Thiazolidinediones (PPARγ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes

FASEB Journal

Volumn 15, Issue 1, 2001, Pages 215-220

  Smith, U ^a   Gogg, S ^a   Johansson, A ^a   Olausson, T ^a   Rotter, V ^a   Svalstedt, B ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Gene transcription; Insulin action; Insulin signaling; IRS 2; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CYCLOHEXIMIDE; INSULIN RECEPTOR SUBSTRATE 2; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; 2,4 THIAZOLIDINEDIONE; 2,4-THIAZOLIDINEDIONE; AKT1 PROTEIN, HUMAN; CELL RECEPTOR; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; ISOPROTEIN; MESSENGER RNA; MUSCLE PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN; PIOGLITAZONE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SLC2A4 PROTEIN, HUMAN; SLC2A4 PROTEIN, MOUSE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

ADIPOCYTE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; GENE EXPRESSION REGULATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ANIMAL; CELL STRAIN 3T3; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM;

ANIMALIA;

3T3 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CULTURE TECHNIQUES; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 0035172839     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0020com     Document Type: Article

References (27)

1. Characterization of new oral antidiabetic agent CS-045
2. The effect of CP 68,722, a thiazolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats
3. Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARγ agonist) action
4. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
5. Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects
6. Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates
7. PPARγ: Adipogenic regulator and thiazolidinedione receptor
8. The organization, promoter analysis, and expression of the human PPARγ gene
9. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
10. Thiazoidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
11. PPARγ induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes
12. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARγ and C/EBPα
13. Thiazolidinediones and insulin resistance: Peroxisome proliferator activated receptor gamma activation stimulates expression of the CAP gene
14. Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells
15. Acquisition of increased hormone sensitivity during in vitro adipocyte development
16. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
17. Studies of human adipose tissue in Culture III. Influence of insulin and medium glucose concentration on cellular metabolism
18. Human adipose tissue in culture. V. Studies on the metabolic effects of insulin
19. Human adipose tissue in culture. VIII. Studies on the insulin-antagonistic effect of glucocorticoids
20. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
21. Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene
22. Human insulin receptor substrate-2: Gene organization and promoter characterization
23. The RXR heterodimers and orphan receptors
24. Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes
25. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
26. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway
27. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signal- ling