-18789.
12. 11a. Fajas, L., and J. Auwerx. Unpublished results.
13. Fajas, L., J. C. Fruchart, and J. Auwerx. 1998. PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett. 438:55-60.
14. Fajas, L., J. C. Fruchart, and J. Auwerx. 1998. Transcriptional control of adipogenesis. Curr. Opin. Cell Biol. 10:165-173.
15. Forman, B. M., P. Tontonoz, J. Chen, R. P. Brun, B. M. Spiegelman, and R. M. Evans. 1995. 15-Deoxy-Δ12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812.
16. Freytag, S. O., and T. J. Geddes. 1992. Reciprocal regulation of adipogenesis by Myc and C/EBPα. Science 256:379-382.
17. Freytag, S. O., D. L. Paielli, and J. D. Gilbert. 1994. Ectopic expression of the CCAAT/enhancer-binding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8:1654-1663.
18. Fried, M. G., and D. M. Crothers. 1983. CAP and RNA polymerase interactions with the lac promoter: binding stoichiometry and long range effects. Nucleic Acids Res. 11:141-158.
19. Ho, S. N., H. D. Hunt, N. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Side directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
20. Hu, E., P. Tontonoz, and B. M. Spiegelman. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. Proc. Natl. Acad. Sci. USA 92:9856-9860.
21. Hua, X., C. Yokoyama, J. Wu, M. R. Briggs, M. S. Brown, J. L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA 90:11603-11607.
22. Kim, J. B., and B. M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10:1096-1107.
23. Kim, J. B., H. M. Wright, M. Wright, and B. M. Spiegelman. 1998. ADD1/ SREBP1 activates PPARγ through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA 95:4333-4337.
24. Kliewer, S. A., J. M. Lenhard, T. M. Willson, I. Patel, D. C. Morris, and J. M. Lehman. 1995. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819.
25. Lehmann, J. M., J. M. Lenhard, B. B. Oliver, G. M. Ringold, and S. A. Kliewer, 1997. Peroxisome proliferator-activated receptors a and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272:3406-3410.
26. Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270:12953-12956.
27. Lin, F. T., and M. D. Lane. 1992. Antisense CCAAT/enhancer binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 adipocytes. Genes Dev. 6:533-544.
28. Lopez, J. M., M. K. Bennett, H. B. Sanchez, J. M. Rosenfeld, and T. F. Osborne. 1996. Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc. Natl. Acad. Sci. USA 93:1049-1053.
29. Mol, M. J. T. M., D. W. Erkelens, J. A. Gevers Leuven, J. A. Schouten, and A. F. H. Stalenhoef. 1986. Effects of synvinolin (MK-733) on plasma lipids in familial hypercholesterolemia. Lancet:936-939.
30. Negrel, R., D. Gaillard, and G. Ailhaud. 1989. Prostacyclin as a potent effector of adipose-cell differentiation. Biochem. J. 257:399-405.
31. Osumi, T., J. K. Wen, and T. Hashimoto. 1991. Two cis-acting regulatory elements in the peroxisome proliferator-responsive element enhancer region of rat acyl-CoA oxidase gene. Biochem. Biophys. Res. Commun. 175:866-871.
32. Sakai, J., E. A. Duncan, R. B. Rawson, X. Hua, M. S. Brown, and J. L. Goldstein. 1996. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85:1037-1046.
33. Saladin, R., P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. 1995. Transient increase in obese gene expression after food intake and insulin administration. Nature 377:527-529.
34. Saladin, R., L. Fajas, S. Dana, Y. D. Halvorsen, J. Auwerx, and M. Briggs. 1999. Differential regulation of peroxisome proliferator activated receptor γl (PPARγ1) and PPARγ2 mRNA expression in early stages of adipogenesis. Cell Growth Differ. 10:43-48.
35. 33a. Schoonjans, K. Unpublished data.
36. Schoonjans, K., G. Martin, B. Staels, and J. Auwerx. 1997. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr. Opin. Lipidol. 8:159-166.
37. Schoonjans, K., J. Peinado-Onsurbe, A. M. Lefebvre, R. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx. 1996. PPARα and PPARγ activators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15:5336-5348.
38. Schoonjans, K., B. Staels, P. Grimaldi, and J. Auwerx. 1993. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation. Eur. J. Biochem. 216:615-622.
39. Schoonjans, K., M. Watanabe, H. Suzuki, A. Mahfoudi, G. Krey, W. Wahli, P. Grimaldi, B. Staels, T. Yamamoto, and J. Auwerx. 1995. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J. Biol. Chem. 270:19269-19276.
40. Shimano, H., J. D. Horton, R. E. Hammer, I. Shimomura, M. S. Brown, and J. L. Goldstein. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP- 1a. J. Clin. Investig. 98:1575-1584.
41. Shimano, H., J. D. Horton, I. Shimomura, R. E. Hammer, M. S. Brown, and J. L. Goldstein. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Investig. 99:846-854.
42. Shimomura, I., Y. Bashmakov, H. Shimano, J. D. Horton, J. L. Goldstein, and M. S. Brown. 1997. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc. Natl. Acad. Sci. USA 94:12345-12359.
43. Shimomura, I., R. E. Hammer, J. A. Richardson, S. Ikemoto, Y. Bashmakov, J. L. Goldstein, and M. S. Brown. 1998. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: a model for congenital generalized lipodystrophy. Genes Dev. 12:3182-3194.
44. Smith, J. R., T. F. Osborne, M. S. Brown, J. L. Goldstein, and G. Gil. 1988. Multiple sterol regulatory elements in the promoter for hamster 3-hydroxy-3-methylglutaryl coenzyme A synthase. J. Biol. Chem. 243:18480-18487.
45. Spiegelman, B. M., and J. S. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87:377-389.
46. Thewke, D. P., S. R. Panini, and M. Sinensky. 1998. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. J. Cell. Biochem. 273:21402-21407.
47. Tontonoz, P., E. Hu, J. Devine, E. G. Beale, and B. M. Spiegelman. 1995. PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:351-357.
48. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
49. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79:1147-1156.
50. Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:4753-4759.
51. Vu-Dac, N., K. Schoonjans, V. Kosykh, J. Dallongeville, J.-C. Fruchart, B. Staels, and J. Auwerx. 1995. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Investig. 96:741-750.
52. Wang, X., R. Sato, M. S. Brown, X. Hua, and J. L. Goldstein. 1994. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62.
53. Willson, T. M., J. E. Cobb, D. J. Cowan, R. W. Wiethe, I. D. Correa, S. R. Prakash, K. D. Beck, L. B. Moore, S. A. Kliewer, and J. M. Lehmann. 1996. The structure activity relationship between peroxisome proliferator activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39:665-668.
54. Worgall, T. S., S. L. Sturley, T. Seo, T. F. Osborne, and R. J. Deckelbaum. 1998. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J. Biol. Chem. 273:25537-25540.
55. Wu, Z., N. L. R. Bucher, and S. R. Farmer. 1996. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol. Cell. Biol. 16:4128-4136.
56. Wu, Z., Y. Xie, N. L. R. Bucher, and S. R Farmer. 1995. Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev. 9:2350-2363.
57. Yeh, W. C., Z. Cao, M. Classon, and S. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168-181.
58. Yokohama, C., X. Wang, M. R. Briggs, A. Admon, J. Wu, X. Hua, J. L. Goldstein, and M. S. Brown. 1993. SREBP-1, a basic helix-loop-helix-leucine zipper protein that controls transcription of the LDL receptor gene. Cell 75:187-197.